Reduced dosage of a single fission yeast MCM protein causes genetic instability and S phase delay

QUICK SEARCH:

[advanced]

	Author:		Keyword(s):

Home Help Feedback Subscriptions Archive Search Table of Contents

This Article

	Summary
	Full Text (PDF)
	Alert me when this article is cited
	Alert me if a correction is posted

Services

	Email this article to a friend
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new issues of the journal
	Download to citation manager


Citing Articles

	Citing Articles via HighWire
	Citing Articles via Google Scholar

Google Scholar

	Articles by Liang, D. T.
	Articles by Forsburg, S. L.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Liang, D. T.
	Articles by Forsburg, S. L.

Aparicio, O. M., Weinstein, D. M. and Bell, S. P (1997). Components and dynamics of DNA replication complexes in S. cerevisiae : redistribution of MCM proteins and Cdc45p during S phase. Cell 91, 59-69.[Medline]

Bodi, Z., Gysler-Junker, A. and Kohli, J (1991). A quantitative assay to measure chromosome stability in Schizosaccharomyces pombe. Mol. Gen. Genet 229, 77-80.[Medline]

Caligiuri, M. and Beach, D (1993). Sct1 functions in partnership with Cdc10 in a transcription complex that activates cell cycle START and inhibits differentiation. Cell 72, 607-619.[Medline]

Carpenter, P. B., Mueller, P. R. and Dunphy, W. G (1996). Role for a Xenopus Orc2-related protein in controlling DNA replication. Nature 379, 357-360.[Medline]

Chong, J. P. J., Mahbubani, H. M., Khoo, C.-Y. and Blow, J. J (1995). Purification of an MCM-containing complex as a component of the DNA replication licensing system. Nature 375, 418-421.[Medline]

Chong, J. P. J., Thommes, P. and Blow, J. J (1996). The role of MCM/P1 proteins in the licensing of DNA replication. Trends Biochem. Sci 21, 102-106.[Medline]

Chu, G., Vollrath, D. and Davis, R. W (1986). Separation of large DNA molecules by contour-clamped homogeneous electric fields. Science 234, 1582-1585.[Abstract/Free Full Text]

Coleman, T. R., Carpenter, P. B. and Dunphy, W. G (1996). The Xenopus Cdc6 protein is essential for the initiation of a single round of DNA replication in cell-free extracts. Cell 87, 53-64.[Medline]

Coxon, A., Maundrell, K. and Kearsey, S. E (1992). Fission yeast cdc21+ belongs to a family of proteins involved in an early step of chromosome replication. Nucl. Acids Res 20, 5571-5577.[Abstract/Free Full Text]

D'Urso, G., Grallert, B. and Nurse, P (1995). DNA polymerase alpha, a component of the replication initiation complex, is essential for the checkpoint coupling S phase to mitosis in fission yeast. J. Cell Sci 108, 3109-3118.[Abstract]

D'Urso, G. and Nurse, P (1997). Schizosaccharomyces pombe cdc20+ encodes DNA polymerase epsilon and is required for chromosomal replication but not for the S phase checkpoint. Proc. Natl. Acad. Sci. USA 94, 12491-12496.[Abstract/Free Full Text]

Donovan, S., Harwood, J., Drury, L. S. and Diffley, J. F. X (1997). Cdc6p-dependent loading of Mcm proteins onto pre-replicative chromatin in budding yeast. Proc. Natl. Acad. Sci. USA 94, 5611-5616.[Abstract/Free Full Text]

Ekwall, K., Javerzat, J. P., Lorentz, A., Schmidt, H., Cranston, G. and Allshire, R (1995). The chromodomain protein Swi6 \320 a key component at fission yeast centromeres. Science 269, 1429-1431.[Abstract/Free Full Text]

Enoch, T. and Nurse, P (1990). Mutation of fission yeast cell cycle control genes abolishes dependence of mitosis on DNA replication. Cell 60, 665-673.[Medline]

Fernandez Sarabia, M.-J., McInerny, C., Harris, P., Gordon, C. and Fantes, P (1993). The cell cycle genes cdc22 +and suc22 +of the fission yeast Schizosaccharomyces pombe encode the large and small subunits of ribonucleotide reductase. Mol. Gen. Genet 238, 241-251.[Medline]

Forsburg, S. L. and Nurse, P (1994). The fission yeast cdc19 +gene encodes a member of the MCM family of replication proteins. J. Cell Sci 107, 2779-2788.[Abstract]

Forsburg, S. L., Sherman, D. A., Ottilie, S., Yasuda, J. R. and Hodson, J. A (1997). Mutational analysis of Cdc19p, a Schizosaccharomyces pombe MCM protein. Genetics 147, 1025-1041.[Abstract]

Francesconi, S., De Recondo, A. M. and Baldacci, G (1995). DNA polymerase delta is required for the replication feedback control of cell cycle progression in Schizosaccharomyces pombe. Mol. Gen. Genet 246, 561-569.[Medline]

Francesconi, S., Park, H. and Wang, T. S. F (1993). Fission yeast with DNA polymerase delta temperature sensitive alleles exhibits cell division cycle phenotype. Nucl. Acids Res 21, 3821-3828.[Abstract/Free Full Text]

Gould, K. L., Burns, C. G., Feoktistova, A., Hu, C.-P., Pasion, S. G. and Forsburg, S. L (1998). Fission yeast cdc24+ encodes a novel replication factor required for chromosome integrity. Genetics 149, 1221-1233.[Abstract/Free Full Text]

Grallert, B. and Nurse, P (1996). The ORC1 homolog orp1 in fission yeast plays a key role in regulating onset of S phase. Genes Dev 10, 2644-2654.[Abstract/Free Full Text]

Hennessy, K. M., Lee, A., Chen, E. and Botstein, D (1991). A group of interacting yeast DNA replication genes. Genes Dev 5, 958-969.[Abstract/Free Full Text]

Iino, Y. and Yamamoto, M (1997). The Schizosaccharomyces pombe cdc6 gene encodes the catalytic subunit of DNA polymerase delta. Mol. Gen. Genet 254, 93-97.[Medline]

Johnston, L., Barker, D. and Nurse, P (1986). Molecular cloning of the Schizosaccharomyces pombe DNA ligase gene cdc17 and an associated sequence promoting high frequency plasmid transformation. Gene 41, 321-325.[Medline]

Kearsey, S. E. and Labib, K (1998). MCM proteins: evolution, properties, and role in DNA replication. Biochim Biophys Acta 1398, 113-136.[Medline]

Kelly, T. J., Martin, G. S., Forsburg, S. L., Stephen, R. J., Russo, A. and Nurse, P (1993). The fission yeast cdc18 +gene product couples S phase to START and mitosis. Cell 74, 371-382.[Medline]

Kubota, Y., Mimura, S., Nishimoto, S.-I., Takisawa, H. and Nojima, H (1995). Identification of the yeast MCM3 related protein as a component of Xenopus DNA replication licensing factor. Cell 81, 601-609.[Medline]

Lei, M., Kawasaki, Y. and Tye, B. K (1996). Physical interactions among MCM proteins and effects of MCM dosage on DNA replication in Saccharomyces cerevisiae. Mol. Cell. Biol 16, 5081-5090.[Abstract]

Lindsay, H. D., Griffiths, D. J. F., Edwards, R. J., Christensen, P. U., Murray, J. M., Osman, F., Walworth, N. and Carr, A. M (1998). S-phase-specific activation of Cds1 kinase defines a subpathway of the checkpoint response in Schizosaccharomyces pombe. Genes Dev 12, 382-395.[Abstract/Free Full Text]

Lorentz, A., Ostermann, K., Fleck, O. and Schmidt, H (1994). Switching gene swi6, involved in repression of silent mating-type loci in fission yeast, encodes a homolog of chromatin-associated proteins from drosophila and mammals. Gene 143, 139-143.[Medline]

Madine, M. A., Khoo, C.-Y., Mills, A. D. and Laskey, R. A (1995). MCM3 complex required for cell cycle regulation of DNA replication in vertebrate cells. Nature 375, 421-424.[Medline]

Maiorano, D., Blom van Assendelft, G. and Kearsey, S. E (1996). Fission yeast cdc21, a member of the MCM protein family, is required for onset ofS phase and located in the nucleus throughout the cell cycle. EMBO J 15, 861-872.[Medline]

Miyake, S., Okishio, N., Samejima, I., Hiraoka, Y., Toda, T., Saitoh, I. and Yanagida, M (1993). Fission yeast genes nda1 +and nda4 +, mutations of which lead to S-phase block, chromatin alteration and Ca2+suppression, are members of the CDC46 / MCM2 family. Mol. Biol. Cell 4, 1003-1015.[Abstract]

Moreno, S., Klar, A. and Nurse, P (1991). Molecular genetic analysis of the fission yeast Schizosaccharomyces pombe. Methods Enzymol 194, 795-823.[Medline]

Nasmyth, K (1977). Temperature-sensitive lethal mutants in the structural gene for DNA ligase in the yeast Schizosaccharomyces pombe. Cell 12, 1109-1120.[Medline]

Nasmyth, K. and Nurse, P (1981). Cell division cycle mutants altered in DNA replication and mitosis in the fission yeast Schizosaccharomyces pombe. Mol. Gen. Genet 182, 119-124.[Medline]

Nurse, P., Thuriaux, P. and Nasmyth, K (1976). Genetic control of the cell division cycle in the fission yeast Schizosaccharomyces pombe. Mol. Gen. Genet 146, 167-178.[Medline]

Ohi, R., Feoktistova, A. and Gould, K. L (1996). Construction of vectors and a genomic library for use with his3 deficient strains of Schizosaccharomyces pombe. Gene 174, 315-318.[Medline]

Okishio, N., Adachi, Y. and Yanagida, M (1996). Fission yeast nda1 and nda4, MCM homologs required for DNA replication, are constitutive nuclear proteins. J. Cell Sci 109, 319-326.[Abstract]

Rhind, N. and Russell, P (1998). The Schizosaccharomyces pombe S-phase checkpoint differentiates between different types of DNA damage. Genetics 149, 1729-1737.[Abstract/Free Full Text]

Romanowski, P., Madine, M. A., Rowles, A., Blow, J. J. and Laskey, R. A (1996). The Xenopus origin recognition complex is essential for DNA replication and MCM binding to chromatin. Curr. Biol 6, 1416-1425.[Medline]

Rowles, A. and Blow, J. J (1997). Chromatin proteins involved in the initiation of DNA replication. Curr. Opin. Genet. Dev 7, 152-157.[Medline]

Rowles, A., Chong, J. P. J., Brown, L., Howell, M., Evan, G. I. and Blow, J. J (1996). Interaction between the origin recognition complex and the replication licensing system in Xenopus. Cell 87, 287-296.[Medline]

Sazer, S. and Sherwood, S. W (1990). Mitochondrial growth and DNA synthesis occur in the absence of nuclear DNA replication in fission yeast. J. Cell Sci 97, 509-516.[Abstract/Free Full Text]

Sherman, D. A. and Forsburg, S. L (1998). Schizosaccharomyces pombe Mcm3p, an essential nuclear protein, associates tightly with Nda4p (Mcm5p). Nucl. Acids Res 26, 3955-3960.[Abstract/Free Full Text]

Sherman, D. A., Pasion, S. G. and Forsburg, S. L (1998). Fission yeast Cdc19p (MCM2) associates with a core complex containing Cdc21p (MCM4) and Mis5p (MCM6). Mol. Biol. Cell 9, 1833-1845.[Abstract/Free Full Text]

Sinha, P., Chang, V. and Tye, B. K (1986). A mutant that affects the function of autonomously replicating sequences in yeast. J. Mol. Biol 192, 805-814.[Medline]

Stewart, E., Chapman, C. R., Al-Khodairy, F., Carr, A. M. and Enoch, T (1997). rqh1+ , a fission yeast gene related to the Bloom's and Werner's syndrome genes, is required for reversible S phase arrest. EMBO J 16, 2682-2692.[Medline]

Takahashi, K., Yamada, H. and Yanagida, M (1994). Fission yeast minichromosome loss mutants mis cause lethal aneuploidy and replication abnormality. Mol. Biol. Cell 5, 1145-1158.[Abstract]

Tanaka, K., Okazaki, K., Okazaki, N., Ueda, T., Sugiyama, A., Nojima, H. and Okayama, H (1992). A new cdc gene required for S phase entry of Schizosaccharomyces pombe encodes a protein similar to the cdc10 +and SWI4 gene products. EMBO J 11, 4923-4932.[Medline]

Tanaka, T., Knapp, D. and Nasmyth, K (1997). Loading of an MCM protein onto DNA replication origins is regulated by Cdc6p and CDKs. Cell 90, 649-660.[Medline]

Toda, T., Nakaseko, Y., Niwa, O. and Yanagida, M (1984). Mapping of rDNA genes by integration of hybrid plasmids in Schizosaccharomyces pombe. Curr. Genet 8, 93-97.

Waseem, N. H., Labib, K., Nurse, P. and Lane, D. P (1992). Isolation and analysis of the fission yeast gene encoding polymeraseaccessory protein PCNA. EMBO J 11, 5111-5120.[Medline]

This article has been cited by other articles:

C. Vogl, C. M. Klein, A. F. Batke, M. E. Schweingruber, and J. Stolz
Characterization of Thi9, a Novel Thiamine (Vitamin B1) Transporter from Schizosaccharomyces pombe
J. Biol. Chem., March 21, 2008; 283(12): 7379 - 7389.
[Abstract] [Full Text] [PDF]

J. M. Bailis, D. D. Luche, T. Hunter, and S. L. Forsburg
Minichromosome Maintenance Proteins Interact with Checkpoint and Recombination Proteins To Promote S-Phase Genome Stability
Mol. Cell. Biol., March 1, 2008; 28(5): 1724 - 1738.
[Abstract] [Full Text] [PDF]

C. M. Lake, K. Teeter, S. L. Page, R. Nielsen, and R. S. Hawley
A Genetic Analysis of the Drosophila mcm5 Gene Defines a Domain Specifically Required for Meiotic Recombination
Genetics, August 1, 2007; 176(4): 2151 - 2163.
[Abstract] [Full Text] [PDF]

K. A. Braun and L. L. Breeden
Nascent Transcription of MCM2-7 Is Important for Nuclear Localization of the Minichromosome Maintenance Complex in G1
Mol. Biol. Cell, April 1, 2007; 18(4): 1447 - 1456.
[Abstract] [Full Text] [PDF]

H. Pan, Y. Deng, and J. W. Pollard
Progesterone blocks estrogen-induced DNA synthesis through the inhibition of replication licensing
PNAS, September 19, 2006; 103(38): 14021 - 14026.
[Abstract] [Full Text] [PDF]

G. Grossmann, M. Opekarova, L. Novakova, J. Stolz, and W. Tanner
Lipid Raft-Based Membrane Compartmentation of a Plant Transport Protein Expressed in Saccharomyces cerevisiae
Eukaryot. Cell, June 1, 2006; 5(6): 945 - 953.
[Abstract] [Full Text] [PDF]

X. Wang, Y. Xu, Y. Han, S. Bao, J. Du, M. Yuan, Z. Xu, and K. Chong
Overexpression of RAN1 in Rice and Arabidopsis Alters Primordial Meristem, Mitotic Progress, and Sensitivity to Auxin
Plant Physiology, January 1, 2006; 140(1): 91 - 101.
[Abstract] [Full Text] [PDF]

P. Reihl and J. Stolz
The Monocarboxylate Transporter Homolog Mch5p Catalyzes Riboflavin (Vitamin B2) Uptake in Saccharomyces cerevisiae
J. Biol. Chem., December 2, 2005; 280(48): 39809 - 39817.
[Abstract] [Full Text] [PDF]

M. Weinberger, L. Ramachandran, L. Feng, K. Sharma, X. Sun, M. Marchetti, J. A. Huberman, and W. C. Burhans
Apoptosis in budding yeast caused by defects in initiation of DNA replication
J. Cell Sci., August 1, 2005; 118(15): 3543 - 3553.
[Abstract] [Full Text] [PDF]

E. Sommariva, T. K. Pellny, N. Karahan, S. Kumar, J. A. Huberman, and J. Z. Dalgaard
Schizosaccharomyces pombe Swi1, Swi3, and Hsk1 Are Components of a Novel S-Phase Response Pathway to Alkylation Damage
Mol. Cell. Biol., April 1, 2005; 25(7): 2770 - 2784.
[Abstract] [Full Text] [PDF]

D. G. Pankratz and S. L. Forsburg
Meiotic S-Phase Damage Activates Recombination without Checkpoint Arrest
Mol. Biol. Cell, April 1, 2005; 16(4): 1651 - 1660.
[Abstract] [Full Text] [PDF]

J. Stolz, H. J. P. Wohrmann, and C. Vogl
Amiloride Uptake and Toxicity in Fission Yeast Are Caused by the Pyridoxine Transporter Encoded by bsu1+ (car1+)
Eukaryot. Cell, February 1, 2005; 4(2): 319 - 326.
[Abstract] [Full Text] [PDF]

H. Y. Yoo, A. Shevchenko, A. Shevchenko, and W. G. Dunphy
Mcm2 Is a Direct Substrate of ATM and ATR during DNA Damage and DNA Replication Checkpoint Responses
J. Biol. Chem., December 17, 2004; 279(51): 53353 - 53364.
[Abstract] [Full Text] [PDF]

D. Shechter, C. Y. Ying, and J. Gautier
DNA Unwinding Is an MCM Complex-dependent and ATP Hydrolysis-dependent Process
J. Biol. Chem., October 29, 2004; 279(44): 45586 - 45593.
[Abstract] [Full Text] [PDF]

J. Stolz, T. Caspari, A. M. Carr, and N. Sauer
Cell Division Defects of Schizosaccharomyces pombe liz1- Mutants Are Caused by Defects in Pantothenate Uptake
Eukaryot. Cell, April 1, 2004; 3(2): 406 - 412.
[Abstract] [Full Text] [PDF]

S. L. Forsburg
Eukaryotic MCM Proteins: Beyond Replication Initiation
Microbiol. Mol. Biol. Rev., March 1, 2004; 68(1): 109 - 131.
[Abstract] [Full Text] [PDF]

J. A. Hodson, J. M. Bailis, and S. L. Forsburg
Efficient labeling of fission yeast Schizosaccharomyces pombe with thymidine and BUdR
Nucleic Acids Res., November 1, 2003; 31(21): e134 - e134.
[Abstract] [Full Text] [PDF]

R. Dziak, D. Leishman, M. Radovic, B. K. Tye, and K. Yankulov
Evidence for a Role of MCM (Mini-chromosome Maintenance)5 in Transcriptional Repression of Sub-telomeric and Ty-proximal Genes in Saccharomyces cerevisiae
J. Biol. Chem., July 18, 2003; 278(30): 27372 - 27381.
[Abstract] [Full Text] [PDF]

C. Gajate, F. An, and F. Mollinedo
Differential Cytostatic and Apoptotic Effects of Ecteinascidin-743 in Cancer Cells. TRANSCRIPTION-DEPENDENT CELL CYCLE ARREST AND TRANSCRIPTION-INDEPENDENT JNK AND MITOCHONDRIAL MEDIATED APOPTOSIS
J. Biol. Chem., October 25, 2002; 277(44): 41580 - 41589.
[Abstract] [Full Text] [PDF]

E. B. Gomez, M. G. Catlett, and S. L. Forsburg
Different Phenotypes in Vivo Are Associated With ATPase Motif Mutations in Schizosaccharomyces pombe Minichromosome Maintenance Proteins
Genetics, April 1, 2002; 160(4): 1305 - 1318.
[Abstract] [Full Text] [PDF]

D. T. Liang and S. L. Forsburg
Characterization of Schizosaccharomyces pombe mcm7+ and cdc23+ (MCM10) and Interactions With Replication Checkpoints
Genetics, October 1, 2001; 159(2): 471 - 486.
[Abstract] [Full Text] [PDF]

H. A. Snaith, G. W. Brown, and S. L. Forsburg
Schizosaccharomyces pombe Hsk1p Is a Potential Cds1p Target Required for Genome Integrity
Mol. Cell. Biol., November 1, 2000; 20(21): 7922 - 7932.
[Abstract] [Full Text]

D. T. Bishop, W. H. McDonald, K. L. Gould, and S. L. Forsburg
Isolation of an essential Schizosaccharomyces pombe gene, prp31+, that links splicing and meiosis
Nucleic Acids Res., June 1, 2000; 28(11): 2214 - 2220.
[Abstract] [Full Text] [PDF]

M. Bezanilla and T. D. Pollard
Myosin-II Tails Confer Unique Functions in Schizosaccharomyces pombe: Characterization of a Novel Myosin-II Tail
Mol. Biol. Cell, January 1, 2000; 11(1): 79 - 91.
[Abstract] [Full Text]

Z. You, Y. Komamura, and Y. Ishimi
Biochemical Analysis of the Intrinsic Mcm4-Mcm6-Mcm7 DNA Helicase Activity
Mol. Cell. Biol., December 1, 1999; 19(12): 8003 - 8015.
[Abstract] [Full Text] [PDF]

S. G. Pasion and S. L. Forsburg
Nuclear Localization of Schizosaccharomyces pombe Mcm2/Cdc19p Requires MCM Complex Assembly
Mol. Biol. Cell, December 1, 1999; 10(12): 4043 - 4057.
[Abstract] [Full Text]

H. A. Snaith and S. L. Forsburg
Rereplication Phenomenon in Fission Yeast Requires MCM Proteins and Other S Phase Genes
Genetics, July 1, 1999; 152(3): 839 - 851.
[Abstract] [Full Text]

D. F. Shechter, C. Y. Ying, and J. Gautier
The Intrinsic DNA Helicase Activity of Methanobacterium thermoautotrophicum Delta H Minichromosome Maintenance Protein
J. Biol. Chem., May 12, 2000; 275(20): 15049 - 15059.
[Abstract] [Full Text] [PDF]

This Article

Summary

Full Text (PDF)

Alert me when this article is cited

Alert me if a correction is posted

Services

Email this article to a friend

Similar articles in this journal

Similar articles in PubMed

Alert me to new issues of the journal

Download to citation manager

Citing Articles

Citing Articles via HighWire

Citing Articles via Google Scholar

Google Scholar

Articles by Liang, D. T.

Articles by Forsburg, S. L.

Search for Related Content

PubMed

PubMed Citation

Articles by Liang, D. T.

Articles by Forsburg, S. L.

				J. M. Bailis, D. D. Luche, T. Hunter, and S. L. Forsburg Minichromosome Maintenance Proteins Interact with Checkpoint and Recombination Proteins To Promote S-Phase Genome Stability Mol. Cell. Biol., March 1, 2008; 28(5): 1724 - 1738. [Abstract] [Full Text] [PDF]

				C. M. Lake, K. Teeter, S. L. Page, R. Nielsen, and R. S. Hawley A Genetic Analysis of the Drosophila mcm5 Gene Defines a Domain Specifically Required for Meiotic Recombination Genetics, August 1, 2007; 176(4): 2151 - 2163. [Abstract] [Full Text] [PDF]

				K. A. Braun and L. L. Breeden Nascent Transcription of MCM2-7 Is Important for Nuclear Localization of the Minichromosome Maintenance Complex in G1 Mol. Biol. Cell, April 1, 2007; 18(4): 1447 - 1456. [Abstract] [Full Text] [PDF]

				H. Pan, Y. Deng, and J. W. Pollard Progesterone blocks estrogen-induced DNA synthesis through the inhibition of replication licensing PNAS, September 19, 2006; 103(38): 14021 - 14026. [Abstract] [Full Text] [PDF]

				G. Grossmann, M. Opekarova, L. Novakova, J. Stolz, and W. Tanner Lipid Raft-Based Membrane Compartmentation of a Plant Transport Protein Expressed in Saccharomyces cerevisiae Eukaryot. Cell, June 1, 2006; 5(6): 945 - 953. [Abstract] [Full Text] [PDF]

				X. Wang, Y. Xu, Y. Han, S. Bao, J. Du, M. Yuan, Z. Xu, and K. Chong Overexpression of RAN1 in Rice and Arabidopsis Alters Primordial Meristem, Mitotic Progress, and Sensitivity to Auxin Plant Physiology, January 1, 2006; 140(1): 91 - 101. [Abstract] [Full Text] [PDF]

				P. Reihl and J. Stolz The Monocarboxylate Transporter Homolog Mch5p Catalyzes Riboflavin (Vitamin B2) Uptake in Saccharomyces cerevisiae J. Biol. Chem., December 2, 2005; 280(48): 39809 - 39817. [Abstract] [Full Text] [PDF]

				M. Weinberger, L. Ramachandran, L. Feng, K. Sharma, X. Sun, M. Marchetti, J. A. Huberman, and W. C. Burhans Apoptosis in budding yeast caused by defects in initiation of DNA replication J. Cell Sci., August 1, 2005; 118(15): 3543 - 3553. [Abstract] [Full Text] [PDF]

				E. Sommariva, T. K. Pellny, N. Karahan, S. Kumar, J. A. Huberman, and J. Z. Dalgaard Schizosaccharomyces pombe Swi1, Swi3, and Hsk1 Are Components of a Novel S-Phase Response Pathway to Alkylation Damage Mol. Cell. Biol., April 1, 2005; 25(7): 2770 - 2784. [Abstract] [Full Text] [PDF]

				D. G. Pankratz and S. L. Forsburg Meiotic S-Phase Damage Activates Recombination without Checkpoint Arrest Mol. Biol. Cell, April 1, 2005; 16(4): 1651 - 1660. [Abstract] [Full Text] [PDF]

				J. Stolz, H. J. P. Wohrmann, and C. Vogl Amiloride Uptake and Toxicity in Fission Yeast Are Caused by the Pyridoxine Transporter Encoded by bsu1+ (car1+) Eukaryot. Cell, February 1, 2005; 4(2): 319 - 326. [Abstract] [Full Text] [PDF]

				H. Y. Yoo, A. Shevchenko, A. Shevchenko, and W. G. Dunphy Mcm2 Is a Direct Substrate of ATM and ATR during DNA Damage and DNA Replication Checkpoint Responses J. Biol. Chem., December 17, 2004; 279(51): 53353 - 53364. [Abstract] [Full Text] [PDF]

				D. Shechter, C. Y. Ying, and J. Gautier DNA Unwinding Is an MCM Complex-dependent and ATP Hydrolysis-dependent Process J. Biol. Chem., October 29, 2004; 279(44): 45586 - 45593. [Abstract] [Full Text] [PDF]

				J. Stolz, T. Caspari, A. M. Carr, and N. Sauer Cell Division Defects of Schizosaccharomyces pombe liz1- Mutants Are Caused by Defects in Pantothenate Uptake Eukaryot. Cell, April 1, 2004; 3(2): 406 - 412. [Abstract] [Full Text] [PDF]

				S. L. Forsburg Eukaryotic MCM Proteins: Beyond Replication Initiation Microbiol. Mol. Biol. Rev., March 1, 2004; 68(1): 109 - 131. [Abstract] [Full Text] [PDF]

				J. A. Hodson, J. M. Bailis, and S. L. Forsburg Efficient labeling of fission yeast Schizosaccharomyces pombe with thymidine and BUdR Nucleic Acids Res., November 1, 2003; 31(21): e134 - e134. [Abstract] [Full Text] [PDF]

				R. Dziak, D. Leishman, M. Radovic, B. K. Tye, and K. Yankulov Evidence for a Role of MCM (Mini-chromosome Maintenance)5 in Transcriptional Repression of Sub-telomeric and Ty-proximal Genes in Saccharomyces cerevisiae J. Biol. Chem., July 18, 2003; 278(30): 27372 - 27381. [Abstract] [Full Text] [PDF]

				C. Gajate, F. An, and F. Mollinedo Differential Cytostatic and Apoptotic Effects of Ecteinascidin-743 in Cancer Cells. TRANSCRIPTION-DEPENDENT CELL CYCLE ARREST AND TRANSCRIPTION-INDEPENDENT JNK AND MITOCHONDRIAL MEDIATED APOPTOSIS J. Biol. Chem., October 25, 2002; 277(44): 41580 - 41589. [Abstract] [Full Text] [PDF]

				E. B. Gomez, M. G. Catlett, and S. L. Forsburg Different Phenotypes in Vivo Are Associated With ATPase Motif Mutations in Schizosaccharomyces pombe Minichromosome Maintenance Proteins Genetics, April 1, 2002; 160(4): 1305 - 1318. [Abstract] [Full Text] [PDF]

				D. T. Liang and S. L. Forsburg Characterization of Schizosaccharomyces pombe mcm7+ and cdc23+ (MCM10) and Interactions With Replication Checkpoints Genetics, October 1, 2001; 159(2): 471 - 486. [Abstract] [Full Text] [PDF]

				H. A. Snaith, G. W. Brown, and S. L. Forsburg Schizosaccharomyces pombe Hsk1p Is a Potential Cds1p Target Required for Genome Integrity Mol. Cell. Biol., November 1, 2000; 20(21): 7922 - 7932. [Abstract] [Full Text]

				D. T. Bishop, W. H. McDonald, K. L. Gould, and S. L. Forsburg Isolation of an essential Schizosaccharomyces pombe gene, prp31+, that links splicing and meiosis Nucleic Acids Res., June 1, 2000; 28(11): 2214 - 2220. [Abstract] [Full Text] [PDF]

				M. Bezanilla and T. D. Pollard Myosin-II Tails Confer Unique Functions in Schizosaccharomyces pombe: Characterization of a Novel Myosin-II Tail Mol. Biol. Cell, January 1, 2000; 11(1): 79 - 91. [Abstract] [Full Text]

				Z. You, Y. Komamura, and Y. Ishimi Biochemical Analysis of the Intrinsic Mcm4-Mcm6-Mcm7 DNA Helicase Activity Mol. Cell. Biol., December 1, 1999; 19(12): 8003 - 8015. [Abstract] [Full Text] [PDF]

				S. G. Pasion and S. L. Forsburg Nuclear Localization of Schizosaccharomyces pombe Mcm2/Cdc19p Requires MCM Complex Assembly Mol. Biol. Cell, December 1, 1999; 10(12): 4043 - 4057. [Abstract] [Full Text]

				H. A. Snaith and S. L. Forsburg Rereplication Phenomenon in Fission Yeast Requires MCM Proteins and Other S Phase Genes Genetics, July 1, 1999; 152(3): 839 - 851. [Abstract] [Full Text]

				D. F. Shechter, C. Y. Ying, and J. Gautier The Intrinsic DNA Helicase Activity of Methanobacterium thermoautotrophicum Delta H Minichromosome Maintenance Protein J. Biol. Chem., May 12, 2000; 275(20): 15049 - 15059. [Abstract] [Full Text] [PDF]