spacer gif spacer gif spacer gif spacer gif spacer gif
 QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    


This Article
Right arrow Summary Freely available
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Piek, E.
Right arrow Articles by ten Dijke, P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Piek, E.
Right arrow Articles by ten Dijke, P.
Chen, Y.-G., Hata, A., Lo, R. S., Wotton, D., Shi, Y., Pavletich, N. and Massague, J (1998). Determinants of specificity in TGF-signal transduction. Genes Dev 12, 2144-2152.[Abstract/Free Full Text]

Chen, Y.-G. and Massague, J (1999). Smad1 recognition and activation by the ALK1 group of transforming growth factor-family receptors. J. Biol. Chem 274, 3672-3677.[Abstract/Free Full Text]

Cui, W., Fowlis, D. J., Bryson, S., Duffie, E., Ireland, H., Balmain, A. and Akhurst, R. J (1996). TGF1 inhibits the formation of benign skin tumors, but enhances progression to invasive spindle carcinomas in transgenic mice. Cell 86, 531-542.[Medline]

Caulin, C., Scholl, F. G., Frontelo, P., Gamallo, C. and Quintanilla, M (1995). Chronic exposure of cultured transformed epidermal cells to transforming growth factor1 induces an epithelial-mesenchymal transdifferentiation and a spindle tumoral phenotype. Cell Growth Differ 6, 1027-1035.[Abstract]

Feng, X. H. and Derynck, R (1997). A kinase subdomain of transforming growth factor-(TGF- ) type I receptor determines the TGF-intracellular signaling activity. EMBO J 16, 3912-3922.[Medline]

Franzen, P., ten Dijke, P., Ichijo, H., Yamashita, H., Schulz, P., Heldin, C.-H. and Miyazono, K (1993). Cloning of a TGF beta type I receptor that forms a heteromeric complex with the TGF beta type II receptor. Cell 75, 681-692.[Medline]

Frolik, C. A., Wakefield, L. M., Smith, D. M. and Sporn, M. B (1984). Characterization of a membrane receptor for transforming growth factor-in normal rat kidney fibroblasts. J. Biol. Chem 25, 10995-11000.

Hata, A., Shi, Y. and Massague, J (1998). TGF-signaling and cancer: structural and functional consequences of mutations in Smads. Mol. Med. Today 4, 257-262.[Medline]

Heine, U. I., Munoz, E. F., Flanders, K. C., Roberts, A. B. and Sporn, M. B (1990). Colocalization of TGF-beta 1 and collagen I and III, fibronectin and glycosaminoglycans during lung branching morphogenesis. Development 109, 29-36.[Abstract]

Heldin, C.-H., Miyazono, K. and ten Dijke, P (1997). TGF-signalling from cell membrane to nucleus through SMAD proteins. Nature 390, 465-471.[Medline]

Hogan, B. L. M. and Yingling, J. M (1998). Epithelial/mesenchymal interactions and branching morphogenesis of the lung. Curr. Opin. Genet. Dev 8, 481-486.[Medline]

Hogan, B. L. M (1999). Morphogenesis. Cell 96, 225-233.[Medline]

Jonk, L. J. C., Itoh, S., Heldin, C.-H., ten Dijke, P. and Kruijer, W (1998). Identification and functional characterization of a Smad binding element (SBE) in the JunB promoter that acts as a transforming growth factor-, activin and bone morphogenetic protein-inducible enhancer. J. Biol. Chem 273, 21145-21152.[Abstract/Free Full Text]

Kingsley, D (1994). The TGF-superfamily: new members, new receptors and new genetic tests of function in different organisms. Genes Dev 8, 133-146.[Free Full Text]

Labbe, E., Silvestri, C., Hoodless, P. A., Wrana, J. L. and Attisano, L (1998). Smad2 and Smad3 positively and negatively regulate TGF-dependent transcription through the forkhead DNA-binding protein FAST2. Mol. Cell 2, 109-120.

Link, B. A. and Nishi, R (1997). Opposing effects of activin A and follistatin on developing skeletal muscle cells. Exp. Cell. Res 233, 350-362.[Medline]

Mac\222as-Silva, M., Hoodless, P. A., Tang, S. J., Buchwald, M. and Wrana, J. L (1998). Specific activation of Smad1 signaling pathways by the BMP7 type I receptor, ALK2. J. Biol. Chem 273, 25628-25636.[Abstract/Free Full Text]

Massague, J (1998). TGF-signal transduction. Annu. Rev. Biochem 67, 753-791.[Medline]

Miettinen, P. J., Ebner, R., Lopez, A. R. and Derynck, R (1994). TGF-induced transdifferentiation of mammary epithelial cells to mesenchymal cells: involvement of type I receptors. J. Cell Biol 127, 2021-2036.[Abstract/Free Full Text]

Miyake, S., Makimura, M., Kanagae, Y., Harada, S., Sato, Y., Takamori, K., Tokuda, C., and Saito, I (1996). Efficient generation of recombinant adenoviruses using adenovirus DNA-terminal protein complex and a cosmidbearing the full length viral genome. Proc. Nat. Acad. Sci. USA 93, 1320-1324.[Abstract/Free Full Text]

Moustakas, A. and Stournaras, C (1999). Regulation of actin organisation by TGF-in H-ras transformed fibroblasts. J. Cell Sci 112, 1169-1179.[Abstract]

Nakao, A., Imamura, T., Souchelnytskyi, S., Kawabata, M., Ishisaki, A., Oeda, E., Tamaki, K., Hanai, J.-I., Heldin, C.-H., Miyazono, K. and ten Dijke, P (1997). TGF-receptor-mediated signalling through Smad2, Smad3, and Smad4. EMBO J 16, 5353-5362.[Medline]

Nishihara, T., Okahashi, N. and Ueda, N (1993). Activin A induces apoptotic cell death. Biochem. Biophys. Res. Commun 197, 985-991.[Medline]

Oft, M., Peli, J., Rudaz, C., Schwarz, H., Beug, H. and Reichmann, E (1996). TGF-1 and Ha-Ras collaborate in modulating the phenotypic plasticity and invasiveness of epithelial tumor cells. Genes Dev 10, 2462-2477.[Abstract/Free Full Text]

Oft, M., Heider, K. H. and Beug, H (1998). TGFsignaling is necessary for carcinoma cell invasiveness and metastasis. Curr. Biol 8, 1243-1252.[Medline]

Ohtsuki, M. and Massague, J (1992). Evidence for the involvement of protein kinase activity in transforming growth factor-signal transduction. Mol. Cell. Biol 12, 261-265.[Abstract/Free Full Text]

Persson, U., Izumi, H., Souchelnytskyi, S., Itoh, S., Grimsby, S., Engstr\232m, U., Heldin, C.-H., Funa, K. and ten Dijke, P (1998). The L45 loop in type I receptors for TGF-family members is a critical determinant in specifying Smad isoform activation. FEBS Lett 434, 83-87.[Medline]

Piek, E., Franzen, P., Heldin, C.-H. and ten Dijke, P (1997). Characterization of a 60-kDa cell surface-associated transforming growth factor-binding protein that can interfere with transforming growth factor- receptor binding. J. Cell. Physiol 173, 447-459.[Medline]

Piek, E., Westermark, U., Kastemar, M., Heldin, C.-H., van Zoelen, E. J. J., Nister, M. and ten Dijke, P (1999). Expression of transforming growth factor (TGF)-receptors and Smad proteins in glioblastoma cell lines with distinct responses to TGF- 1. Int. J. Cancer 80, 756-763.[Medline]

Portella, G., Cumming, S. A., Liddell, J., Cui, W., Ireland, H., Akhurst, R. J. and Balmain, A (1998). Transforming growth factoris essential for spindle cell conversion of mouse skin carcinoma in vivo: implications for tumor invasion. Cell Growth Differ 9, 393-404.[Abstract]

Qui, R. G., Chen, J., McCormick, F. and Symons, M (1995). A role for Rho in Ras transformation. Proc. Nat. Acad. Sci. USA 92, 11781-11785.[Abstract/Free Full Text]

Qui, R. G., Abo, A., McCormick, F. and Symons, M (1997). Cdc42 regulates anchorage-independent growth and is necessary for Ras transformation. Mol. Cell. Biol 17, 3449-3458.[Abstract]

Robinson, S. D., Silberstein, G. B., Roberts, A. B., Flanders, K. C. and Daniel, C. W (1991). Regulated expression and growth inhibitory effects of transforming growth factor-beta isoforms in mouse mammary gland development. Development 113, 867-878.[Abstract]

Rogers, S. A., Ryan, G., Purchio, A. F. and Hammerman, M. R (1993). Metanephric transforming growth factor-1 regulates nephrogenesis in vitro. Am. J. Physiol 264, 996-1002.

Rosenzweig, B. L., Imamura, T., Okadome, T., Cox, G. N., Yamashita, H., ten Dijke, P., Heldin, C.-H. and Miyazono, K (1995). Cloning and characterization of a human type II receptor for bone morphogenetic proteins. Proc. Nat. Acad. Sci. USA 92, 7632-7636.[Abstract/Free Full Text]

Seidel-Dugan, C., Meyer, B. E., Thomas, S. M. and Brugge, J. S (1992). Effects of SH2 and SH3 deletions on the functional activities of wild-type and transforming variants of c-Src. Mol. Cell. Biol 12, 1835-1845.[Abstract/Free Full Text]

Silberstein, G. B. and Daniel, C. W (1987). Reversible inhibition of mammary gland growth by transforming growth factor-1. Science 237, 291-293.[Abstract/Free Full Text]

ten Dijke, P., Yamashita, H., Ichijo, H., Franzen, P., Laiho, M., Miyazono, K. and Heldin, C.-H (1994). Characterization of type I receptors for transforming growth factor-and activin. Science 264, 101-104.[Abstract/Free Full Text]

Torii, Y., Hitomi, K. and Tsukagoshi, N (1996). Synergistic effect of BMP-2 and ascorbate on the phenotypic expression of osteoblastic MC3T3-E1 cells. Mol. Cell. Biochem 165, 25-29.[Medline]

Wennstr\232m, S., Hawkins, P., Cooke, F., Hara, K., Yonezawa, K., Kasuga, M., Jackson, T., Claesson-Welsh, L. and Stephens, L (1994). Activation of phosphoinositide 3-kinase is required for PDGF-stimulated membrane ruffling. Curr. Biol 4, 385-393.[Medline]

Whitman, M (1998). Smads and early developmental signaling by the TGFsuperfamily. Genes Dev 12, 2445-2462.[Free Full Text]

Wrana, J. L., Attisano, L., Wieser, R., Ventura, F. and Massague, J (1994). Mechanism of activation of the TGF-receptor. Nature 370, 341-347.[Medline]

Yamashita, H., ten Dijke, P., Huylebroeck, D., Sampath, T. K., Andries, M., Smith, J. C., Heldin, C.-H. and Miyazono, K (1995). Osteogenic protein-1 binds to activin type II receptors and induces certain activin-like effects. J. Cell Biol 130, 217-226.[Abstract/Free Full Text]




This article has been cited by other articles:


Home page
Am. J. Physiol. Renal Physiol.Home page
J. J. Kattla, R. M. Carew, M. Heljic, C. Godson, and D. P. Brazil
Protein kinase B/Akt activity is involved in renal TGF-{beta}1-driven epithelial-mesenchymal transition in vitro and in vivo
Am J Physiol Renal Physiol, July 1, 2008; 295(1): F215 - F225.
[Abstract] [Full Text] [PDF]


Home page
J. Cell Sci.Home page
M. J. Wheelock, Y. Shintani, M. Maeda, Y. Fukumoto, and K. R. Johnson
Cadherin switching
J. Cell Sci., March 15, 2008; 121(6): 727 - 735.
[Abstract] [Full Text] [PDF]


Home page
J. Biol. Chem.Home page
M. Zhang, C.-H. Lee, D. D. Luo, A. Krupa, D. Fraser, and A. Phillips
Polarity of Response to Transforming Growth Factor-beta1 in Proximal Tubular Epithelial Cells Is Regulated by beta-Catenin
J. Biol. Chem., September 28, 2007; 282(39): 28639 - 28647.
[Abstract] [Full Text] [PDF]


Home page
Cancer Res.Home page
J. T. Buijs, N. V. Henriquez, P. G.M. van Overveld, G. van der Horst, I. Que, R. Schwaninger, C. Rentsch, P. ten Dijke, A.-M. Cleton-Jansen, K. Driouch, et al.
Bone Morphogenetic Protein 7 in the Development and Treatment of Bone Metastases from Breast Cancer
Cancer Res., September 15, 2007; 67(18): 8742 - 8751.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Pathol.Home page
J. T. Buijs, C. A. Rentsch, G. van der Horst, P. G.M. van Overveld, A. Wetterwald, R. Schwaninger, N. V. Henriquez, P. ten Dijke, F. Borovecki, R. Markwalder, et al.
BMP7, a Putative Regulator of Epithelial Homeostasis in the Human Prostate, Is a Potent Inhibitor of Prostate Cancer Bone Metastasis in Vivo
Am. J. Pathol., September 1, 2007; 171(3): 1047 - 1057.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
B. C. Willis and Z. Borok
TGF-beta-induced EMT: mechanisms and implications for fibrotic lung disease
Am J Physiol Lung Cell Mol Physiol, September 1, 2007; 293(3): L525 - L534.
[Abstract] [Full Text] [PDF]


Home page
Mol. Biol. CellHome page
T. Shirakihara, M. Saitoh, and K. Miyazono
Differential Regulation of Epithelial and Mesenchymal Markers by {delta}EF1 Proteins in Epithelial Mesenchymal Transition Induced by TGF-beta
Mol. Biol. Cell, September 1, 2007; 18(9): 3533 - 3544.
[Abstract] [Full Text] [PDF]


Home page
J. Biol. Chem.Home page
S. Zhu, W. Wang, D. C. Clarke, and X. Liu
Activation of Mps1 Promotes Transforming Growth Factor-beta-independent Smad Signaling
J. Biol. Chem., June 22, 2007; 282(25): 18327 - 18338.
[Abstract] [Full Text] [PDF]


Home page
IOVSHome page
J. Choi, S. Y. Park, and C.-K. Joo
Transforming Growth Factor-{beta}1 Represses E-Cadherin Production via Slug Expression in Lens Epithelial Cells
Invest. Ophthalmol. Vis. Sci., June 1, 2007; 48(6): 2708 - 2718.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
A. M. Reynolds, W. Xia, M. D. Holmes, S. J. Hodge, S. Danilov, D. T. Curiel, N. W. Morrell, and P. N. Reynolds
Bone morphogenetic protein type 2 receptor gene therapy attenuates hypoxic pulmonary hypertension
Am J Physiol Lung Cell Mol Physiol, May 1, 2007; 292(5): L1182 - L1192.
[Abstract] [Full Text] [PDF]


Home page
Molecular Cancer TherapeuticsHome page
D. Mahadevan and D. D. Von Hoff
Tumor-stroma interactions in pancreatic ductal adenocarcinoma
Mol. Cancer Ther., April 1, 2007; 6(4): 1186 - 1197.
[Abstract] [Full Text] [PDF]


Home page
Cancer Res.Home page
C. D. Andl, B. B. Fargnoli, T. Okawa, M. Bowser, M. Takaoka, H. Nakagawa, A. Klein-Szanto, X. Hua, M. Herlyn, and A. K. Rustgi
Coordinated Functions of E-Cadherin and Transforming Growth Factor {beta} Receptor II In vitro and In vivo.
Cancer Res., October 15, 2006; 66(20): 9878 - 9885.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Pathol.Home page
M. Zhang, D. Fraser, and A. Phillips
ERK, p38, and Smad Signaling Pathways Differentially Regulate Transforming Growth Factor-{beta}1 Autoinduction in Proximal Tubular Epithelial Cells
Am. J. Pathol., October 1, 2006; 169(4): 1282 - 1293.
[Abstract] [Full Text] [PDF]


Home page
Mol. Biol. CellHome page
B. M. Zhao and F. M. Hoffmann
Inhibition of Transforming Growth Factor-beta1-induced Signaling and Epithelial-to-Mesenchymal Transition by the Smad-binding Peptide Aptamer Trx-SARA
Mol. Biol. Cell, September 1, 2006; 17(9): 3819 - 3831.
[Abstract] [Full Text] [PDF]


Home page
Clin. Cancer Res.Home page
R. Ge, V. Rajeev, P. Ray, E. Lattime, S. Rittling, S. Medicherla, A. Protter, A. Murphy, J. Chakravarty, S. Dugar, et al.
Inhibition of Growth and Metastasis of Mouse Mammary Carcinoma by Selective Inhibitor of Transforming Growth Factor-{beta} Type I Receptor Kinase In vivo.
Clin. Cancer Res., July 15, 2006; 12(14): 4315 - 4330.
[Abstract] [Full Text] [PDF]


Home page
Mol. Biol. CellHome page
Y. Shintani, M. J. Wheelock, and K. R. Johnson
Phosphoinositide-3 Kinase-Rac1-c-Jun NH2-terminal Kinase Signaling Mediates Collagen I-induced Cell Scattering and Up-Regulation of N-Cadherin Expression in Mouse Mammary Epithelial Cells
Mol. Biol. Cell, July 1, 2006; 17(7): 2963 - 2975.
[Abstract] [Full Text] [PDF]


Home page
Cancer Res.Home page
M. Deckers, M. van Dinther, J. Buijs, I. Que, C. Lowik, G. van der Pluijm, and P. ten Dijke
The Tumor Suppressor Smad4 Is Required for Transforming Growth Factor {beta}-Induced Epithelial to Mesenchymal Transition and Bone Metastasis of Breast Cancer Cells
Cancer Res., February 15, 2006; 66(4): 2202 - 2209.
[Abstract] [Full Text] [PDF]


Home page
J. Biol. Chem.Home page
M. Maeda, Y. Shintani, M. J. Wheelock, and K. R. Johnson
Src Activation Is Not Necessary for Transforming Growth Factor (TGF)-{beta}-mediated Epithelial to Mesenchymal Transitions (EMT) in Mammary Epithelial Cells: PP1 DIRECTLY INHIBITS TGF-{beta} RECEPTORS I AND II
J. Biol. Chem., January 6, 2006; 281(1): 59 - 68.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Pathol.Home page
F. Sotgia, T. M. Williams, W. Schubert, F. Medina, C. Minetti, R. G. Pestell, and M. P. Lisanti
Caveolin-1 Deficiency (-/-) Conveys Premalignant Alterations in Mammary Epithelia, with Abnormal Lumen Formation, Growth Factor Independence, and Cell Invasiveness
Am. J. Pathol., January 1, 2006; 168(1): 292 - 309.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Physiol. Cell Physiol.Home page
S. Saika, K. Ikeda, O. Yamanaka, K. C. Flanders, Y. Ohnishi, Y. Nakajima, Y. Muragaki, and A. Ooshima
Adenoviral gene transfer of BMP-7, Id2, or Id3 suppresses injury-induced epithelial-to-mesenchymal transition of lens epithelium in mice
Am J Physiol Cell Physiol, January 1, 2006; 290(1): C282 - C289.
[Abstract] [Full Text] [PDF]


Home page
Cancer Res.Home page
M. C. Wilkes, H. Mitchell, S. G. Penheiter, J. J. Dore, K. Suzuki, M. Edens, D. K. Sharma, R. E. Pagano, and E. B. Leof
Transforming Growth Factor-{beta} Activation of Phosphatidylinositol 3-Kinase Is Independent of Smad2 and Smad3 and Regulates Fibroblast Responses via p21-Activated Kinase-2
Cancer Res., November 15, 2005; 65(22): 10431 - 10440.
[Abstract] [Full Text] [PDF]


Home page
J Bone Joint Surg BrHome page
S. A. Lietman, N. Inoue, B. Rafiee, L. W. Deitz, and E. Y. S. Chao
The effect of recombinant human osteogenic protein-1 on allograft incorporation
J Bone Joint Surg Br, September 1, 2005; 87-B(9): 1292 - 1297.
[Abstract] [Full Text] [PDF]


Home page
CarcinogenesisHome page
A. N.M. Fischer, B. Herrera, M. Mikula, V. Proell, E. Fuchs, J. Gotzmann, R. Schulte-Hermann, H. Beug, and W. Mikulits
Integration of Ras subeffector signaling in TGF-{beta} mediated late stage hepatocarcinogenesis
Carcinogenesis, May 1, 2005; 26(5): 931 - 942.
[Abstract] [Full Text] [PDF]


Home page
J. Biol. Chem.Home page
C. Prunier and P. H. Howe
Disabled-2 (Dab2) Is Required for Transforming Growth Factor {beta}-induced Epithelial to Mesenchymal Transition (EMT)
J. Biol. Chem., April 29, 2005; 280(17): 17540 - 17548.
[Abstract] [Full Text] [PDF]


Home page
J. Biol. Chem.Home page
X. L. Zhang, N. Topley, T. Ito, and A. Phillips
Interleukin-6 Regulation of Transforming Growth Factor (TGF)-{beta} Receptor Compartmentalization and Turnover Enhances TGF-{beta}1 Signaling
J. Biol. Chem., April 1, 2005; 280(13): 12239 - 12245.
[Abstract] [Full Text] [PDF]


Home page
Mol. Biol. CellHome page
U. Valcourt, M. Kowanetz, H. Niimi, C.-H. Heldin, and A. Moustakas
TGF-{beta} and the Smad Signaling Pathway Support Transcriptomic Reprogramming during Epithelial-Mesenchymal Cell Transition
Mol. Biol. Cell, April 1, 2005; 16(4): 1987 - 2002.
[Abstract] [Full Text] [PDF]


Home page
J. Biol. Chem.Home page
L. Vardouli, A. Moustakas, and C. Stournaras
LIM-kinase 2 and Cofilin Phosphorylation Mediate Actin Cytoskeleton Reorganization Induced by Transforming Growth Factor-{beta}
J. Biol. Chem., March 25, 2005; 280(12): 11448 - 11457.
[Abstract] [Full Text] [PDF]


Home page
JCOHome page
R. L. Elliott and G. C. Blobe
Role of Transforming Growth Factor Beta in Human Cancer
J. Clin. Oncol., March 20, 2005; 23(9): 2078 - 2093.
[Abstract] [Full Text] [PDF]


Home page
J. Cell Sci.Home page
M. Maeda, K. R. Johnson, and M. J. Wheelock
Cadherin switching: essential for behavioral but not morphological changes during an epithelium-to-mesenchyme transition
J. Cell Sci., March 1, 2005; 118(5): 873 - 887.
[Abstract] [Full Text] [PDF]


Home page
J. Am. Soc. Nephrol.Home page
D. Y. Rhyu, Y. Yang, H. Ha, G. T. Lee, J. S. Song, S.-t. Uh, and H. B. Lee
Role of Reactive Oxygen Species in TGF-{beta}1-Induced Mitogen-Activated Protein Kinase Activation and Epithelial-Mesenchymal Transition in Renal Tubular Epithelial Cells
J. Am. Soc. Nephrol., March 1, 2005; 16(3): 667 - 675.
[Abstract] [Full Text] [PDF]


Home page
J. Biol. Chem.Home page
A. K. Kamaraju and A. B. Roberts
Role of Rho/ROCK and p38 MAP Kinase Pathways in Transforming Growth Factor-{beta}-mediated Smad-dependent Growth Inhibition of Human Breast Carcinoma Cells in Vivo
J. Biol. Chem., January 14, 2005; 280(2): 1024 - 1036.
[Abstract] [Full Text] [PDF]


Home page
Hum Exp ToxicolHome page
R. M Greene and M M. Pisano
Recent advances in understanding transforming growth factor {beta} regulation of orofacial development
Human and Experimental Toxicology, January 1, 2005; 24(1): 1 - 12.
[Abstract] [PDF]


Home page
Crit. Rev. Oral Biol. Med.Home page
S.S. Prime, M. Davies, M. Pring, and I.C. Paterson
THE ROLE OF TGF-{beta} IN EPITHELIAL MALIGNANCY AND ITS RELEVANCE TO THE PATHOGENESIS OF ORAL CANCER (PART II)
Crit. Rev. Oral. Biol. Med., November 1, 2004; 15(6): 337 - 347.
[Abstract] [Full Text] [PDF]


Home page
Mol. Biol. CellHome page
A. V. Bakin, A. Safina, C. Rinehart, C. Daroqui, H. Darbary, and D. M. Helfman
A Critical Role of Tropomyosins in TGF-{beta} Regulation of the Actin Cytoskeleton and Cell Motility in Epithelial Cells
Mol. Biol. Cell, October 1, 2004; 15(10): 4682 - 4694.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Pathol.Home page
X. L. Zhang, W. Selbi, C. de la Motte, V. Hascall, and A. Phillips
Renal Proximal Tubular Epithelial Cell Transforming Growth Factor-{beta}1 Generation and Monocyte Binding
Am. J. Pathol., September 1, 2004; 165(3): 763 - 773.
[Abstract] [Full Text] [PDF]


Home page
Cancer Res.Home page
G. Subramanian, R. E. Schwarz, L. Higgins, G. McEnroe, S. Chakravarty, S. Dugar, and M. Reiss
Targeting Endogenous Transforming Growth Factor {beta} Receptor Signaling in SMAD4-Deficient Human Pancreatic Carcinoma Cells Inhibits Their Invasive Phenotype1
Cancer Res., August 1, 2004; 64(15): 5200 - 5211.
[Abstract] [Full Text] [PDF]


Home page
J. Biol. Chem.Home page
T. Ito, J. D. Williams, D. J. Fraser, and A. O. Phillips
Hyaluronan Regulates Transforming Growth Factor-{beta}1 Receptor Compartmentalization
J. Biol. Chem., June 11, 2004; 279(24): 25326 - 25332.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Pathol.Home page
T. Ito, J. D. Williams, D. Fraser, and A. O. Phillips
Hyaluronan Attenuates Transforming Growth Factor-{beta}1-Mediated Signaling in Renal Proximal Tubular Epithelial Cells
Am. J. Pathol., June 1, 2004; 164(6): 1979 - 1988.
[Abstract] [Full Text] [PDF]


Home page
Mol. Cell. Biol.Home page
M. Kowanetz, U. Valcourt, R. Bergstrom, C.-H. Heldin, and A. Moustakas
Id2 and Id3 Define the Potency of Cell Proliferation and Differentiation Responses to Transforming Growth Factor {beta} and Bone Morphogenetic Protein
Mol. Cell. Biol., May 15, 2004; 24(10): 4241 - 4254.
[Abstract] [Full Text] [PDF]


Home page
BloodHome page
G. Prindull and D. Zipori
Environmental guidance of normal and tumor cell plasticity: epithelial mesenchymal transitions as a paradigm
Blood, April 15, 2004; 103(8): 2892 - 2899.
[Abstract] [Full Text] [PDF]


Home page
Mol. Biol. CellHome page
M. Takeda, M. Mizuide, M. Oka, T. Watabe, H. Inoue, H. Suzuki, T. Fujita, T. Imamura, K. Miyazono, and K. Miyazawa
Interaction with Smad4 Is Indispensable for Suppression of BMP Signaling by c-Ski
Mol. Biol. Cell, March 1, 2004; 15(3): 963 - 972.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Pathol.Home page
S. Saika, S. Kono-Saika, Y. Ohnishi, M. Sato, Y. Muragaki, A. Ooshima, K. C. Flanders, J. Yoo, M. Anzano, C.-Y. Liu, et al.
Smad3 Signaling Is Required for Epithelial-Mesenchymal Transition of Lens Epithelium after Injury
Am. J. Pathol., February 1, 2004; 164(2): 651 - 663.
[Abstract] [Full Text] [PDF]


Home page
Hum ReprodHome page
A.Y. Demir, P.G. Groothuis, A.W. Nap, C. Punyadeera, A.F.P.M.d. Goeij, J.L.H. Evers, and G.A.J. Dunselman
Menstrual effluent induces epithelial-mesenchymal transitions in mesothelial cells
Hum. Reprod., January 1, 2004; 19(1): 21 - 29.
[Abstract] [Full Text] [PDF]


Home page
J. Cell Biol.Home page
A. Nawshad and E. D. Hay
TGF{beta}3 signaling activates transcription of the LEF1 gene to induce epithelial mesenchymal transformation during mouse palate development
J. Cell Biol., December 22, 2003; 163(6): 1291 - 1301.
[Abstract] [Full Text] [PDF]


Home page
J. Biol. Chem.Home page
T. Ohshima and K. Shimotohno
Transforming Growth Factor-{beta}-mediated Signaling via the p38 MAP Kinase Pathway Activates Smad-dependent Transcription through SUMO-1 Modification of Smad4
J. Biol. Chem., December 19, 2003; 278(51): 50833 - 50842.
[Abstract] [Full Text] [PDF]


Home page
DevelopmentHome page
W. Li, W. Qiao, L. Chen, X. Xu, X. Yang, D. Li, C. Li, S. G. Brodie, M. M. Meguid, L. Hennighausen, et al.
Squamous cell carcinoma and mammary abscess formation through squamous metaplasia in Smad4/Dpc4 conditional knockout mice
Development, December 15, 2003; 130(24): 6143 - 6153.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Pathol.Home page
D. Fraser, N. Brunskill, T. Ito, and A. Phillips
Long-Term Exposure of Proximal Tubular Epithelial Cells to Glucose Induces Transforming Growth Factor-{beta}1 Synthesis via an Autocrine PDGF Loop
Am. J. Pathol., December 1, 2003; 163(6): 2565 - 2574.
[Abstract] [Full Text]


Home page
Proc. Natl. Acad. Sci. USAHome page
Y.-C. Yang, E. Piek, J. Zavadil, D. Liang, D. Xie, J. Heyer, P. Pavlidis, R. Kucherlapati, A. B. Roberts, and E. P. Bottinger
Hierarchical model of gene regulation by transforming growth factor {beta}
PNAS, September 2, 2003; 100(18): 10269 - 10274.
[Abstract] [Full Text] [PDF]


Home page
J. Biol. Chem.Home page
A. Moren, U. Hellman, Y. Inada, T. Imamura, C.-H. Heldin, and A. Moustakas
Differential Ubiquitination Defines the Functional Status of the Tumor Suppressor Smad4
J. Biol. Chem., August 29, 2003; 278(35): 33571 - 33582.
[Abstract] [Full Text] [PDF]


Home page
CarcinogenesisHome page
M.-H. Wang, D. Wang, and Y.-Q. Chen
Oncogenic and invasive potentials of human macrophage-stimulating protein receptor, the RON receptor tyrosine kinase
Carcinogenesis, August 1, 2003; 24(8): 1291 - 1300.
[Abstract] [Full Text] [PDF]


Home page
Mol. Cell. Biol.Home page
K. Kurisaki, A. Kurisaki, U. Valcourt, A. A. Terentiev, K. Pardali, P. ten Dijke, C.-H. Heldin, J. Ericsson, and A. Moustakas
Nuclear Factor YY1 Inhibits Transforming Growth Factor {beta}- and Bone Morphogenetic Protein-Induced Cell Differentiation
Mol. Cell. Biol., July 1, 2003; 23(13): 4494 - 4510.
[Abstract] [Full Text] [PDF]


Home page
J. Biol. Chem.Home page
H. Peinado, M. Quintanilla, and A. Cano
Transforming Growth Factor {beta}-1 Induces Snail Transcription Factor in Epithelial Cell Lines: MECHANISMS FOR EPITHELIAL MESENCHYMAL TRANSITIONS
J. Biol. Chem., May 30, 2003; 278(23): 21113 - 21123.
[Abstract] [Full Text] [PDF]


Home page
J. Biol. Chem.Home page
B. Schmierer, M. K. Schuster, A. Shkumatava, and K. Kuchler
Activin A Signaling Induces Smad2, but Not Smad3, Requiring Protein Kinase A Activity in Granulosa Cells from the Avian Ovary
J. Biol. Chem., May 30, 2003; 278(23): 21197 - 21203.
[Abstract]