Regulation of p190 Rho-GAP by v-Src is linked to cytoskeletal disruption during transformation

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Bell, J. G., Wyke, J. A. and MacPherson, I. A (1975). Transformation by a temperature sensitive mutant of Rous sarcoma virus in the absence of serum. J. Gen. Virol 27, 127-134.[Abstract/Free Full Text]

Beug, H., Claviez, M., Jockusch, B. M. and Graf, T (1978). Differential expression of Rous sarcoma virus-specific transformation parameters in enucleated cells. Cell 14, 843-856.[Medline]

Bryant, S. S., Briggs, S., Smithgall, T. E., Martin, G. A., McCormick, F., Chang, J. H., Parsons, S. J. and Jove, R (1995). 2 SH2 domains of p120 Ras GTPase-activating protein bind synergistically to tyrosine phosphorylated p190 Rho-GTPase-activating protein. J. Biol. Chem 270, 17947-17952.[Abstract/Free Full Text]

Catling, A. D., Wyke, J. A. and Frame, M. C (1993). Mitogenesis of quiescent chick fibroblasts by v-Src: dependence on events at the membrane leading to early changes in AP-1. Oncogene 8, 1875-1886.[Medline]

Chang, J.-H., Gill, S., Settleman, J. and Parsons, S. J (1995). c-Src regulates the simultaneous rearrangement of actin cytoskeleton, p190RhoGAP, and p120RasGAP following epidermal growth factor stimulation. J. Cell Biol 130, 355-368.[Abstract/Free Full Text]

Ellis, C., Moran, M., McCormick, F. and Pawson, T (1990). Phosphorylation of GAP and GAP-associated proteins by transforming and mitogenic tyrosine kinases. Nature 343, 377-381.[Medline]

Fincham, V. J., Wyke, J. A. and Frame, M. C (1995). v-Src-induced degradation of focal adhesion kinase during morphological transformation of chicken-embryo fibroblasts. Oncogene 10, 2247-2252.[Medline]

Fincham, W. J. and Frame, M. C (1998). The catalytic activity of Src is dispensable for translocation to focal adhesions but controls the turnover of these structures during cell motility. EMBO J 16, 81-92.

Frame, M. C., Simpson, K., Fincham, V. J. and Crouch, D. H (1994). Separation of v-Src-induced mitogenesis and morphological transformation by inhibition of AP-1. Mol. Cell Biol 5, 1177-1184.

Fuerstenberg, S.,Beug, H., Introna, M., Khazaie, K., Munoz, A., Ness, S., Nordstrom, K., Sap, J., Stanley, I., Zenke, M. and Vennstrom, B (1990). Ectopic expression of the erythrocyte band 3 anion exchange protein, using a new avian retrovirus vector. J. Virol 64, 5891-5902.[Abstract/Free Full Text]

Hildebrand, J. D., Taylor, J. M. and Parsons, J. T (1996). An SH3 domain-containing GTPase-activating protein for Rho and CDC42 associates with focal adhesion kinase. Mol. Cell. Biol 16, 3169-3178.[Abstract]

Hu, K.-Q. and Settleman, J (1997). Tandem SH2 binding sites mediate the RasGAP-RhoGAP interaction: a conformational mechanism for SH3 domain regulation. EMBO J 16, 473-483.[Medline]

Ilic, D., Furuta, Y., Kanazawa, S., Takeda, N., Sobue, K., Nakatsuji, N., Nomura, S., Fujimoto, J., Okada, M., Yamamoto, T. and Aizawa, S (1995). Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient mice. Nature 377, 539-544.[Medline]

Kaplan, K. B., Bibbins, K. B., Swedlow, J. R., Arnaud, M., Morgan, D. O and Varmus H. E (1994). Association of the amino-terminal half of c-Src with focal adhesions alters their properties and is regulated by phosphorylation of tyrosine 527. EMBO J 13, 4745-4756.[Medline]

McGlade, J., Brunkhorst, B., Anderson, D., Mbamalu, G., Settleman, J., Dedhar, S., Rozakis-Adcock, M., Chen, L. B. and Pawson, T (1993). The N-terminal region of GAP regulates cytoskeletal structure and cell adhesion. EMBO J 12, 3073-3081.[Medline]

Nobes, C. D. and Hall, A (1995). Rho, Rac, and CDC42 GTPases regulatethe assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia. Cell 81, 53-62.[Medline]

Paterson, H. F., Self, A. J., Garrett, M. D., Just, I., Aktories, K. and Hall, A (1990). Microinjection of recombinant p21rhoinduces rapid changes in cell morphology. J. Cell Biol 111, 1001-1007.[Abstract/Free Full Text]

Richardson, A. and Parsons, J. T (1996). A mechanism for regulation of the adhesion-associated protein tyrosine kinase pp125FAK. Nature 380, 538-540.[Medline]

Ridley, A. J. and Hall, A (1992). The small GTP-binding protein Rho regulates the assembly of focal adhesions and actin stress fibres in response to growth factors. Cell 70, 389-399.[Medline]

Ridley, A. J., Self, A. J., Kasmi, F., Paterson, H. F., Hall, A., Marshall, C. J. and Ellis, C (1993). Rho family GTPase activating proteins p190, bcr and rhoGAP show distinct specificities in vitro and in vivo. EMBO J 12, 5151-5160.[Medline]

Self, A. J. and Hall, A (1995). Purification off recombinant Rho/Rac/G25K from Escherichia coli. Meth. Enzymol 256, 3-10.[Medline]

Self, A. J. and Hall, A (1995). Measurement of intrinsic exchange and GTP hydrolysis rates. Meth. Enzymol 256, 67-76.[Medline]

Settleman, J., Narasimhan, V., Foster, L. C. and Weinberg, R. A (1992). Molecular cloning of cDNAs encoding the GAP-associated protein p190: implications for a signaling pathway from Ras to the nucleus. Cell 69, 539-549.[Medline]

Settleman, J., Albright, C. F., Foster, L. C. and Weinberg, R. A (1992). Association between GTPase activators for Rho and Ras families. Nature 359, 153-154.[Medline]

Turner, C. E. and Burridge, K (1991). Transmembrane molecular assemblies in cell-extracellular matrix interactions. Curr. Opin. Cell Biol 3, 849-853.[Medline]

van der Geer, P., Henkemeyer, M., Jacks, T. and Pawson, T (1997). Aberrant Ras regulation and reduced p190 tyrosine phosphorylation in cells lacking p120-gap. Mol. Cell. Biol 17, 1840-1847.[Abstract]

Welham, M. J. and Wyke, J. A (1988). A single point mutation has pleiotropic effects on pp60v-srcfunction. J. Virol 62, 1898-1906.[Abstract/Free Full Text]

Wyke, A. W., Frame, M. C., Gillespie, D. A. F., Chudleigh, A. and Wyke,J. A (1995). Mitogenesis by v-Src: fluctuations throughout G1of classical immediate early AP-1 and mitogen-activated protein kinase responses that parallel the need for the oncoprotein. Cell Growth Differ 6, 1225-1234.[Abstract]

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				V. G. Brunton, E. Avizienyte, V. J. Fincham, B. Serrels, C. A. Metcalf III, T. K. Sawyer, and M. C. Frame Identification of Src-Specific Phosphorylation Site on Focal Adhesion Kinase: Dissection of the Role of Src SH2 and Catalytic Functions and Their Consequences for Tumor Cell Behavior Cancer Res., February 15, 2005; 65(4): 1335 - 1342. [Abstract] [Full Text] [PDF]

				A. Gatesman, V. G. Walker, J. M. Baisden, S. A. Weed, and D. C. Flynn Protein Kinase C{alpha} Activates c-Src and Induces Podosome Formation via AFAP-110 Mol. Cell. Biol., September 1, 2004; 24(17): 7578 - 7597. [Abstract] [Full Text] [PDF]

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				M. C. Frame Newest findings on the oldest oncogene; how activated src does it J. Cell Sci., March 1, 2004; 117(7): 989 - 998. [Abstract] [Full Text] [PDF]

				G. Burgstaller and M. Gimona Actin cytoskeleton remodelling via local inhibition of contractility at discrete microdomains J. Cell Sci., January 15, 2004; 117(2): 223 - 231. [Abstract] [Full Text] [PDF]

				L. Su, J. M. Agati, and S. J. Parsons p190RhoGAP is cell cycle regulated and affects cytokinesis J. Cell Biol., November 10, 2003; 163(3): 571 - 582. [Abstract] [Full Text] [PDF]

				S. Dadke and J. Chernoff Protein-tyrosine Phosphatase 1B Mediates the Effects of Insulin on the Actin Cytoskeleton in Immortalized Fibroblasts J. Biol. Chem., October 17, 2003; 278(42): 40607 - 40611. [Abstract] [Full Text] [PDF]

				J. M. Summy, Y. Qian, B.-H. Jiang, A. Guappone-Koay, A. Gatesman, X. Shi, and D. C. Flynn The SH4-Unique-SH3-SH2 domains dictate specificity in signaling that differentiate c-Yes from c-Src J. Cell Sci., June 15, 2003; 116(12): 2585 - 2598. [Abstract] [Full Text] [PDF]

				N. K. Noren, W. T. Arthur, and K. Burridge Cadherin Engagement Inhibits RhoA via p190RhoGAP J. Biol. Chem., April 11, 2003; 278(16): 13615 - 13618. [Abstract] [Full Text] [PDF]

				D. A. Hsia, S. K. Mitra, C. R. Hauck, D. N. Streblow, J. A. Nelson, D. Ilic, S. Huang, E. Li, G. R. Nemerow, J. Leng, et al. Differential regulation of cell motility and invasion by FAK J. Cell Biol., March 3, 2003; 160(5): 753 - 767. [Abstract] [Full Text] [PDF]

				S. Y. Moon, H. Zang, and Y. Zheng Characterization of a Brain-specific Rho GTPase-activating Protein, p200RhoGAP J. Biol. Chem., January 31, 2003; 278(6): 4151 - 4159. [Abstract] [Full Text] [PDF]

				J. C. Chen, S. Zhuang, T. H. Nguyen, G. R. Boss, and R. B. Pilz Oncogenic Ras Leads to Rho Activation by Activating the Mitogen-activated Protein Kinase Pathway and Decreasing Rho-GTPase-activating Protein Activity J. Biol. Chem., January 24, 2003; 278(5): 2807 - 2818. [Abstract] [Full Text] [PDF]

				J. W. Copeland and R. Treisman The Diaphanous-related Formin mDia1 Controls Serum Response Factor Activity through its Effects on Actin Polymerization Mol. Biol. Cell, November 1, 2002; 13(11): 4088 - 4099. [Abstract] [Full Text] [PDF]

				W. R. Reenstra, D. L. Orlow, and K. K. H. Svoboda ECM-Stimulated Signaling and Actin Reorganization in Embryonic Corneal Epithelia Are Rho Dependent Invest. Ophthalmol. Vis. Sci., October 1, 2002; 43(10): 3181 - 3189. [Abstract] [Full Text] [PDF]

				G. Pawlak and D. M. Helfman MEK Mediates v-Src-induced Disruption of the Actin Cytoskeleton via Inactivation of the Rho-ROCK-LIM Kinase Pathway J. Biol. Chem., July 19, 2002; 277(30): 26927 - 26933. [Abstract] [Full Text] [PDF]

				D. Brandt, M. Gimona, M. Hillmann, H. Haller, and H. Mischak Protein Kinase C Induces Actin Reorganization via a Src- and Rho-dependent Pathway J. Biol. Chem., May 31, 2002; 277(23): 20903 - 20910. [Abstract] [Full Text] [PDF]

				W. T. Arthur and K. Burridge RhoA Inactivation by p190RhoGAP Regulates Cell Spreading and Migration by Promoting Membrane Protrusion and Polarity Mol. Biol. Cell, September 1, 2001; 12(9): 2711 - 2720. [Abstract] [Full Text] [PDF]

				T. Hosooka, T. Noguchi, H. Nagai, T. Horikawa, T. Matozaki, M. Ichihashi, and M. Kasuga Inhibition of the Motility and Growth of B16F10 Mouse Melanoma Cells by Dominant Negative Mutants of Dok-1 Mol. Cell. Biol., August 15, 2001; 21(16): 5437 - 5446. [Abstract] [Full Text] [PDF]

				M. Haskell, A. Nickles, J. Agati, L Su, B. Dukes, and S. Parsons Phosphorylation of p190 on Tyr1105 by c-Src is necessary but not sufficient for EGF-induced actin disassembly in C3H10T1/2 fibroblasts J. Cell Sci., January 5, 2001; 114(9): 1699 - 1708. [Abstract] [PDF]

				M. Amyere, B. Payrastre, U. Krause, P. V. D. Smissen, A. Veithen, and P. J. Courtoy Constitutive Macropinocytosis in Oncogene-transformed Fibroblasts Depends on Sequential Permanent Activation of Phosphoinositide 3-Kinase and Phospholipase C Mol. Biol. Cell, October 1, 2000; 11(10): 3453 - 3467. [Abstract] [Full Text]

				J. N. Lavoie, C. Champagne, M.-C. Gingras, and A. Robert Adenovirus E4 Open Reading Frame 4-induced Apoptosis Involves Dysregulation of Src Family Kinases J. Cell Biol., September 5, 2000; 150(5): 1037 - 1056. [Abstract] [Full Text] [PDF]