Formation of a primitive ectoderm like cell population, EPL cells, from ES cells in response to biologically derived factors

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				B.V. Johnson, N. Shindo, P.D. Rathjen, J. Rathjen, and R.A. Keough Understanding pluripotency--how embryonic stem cells keep their options open Mol. Hum. Reprod., September 1, 2008; 14(9): 513 - 520. [Abstract] [Full Text] [PDF]

				A. K. Yocum, T. E. Gratsch, N. Leff, J. R. Strahler, C. L. Hunter, A. K. Walker, G. Michailidis, G. S. Omenn, K. S. O'Shea, and P. C. Andrews Coupled Global and Targeted Proteomics of Human Embryonic Stem Cells during Induced Differentiation Mol. Cell. Proteomics, April 1, 2008; 7(4): 750 - 767. [Abstract] [Full Text] [PDF]

				Y. Toyooka, D. Shimosato, K. Murakami, K. Takahashi, and H. Niwa Identification and characterization of subpopulations in undifferentiated ES cell culture Development, March 1, 2008; 135(5): 909 - 918. [Abstract] [Full Text] [PDF]

				M. P. Stavridis, J. S. Lunn, B. J. Collins, and K. G. Storey A discrete period of FGF-induced Erk1/2 signalling is required for vertebrate neural specification Development, August 15, 2007; 134(16): 2889 - 2894. [Abstract] [Full Text] [PDF]

				T. Kunath, M. K. Saba-El-Leil, M. Almousailleakh, J. Wray, S. Meloche, and A. Smith FGF stimulation of the Erk1/2 signalling cascade triggers transition of pluripotent embryonic stem cells from self-renewal to lineage commitment Development, August 15, 2007; 134(16): 2895 - 2902. [Abstract] [Full Text] [PDF]

				T. Kato, T. Heike, K. Okawa, M. Haruyama, K. Shiraishi, M. Yoshimoto, M. Nagato, M. Shibata, T. Kumada, Y. Yamanaka, et al. A neurosphere-derived factor, cystatin C, supports differentiation of ES cells into neural stem cells PNAS, April 11, 2006; 103(15): 6019 - 6024. [Abstract] [Full Text] [PDF]

				H. Darr, Y. Mayshar, and N. Benvenisty Overexpression of NANOG in human ES cells enables feeder-free growth while inducing primitive ectoderm features. Development, March 1, 2006; 133(6): 1193 - 1201. [Abstract] [Full Text] [PDF]

				A. Kubo, V. Chen, M. Kennedy, E. Zahradka, G. Q. Daley, and G. Keller The homeobox gene HEX regulates proliferation and differentiation of hemangioblasts and endothelial cells during ES cell differentiation Blood, June 15, 2005; 105(12): 4590 - 4597. [Abstract] [Full Text] [PDF]

				G. Keller Embryonic stem cell differentiation: emergence of a new era in biology and medicine Genes & Dev., May 15, 2005; 19(10): 1129 - 1155. [Abstract] [Full Text] [PDF]

				A. M. Wobus and K. R. Boheler Embryonic Stem Cells: Prospects for Developmental Biology and Cell Therapy Physiol Rev, April 1, 2005; 85(2): 635 - 678. [Abstract] [Full Text] [PDF]

				J. White, E. Stead, R. Faast, S. Conn, P. Cartwright, and S. Dalton Developmental Activation of the Rb-E2F Pathway and Establishment of Cell Cycle-regulated Cyclin-dependent Kinase Activity during Embryonic Stem Cell Differentiation Mol. Biol. Cell, April 1, 2005; 16(4): 2018 - 2027. [Abstract] [Full Text] [PDF]

				S. J. Kavanagh, T. C. Schulz, P. Davey, C. Claudianos, C. Russell, and P. D. Rathjen A family of RS domain proteins with novel subcellular localization and trafficking Nucleic Acids Res., March 1, 2005; 33(4): 1309 - 1322. [Abstract] [Full Text] [PDF]

				T. P. Zwaka and J. A. Thomson A germ cell origin of embryonic stem cells? Development, January 15, 2005; 132(2): 227 - 233. [Abstract] [Full Text] [PDF]

				R. R. Rao and S. L. Stice Gene Expression Profiling of Embryonic Stem Cells Leads to Greater Understanding of Pluripotency and Early Developmental Events Biol Reprod, December 1, 2004; 71(6): 1772 - 1778. [Abstract] [Full Text] [PDF]

				K. S. O'Shea Self-renewal vs. Differentiation of Mouse Embryonic Stem Cells Biol Reprod, December 1, 2004; 71(6): 1755 - 1765. [Abstract] [Full Text] [PDF]

				A. Kubo, K. Shinozaki, J. M. Shannon, V. Kouskoff, M. Kennedy, S. Woo, H. J. Fehling, and G. Keller Development of definitive endoderm from embryonic stem cells in culture Development, April 1, 2004; 131(7): 1651 - 1662. [Abstract] [Full Text] [PDF]

				G. Lacaud, V. Kouskoff, A. Trumble, S. Schwantz, and G. Keller Haploinsufficiency of Runx1 results in the acceleration of mesodermal development and hemangioblast specification upon in vitro differentiation of ES cells Blood, February 1, 2004; 103(3): 886 - 889. [Abstract] [Full Text] [PDF]

				J. Rathjen, J. M. Washington, M. D. Bettess, and P. D. Rathjen Identification of a Biological Activity That Supports Maintenance and Proliferation of Pluripotent Cells from the Primitive Ectoderm of the Mouse Biol Reprod, December 1, 2003; 69(6): 1863 - 1871. [Abstract] [Full Text] [PDF]

				C. M. Ward, K. Barrow, A. M. Woods, and P. L. Stern The 5T4 oncofoetal antigen is an early differentiation marker of mouse ES cells and its absence is a useful means to assess pluripotency J. Cell Sci., November 15, 2003; 116(22): 4533 - 4542. [Abstract] [Full Text] [PDF]

				C. Mummery, D. Ward-van Oostwaard, P. Doevendans, R. Spijker, S. van den Brink, R. Hassink, M. van der Heyden, T. Opthof, M. Pera, A. B. de la Riviere, et al. Differentiation of Human Embryonic Stem Cells to Cardiomyocytes: Role of Coculture With Visceral Endoderm-Like Cells Circulation, June 3, 2003; 107(21): 2733 - 2740. [Abstract] [Full Text] [PDF]

				R. Passier and C. Mummery Origin and use of embryonic and adult stem cells in differentiation and tissue repair Cardiovasc Res, May 1, 2003; 58(2): 324 - 335. [Abstract] [Full Text] [PDF]

				T. A. Pelton, S. Sharma, T. C. Schulz, J. Rathjen, and P. D. Rathjen Transient pluripotent cell populations during primitive ectoderm formation: correlation of in vivo and in vitro pluripotent cell development. J. Cell Sci., January 15, 2002; 115(2): 329 - 339. [Abstract] [Full Text] [PDF]

				J. Rathjen, B. P. Haines, K. M. Hudson, A. Nesci, S. Dunn, and P. D. Rathjen Directed differentiation of pluripotent cells to neural lineages: homogeneous formation and differentiation of a neurectoderm population Development, January 6, 2002; 129(11): 2649 - 2661. [Abstract] [Full Text] [PDF]

				J. Nichols, I. Chambers, T. Taga, and A. Smith Physiological rationale for responsiveness of mouse embryonic stem cells to gp130 cytokines Development, June 15, 2001; 128(12): 2333 - 2339. [Abstract] [Full Text] [PDF]

				P. Murray and D. Edgar Regulation of Programmed Cell Death by Basement Membranes in Embryonic Development J. Cell Biol., September 4, 2000; 150(5): 1215 - 1221. [Abstract] [Full Text] [PDF]

				J Lake, J Rathjen, J Remiszewski, and P. Rathjen Reversible programming of pluripotent cell differentiation J. Cell Sci., January 2, 2000; 113(3): 555 - 566. [Abstract] [PDF]

				M. Pera, B Reubinoff, and A Trounson Human embryonic stem cells J. Cell Sci., January 1, 2000; 113(1): 5 - 10. [Abstract] [PDF]

				S. Rodda, S. Sharma, M. Scherer, G. Chapman, and P. Rathjen CRTR-1, a Developmentally Regulated Transcriptional Repressor Related to the CP2 Family of Transcription Factors J. Biol. Chem., January 26, 2001; 276(5): 3324 - 3332. [Abstract] [Full Text] [PDF]