Groucho/TLE/R-esp proteins associate with the nuclear matrix and repress RUNX (CBF(alpha)/AML/PEBP2(alpha)) dependent activation of tissue-specific gene transcription

QUICK SEARCH:

[advanced]

	Author:		Keyword(s):

Home Help Feedback Subscriptions Archive Search Table of Contents

This Article

	Summary
	Full Text (PDF)
	Alert me when this article is cited
	Alert me if a correction is posted

Services

	Email this article to a friend
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new issues of the journal
	Download to citation manager


Citing Articles

	Citing Articles via HighWire
	Citing Articles via Google Scholar

Google Scholar

	Articles by Javed, A.
	Articles by Stein, G. S.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Javed, A.
	Articles by Stein, G. S.

Ahn, M. Y., Huang, G., Bae, S. C., Wee, H. J., Kim, W. Y., and Ito, Y (1998). Negative regulation of granulocytic differentiation in the myeloid precursor cell line 32Dcl3 by ear-2, a mammalian homolog of Drosophila seven-up and a chimeric leukemogenic gene, AML1/ETO. Proc. Nat. Acad. Sci. USA 95, 1812-1817.[Abstract/Free Full Text]

Aronson, B. D., Fisher, A. L., Blechman, K., Caudy, M. and Gergen, J. P (1997). Groucho-dependent and-independent repression activities of Runt domain proteins. Mol. Cell Biol 17, 5581-5587.[Abstract]

Banerjee, C., Hiebert, S. W., Stein, J. L., Lian, J. B. and Stein, G. S (1996). An AML-1 consensus sequence binds an osteoblast-specific complex and transcriptionally activates the osteocalcin gene. Proc. Nat. Acad. Sci. USA 93, 4968-4973.[Abstract/Free Full Text]

Banerjee, C., McCabe, L. R., Choi, J.-Y., Hiebert, S. W., Stein, J. L., Stein, G. S. and Lian, J. B (1997). Runt homology domain proteins in osteoblast differentiation: AML-3/CBFA1 is a major component of a bone specific complex. J. Cell. Biochem 66, 1-8.[Medline]

Bruhn, L., Munnerlyn, A. and Grosschedl, R (1997). ALY, a context-dependent coactivator of LEF-1 and AML-1, is required for TCRalpha enhancer function. Genes Dev 11, 640-653.[Abstract/Free Full Text]

Carrington, W. A., Lynch, R. M., Moore, E. D., Isenberg, G., Fogarty, K. E. and Fay, F. S (1995). Superresolution three-dimensional images of fluorescence in cells with minimal light exposure. Science 268, 1483-1487.[Abstract/Free Full Text]

Chen, G., Fernandez, J., Mische, S. and Courey, A. J (1999). A functional interaction between the histone deacetylase Rpd3 and the corepressor groucho in Drosophila development. Genes Dev 13, 2218-2230.[Abstract/Free Full Text]

Choi, J.-Y., van Wijnen, A. J., Aslam, F., Leszyk, J. D., Stein, J. L., Stein, G. S., Lian, J. B. and Penman, S (1998). Developmental association of the-galactoside-binding protein galectin-1 with the nuclear matrix of rat calvarial osteoblasts. J. Cell Sci 111, 3035-3043.[Abstract]

Chomczynski, P. and Sacchi, N (1987). Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem 162, 156-159.[Medline]

Cockerill, P. N., Osborne, C. S., Bert, A. G. and Grotto, R. J (1996). Regulation of GM-CSF gene transcription by core-binding factor. Cell Growth Differ 7, 917-922.[Abstract]

Ducy, P., Zhang, R., Geoffroy, V., Ridall, A. L. and Karsenty, G (1997). Osf2/Cbfa1: a transcriptional activator of osteoblast differentiation. Cell 89, 747-754.[Medline]

Frank, R., Zhang, J., Uchida, H., Meyers, S., Hiebert, S. W. and Nimer, S. D (1995). The AML1/ETO fusion protein blocks transactivation of the GM-CSF promoter by AML1B. Oncogene 11, 2667-2674.[Medline]

Golub, T. R., Barker, G. F., Bohlander, S. K., Hiebert, S. W., Ward, D. C., Bray-Ward, P., Morgan, E., Raimondi, S. C., Rowley, J. D. and Gilliland, D. G (1995). Fusion of the TEL gene on 12p13 to the AML1 gene on 21q22 in acute lymphoblastic leukemia. Proc. Nat. Acad. Sci. USA 92, 4917-4921.[Abstract/Free Full Text]

Guo, B., Odgren, P. R., van Wijnen, A. J., Last, T. J., Nickerson, J., Penman, S., Lian, J. B., Stein, J. L. and Stein, G. S (1995). The nuclear matrix protein NMP-1 is the transcription factor YY1. Proc. Nat. Acad. Sci. USA 92, 10526-10530.[Abstract/Free Full Text]

Hanai, J., Chen, L. F., Kanno, T., Ohtani-Fujita, N., Kim, W. Y., Guo, W.-H., Imamura, T., Ishidou, Y., Fukuchi, M., Shi, M. J., Stavnezer, J., Kawabata, M., Miyazono, K. and Ito, Y (1999). Interaction and functional cooperation of PEBP2/CBF with smads. Synergistic induction of the immmunoglobulin germline cpromoter. J. Biol. Chem 274, 31577-31582.[Abstract/Free Full Text]

Imai, Y., Kurokawa, M., Tanaka, K., Friedman, A. D., Ogawa, S., Mitani, K., Yazaki, Y. and Hirai, H (1998). TLE, the human homolog of groucho, interacts with AML1 and acts as a repressor of AML1-induced transactivation. Biochem. Biophys. Res. Commun 252, 582-589.[Medline]

Javed, A., Gutierrez, S., Montecino, M., van Wijnen, A. J., Stein, J. L., Stein, G. S. and Lian, J. B (1999). Multiple Cbfa/AML sites in the rat osteocalcin promoter are required for basal and vitamin D responsive transcription and contribute to chromatin organization. Mol. Cell. Biol 19, 7491-7500.[Abstract/Free Full Text]

Jimenez, M. J., Balbin, M., Lopez, J. M., Alvarez, J., Komori, T. and Lopez-Otin, C (1999). Collagenase 3 is a target of Cbfa1, a transcription factor of the runt gene family involved in bone formation. Mol. Cell Biol 19, 4431-4442.[Abstract/Free Full Text]

Kanno, T., Kanno, Y., Chen, L. F., Ogawa, E., Kim, W. Y. and Ito, Y (1998). Intrinsic transcriptional activation-inhibition domains of the polyomavirus enhancer binding protein 2/core binding factor alpha subunit revealed in the presence of the beta subunit. Mol. Cell Biol 18, 2444-2454.[Abstract/Free Full Text]

Kitabayashi, I., Yokoyama, A., Shimizu, K. and Ohki, M (1998). Interaction and functional cooperation of the leukemia-associated factorsAML1 and p300 in myeloid cell differentiation. EMBO J 17, 2994-3004.[Medline]

Komori, T., Yagi, H., Nomura, S., Yamaguchi, A., Sasaki, K., Deguchi, K., Shimizu, Y., Bronson, R. T., Gao, Y.-H., Inada, M., Sato, M., Okamoto, R., Kitamura, Y., Yoshiki, S. and Kishimoto, T (1997). Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts. Cell 89, 755-764.[Medline]

Levanon, D., Goldstein, R. E., Bernstein, Y., Tang, H., Goldenberg, D., Stifani, S., Paroush, Z. and Groner, Y (1998). Transcriptional repression by AML1 and LEF-1 is mediated by the TLE/Groucho corepressors. Proc. Nat. Acad. Sci. USA 95, 11590-11595.[Abstract/Free Full Text]

Lu, J., Maruyama, M., Satake, M., Bae, S. C., Ogawa, E., Kagoshima, H., Shigesada, K. and Ito, Y (1995). Subcellular localization of the alpha and beta subunits of the acute myeloid leukemia-linked transcription factor PEBP2/CBF. Mol. Cell. Biol 15, 1651-1661.[Abstract]

Lutterbach, B., Westendorf, J. J., Linggi, B., Patten, A., Moniwa, M., Davie, J. R., Huynh, K. D., Bardwell, V. J., Lavinsky, R. M., Rosenfeld, M. G., Glass, C., Seto, E. and Hiebert, S. W (1998). ETO, a target of t(8;21) in acute leukemia, interacts with the N-CoR and mSin3 corepressors. Mol. Cell Biol 18, 7176-7184.[Abstract/Free Full Text]

Lutterbach, B., Sun, D., Schuetz, J. and Hiebert, S. W (1998). The MYND motif is required for repression of basal transcription from the multidrug resistance 1 promoter by the t(8;21) fusion protein. Mol. Cell Biol 18, 3604-3611.[Abstract/Free Full Text]

Martiney, M. J., Rulli, K., Beaty, R., Levy, L. S. and Lenz, J (1999). Selection of reversions and suppressors of a mutation in the CBF binding site of a lymphomagenic retrovirus. J. Virol 73, 7599-7606.[Abstract/Free Full Text]

McCabe, L. R., Kockx, M., Lian, J., Stein, J. and Stein, G (1995). Selective expression of fos-and jun-related genes during osteoblast proliferation and differentiation. Exp. Cell Res 218, 255-262.[Medline]

McLarren, K. W., Lo, R., Grbavec, D., Thirunavukkarasu, K., Karsenty, G. and Stifani, S (2000). The mammalian basic helix loop helix protein HES-1 binds to and modulates the transactivating function of the runt-related factor cbfa1. J. Biol. Chem 275, 530-538.[Abstract/Free Full Text]

McNeil, S., Zeng, C., Harrington, K. S., Hiebert, S., Lian, J. B., Stein, J.L., van Wijnen, A. J. and Stein, G. S (1999). The t(8;21) chromosomal translocation in acute myelogenous leukemia modifies intranuclear targeting of the AML1/CBFalpha2 transcription factor. Proc. Nat. Acad. Sci. USA 96, 14882-14887.[Abstract/Free Full Text]

Merriman, H. L., van Wijnen, A. J., Hiebert, S., Bidwell, J. P., Fey, E., Lian, J., Stein, J. and Stein, G. S (1995). The tissue-specific nuclear matrix protein, NMP-2, is a member of the AML/CBF/PEBP2/runt domain transcription factor family: interactions with the osteocalcin gene promoter. Biochemistry 34, 13125-13132.[Medline]

Meyers, S., Downing, J. R. and Hiebert, S. W (1993). Identification of AML-1 and the t(8;21) translocation protein (AML-1/ETO) as sequence-specific DNA-binding proteins; the runt homology domain is required for DNA binding and protein-protein interactions. Mol. Cell. Biol 13, 6336-6345.[Abstract/Free Full Text]

Meyers, S., Lenny, N., Sun, W.-H. and Hiebert, S. W (1996). AML-2 is a potential target for transcriptional regulation by the t(8;21) and t(12;21) fusion proteins in acute leukemia. Oncogene 13, 303-312.[Medline]

Mitani, K., Ogawa, S., Tanaka, T., Miyoshi, H., Kurokawa, M., Mano, H., Yazaki, Y., Ohki, M. and Hirai, H (1994). Generation of the AML1-EVI-1 fusion gene in the t(3;21)(q26;q22) causes blastic crisis in chronic myelocytic leukemia. EMBO J 13, 504-510.[Medline]

Nucifora, G. and Rowley, J. D (1995). AML1 and the 8;21 and 3;21 translocations in acute and chronic myeloid leukemia. Blood 86, 1-14.[Free Full Text]

Okuda, T., van Deursen, J., Hiebert, S. W., Grosveld, G. and Downing, J. R (1996). AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis. Cell 84, 321-330.[Medline]

Otto, F., Thornell, A. P., Crompton, T., Denzel, A., Gilmour, K. C., Rosewell, I. R., Stamp, G. W. H., Beddington, R. S. P., Mundlos, S., Olsen, B. R., Selby, P. B. and Owen, M. J (1997). Cbfa1 , a candidate gene for cleidocranial dysplasia syndrome, is essential for osteoblast differentiation and bone development. Cell 89, 765-771.[Medline]

Palaparti, A., Baratz, A. and Stifani, S (1997). The Groucho/transducin-like enhancer of split transcriptional repressors interact with the genetically defined amino-terminal silencing domain of histone H3. J. Biol. Chem 272, 26604-26610.[Abstract/Free Full Text]

Petrovick, M. S., Hiebert, S. W., Friedman, A. D., Hetherington, C. J., Tenen, D. G. and Zhang, D. E (1998). Multiple functional domains of AML1: PU.1 and C/EBPalpha synergize with different regions of AML1. Mol. Cell Biol 18, 3915-3925.[Abstract/Free Full Text]

Shi, M. J. and Stavnezer, J (1998). CBF alpha3 (AML2) is induced by TGF-beta1 to bind and activate the mouse germline Ig alpha promoter. J. Immunol 161, 6751-6760.[Abstract/Free Full Text]

Song, W. J., Sullivan, M. G., Legare, R. D., Hutchings, S., Tan, X., Kufrin, D., Ratajczak, J., Resende, I. C., Haworth, C., Hock, R., Loh, M., Felix, C., Roy, D. C., Busque, L., Kurnit, D., Willman, C., Gewirtz, A. M., Speck, N. A., Bushweller, J. H., Li, F. P., Gardiner, K., Poncz, M., Maris, J. M. and Gilliland, D. G (1999). Haploinsufficiency of CBFA2 causes familial thrombocytopenia with propensity to develop acute myelogenous leukaemia. Nature Genet 23, 166-175.[Medline]

Speck, N. A. and Stacy, T (1995). A new transcription factor family associated with human leukemias. Crit. Rev. Euk. Gene Exp 5, 337-364.[Medline]

Speck, N. A., Stacy, T., Wang, Q., North, T., Gu, T. L., Miller, J., Binder, M. and Marin-Padilla, M (1999). Core-binding factor: a central player in hematopoiesis and leukemia. Cancer Res 59, 1789-.

Stein, G. S. and Lian, J. B (1993). Molecular mechanisms mediating proliferation/differentiation interrelationships during progressive development of the osteoblast phenotype. Endocr. Rev 14, 424-442.[Medline]

Stein, G. S., van Wijnen, A. J., Stein, J. L., Lian, J. B., Pockwinse, S. and McNeil, S (1998). Interrelationships of nuclear structure and transcriptional control: functional consequences of being in the right place at the right time. J. Cell. Biochem 70, 200-212.[Medline]

Stifani, S., Blaumueller, C. M., Redhead, N. J., Hill, R. E. and Artavanis-Tsakonas, S (1992). Human homologs of a Drosophila Enhancer of split gene product define a novel family of nuclear proteins. Nature Genet 2, 119-127.[Medline]

Sun, W., Graves, B. J. and Speck, N. A (1995). Transactivation of the Moloney murine leukemia virus and T-cell receptor beta-chain enhancers by cbf and ets requires intact binding sites for both proteins. J. Virol 69, 4941-4949.[Abstract]

Tang, L., Guo, B., Javed, A., Choi, J.-Y., Hiebert, S., Lian, J. B., van Wijnen, A. J., Stein, J. L., Stein, G. S. and Zhou, G. W (1999). Crystal structure of the nuclear matrix targeting signal of the transcription factor AML-1/PEBP2B/CBF 2. J. Biol. Chem 274, 33580-33586.[Abstract/Free Full Text]

Tenen, D. G., Hromas, R., Licht, J. D. and Zhang, D. E (1997). Transcription factors, normal myeloid development and leukemia. Blood 90, 489-519.[Free Full Text]

Thirunavukkarasu, K., Mahajan, M., McLarren, K. W., Stifani, S. and Karsenty, G (1998). Two domains unique to osteoblast-specific transcription factor Osf2/Cbfa1 contribute to its transactivation function and its inability to heterodimerize with Cbf beta. Mol. Cell Biol 18, 4197-4208.[Abstract/Free Full Text]

Thottassery, J. V., Zambetti, G. P., Arimori, K., Schuetz, E. G. and Schuetz, J. D (1997). p53-dependent regulation of MDR1 gene expression causes selective resistance to chemotherapeutic agents. Proc. Nat. Acad. Sci. USA 94, 11037-11042.[Abstract/Free Full Text]

Uchida, H., Zhang, J. and Nimer, S. D (1997). AML1A and AML1B can transactivate the human IL-3 promoter. J. Immunol 158, 2251-2258.[Abstract]

Wang, Q., Stacy, T., Miller, J. D., Lewis, A. F., Gu, T. L., Huang, X., Bushweller, J. H., Bories, J. C., Alt, F. W., Ryan, G., Liu, P. P., Wynshaw-Boris, A., Binder, M., Marin-Padilla, M., Sharpe, A. H. and Speck, N. A (1996). The CBFbeta subunit is essential for CBFalpha2 (AML1) function in vivo. Cell 87, 697-708.[Medline]

Wang, Q., Stacy, T., Binder, M., Marin-Padilla, M., Sharpe, A. H. and Speck, N. A (1996). Disruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central nervous system and blocks definitive hematopoiesis. Proc. Nat. Acad. Sci. USA 93, 3444-3449.[Abstract/Free Full Text]

Westendorf, J. J., Yamamoto, C. M., Lenny, N., Downing, J. R., Selsted, M. E. and Hiebert, S. W (1998). The t(8;21) fusion product, AML-1-ETO, associates with C/EBP-alpha, inhibits C/EBP-alpha-dependent transcription and blocks granulocytic differentiation. Mol. Cell Biol 18, 322-333.[Abstract/Free Full Text]

Yagi, R., Chen, L. F., Shigesada, K., Murakami, Y. and Ito, Y (1999). A WW domain-containing yes-associated protein (YAP) is a novel transcriptional co-activator. EMBO J 18, 2551-2562.[Medline]

Yang, R. and Gerstenfeld, L. C (1997). Structural analysis and characterization of tissue and hormonal responsive expression of the avian bone sialoprotein (BSP) gene. J. Cell. Biochem 64, 77-93.[Medline]

Yergeau, D. A., Hetherington, C. J., Wang, Q., Zhang, P., Sharpe, A. H., Binder, M., Marin-Padilla, M., Tenen, D. G., Speck, N. A. and Zhang, D. E (1997). Embryonic lethality and impairment of haematopoiesis in mice heterozygous for an AML1-ETO fusion gene. Nature Genet 15, 303-306.[Medline]

Zaiman, A. L. and Lenz, J (1996). Transcriptional activation of a retrovirus enhancer by CBF (AML1) requires a second factor: evidence for cooperativity with c-Myb. J. Virol 70, 5618-5629.[Abstract/Free Full Text]

Zeng, C., van Wijnen, A. J., Stein, J. L., Meyers, S., Sun, W., Shopland, L., Lawrence, J. B., Penman, S., Lian, J. B., Stein, G. S. and Hiebert, S. W (1997). Identification of a nuclear matrix targeting signal in the leukemia and bone-related AML/CBFtranscription factors. Proc. Nat. Acad. Sci. USA 94, 6746-6751.[Abstract/Free Full Text]

Zeng, C., McNeil, S., Pockwinse, S., Nickerson, J. A., Shopland, L., Lawrence, J. B., Penman, S., Hiebert, S. W., Lian, J. B., van Wijnen, A. J., Stein, J. L. and Stein, G. S (1998). Intranuclear targeting of AML/CBFregulatory factors to nuclear matrix-associated transcriptional domains. Proc. Nat. Acad. Sci. USA 95, 1585-1589.[Abstract/Free Full Text]

This article has been cited by other articles:

L. J. Marshall, A. C. Moore, M. Ohki, I. Kitabayashi, D. Patterson, and D. A. Ornelles
RUNX1 Permits E4orf6-Directed Nuclear Localization of the Adenovirus E1B-55K Protein and Associates with Centers of Viral DNA and RNA Synthesis
J. Virol., July 1, 2008; 82(13): 6395 - 6408.
[Abstract] [Full Text] [PDF]

A. Javed, J.-S. Bae, F. Afzal, S. Gutierrez, J. Pratap, S. K. Zaidi, Y. Lou, A. J. van Wijnen, J. L. Stein, G. S. Stein, et al.
Structural Coupling of Smad and Runx2 for Execution of the BMP2 Osteogenic Signal
J. Biol. Chem., March 28, 2008; 283(13): 8412 - 8422.
[Abstract] [Full Text] [PDF]

V. Lamour, C. Detry, C. Sanchez, Y. Henrotin, V. Castronovo, and A. Bellahcene
Runx2- and Histone Deacetylase 3-mediated Repression Is Relieved in Differentiating Human Osteoblast Cells to Allow High Bone Sialoprotein Expression
J. Biol. Chem., December 14, 2007; 282(50): 36240 - 36249.
[Abstract] [Full Text] [PDF]

S. K. Zaidi, S. Pande, J. Pratap, T. Gaur, S. Grigoriu, S. A. Ali, J. L. Stein, J. B. Lian, A. J. van Wijnen, and G. S. Stein
Runx2 deficiency and defective subnuclear targeting bypass senescence to promote immortalization and tumorigenic potential
PNAS, December 11, 2007; 104(50): 19861 - 19866.
[Abstract] [Full Text] [PDF]

T. Egawa, R. E. Tillman, Y. Naoe, I. Taniuchi, and D. R. Littman
The role of the Runx transcription factors in thymocyte differentiation and in homeostasis of naive T cells
J. Exp. Med., August 6, 2007; 204(8): 1945 - 1957.
[Abstract] [Full Text] [PDF]

M. Q. Hassan, R. Tare, S. H. Lee, M. Mandeville, B. Weiner, M. Montecino, A. J. van Wijnen, J. L. Stein, G. S. Stein, and J. B. Lian
HOXA10 Controls Osteoblastogenesis by Directly Activating Bone Regulatory and Phenotypic Genes
Mol. Cell. Biol., May 1, 2007; 27(9): 3337 - 3352.
[Abstract] [Full Text] [PDF]

Y. Babaie, R. Herwig, B. Greber, T. C. Brink, W. Wruck, D. Groth, H. Lehrach, T. Burdon, and J. Adjaye
Analysis of Oct4-Dependent Transcriptional Networks Regulating Self-Renewal and Pluripotency in Human Embryonic Stem Cells
Stem Cells, February 1, 2007; 25(2): 500 - 510.
[Abstract] [Full Text] [PDF]

T. Heimbucher, C. Murko, B. Bajoghli, N. Aghaallaei, A. Huber, R. Stebegg, D. Eberhard, M. Fink, A. Simeone, and T. Czerny
Gbx2 and Otx2 Interact with the WD40 Domain of Groucho/Tle Corepressors
Mol. Cell. Biol., January 1, 2007; 27(1): 340 - 351.
[Abstract] [Full Text] [PDF]

C. S. Shin, M. J. Jeon, J.-Y. Yang, S.-J. Her, D. Kim, S. W. Kim, and S. Y. Kim
CCAAT/enhancer-binding protein {delta} activates the Runx2-mediated transcription of mouse osteocalcin II promoter.
J. Mol. Endocrinol., June 1, 2006; 36(3): 531 - 546.
[Abstract] [Full Text] [PDF]

K. S. Moorefield, H. Yin, T. D. Nichols, C. Cathcart, S. O. Simmons, and J. M. Horowitz
Sp2 Localizes to Subnuclear Foci Associated with the Nuclear Matrix
Mol. Biol. Cell, April 1, 2006; 17(4): 1711 - 1722.
[Abstract] [Full Text] [PDF]

Q. Shen and S. Christakos
The Vitamin D Receptor, Runx2, and the Notch Signaling Pathway Cooperate in the Transcriptional Regulation of Osteopontin
J. Biol. Chem., December 9, 2005; 280(49): 40589 - 40598.
[Abstract] [Full Text] [PDF]

L. F. Peterson, A. Boyapati, V. Ranganathan, A. Iwama, D. G. Tenen, S. Tsai, and D.-E. Zhang
The Hematopoietic Transcription Factor AML1 (RUNX1) Is Negatively Regulated by the Cell Cycle Protein Cyclin D3
Mol. Cell. Biol., December 1, 2005; 25(23): 10205 - 10219.
[Abstract] [Full Text] [PDF]

C. Sakakura, K. Hasegawa, K. Miyagawa, S. Nakashima, T. Yoshikawa, S. Kin, Y. Nakase, S. Yazumi, H. Yamagishi, T. Okanoue, et al.
Possible Involvement of RUNX3 Silencing in the Peritoneal Metastases of Gastric Cancers
Clin. Cancer Res., September 15, 2005; 11(18): 6479 - 6488.
[Abstract] [Full Text] [PDF]

G. Xiao, D. Jiang, C. Ge, Z. Zhao, Y. Lai, H. Boules, M. Phimphilai, X. Yang, G. Karsenty, and R. T. Franceschi
Cooperative Interactions between Activating Transcription Factor 4 and Runx2/Cbfa1 Stimulate Osteoblast-specific Osteocalcin Gene Expression
J. Biol. Chem., September 2, 2005; 280(35): 30689 - 30696.
[Abstract] [Full Text] [PDF]

Y. Fukushima-Nakase, Y. Naoe, I. Taniuchi, H. Hosoi, T. Sugimoto, and T. Okuda
Shared and distinct roles mediated through C-terminal subdomains of acute myeloid leukemia/Runt-related transcription factor molecules in murine development
Blood, June 1, 2005; 105(11): 4298 - 4307.
[Abstract] [Full Text] [PDF]

M. Galindo, J. Pratap, D. W. Young, H. Hovhannisyan, H.-J. Im, J.-Y. Choi, J. B. Lian, J. L. Stein, G. S. Stein, and A. J. van Wijnen
The Bone-specific Expression of Runx2 Oscillates during the Cell Cycle to Support a G1-related Antiproliferative Function in Osteoblasts
J. Biol. Chem., May 27, 2005; 280(21): 20274 - 20285.
[Abstract] [Full Text] [PDF]

D. Vradii, S. K. Zaidi, J. B. Lian, A. J. van Wijnen, J. L. Stein, and G. S. Stein
Point mutation in AML1 disrupts subnuclear targeting, prevents myeloid differentiation, and effects a transformation-like phenotype
PNAS, May 17, 2005; 102(20): 7174 - 7179.
[Abstract] [Full Text] [PDF]

H.-I. Trompeter, N. Gomez-Lozano, S. Santourlidis, B. Eisermann, P. Wernet, C. Vilches, and M. Uhrberg
Three Structurally and Functionally Divergent Kinds of Promoters Regulate Expression of Clonally Distributed Killer Cell Ig-Like Receptors (KIR), of KIR2DL4, and of KIR3DL3
J. Immunol., April 1, 2005; 174(7): 4135 - 4143.
[Abstract] [Full Text] [PDF]

A. Javed, G. L. Barnes, J. Pratap, T. Antkowiak, L. C. Gerstenfeld, A. J. van Wijnen, J. L. Stein, J. B. Lian, and G. S. Stein
Impaired intranuclear trafficking of Runx2 (AML3/CBFA1) transcription factors in breast cancer cells inhibits osteolysis in vivo
PNAS, February 1, 2005; 102(5): 1454 - 1459.
[Abstract] [Full Text] [PDF]

S. K. Zaidi, D. W. Young, J.-Y. Choi, J. Pratap, A. Javed, M. Montecino, J. L. Stein, J. B. Lian, A. J. van Wijnen, and G. S. Stein
Intranuclear Trafficking: Organization and Assembly of Regulatory Machinery for Combinatorial Biological Control
J. Biol. Chem., October 15, 2004; 279(42): 43363 - 43366.
[Abstract] [Full Text] [PDF]

H. N. Nuthall, K. Joachim, and S. Stifani
Phosphorylation of Serine 239 of Groucho/TLE1 by Protein Kinase CK2 Is Important for Inhibition of Neuronal Differentiation
Mol. Cell. Biol., October 1, 2004; 24(19): 8395 - 8407.
[Abstract] [Full Text] [PDF]

T. M. Schroeder, R. A. Kahler, X. Li, and J. J. Westendorf
Histone Deacetylase 3 Interacts with Runx2 to Repress the Osteocalcin Promoter and Regulate Osteoblast Differentiation
J. Biol. Chem., October 1, 2004; 279(40): 41998 - 42007.
[Abstract] [Full Text] [PDF]

D. W. Young, S. K. Zaidi, P. S. Furcinitti, A. Javed, A. J. van Wijnen, J. L. Stein, J. B. Lian, and G. S. Stein
Quantitative signature for architectural organization of regulatory factors using intranuclear informatics
J. Cell Sci., October 1, 2004; 117(21): 4889 - 4896.
[Abstract] [Full Text] [PDF]

G. L. Barnes, K. E. Hebert, M. Kamal, A. Javed, T. A. Einhorn, J. B. Lian, G. S. Stein, and L. C. Gerstenfeld
Fidelity of Runx2 Activity in Breast Cancer Cells Is Required for the Generation of Metastases-Associated Osteolytic Disease
Cancer Res., July 1, 2004; 64(13): 4506 - 4513.
[Abstract] [Full Text] [PDF]

T. Yoshizawa, F. Takizawa, F. Iizawa, O. Ishibashi, H. Kawashima, A. Matsuda, N. Endo, and H. Kawashima
Homeobox Protein Msx2 Acts as a Molecular Defense Mechanism for Preventing Ossification in Ligament Fibroblasts
Mol. Cell. Biol., April 15, 2004; 24(8): 3460 - 3472.
[Abstract] [Full Text] [PDF]

M. Nishimura, Y. Fukushima-Nakase, Y. Fujita, M. Nakao, S. Toda, N. Kitamura, T. Abe, and T. Okuda
VWRPY motif-dependent and -independent roles of AML1/Runx1 transcription factor in murine hematopoietic development
Blood, January 15, 2004; 103(2): 562 - 570.
[Abstract] [Full Text] [PDF]

F. LOMBARDO, D. KOMATSU, and M. HADJIARGYROU
Molecular cloning and characterization of Mustang, a novel nuclear protein expressed during skeletal development and regeneration
FASEB J, January 1, 2004; 18(1): 52 - 61.
[Abstract] [Full Text] [PDF]

S. K. Zaidi, D. W. Young, S. M. Pockwinse, A. Javed, J. B. Lian, J. L. Stein, A. J. van Wijnen, and G. S. Stein
Mitotic partitioning and selective reorganization of tissue-specific transcription factors in progeny cells
PNAS, December 9, 2003; 100(25): 14852 - 14857.
[Abstract] [Full Text] [PDF]

M. Ehlers, K. Laule-Kilian, M. Petter, C. J. Aldrian, B. Grueter, A. Wurch, N. Yoshida, T. Watanabe, M. Satake, and V. Steimle
Morpholino Antisense Oligonucleotide-Mediated Gene Knockdown During Thymocyte Development Reveals Role for Runx3 Transcription Factor in CD4 Silencing During Development of CD4-/CD8+ Thymocytes
J. Immunol., October 1, 2003; 171(7): 3594 - 3604.
[Abstract] [Full Text] [PDF]

M. J. Jeon, J. A. Kim, S. H. Kwon, S. W. Kim, K. S. Park, S.-W. Park, S. Y. Kim, and C. S. Shin
Activation of Peroxisome Proliferator-activated Receptor-{gamma} Inhibits the Runx2-mediated Transcription of Osteocalcin in Osteoblasts
J. Biol. Chem., June 20, 2003; 278(26): 23270 - 23277.
[Abstract] [Full Text] [PDF]

C. A. P. Bristow and P. Shore
Transcriptional regulation of the human MIP-1{alpha} promoter by RUNX1 and MOZ
Nucleic Acids Res., June 1, 2003; 31(11): 2735 - 2744.
[Abstract] [Full Text] [PDF]

J. Shen, H. Hovhannisyan, J. B. Lian, M. A. Montecino, G. S. Stein, J. L. Stein, and A. J. van Wijnen
Transcriptional Induction of the Osteocalcin Gene During Osteoblast Differentiation Involves Acetylation of Histones H3 and H4
Mol. Endocrinol., April 1, 2003; 17(4): 743 - 756.
[Abstract] [Full Text] [PDF]

H. N. Nuthall, K. Joachim, A. Palaparti, and S. Stifani
A Role for Cell Cycle-regulated Phosphorylation in Groucho-mediated Transcriptional Repression
J. Biol. Chem., December 20, 2002; 277(52): 51049 - 51057.
[Abstract] [Full Text] [PDF]

M. Lepourcelet and R. A. Shivdasani
Characterization of a Novel Mammalian Groucho Isoform and Its Role in Transcriptional Regulation
J. Biol. Chem., November 27, 2002; 277(49): 47732 - 47740.
[Abstract] [Full Text] [PDF]

J. J. Westendorf, S. K. Zaidi, J. E. Cascino, R. Kahler, A. J. van Wijnen, J. B. Lian, M. Yoshida, G. S. Stein, and X. Li
Runx2 (Cbfa1, AML-3) Interacts with Histone Deacetylase 6 and Represses the p21CIP1/WAF1 Promoter
Mol. Cell. Biol., November 15, 2002; 22(22): 7982 - 7992.
[Abstract] [Full Text] [PDF]

S. K. Zaidi, A. J. Sullivan, A. J. van Wijnen, J. L. Stein, G. S. Stein, and J. B. Lian
Integration of Runx and Smad regulatory signals at transcriptionally active subnuclear sites
PNAS, June 11, 2002; 99(12): 8048 - 8053.
[Abstract] [Full Text] [PDF]

H. N. Nuthall, J. Husain, K. W. McLarren, and S. Stifani
Role for Hes1-Induced Phosphorylation in Groucho-Mediated Transcriptional Repression
Mol. Cell. Biol., January 15, 2002; 22(2): 389 - 399.
[Abstract] [Full Text] [PDF]

K. S. Harrington, A. Javed, H. Drissi, S. McNeil, J. B. Lian, J. L. Stein, A. J. van Wijnen, Y.-L. Wang, and G. S. Stein
Transcription factors RUNX1/AML1 and RUNX2/Cbfa1 dynamically associate with stationary subnuclear domains
J. Cell Sci., January 11, 2002; 115(21): 4167 - 4176.
[Abstract] [Full Text] [PDF]

R. C. D'Alonzo, N. Selvamurugan, G. Karsenty, and N. C. Partridge
Physical Interaction of the Activator Protein-1 Factors c-Fos and c-Jun with Cbfa1 for Collagenase-3 Promoter Activation
J. Biol. Chem., January 4, 2002; 277(1): 816 - 822.
[Abstract] [Full Text]

W. Liu, S. Toyosawa, T. Furuichi, N. Kanatani, C. Yoshida, Y. Liu, M. Himeno, S. Narai, A. Yamaguchi, and T. Komori
Overexpression of Cbfa1 in osteoblasts inhibits osteoblast maturation and causes osteopenia with multiple fractures
J. Cell Biol., October 1, 2001; 155(1): 157 - 166.
[Abstract] [Full Text] [PDF]

C. Banerjee, A. Javed, J.-Y. Choi, J. Green, V. Rosen, A. J. van Wijnen, J. L. Stein, J. B. Lian, and G. S. Stein
Differential Regulation of the Two Principal Runx2/Cbfa1 N-Terminal Isoforms in Response to Bone Morphogenetic Protein-2 during Development of the Osteoblast Phenotype
Endocrinology, September 1, 2001; 142(9): 4026 - 4039.
[Abstract] [Full Text] [PDF]

J.-Y. Choi, J. Pratap, A. Javed, S. K. Zaidi, L. Xing, E. Balint, S. Dalamangas, B. Boyce, A. J. van Wijnen, J. B. Lian, et al.
Subnuclear targeting of Runx/Cbfa/AML factors is essential for tissue-specific differentiation during embryonic development
PNAS, June 28, 2001; (2001) 151236498.
[Abstract] [Full Text] [PDF]

A. Javed, G. L. Barnes, B. O. Jasanya, J. L. Stein, L. Gerstenfeld, J. B. Lian, and G. S. Stein
runt Homology Domain Transcription Factors (Runx, Cbfa, and AML) Mediate Repression of the Bone Sialoprotein Promoter: Evidence for Promoter Context-Dependent Activity of Cbfa Proteins
Mol. Cell. Biol., April 15, 2001; 21(8): 2891 - 2905.
[Abstract] [Full Text]

S. K. Zaidi, A. Javed, J.-Y. Choi, A. J. van Wijnen, J. L. Stein, J. B. Lian, and G. S. Stein
A specific targeting signal directs Runx2/Cbfa1 to subnuclear domains and contributes to transactivation of the osteocalcin gene
J. Cell Sci., January 9, 2001; 114(17): 3093 - 3102.
[Abstract] [Full Text] [PDF]

K. W. McLarren, F. M. Theriault, and S. Stifani
Association with the Nuclear Matrix and Interaction with Groucho and RUNX Proteins Regulate the Transcription Repression Activity of the Basic Helix Loop Helix Factor Hes1
J. Biol. Chem., January 5, 2001; 276(2): 1578 - 1584.
[Abstract] [Full Text] [PDF]

J. Hess, D. Porte, C. Munz, and P. Angel
AP-1 and Cbfa/Runt Physically Interact and Regulate Parathyroid Hormone-dependent MMP13 Expression in Osteoblasts through a New Osteoblast-specific Element 2/AP-1 Composite Element
J. Biol. Chem., June 1, 2001; 276(23): 20029 - 20038.
[Abstract] [Full Text] [PDF]

S. Gutierrez, A. Javed, D. K. Tennant, M. van Rees, M. Montecino, G. S. Stein, J. L. Stein, and J. B. Lian
CCAAT/Enhancer-binding Proteins (C/EBP) beta and delta Activate Osteocalcin Gene Transcription and Synergize with Runx2 at the C/EBP Element to Regulate Bone-specific Expression
J. Biol. Chem., January 4, 2002; 277(2): 1316 - 1323.

				A. Javed, J.-S. Bae, F. Afzal, S. Gutierrez, J. Pratap, S. K. Zaidi, Y. Lou, A. J. van Wijnen, J. L. Stein, G. S. Stein, et al. Structural Coupling of Smad and Runx2 for Execution of the BMP2 Osteogenic Signal J. Biol. Chem., March 28, 2008; 283(13): 8412 - 8422. [Abstract] [Full Text] [PDF]

				V. Lamour, C. Detry, C. Sanchez, Y. Henrotin, V. Castronovo, and A. Bellahcene Runx2- and Histone Deacetylase 3-mediated Repression Is Relieved in Differentiating Human Osteoblast Cells to Allow High Bone Sialoprotein Expression J. Biol. Chem., December 14, 2007; 282(50): 36240 - 36249. [Abstract] [Full Text] [PDF]

				S. K. Zaidi, S. Pande, J. Pratap, T. Gaur, S. Grigoriu, S. A. Ali, J. L. Stein, J. B. Lian, A. J. van Wijnen, and G. S. Stein Runx2 deficiency and defective subnuclear targeting bypass senescence to promote immortalization and tumorigenic potential PNAS, December 11, 2007; 104(50): 19861 - 19866. [Abstract] [Full Text] [PDF]

				T. Egawa, R. E. Tillman, Y. Naoe, I. Taniuchi, and D. R. Littman The role of the Runx transcription factors in thymocyte differentiation and in homeostasis of naive T cells J. Exp. Med., August 6, 2007; 204(8): 1945 - 1957. [Abstract] [Full Text] [PDF]

				M. Q. Hassan, R. Tare, S. H. Lee, M. Mandeville, B. Weiner, M. Montecino, A. J. van Wijnen, J. L. Stein, G. S. Stein, and J. B. Lian HOXA10 Controls Osteoblastogenesis by Directly Activating Bone Regulatory and Phenotypic Genes Mol. Cell. Biol., May 1, 2007; 27(9): 3337 - 3352. [Abstract] [Full Text] [PDF]

				Y. Babaie, R. Herwig, B. Greber, T. C. Brink, W. Wruck, D. Groth, H. Lehrach, T. Burdon, and J. Adjaye Analysis of Oct4-Dependent Transcriptional Networks Regulating Self-Renewal and Pluripotency in Human Embryonic Stem Cells Stem Cells, February 1, 2007; 25(2): 500 - 510. [Abstract] [Full Text] [PDF]

				T. Heimbucher, C. Murko, B. Bajoghli, N. Aghaallaei, A. Huber, R. Stebegg, D. Eberhard, M. Fink, A. Simeone, and T. Czerny Gbx2 and Otx2 Interact with the WD40 Domain of Groucho/Tle Corepressors Mol. Cell. Biol., January 1, 2007; 27(1): 340 - 351. [Abstract] [Full Text] [PDF]

				C. S. Shin, M. J. Jeon, J.-Y. Yang, S.-J. Her, D. Kim, S. W. Kim, and S. Y. Kim CCAAT/enhancer-binding protein {delta} activates the Runx2-mediated transcription of mouse osteocalcin II promoter. J. Mol. Endocrinol., June 1, 2006; 36(3): 531 - 546. [Abstract] [Full Text] [PDF]

				K. S. Moorefield, H. Yin, T. D. Nichols, C. Cathcart, S. O. Simmons, and J. M. Horowitz Sp2 Localizes to Subnuclear Foci Associated with the Nuclear Matrix Mol. Biol. Cell, April 1, 2006; 17(4): 1711 - 1722. [Abstract] [Full Text] [PDF]

				Q. Shen and S. Christakos The Vitamin D Receptor, Runx2, and the Notch Signaling Pathway Cooperate in the Transcriptional Regulation of Osteopontin J. Biol. Chem., December 9, 2005; 280(49): 40589 - 40598. [Abstract] [Full Text] [PDF]

				L. F. Peterson, A. Boyapati, V. Ranganathan, A. Iwama, D. G. Tenen, S. Tsai, and D.-E. Zhang The Hematopoietic Transcription Factor AML1 (RUNX1) Is Negatively Regulated by the Cell Cycle Protein Cyclin D3 Mol. Cell. Biol., December 1, 2005; 25(23): 10205 - 10219. [Abstract] [Full Text] [PDF]

				C. Sakakura, K. Hasegawa, K. Miyagawa, S. Nakashima, T. Yoshikawa, S. Kin, Y. Nakase, S. Yazumi, H. Yamagishi, T. Okanoue, et al. Possible Involvement of RUNX3 Silencing in the Peritoneal Metastases of Gastric Cancers Clin. Cancer Res., September 15, 2005; 11(18): 6479 - 6488. [Abstract] [Full Text] [PDF]

				G. Xiao, D. Jiang, C. Ge, Z. Zhao, Y. Lai, H. Boules, M. Phimphilai, X. Yang, G. Karsenty, and R. T. Franceschi Cooperative Interactions between Activating Transcription Factor 4 and Runx2/Cbfa1 Stimulate Osteoblast-specific Osteocalcin Gene Expression J. Biol. Chem., September 2, 2005; 280(35): 30689 - 30696. [Abstract] [Full Text] [PDF]

				Y. Fukushima-Nakase, Y. Naoe, I. Taniuchi, H. Hosoi, T. Sugimoto, and T. Okuda Shared and distinct roles mediated through C-terminal subdomains of acute myeloid leukemia/Runt-related transcription factor molecules in murine development Blood, June 1, 2005; 105(11): 4298 - 4307. [Abstract] [Full Text] [PDF]

				M. Galindo, J. Pratap, D. W. Young, H. Hovhannisyan, H.-J. Im, J.-Y. Choi, J. B. Lian, J. L. Stein, G. S. Stein, and A. J. van Wijnen The Bone-specific Expression of Runx2 Oscillates during the Cell Cycle to Support a G1-related Antiproliferative Function in Osteoblasts J. Biol. Chem., May 27, 2005; 280(21): 20274 - 20285. [Abstract] [Full Text] [PDF]

				D. Vradii, S. K. Zaidi, J. B. Lian, A. J. van Wijnen, J. L. Stein, and G. S. Stein Point mutation in AML1 disrupts subnuclear targeting, prevents myeloid differentiation, and effects a transformation-like phenotype PNAS, May 17, 2005; 102(20): 7174 - 7179. [Abstract] [Full Text] [PDF]

				H.-I. Trompeter, N. Gomez-Lozano, S. Santourlidis, B. Eisermann, P. Wernet, C. Vilches, and M. Uhrberg Three Structurally and Functionally Divergent Kinds of Promoters Regulate Expression of Clonally Distributed Killer Cell Ig-Like Receptors (KIR), of KIR2DL4, and of KIR3DL3 J. Immunol., April 1, 2005; 174(7): 4135 - 4143. [Abstract] [Full Text] [PDF]

				A. Javed, G. L. Barnes, J. Pratap, T. Antkowiak, L. C. Gerstenfeld, A. J. van Wijnen, J. L. Stein, J. B. Lian, and G. S. Stein Impaired intranuclear trafficking of Runx2 (AML3/CBFA1) transcription factors in breast cancer cells inhibits osteolysis in vivo PNAS, February 1, 2005; 102(5): 1454 - 1459. [Abstract] [Full Text] [PDF]

				S. K. Zaidi, D. W. Young, J.-Y. Choi, J. Pratap, A. Javed, M. Montecino, J. L. Stein, J. B. Lian, A. J. van Wijnen, and G. S. Stein Intranuclear Trafficking: Organization and Assembly of Regulatory Machinery for Combinatorial Biological Control J. Biol. Chem., October 15, 2004; 279(42): 43363 - 43366. [Abstract] [Full Text] [PDF]

				H. N. Nuthall, K. Joachim, and S. Stifani Phosphorylation of Serine 239 of Groucho/TLE1 by Protein Kinase CK2 Is Important for Inhibition of Neuronal Differentiation Mol. Cell. Biol., October 1, 2004; 24(19): 8395 - 8407. [Abstract] [Full Text] [PDF]

				T. M. Schroeder, R. A. Kahler, X. Li, and J. J. Westendorf Histone Deacetylase 3 Interacts with Runx2 to Repress the Osteocalcin Promoter and Regulate Osteoblast Differentiation J. Biol. Chem., October 1, 2004; 279(40): 41998 - 42007. [Abstract] [Full Text] [PDF]

				D. W. Young, S. K. Zaidi, P. S. Furcinitti, A. Javed, A. J. van Wijnen, J. L. Stein, J. B. Lian, and G. S. Stein Quantitative signature for architectural organization of regulatory factors using intranuclear informatics J. Cell Sci., October 1, 2004; 117(21): 4889 - 4896. [Abstract] [Full Text] [PDF]

				G. L. Barnes, K. E. Hebert, M. Kamal, A. Javed, T. A. Einhorn, J. B. Lian, G. S. Stein, and L. C. Gerstenfeld Fidelity of Runx2 Activity in Breast Cancer Cells Is Required for the Generation of Metastases-Associated Osteolytic Disease Cancer Res., July 1, 2004; 64(13): 4506 - 4513. [Abstract] [Full Text] [PDF]

				T. Yoshizawa, F. Takizawa, F. Iizawa, O. Ishibashi, H. Kawashima, A. Matsuda, N. Endo, and H. Kawashima Homeobox Protein Msx2 Acts as a Molecular Defense Mechanism for Preventing Ossification in Ligament Fibroblasts Mol. Cell. Biol., April 15, 2004; 24(8): 3460 - 3472. [Abstract] [Full Text] [PDF]

				M. Nishimura, Y. Fukushima-Nakase, Y. Fujita, M. Nakao, S. Toda, N. Kitamura, T. Abe, and T. Okuda VWRPY motif-dependent and -independent roles of AML1/Runx1 transcription factor in murine hematopoietic development Blood, January 15, 2004; 103(2): 562 - 570. [Abstract] [Full Text] [PDF]

				F. LOMBARDO, D. KOMATSU, and M. HADJIARGYROU Molecular cloning and characterization of Mustang, a novel nuclear protein expressed during skeletal development and regeneration FASEB J, January 1, 2004; 18(1): 52 - 61. [Abstract] [Full Text] [PDF]

				S. K. Zaidi, D. W. Young, S. M. Pockwinse, A. Javed, J. B. Lian, J. L. Stein, A. J. van Wijnen, and G. S. Stein Mitotic partitioning and selective reorganization of tissue-specific transcription factors in progeny cells PNAS, December 9, 2003; 100(25): 14852 - 14857. [Abstract] [Full Text] [PDF]

				M. Ehlers, K. Laule-Kilian, M. Petter, C. J. Aldrian, B. Grueter, A. Wurch, N. Yoshida, T. Watanabe, M. Satake, and V. Steimle Morpholino Antisense Oligonucleotide-Mediated Gene Knockdown During Thymocyte Development Reveals Role for Runx3 Transcription Factor in CD4 Silencing During Development of CD4-/CD8+ Thymocytes J. Immunol., October 1, 2003; 171(7): 3594 - 3604. [Abstract] [Full Text] [PDF]

				M. J. Jeon, J. A. Kim, S. H. Kwon, S. W. Kim, K. S. Park, S.-W. Park, S. Y. Kim, and C. S. Shin Activation of Peroxisome Proliferator-activated Receptor-{gamma} Inhibits the Runx2-mediated Transcription of Osteocalcin in Osteoblasts J. Biol. Chem., June 20, 2003; 278(26): 23270 - 23277. [Abstract] [Full Text] [PDF]

				C. A. P. Bristow and P. Shore Transcriptional regulation of the human MIP-1{alpha} promoter by RUNX1 and MOZ Nucleic Acids Res., June 1, 2003; 31(11): 2735 - 2744. [Abstract] [Full Text] [PDF]