Intracellular processing of endocytosed triglyceride-rich lipoproteins comprises both recycling and degradation

QUICK SEARCH:

[advanced]

	Author:		Keyword(s):

Home Help Feedback Subscriptions Archive Search Table of Contents

This Article

	Summary
	Full Text (PDF)
	Alert me when this article is cited
	Alert me if a correction is posted

Services

	Email this article to a friend
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new issues of the journal
	Download to citation manager


Citing Articles

	Citing Articles via HighWire
	Citing Articles via Google Scholar

Google Scholar

	Articles by Heeren, J.
	Articles by Beisiegel, U.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Heeren, J.
	Articles by Beisiegel, U.

Aulinskas, T. H., van der Westhuyzen, D. R., Bierman, E. L., Gevers, W. and Coetzee, G. A (1981). Retro-endocytosis of low density lipoprotein by cultured bovine aortic smooth muscle cells. Biochim. Biophys. Acta 664, 255-265.[Medline]

Aulinskas, T. H., Oram, J. F., Bierman, E. L., Coetzee, G. A., Gevers, W. and van der Westhuyzen, D. R (1985). Retro-endocytosis of low density lipoprotein by cultured human skin fibroblasts. Arteriosclerosis 5, 45-54.[Abstract/Free Full Text]

Beisiegel, U., Weber, W., Ihrke, G., Herz, J. and Stanley, K. K (1989). The LDL-receptor-related protein, LRP, is an apolipoprotein E-binding protein. Nature 341, 162-164.[Medline]

Beisiegel, U., Weber, W. and Bengtsson-Olivecrona, G (1991). Lipoprotein lipase enhances the binding of chylomicrons to low density lipoprotein receptor-related protein. Proc. Nat. Acad. Sci. USA 88, 8342-8346.[Abstract/Free Full Text]

Beisiegel, U (1995). Receptors for triglyceride-rich lipoproteins and their role in lipoprotein metabolism. Curr. Opin. Lipidol 6, 117-122.[Medline]

Bradley, W. A. and Gianturco, S. H (1986). ApoE is necessary and sufficient for the binding of large triglyceride-rich lipoproteins to the LDL receptor; apoB is unnecessary. J. Lipid Res 27, 40-48.[Abstract]

Brown, M. S., Anderson, R. G. and Goldstein, J. L (1983). Recycling receptors: the round-trip itinerary of migrant membrane proteins. Cell 32, 663-667.[Medline]

Carlsson, S. R., Roth, J., Piller, F. and Fukuda, M (1988). Isolation and characterization of human lysosomal membrane glycoproteins, h-lamp-1 and h-lamp-2. Major sialoglycoproteins carrying polylactosaminoglycan. J. Biol.Chem 263, 18911-18919.[Abstract/Free Full Text]

Carpentier, J. L., Gorden, P., Anderson, R. G., Goldstein, J. L., Brown, M. S., Cohen, S. and Orci, L (1982). Co-localization of 125I-epidermal growth factor and ferritin-low density lipoprotein in coated pits: a quantitative electron microscopic study in normal and mutant human fibroblasts. J. Cell Biol 95, 73-77.[Abstract/Free Full Text]

Chappell, D. A., Fry, G. L., Waknitz, M. A., Iverius, P. H., Williams, S. E. and Strickland, D. K (1992). The low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor binds and mediates catabolism of bovine milk lipoprotein lipase. J. Biol. Chem 267, 25764-25767.[Abstract/Free Full Text]

Ciechanover, A., Schwartz, A. L., Dautry-Varsat, A. and Lodish, H. F (1983). Kinetics of internalization and recycling of transferrin and the transferrin receptor in a human hepatoma cell line. Effect of lysosomotropic agents. J. Biol. Chem 258, 9681-9689.[Abstract/Free Full Text]

Cooper, A. D (1998). Hepatic uptake of chylomicron remnants. J. Lipid Res 38, 2173-2192.[Abstract]

Dautry-Varsat, A., Ciechanover, A. and Lodish, H. F (1983). pH and the recycling of transferrin during receptor-mediated endocytosis. Proc. Nat. Acad.Sci. USA 80, 2258-2262.[Abstract/Free Full Text]

Davis, C. G., Goldstein, J. L., Suedhof, T. C., Anderson, R. G., Russell, D. W. and Brown, M. S (1987). Acid-dependent ligand dissociation and recycling of LDL receptor mediated by growth factor homology region. Nature 326, 760-765.[Medline]

Felts, J. M., Itakura, H. and Crane, R. T (1975). The mechanism ofassimilation of constituents of chylomicrons, very low density lipoproteins and remnants \320 a new theory. Biochem. Biophys. Res. Commun 66, 1467-1475.[Medline]

Forte, T. M., McCall, M. R., Knowles, B. B. and Shore, V. G (1989). Isolation and characterization of lipoproteins produced by human hepatoma-derived cell lines other than HepG2. J. Lipid Res 30, 817-829.[Abstract]

Fraker, P. J. and Speck, J. C. J (1978). Protein and cell membrane iodinations with a sparingly soluble chloroamide, 1,3,4,6-tetrachloro-3a, 6a-diphrenylglycoluril. Biochem. Biophys. Res. Commun 80, 849-857.[Medline]

Futter, C. E., Pearse, A., Hewlett, L. J. and Hopkins, C. R (1996). Multivesicular endosomes containing internalized EGF-EGF receptor complexes mature and then fuse directly with lysosomes. J. Cell Biol 132, 1011-1023.[Abstract/Free Full Text]

Ghosh, R. N., Gelman, D. L. and Maxfield, F. R (1994). Quantification of low density lipoprotein and transferrin endocytic sorting HEp2 cells using confocal microscopy. J. Cell Sci 107, 2177-2189.[Abstract]

Goldberg, I. J., Kandel, J. J., Blum, C. B. and Ginsberg, H. N (1986). Association of plasma lipoproteins with postheparin lipase activities. J. Clin. Invest 78, 1523-1528.

Goldstein, J. L. and Brown, M. S (1974). Binding and degradation of low density lipoproteins by cultured human fibroblasts. Comparison of cells from a normal subject and from a patient with homozygous familial hypercholesterolemia. J. Biol. Chem 249, 5153-5162.[Abstract/Free Full Text]

Goldstein, J. L., Basu, S. K. and Brown, M. S (1983). Receptor-mediated endocytosis of low-density lipoprotein in cultured cells. Meth. Enzymol 98, 241-260.[Medline]

Goldstein, J. L., Brown, M. S., Anderson, R. G., Russell, D. W. and Schneider, W. J (1985). Receptor-mediated endocytosis: concepts emerging from the LDL receptor system. Annu. Rev. Cell 1, 1-39.

Griffin, B. A. and Packard, C. J (1994). Metabolism of VLDL and LDL subclasses. Curr. Opin. Lipidol 5, 200-206.[Medline]

Havel, R. J (1984). The formation of LDL: mechanisms and regulation. J. LipidRes 25, 1570-1576.[Medline]

Havel, R. J (1995). Chylomicron remnants: hepatic receptors and metabolism. Curr. Opin. Lipidol 6, 312-316.[Medline]

Hui, D. Y., Innerarity, T. L., Milne, R. W., Marcel, Y. L. and Mahley, R. W (1984). Binding of chylomicron remnants and beta-very low density lipoproteins to hepatic and extrahepatic lipoprotein receptors. A process independent of apolipoprotein B48. J. Biol. Chem 259, 15060-15068.[Abstract/Free Full Text]

Jensen, T. G., Roses, A. D. and Jorgensen, A. L (1994). Apolipoprotein E uptake and degradation via chloroquine sensitive pathway in cultivated monkey cells overexpressing low density lipoprotein receptor. Neurosci. Lett 180, 193-196.[Medline]

Jones, A. L., Hradek, G. T., Hornick, C., Renaud, G., Windler, E. E. and Havel, R. J (1984). Uptake and processing of remnants of chylomicrons and very low density lipoproteins by rat liver. J. Lipid Res 25, 1151-1158.[Abstract]

Kambouris, A. M., Roach, P. D., Calvert, G. D. and Nestel, P. J (1990). Retroendocytosis of high density lipoproteins by the human hepatoma cell line, HepG2. Arteriosclerosis 10, 582-590.[Abstract/Free Full Text]

Klausner, R. D., Ashwell, G., van Renswoude, J., Harford, J. B. and Bridges, K. R (1983). Binding of apotransferrin to K562 cells: explanation of the transferrin cycle. Proc. Nat. Acad. Sci. USA 80, 2263-2266.[Abstract/Free Full Text]

Kowal, R. C., Herz, J., Goldstein, J. L., Esser, V. and Brown, M. S (1989). Low density lipoprotein receptor-related protein mediates uptake of cholesteryl esters derived from apoprotein E-enriched lipoproteins. Proc. Nat. Acad. Sci.USA 86, 5810-5814.[Abstract/Free Full Text]

Lombardi, P., Mulder, M., van der Boom, H., Frants, R. R. and Havekes, L. M (1993). Inefficient degradation of triglyceride-rich lipoprotein by HepG2 cells is due to a retarded transport to the lysosomal compartment. J. Biol.Chem 268, 26113-26119.[Abstract/Free Full Text]

Lookene, A., Skottova, N. and Olivecrona, G (1994). Interactions of lipoprotein lipase with the active-site inhibitor tetrahydrolipstatin (Orlistat). Eur.J. Biochem 222, 395-403.[Medline]

Mann, W. A., Meyer, N., Weber, W., Rinninger, F., Greten, H. and Beisiegel, U (1995). Apolipoprotein E and lipoprotein lipase co-ordinately enhance binding and uptake of chylomicrons by human hepatocytes. Eur. J. Clin. Invest 25, 880-882.[Medline]

Marsh, E. W., Leopold, P. L., Jones, N. L. and Maxfield, F. R (1995). Oligomerized transferrin receptors are selectively retained by a lumenal sorting signal in a long-lived endocytic recycling compartment. J. Cell Biol 129, 1509-1522.[Abstract/Free Full Text]

Mayor, S., Presley, J. F. and Maxfield, F. R (1993). Sorting of membrane components from endosomes and subsequent recycling to the cell surface occurs by a bulk flow process. J. Cell Biol 121, 1257-1269.[Abstract/Free Full Text]

Mortimer, B. C., Beveridge, D. J., Martins, I. J. and Redgrave, T. G (1995). Intracellular localization and metabolism of chylomicron remnants in the livers of low density lipoprotein receptor-deficient mice and apoE-deficient mice. Evidence for slow metabolism via an alternative apoE-dependent pathway. J.Biol. Chem 270, 28767-28776.[Abstract/Free Full Text]

Myers, J. N., Tabas, I., Jones, N. L. and Maxfield, F. R (1993). Beta-very low density lipoprotein is sequestered in surface-connected tubules in mouse peritoneal macrophages. J. Cell Biol 123, 396-402.

Nykjaer, A., Bengtsson-Olivecrona, G., Lookene, A., Moestrup, S. K., Petersen, C. M., Weber, W., Beisiegel, U. and Gliemann, J (1993). The alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein binds lipoprotein lipase and beta-migrating very low density lipoprotein associated with the lipase. J. Biol. Chem 268, 15048-15055.[Abstract/Free Full Text]

Pastan, I. H. and Willingham, M. C (1981). Journey to the center of the cell: role of the receptosome. Science 214, 504-509.[Abstract/Free Full Text]

Pitas, R. E., Innerarity, T. L., Weinstein, J. N. and Mahley, R. W (1981). Acetoacetylated lipoproteins used to distinguish fibroblasts from macrophages in vitro by fluorescence microscopy. Arteriosclerosis 1, 177-185.[Abstract/Free Full Text]

Reynolds, G. D. and St Clair (1985). A comparative microscopic and biochemical study of the uptake of fluorescent and 125I-labeled lipoproteins by skin fibroblasts, smooth muscle cells, and peritoneal macrophages in culture. Am. J.Pathol 121, 200-211.[Abstract]

Skerka, C., Hellwage, J., Weber, W., Tilkorn, A., Buck, F., Marti, T., Kampen, E., Beisiegel, U. and Zipfel, P. F (1997). The human factor H-related protein 4 (FHR-4). A novel short consensus repeat-containing protein is associated with human triglyceride-rich lipoproteins. J. Biol. Chem 272, 5627-5634.[Abstract/Free Full Text]

Stoorvogel, W., Geuze, H. J., Griffith, J. M. and Strous, G. J (1988). The pathways of endocytosed transferrin and secretory protein are connected in the trans-Golgi reticulum. J. Biol. Chem 106, 1821-1829.

Stoorvogel, W., Geuze, H. J. and Strous, G. J (1987). Sorting of endocytosed transferrin and asialoglycoprotein occurs immediately after internalization in HepG2 cells. J. Biol. Chem 104, 1261-1268.

Stoorvogel, W., Strous, G. J., Geuze, H. J., Oorschot, V. and Schwartz, A. L (1991). Late endosomes derive from early endosomes by maturation. Cell 65, 417-427.[Medline]

Tabas, I., Lim, S., Xu, X. X. and Maxfield, F. R (1990). Endocytosed beta-VLDL and LDL are delivered to different intracellular vesicles in mouse peritoneal macrophages. J. Cell Biol 111, 929-940.[Abstract/Free Full Text]

Tabas, I., Myers, J. N., Innerarity, T. L., Xu, X. X., Arnold, K., Boyles, J. and Maxfield, F. R (1991). The influence of particle size and multiple apoprotein E-receptor interactions on the endocytic targeting of beta-VLDL in mouse peritoneal macrophages. J. Cell Biol 115, 1547-1560.[Abstract/Free Full Text]

Wileman, T., Harding, C. and Stahl, P (1985). Receptor-mediated endocytosis. Biochem. J 232, 1-14.[Medline]

Willnow, T. E., Sheng, Z., Ishibashi, S. and Herz, J (1994). Inhibition of hepatic chylomicron remnant uptake by gene transfer of a receptor antagonist. Science 264, 1471-1474.[Abstract/Free Full Text]

Yamashiro, D. J., Tycko, B., Fluss, S. R., Maxfield, F. R., Willingham, M. C., Hanover, J. A., Dickson, R. B. and Pastan, I (1984). Segregation of transferrin to a mildly acidic (pH 6. 5) para-Golgi compartment in the recycling pathway. Cell 81, 175-179.

Zambon, A., Schmidt, I., Beisiegel, U. and Brunzell, J. D (1996). Dimeric lipoprotein lipase is bound to triglyceride-rich plasma lipoproteins. J. Lipid Res 37, 2394-2404.[Abstract]

This article has been cited by other articles:

A. Kontush and M. J. Chapman
Functionally Defective High-Density Lipoprotein: A New Therapeutic Target at the Crossroads of Dyslipidemia, Inflammation, and Atherosclerosis
Pharmacol. Rev., September 1, 2006; 58(3): 342 - 374.
[Abstract] [Full Text] [PDF]

B. Sun, E. R. M. Eckhardt, S. Shetty, D. R. van der Westhuyzen, and N. R. Webb
Quantitative analysis of SR-BI-dependent HDL retroendocytosis in hepatocytes and fibroblasts
J. Lipid Res., August 1, 2006; 47(8): 1700 - 1713.
[Abstract] [Full Text] [PDF]

J. Heeren, U. Beisiegel, and T. Grewal
Apolipoprotein E Recycling: Implications for Dyslipidemia and Atherosclerosis
Arterioscler. Thromb. Vasc. Biol., March 1, 2006; 26(3): 442 - 448.
[Abstract] [Full Text] [PDF]

A. H. Hasty, M. R. Plummer, K. H. Weisgraber, M. F. Linton, S. Fazio, and L. L. Swift
The recycling of apolipoprotein E in macrophages: influence of HDL and apolipoprotein A-I
J. Lipid Res., July 1, 2005; 46(7): 1433 - 1439.
[Abstract] [Full Text] [PDF]

D. Van Hoof, K. W. Rodenburg, and D. J. Van der Horst
Intracellular fate of LDL receptor family members depends on the cooperation between their ligand-binding and EGF domains
J. Cell Sci., March 15, 2005; 118(6): 1309 - 1320.
[Abstract] [Full Text] [PDF]

J. Heeren, T. Grewal, A. Laatsch, N. Becker, F. Rinninger, K.-A. Rye, and U. Beisiegel
Impaired Recycling of Apolipoprotein E4 Is Associated with Intracellular Cholesterol Accumulation
J. Biol. Chem., December 31, 2004; 279(53): 55483 - 55492.
[Abstract] [Full Text] [PDF]

M. H. Farkas, K. H. Weisgraber, V. L. Shepherd, M. F. Linton, S. Fazio, and L. L. Swift
The recycling of apolipoprotein E and its amino-terminal 22 kDa fragment: evidence for multiple redundant pathways
J. Lipid Res., August 1, 2004; 45(8): 1546 - 1554.
[Abstract] [Full Text] [PDF]

M. Brundert, J. Heeren, H. Greten, and F. Rinninger
Hepatic lipase mediates an increase in selective uptake of HDL-associated cholesteryl esters by cells in culture independent from SR-BI
J. Lipid Res., May 1, 2003; 44(5): 1020 - 1032.
[Abstract] [Full Text] [PDF]

J. Heeren, T. Grewal, A. Laatsch, D. Rottke, F. Rinninger, C. Enrich, and U. Beisiegel
Recycling of Apoprotein E Is Associated with Cholesterol Efflux and High Density Lipoprotein Internalization
J. Biol. Chem., April 11, 2003; 278(16): 14370 - 14378.
[Abstract] [Full Text] [PDF]

M. H. Farkas, L. L. Swift, A. H. Hasty, M. F. Linton, and S. Fazio
The Recycling of Apolipoprotein E in Primary Cultures of Mouse Hepatocytes. EVIDENCE FOR A PHYSIOLOGIC CONNECTION TO HIGH DENSITY LIPOPROTEIN METABOLISM
J. Biol. Chem., March 7, 2003; 278(11): 9412 - 9417.
[Abstract] [Full Text] [PDF]

D. Van Hoof, K. W. Rodenburg, and D. J. Van der Horst
Insect lipoprotein follows a transferrin-like recycling pathway that is mediated by the insect LDL receptor homologue
J. Cell Sci., January 11, 2002; 115(21): 4001 - 4012.
[Abstract] [Full Text] [PDF]

J. Heeren, T. Grewal, S. Jackle, and U. Beisiegel
Recycling of Apolipoprotein E and Lipoprotein Lipase through Endosomal Compartments in Vivo
J. Biol. Chem., November 2, 2001; 276(45): 42333 - 42338.
[Abstract] [Full Text] [PDF]

S. Santamarina-Fojo, A. T. Remaley, E. B. Neufeld, and H. B. Brewer Jr.
Regulation and intracellular trafficking of the ABCA1 transporter
J. Lipid Res., September 1, 2001; 42(9): 1339 - 1345.
[Abstract] [Full Text] [PDF]

A. VON ECKARDSTEIN, C. LANGER, T. ENGEL, I. SCHAUKAL, A. CIGNARELLA, J. REINHARDT, S. LORKOWSKI, Z. LI, X. ZHOU, P. CULLEN, et al.
ATP binding cassette transporter ABCA1 modulates the secretion of apolipoprotein E from human monocyte-derived macrophages
FASEB J, July 1, 2001; 15(9): 1555 - 1561.
[Abstract] [Full Text] [PDF]

A. von Eckardstein, J.-R. Nofer, and G. Assmann
High Density Lipoproteins and Arteriosclerosis : Role of Cholesterol Efflux and Reverse Cholesterol Transport
Arterioscler. Thromb. Vasc. Biol., January 1, 2001; 21(1): 13 - 27.
[Abstract] [Full Text] [PDF]

P. C. N. Rensen, M. C. Jong, L. C. van Vark, H. van der Boom, W. L. Hendriks, T. J. C. van Berkel, E. A. L. Biessen, and L. M. Havekes
Apolipoprotein E Is Resistant to Intracellular Degradation in Vitro and in Vivo. EVIDENCE FOR RETROENDOCYTOSIS
J. Biol. Chem., March 17, 2000; 275(12): 8564 - 8571.
[Abstract] [Full Text] [PDF]

Y. Takahashi and J. D. Smith
Cholesterol efflux to apolipoprotein AI involves endocytosis and resecretion in a calcium-dependent pathway
PNAS, September 28, 1999; 96(20): 11358 - 11363.
[Abstract] [Full Text] [PDF]

L. L. Swift, M. H. Farkas, A. S. Major, K. Valyi-Nagy, M. F. Linton, and S. Fazio
A Recycling Pathway for Resecretion of Internalized Apolipoprotein E in Liver Cells
J. Biol. Chem., June 15, 2001; 276(25): 22965 - 22970.
[Abstract] [Full Text] [PDF]

E. B. Neufeld, A. T. Remaley, S. J. Demosky, J. A. Stonik, A. M. Cooney, M. Comly, N. K. Dwyer, M. Zhang, J. Blanchette-Mackie, S. Santamarina-Fojo, et al.
Cellular Localization and Trafficking of the Human ABCA1 Transporter
J. Biol. Chem., July 13, 2001; 276(29): 27584 - 27590.
[Abstract] [Full Text] [PDF]

This Article

Summary

Full Text (PDF)

Alert me when this article is cited

Alert me if a correction is posted

Services

Email this article to a friend

Similar articles in this journal

Similar articles in PubMed

Alert me to new issues of the journal

Download to citation manager

Citing Articles

Citing Articles via HighWire

Citing Articles via Google Scholar

Google Scholar

Articles by Heeren, J.

Articles by Beisiegel, U.

Search for Related Content

PubMed

PubMed Citation

Articles by Heeren, J.

Articles by Beisiegel, U.

				B. Sun, E. R. M. Eckhardt, S. Shetty, D. R. van der Westhuyzen, and N. R. Webb Quantitative analysis of SR-BI-dependent HDL retroendocytosis in hepatocytes and fibroblasts J. Lipid Res., August 1, 2006; 47(8): 1700 - 1713. [Abstract] [Full Text] [PDF]

				J. Heeren, U. Beisiegel, and T. Grewal Apolipoprotein E Recycling: Implications for Dyslipidemia and Atherosclerosis Arterioscler. Thromb. Vasc. Biol., March 1, 2006; 26(3): 442 - 448. [Abstract] [Full Text] [PDF]

				A. H. Hasty, M. R. Plummer, K. H. Weisgraber, M. F. Linton, S. Fazio, and L. L. Swift The recycling of apolipoprotein E in macrophages: influence of HDL and apolipoprotein A-I J. Lipid Res., July 1, 2005; 46(7): 1433 - 1439. [Abstract] [Full Text] [PDF]

				D. Van Hoof, K. W. Rodenburg, and D. J. Van der Horst Intracellular fate of LDL receptor family members depends on the cooperation between their ligand-binding and EGF domains J. Cell Sci., March 15, 2005; 118(6): 1309 - 1320. [Abstract] [Full Text] [PDF]

				J. Heeren, T. Grewal, A. Laatsch, N. Becker, F. Rinninger, K.-A. Rye, and U. Beisiegel Impaired Recycling of Apolipoprotein E4 Is Associated with Intracellular Cholesterol Accumulation J. Biol. Chem., December 31, 2004; 279(53): 55483 - 55492. [Abstract] [Full Text] [PDF]

				M. H. Farkas, K. H. Weisgraber, V. L. Shepherd, M. F. Linton, S. Fazio, and L. L. Swift The recycling of apolipoprotein E and its amino-terminal 22 kDa fragment: evidence for multiple redundant pathways J. Lipid Res., August 1, 2004; 45(8): 1546 - 1554. [Abstract] [Full Text] [PDF]

				M. Brundert, J. Heeren, H. Greten, and F. Rinninger Hepatic lipase mediates an increase in selective uptake of HDL-associated cholesteryl esters by cells in culture independent from SR-BI J. Lipid Res., May 1, 2003; 44(5): 1020 - 1032. [Abstract] [Full Text] [PDF]

				J. Heeren, T. Grewal, A. Laatsch, D. Rottke, F. Rinninger, C. Enrich, and U. Beisiegel Recycling of Apoprotein E Is Associated with Cholesterol Efflux and High Density Lipoprotein Internalization J. Biol. Chem., April 11, 2003; 278(16): 14370 - 14378. [Abstract] [Full Text] [PDF]

				M. H. Farkas, L. L. Swift, A. H. Hasty, M. F. Linton, and S. Fazio The Recycling of Apolipoprotein E in Primary Cultures of Mouse Hepatocytes. EVIDENCE FOR A PHYSIOLOGIC CONNECTION TO HIGH DENSITY LIPOPROTEIN METABOLISM J. Biol. Chem., March 7, 2003; 278(11): 9412 - 9417. [Abstract] [Full Text] [PDF]

				J. Heeren, T. Grewal, S. Jackle, and U. Beisiegel Recycling of Apolipoprotein E and Lipoprotein Lipase through Endosomal Compartments in Vivo J. Biol. Chem., November 2, 2001; 276(45): 42333 - 42338. [Abstract] [Full Text] [PDF]

				S. Santamarina-Fojo, A. T. Remaley, E. B. Neufeld, and H. B. Brewer Jr. Regulation and intracellular trafficking of the ABCA1 transporter J. Lipid Res., September 1, 2001; 42(9): 1339 - 1345. [Abstract] [Full Text] [PDF]

				A. VON ECKARDSTEIN, C. LANGER, T. ENGEL, I. SCHAUKAL, A. CIGNARELLA, J. REINHARDT, S. LORKOWSKI, Z. LI, X. ZHOU, P. CULLEN, et al. ATP binding cassette transporter ABCA1 modulates the secretion of apolipoprotein E from human monocyte-derived macrophages FASEB J, July 1, 2001; 15(9): 1555 - 1561. [Abstract] [Full Text] [PDF]

				A. von Eckardstein, J.-R. Nofer, and G. Assmann High Density Lipoproteins and Arteriosclerosis : Role of Cholesterol Efflux and Reverse Cholesterol Transport Arterioscler. Thromb. Vasc. Biol., January 1, 2001; 21(1): 13 - 27. [Abstract] [Full Text] [PDF]

				P. C. N. Rensen, M. C. Jong, L. C. van Vark, H. van der Boom, W. L. Hendriks, T. J. C. van Berkel, E. A. L. Biessen, and L. M. Havekes Apolipoprotein E Is Resistant to Intracellular Degradation in Vitro and in Vivo. EVIDENCE FOR RETROENDOCYTOSIS J. Biol. Chem., March 17, 2000; 275(12): 8564 - 8571. [Abstract] [Full Text] [PDF]

				Y. Takahashi and J. D. Smith Cholesterol efflux to apolipoprotein AI involves endocytosis and resecretion in a calcium-dependent pathway PNAS, September 28, 1999; 96(20): 11358 - 11363. [Abstract] [Full Text] [PDF]

				L. L. Swift, M. H. Farkas, A. S. Major, K. Valyi-Nagy, M. F. Linton, and S. Fazio A Recycling Pathway for Resecretion of Internalized Apolipoprotein E in Liver Cells J. Biol. Chem., June 15, 2001; 276(25): 22965 - 22970. [Abstract] [Full Text] [PDF]

				E. B. Neufeld, A. T. Remaley, S. J. Demosky, J. A. Stonik, A. M. Cooney, M. Comly, N. K. Dwyer, M. Zhang, J. Blanchette-Mackie, S. Santamarina-Fojo, et al. Cellular Localization and Trafficking of the Human ABCA1 Transporter J. Biol. Chem., July 13, 2001; 276(29): 27584 - 27590. [Abstract] [Full Text] [PDF]