Galectin-8 binding to integrins inhibits cell adhesion and induces apoptosis

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Akiyama, S. K., Yamada, S. S., Yamada, K. M. and LaFlamme, S. E (1994). Transmembrane signal transduction by integrin cytoplasmic domains expressed in single-subunit chimeras. J. Biol. Chem 269, 15961-15964.[Abstract/Free Full Text]

Barondes, S. H., Castronovo, V., Cooper, D. N., Cummings, R. D., Drickamer, K., Feizi, T., Gitt, M. A., Hirabayashi, J., Hughes, C., Kasai, K. et al (1994). Galectins: a family of animal beta-galactoside-binding lectins [letter]. Cell 76, 597-598.[Medline]

Barondes, S. H., Cooper, D. N. W., Gitt, M. A. and Leffler, H (1994). Galectins. Structure and function of a large family of animal lectins. J. Biol. Chem 269, 20807-20810.[Free Full Text]

Blystone, S. D., Graham, I. L., Lindberg, F. P. and Brown, E. J (1994). Integrin alpha v beta 3 differentially regulates adhesive and phagocytic functions of the fibronectin receptor alpha 5 beta 1. J. Cell Biol 127, 1129-1137.[Abstract/Free Full Text]

Bouzon, M., Dussert, C., Lissitzky, J. C. and Martin, P. M (1990). Spreading of B16 F1 cells on laminin and its proteolytic fragments P1 and E8: involvement of laminin carbohydrate chains. Exp. Cell Res 190, 47-56.[Medline]

Cadone, M. H., Salvesen, G. S., Widmann, C., Johnson, G. and Frisch, S. M (1997). The regulation of anoikis: MEKK-1 activation requires cleavage by Caspases. Cell 90, 315-323.[Medline]

Carter, W. G., Rauvala, H. and Hakamori, S. I (1981). Studies on cell adhesion and recognition II. The kinetics of cell adhesion and cell spreading on surfaces coated with carbohydrate-reactive proteins (glycosidases and lectins) and fibronectin. J. Cell Biol 88, 138-148.[Abstract/Free Full Text]

Clark, E. A. and Brugge, J. S (1995). Integrins and signal transduction pathways: the road taken. Science 268, 233-239.[Abstract/Free Full Text]

Cooper, D. N., Massa, S. M. and Barondes, S. H (1991). Endogenous muscle lectin inhibits myoblast adhesion to laminin. J. Cell Biol 115, 1437-1448.[Abstract/Free Full Text]

Dean, J., Chandrasekaran, S. and Tanzer, M. L (1990). A biological role of the carbohydrate moieties of laminin. J. Biol. Chem 265, 12553-12562.[Abstract/Free Full Text]

Diaz-Gonzalez, F., Forsyth, J., Steiner, B. and Ginsberg, M. H (1996). Trans-dominant inhibition of integrin function. Mol. Biol. Cell 7, 1939-1951.[Abstract]

DiPersio, C. M., Shah, S. and Hynes, R. O (1995). Alpha 3A beta 1 integrin localizes to focal contacts in response to diverse extracellular matrix proteins. J. Cell Sci 108, 2321-2336.[Abstract]

Elices, M. J., Urry, L. A. and Hemler, M. E (1991). Receptor functions for the integrin VLA-3: fibronectin, collagen, and laminin binding are differentially influenced by Arg-Gly-Asp peptide and by divalent cations. J. Cell Biol 112, 169-181.[Abstract/Free Full Text]

Frisch, S. M. and Francis, H (1994). Disruption of epithelial cell-matrix interactions induces apoptosis. J. Cell Biol 124, 619-626.[Abstract/Free Full Text]

Giancotti, F. G. and Ruoslahti, E (1999). Integrin signaling. Science 285, 1028-1032.[Abstract/Free Full Text]

Ginsberg, M. H., Du, X. and Plow, E. F (1992). Inside-out Integrin signalling. Curr. Opin. Cell Biol 4, 766-771.[Medline]

Gu, M., Wang, W., Song, W. K., Cooper, D. N. and Kaufman, S. J (1994). Selective modulation of the interaction of alpha 7 beta 1 integrin with fibronectin and laminin by L-14 lectin during skeletal muscle differentiation. J. Cell Sci 107, 175-181.[Abstract]

Hadari, Y. R., Geiger, B., Nadiv, O., Sabanay, I., Roberts Jr, C. T., LeRoith, D. and Zick, Y (1993). Hepatic tyrosine phosphorylated proteins identified and localized following in vivo inhibition of protein tyrosine phosphatases: Effects of H2O2and vanadate administration into rat livers. Mol. Cell. Endocrinol 97, 9-17.[Medline]

Hadari, Y. R., Haring, H. U. and Zick, Y (1997). p75, a member of the heat shock protein family, undergoes tyrosine phosphorylation in response to oxidative stress. J. Biol. Chem 272, 657-662.[Abstract/Free Full Text]

Hadari, Y. R., Paz, K., Dekel, R., Mestrovic, T., Accili, D. and Zick, Y (1995). Galectin-8: a new rat lectin, related to galectin-4. J. Biol. Chem 270, 3447-3453.[Abstract/Free Full Text]

Hannigan, G. E., Leung-Hagesteijn, H., Fitz-Gibbon, L., Coppolino, M. G., Radeva, G., Filmus, J., Bell, J. C. and Dedhar, S (1996). Regulation of cell adhesion and anchorage-dependent growth by a new b1-integrin-linked protein kinase. Nature 379, 91-96.[Medline]

Hughes, P. E., Diaz, G. F., Leong, L., Wu, C., McDonald, J. A., Shattil, S. J. and Ginsberg, M. H (1996). Breaking the integrin hinge. A defined structural constraint regulates integrin signaling. J. Biol. Chem 271, 6571-6574.[Abstract/Free Full Text]

Hughes, P. E., Renshaw, M. W., Pfaff, M., Forsyth, J., Keivens, V. M., Schwartz, M. A. and Ginsberg, M. H (1997). Suppression of integrin activation: a novel function of a Ras/Raf-initiated MAP kinase pathway. Cell 88, 521-530.[Medline]

Hughes, R. C (1999). Secretion of the galectin family of mammalian carbohydrate-binding proteins. Biochim. Biophys. Acta 1473, 172-185.[Medline]

Huhtala, P., Humphries, M. J., McCarthy, J. B., Tremble, P. M., Werb, Z. and Damsky, C. H (1995). Cooperative signaling by alpha 5 beta 1 and alpha 4 beta 1 integrins regulates metalloproteinase gene expression in fibroblasts adhering to fibronectin. J. Cell Biol 129, 867-879.[Abstract/Free Full Text]

Hynes, R. O (1992). Integrins: versatility, modulation, and signaling in cell adhesion. Cell 69, 11-25.[Medline]

Kuwabara, I. and Liu, F. T (1996). Galectin-3 promotes adhesion of human neutrophils to laminin. J. Immunol 156, 3939-3944.[Abstract]

Laemmli, U. K (1970). Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227, 680-685.[Medline]

Lewis, J. M. and Schwartz, M. A (1995). Mapping in vivo association of cytoplasmic proteins with integrin b1 cytoplasmic domain mutants. Mol. Biol. Cell 6, 151-160.[Abstract]

Lis, H. and Sharon, N (1972). Soybean (Glycine max) agglutinin. Meth. Enzymol 28, 360-368.

Mahanthappa, N. K., Cooper, D. N. W., Barondes, S. H. and Schwarting, G. A (1994). Rat olfactory neurins can utilize the endogenous lectin, L-14, in a novel adhesion mechanism. Development 120, 1373-1384.[Abstract]

Mitsudomi, T., Steinberg, S. M., Nau, M. M., Carbone, D., D'Amico, D., Bodner, S., Oie, H. K., Linnoila, R. I., Mulshine, J. L., Minna, J. D. et al (1992). p53 gene mutations in non-small-cell lung cancer cell lines and their correlation with the presence of ras mutations and clinical features. Oncogene 7, 171-180.[Medline]

Miyamoto, S., Akiyama, S. K. and Yamada, K. M (1995). Synergistic roles for receptor occupancy and aggregation in integrin transmembrane function. Science 267, 883-885.[Abstract/Free Full Text]

Miyamoto, S., Teramoto, H., Coso, O. A., Gutkind, J. S., Burbelo, P. D., Akiyama, S. K. and Yamada, K. M (1995). Integrin function: molecular hierarchies of cytoskeletal and signaling molecules. J. Cell Biol 131, 791-805.[Abstract/Free Full Text]

O'Toole, T. E., Katagiri, Y., Faull, R. J., Peter, K., Tamura, R., Quaranta, V., Loftus, J. C., Shattil, S. J. and Ginsberg, M. H (1994). Integrin cytoplasmic domains mediate inside-out signal transduction. J. Cell Biol 124, 1047-1059.[Abstract/Free Full Text]

Oppenheimer-Marks, N. and Grinnel, F (1981). Effects of plant lectins on the adhesive properties of baby hamster kidney cells. Eur. J. Cell Biol 23, 286-294.[Medline]

Perillo, N. L., Pace, K. E., Seilhamer, J. J. and Baum, L. G (1995). Apoptosis of T cells mediated by galectin-1. Nature 378, 736-739.[Medline]

Potts, J. R. and Campbell, I. D (1994). Fibronectin structure and assembly. Curr. Opin. Cell Biol 6, 648-655.[Medline]

Ruoslahti, E. and Reed, C. J (1994). Anchorage dependence, integrins, and apoptosis. Cell 77, 477-478.[Medline]

Sato, S. and Hughes, R. C (1992). Binding specificity of a baby hamster kidney lectin for H type I and II chains, polylactosamine glycans, and appropriately glycosylated forms of laminin and fibronectin. J. Biol. Chem 267, 6983-6990.[Abstract/Free Full Text]

Schwartz, M. A., Schaller, M. D. and Ginsberg, M. H (1995). Integrins: emerging paradigms of signal transduction. Annu. Rev. Cell Biol 11, 549-599.[Medline]

Sharon, N. and Lis, H (1995). Lectins-proteins with a sweet tooth: function in cell recognition. Essays Biochem 30, 59-75.[Medline]

Springer, T. A (1995). Traffic signals on endothelium for lymphocyte recirculation and leukocyte emigration. Annu. Rev. Physiol 57, 827-872.[Medline]

Stuiver, I. and O'Toole, T. E (1995). Regulation of integrin function and cellular adhesion. Stem Cells 13, 250-262.[Abstract]

Su, Z.-Z., Lin, J., Shen, R., Fisher, P. E., Goldstein, N. I. and Fisher, P. B (1996). Surface-epitope masking and expression cloning identifies the human prostate carcinoma tumor antigen PCTA-1 a member of the galectin gene family. Proc. Natl. Acad. Sci. USA 93, 7252-7257.[Abstract/Free Full Text]

Symington, B. E., Takada, Y. and Carter, W. G (1993). Interaction of integrins alpha 3 beta 1 and alpha 2 beta 1: potential role in keratinocyte intercellular adhesion. J. Cell Biol 120, 523-535.[Abstract/Free Full Text]

Vassbotn, F. S., Havnen, O. K., Heldin, C. H. and Holmsen, H (1994). Negative feedback regulation of human platelets via autocrine activation of the platelet-derived growth factor alpha-receptor. J. Biol. Chem 269, 13874-13879.[Abstract/Free Full Text]

Zhang, Z., Vuori, K., Wang, H., Reed, J. C. and Ruoslahti, E (1996). Integrin activation by R-ras. Cell 85, 61-69.[Medline]

Zhou, Q. and Cummings, R. D (1993). L-14 lectin recognition of laminin and its promotion of in vitro cell adhesion. Arch. Biochem. Biophys 300, 6-17.[Medline]

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				H. Yamamoto, N. Nishi, H. Shoji, A. Itoh, L.-H. Lu, M. Hirashima, and T. Nakamura Induction of Cell Adhesion by Galectin-8 and its Target Molecules in Jurkat T-Cells J. Biochem., March 1, 2008; 143(3): 311 - 324. [Abstract] [Full Text] [PDF]

				M. V. Tribulatti, J. Mucci, V. Cattaneo, F. Aguero, T. Gilmartin, S. R. Head, and O. Campetella Galectin-8 Induces Apoptosis in the CD4highCD8high Thymocyte Subpopulation Glycobiology, December 1, 2007; 17(12): 1404 - 1412. [Abstract] [Full Text] [PDF]

				D. NAOR, S. NEDVETZKI, M. WALMSLEY, A. YAYON, E. A. TURLEY, I. GOLAN, D. CASPI, L. E. SEBBAN, Y. ZICK, T. GARIN, et al. CD44 Involvement in Autoimmune Inflammations: The Lesson to be Learned from CD44-Targeting by Antibody or from Knockout Mice Ann. N.Y. Acad. Sci., September 1, 2007; 1110(1): 233 - 247. [Abstract] [Full Text] [PDF]

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				Y. Levy, S. Auslender, M. Eisenstein, R. R. Vidavski, D. Ronen, A. D. Bershadsky, and Y. Zick It depends on the hinge: a structure-functional analysis of galectin-8, a tandem-repeat type lectin Glycobiology, June 1, 2006; 16(6): 463 - 476. [Abstract] [Full Text] [PDF]

				A. Lagana, J. G. Goetz, P. Cheung, A. Raz, J. W. Dennis, and I. R. Nabi Galectin Binding to Mgat5-Modified N-Glycans Regulates Fibronectin Matrix Remodeling in Tumor Cells Mol. Cell. Biol., April 15, 2006; 26(8): 3181 - 3193. [Abstract] [Full Text] [PDF]

				B. N. Stillman, D. K. Hsu, M. Pang, C. F. Brewer, P. Johnson, F.-T. Liu, and L. G. Baum Galectin-3 and Galectin-1 Bind Distinct Cell Surface Glycoprotein Receptors to Induce T Cell Death J. Immunol., January 15, 2006; 176(2): 778 - 789. [Abstract] [Full Text] [PDF]

				C. Fischer, H. Sanchez-Ruderisch, M. Welzel, B. Wiedenmann, T. Sakai, S. Andre, H.-J. Gabius, L. Khachigian, K. M. Detjen, and S. Rosewicz Galectin-1 Interacts with the {alpha}5{beta}1 Fibronectin Receptor to Restrict Carcinoma Cell Growth via Induction of p21 and p27 J. Biol. Chem., November 4, 2005; 280(44): 37266 - 37277. [Abstract] [Full Text] [PDF]

				M. Baba, J. Wada, J. Eguchi, I. Hashimoto, T. Okada, A. Yasuhara, K. Shikata, Y. S. Kanwar, and H. Makino Galectin-9 Inhibits Glomerular Hypertrophy in db/db Diabetic Mice via Cell-Cycle-Dependent Mechanisms J. Am. Soc. Nephrol., November 1, 2005; 16(11): 3222 - 3234. [Abstract] [Full Text] [PDF]

				R. Arbel-Goren, Y. Levy, D. Ronen, and Y. Zick Cyclin-dependent Kinase Inhibitors and JNK Act as Molecular Switches, Regulating the Choice between Growth Arrest and Apoptosis Induced by Galectin-8 J. Biol. Chem., May 13, 2005; 280(19): 19105 - 19114. [Abstract] [Full Text] [PDF]

				A. Sturm, M. Lensch, S. Andre, H. Kaltner, B. Wiedenmann, S. Rosewicz, A. U. Dignass, and H.-J. Gabius Human Galectin-2: Novel Inducer of T Cell Apoptosis with Distinct Profile of Caspase Activation J. Immunol., September 15, 2004; 173(6): 3825 - 3837. [Abstract] [Full Text] [PDF]

				K. K. Hoyer, M. Pang, D. Gui, I. P. Shintaku, I. Kuwabara, F.-T. Liu, J. W. Said, L. G. Baum, and M. A. Teitell An Anti-Apoptotic Role for Galectin-3 in Diffuse Large B-Cell Lymphomas Am. J. Pathol., March 1, 2004; 164(3): 893 - 902. [Abstract] [Full Text] [PDF]

				T. Fukumori, Y. Takenaka, T. Yoshii, H.-R. C. Kim, V. Hogan, H. Inohara, S. Kagawa, and A. Raz CD29 and CD7 Mediate Galectin-3-Induced Type II T-Cell Apoptosis Cancer Res., December 1, 2003; 63(23): 8302 - 8311. [Abstract] [Full Text] [PDF]

				N. Nishi, H. Shoji, M. Seki, A. Itoh, H. Miyanaka, K. Yuube, M. Hirashima, and T. Nakamura Galectin-8 modulates neutrophil function via interaction with integrin {alpha}M Glycobiology, November 1, 2003; 13(11): 755 - 763. [Abstract] [Full Text] [PDF]

				H. Ideo, A. Seko, I. Ishizuka, and K. Yamashita The N-terminal carbohydrate recognition domain of galectin-8 recognizes specific glycosphingolipids with high affinity Glycobiology, October 1, 2003; 13(10): 713 - 723. [Abstract] [Full Text] [PDF]

				S. Boura-Halfon, H. Voliovitch, R. Feinstein, K. Paz, and Y. Zick Extracellular Matrix Proteins Modulate Endocytosis of the Insulin Receptor J. Biol. Chem., April 25, 2003; 278(18): 16397 - 16404. [Abstract] [Full Text] [PDF]

				Y. Levy, D. Ronen, A. D. Bershadsky, and Y. Zick Sustained Induction of ERK, Protein Kinase B, and p70 S6 Kinase Regulates Cell Spreading and Formation of F-actin Microspikes Upon Ligation of Integrins by Galectin-8, a Mammalian Lectin J. Biol. Chem., April 11, 2003; 278(16): 14533 - 14542. [Abstract] [Full Text] [PDF]

				Y. Kashio, K. Nakamura, M. J. Abedin, M. Seki, N. Nishi, N. Yoshida, T. Nakamura, and M. Hirashima Galectin-9 Induces Apoptosis Through the Calcium-Calpain-Caspase-1 Pathway J. Immunol., April 1, 2003; 170(7): 3631 - 3636. [Abstract] [Full Text] [PDF]

				J. D. Hernandez and L. G. Baum Ah, sweet mystery of death! Galectins and control of cell fate Glycobiology, October 1, 2002; 12(10): 127R - 136R. [Abstract] [Full Text] [PDF]

				G. A. Rabinovich, N. Rubinstein, and L. Fainboim Unlocking the secrets of galectins: a challenge at the frontier of glyco-immunology J. Leukoc. Biol., May 1, 2002; 71(5): 741 - 752. [Abstract] [Full Text] [PDF]

				J. L. Dunphy, G. J. Barcham, R. J. Bischof, A. R. Young, A. Nash, and E. N. T. Meeusen Isolation and Characterization of a Novel Eosinophil-specific Galectin Released into the Lungs in Response to Allergen Challenge J. Biol. Chem., April 19, 2002; 277(17): 14916 - 14924. [Abstract] [Full Text] [PDF]

				K. E. Pace, T. Lebestky, T. Hummel, P. Arnoux, K. Kwan, and L. G. Baum Characterization of a Novel Drosophila melanogaster Galectin. EXPRESSION IN DEVELOPING IMMUNE, NEURAL, AND MUSCLE TISSUES J. Biol. Chem., April 5, 2002; 277(15): 13091 - 13098. [Abstract] [Full Text] [PDF]

				N Nagy, Y Bronckart, I Camby, H Legendre, H Lahm, H Kaltner, Y Hadari, P Van Ham, P Yeaton, J-C Pector, et al. Galectin-8 expression decreases in cancer compared with normal and dysplastic human colon tissue and acts significantly on human colon cancer cell migration as a suppressor Gut, March 1, 2002; 50(3): 392 - 401. [Abstract] [Full Text] [PDF]

				I. Kuwabara, Y. Kuwabara, R.-Y. Yang, M. Schuler, D. R. Green, B. L. Zuraw, D. K. Hsu, and F.-T. Liu Galectin-7 (PIG1) Exhibits Pro-apoptotic Function through JNK Activation and Mitochondrial Cytochrome c Release J. Biol. Chem., January 25, 2002; 277(5): 3487 - 3497. [Abstract] [Full Text] [PDF]

				P. M. Timmons, P. W. J. Rigby, and F. Poirier The murine seminiferous epithelial cycle is pre-figured in the Sertoli cells of the embryonic testis Development, January 2, 2002; 129(3): 635 - 647. [Abstract] [Full Text] [PDF]

				Y. Levy, R. Arbel-Goren, Y. R. Hadari, S. Eshhar, D. Ronen, E. Elhanany, B. Geiger, and Y. Zick Galectin-8 Functions as a Matricellular Modulator of Cell Adhesion J. Biol. Chem., August 10, 2001; 276(33): 31285 - 31295. [Abstract] [Full Text] [PDF]

				K. Hotta, T. Funahashi, Y. Matsukawa, M. Takahashi, H. Nishizawa, K. Kishida, M. Matsuda, H. Kuriyama, S. Kihara, T. Nakamura, et al. Galectin-12, an Adipose-expressed Galectin-like Molecule Possessing Apoptosis-inducing Activity J. Biol. Chem., August 31, 2001; 276(36): 34089 - 34097. [Abstract] [Full Text] [PDF]