Protein kinase C activation leads to dephosphorylation of occludin and tight junction permeability increase in LLC-PK1 epithelial cell sheets

QUICK SEARCH:

[advanced]

	Author:		Keyword(s):

Home Help Feedback Subscriptions Archive Search Table of Contents

This Article

	Summary
	Full Text (PDF)
	Alert me when this article is cited
	Alert me if a correction is posted

Services

	Email this article to a friend
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new issues of the journal
	Download to citation manager


Citing Articles

	Citing Articles via HighWire
	Citing Articles via Google Scholar

Google Scholar

	Articles by Clarke, H.
	Articles by Mullin, J. M.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Clarke, H.
	Articles by Mullin, J. M.

Anderson, J. M. and Van Itallie, C. M (1995). Tight junctions and the molecular basis for regulation of paracellular permeability. Am. J. Physiol 269, 467-.

Ando-Akatsuka, Y., Saitou, M., Hirase, T., Kishi, M., Sakakibara, A., Itoh, M., Yonemura, S., Furuse, M. and Tsukita, S (1996). Interspecies diversity of the occludin sequence: cDNA cloning of human, mouse, dog and rat-kangaroo homologues. J. Cell Biol 133, 43-47.[Abstract/Free Full Text]

Balda, M. S., Gonzalez-Mariscal, R. G., Contreras, M., Macias-Silva, M., Torres-Marquez, M. E., Garcia-Sainz, J. A. and Cereijido, M (1991). Assembly and sealing of tight junctions: possible participation of G-proteins, phospholipase C, protein kinase C and calmodulin. J. Membr. Biol 122, 193-202.[Medline]

Balda, M. S., Gonzalez-Mariscal, L., Matter, K., Cereijido, M. and Anderson, J. M (1993). Assembly of the tight junction: the role of diacylglycerol. J. Cell Biol 123, 293-302.[Abstract/Free Full Text]

Balda, M. S., Whitney, J. A., Flores, C., Gonzalez-Mariscal, L., Cereijido, M. and Matter, K (1996). Functional dissociation of paracellularpermeability and transepithelial electrical resistance and disruption of the apical-basolateral intramembrane diffusion barrier by the expression of a mutant tight junction membrane protein. J. Cell Biol 134, 1031-1049.[Abstract/Free Full Text]

Bentzel, C. J., Hainau, S., Ho, S., Hui, S. W., Edelman, A., Anagnostopoulos, T. and Benedetti, E. L (1980). Cytoplasmic regulation of tight junction permeability: effect of plant cytokines. Am. J. Physiol 239, 75-.

Canfield, P. E., Geerdes, A. M and Molitoris, B. A (1991). Effect of reversible ATP depletion on tight junction integrity in LLC-PK1 cells. Am. J. Physiol 261, 1038-.

Cereijido, M., Robbins, E. S., Dolan, W. J., Rotunno, C. A. and Sabatini, D. D (1978). Polarized monolayers formed by epithelial cells on a permeable and translucent support. J. Cell Biol 77, 853-880.[Abstract/Free Full Text]

Chen, Y., Merzdorf, C., Paul, D. L. and Goodenough, D. A (1997). COOH terminus of occludin is required for tight junction barrier function in early Xenopus embryos. J. Cell Biol 138, 891-899.[Abstract/Free Full Text]

Chen, Y., Lu, Q., Schneeberger, E. E. and Goodenough, D. A (2000). Restoration of tight junction structure and barrier function by downregulation of the mitogen-activated protein kinase pathway in Ras-transformed Madin-Darby Canine Kidney cells. Mol. Biol. Cell 11, 849-862.[Abstract/Free Full Text]

Citi, S., Sabanay, H., Jakes, R., Geiger, B. and Kendrick-Jones, J (1988). Cingulin, a new peripheral component of tight junctions. Nature 333, 272-276.[Medline]

Citi, S. and Denisenko, N (1995). Phosphorylation fo the tight junction protein cingulin and the effects of protein kinase inhibitors and activators in MDCK epithelial cells. J. Cell Sci 108, 2917-2926.[Abstract]

Cordenonsi, M., Mazzon, E., De Rigo, L., Baraldo, S., Meggio, F. and Citi, S (1997). Occludin dephosphorylation in early development of Xenopus laevis. J. Cell Sci 110, 3131-3139.[Abstract]

Dodane, V. and Kachar, B (1996). Identification of isoforms of G proteins that colocalize with tight junctions. J. Membr. Biol 149, 199-209.[Medline]

Fanning, A. S., Jameson, B. J., Jesaitis, L. A. and Anderson, J. M (1998). The tight junction protein ZO-1 establishes a link between the transmembrane protein occludin and the actin cytoskeleton. J. Biol. Chem 273, 29745-29753.[Abstract/Free Full Text]

Farshori, P. and Kachar, B (1999). Redistribution and phosphorylation of occludin during opening and resealing of tight junction junctions in cultured epithelial cells. J. Membr. Biol 170, 147-156.[Medline]

Fasano, A., Fiorentini, C., Donelli, G., Uzzau, S., Kaper, J. B., Margaretten, K., Guandalini, S., Comstock, L. and Goldblum, S. E (1995). Zonula occludens toxin modulates tight junctions through protein kinase C-dependent actin reorganization, in vitro. J. Clin. Invest 96, 710-720.

Fujimoto, K (1995). Freeze-fracture replica electron microscopy combined with SDS digestion for cytochemical labeling of integral membrane proteins. Application to the immunogold labeling of intercellular junctional complexes. J. Cell Biol 123, 1777-1788.[Abstract/Free Full Text]

Furuse, M., Hirase, T., Itoh, M., Nagafuchi, A., Yonemura, S., Tsukita, S. and Tsukita, S (1993). Occludin: a novel integral membrane protein localizing at tight junctions. J. Cell Biol 123, 1777-1788.

Furuse, M., Itoh, M., Hirase, T., Nagafuchi, A., Yonemura, S., Tsukita, S. and Tsukita, S (1994). Direct association of occludin with ZO-1 and its possible involvement in the localization of occludin at tight junctions. J. Cell Biol 127, 1617-1626.[Abstract/Free Full Text]

Furuse, M., Fujimoto, K., Sato, N., Hirase, T., Tsukita, S. and Tsukita, S (1996). Overexpression of occludin, a tight junction-associated integral protein, induces the formation of multilamellar bodies bearing tight junction-like structures. J. Cell Sci 109, 429-435.[Abstract]

Furuse, M., Fujita, K., Hiiragi, T., Fujimoto, K. and Tsukita, S (1998). Claudin-1 and-2: novel membrane proteins localizing at tight junctions with no sequence similarity to occludin. J. Cell Biol 141, 1539-1550.[Abstract/Free Full Text]

Furuse, M., Sasaki, H., Fujimoto, K. and Tsukita, S (1998). A single gene product, claudin-1 or2 reconstitutes tight junction strands and recruits occludin in fibroblasts. J. Cell Biol 143, 391-401.[Abstract/Free Full Text]

Gopalakrishnan, S., Raman, N., Atkinson, S. and Marrs, J. A (1998). Rho GTPase signaling regulates tight junction assembly and protects tight junctions during ATP depletion. Am. J. Physiol 275, 798-.

Gumbiner, B (1990). Generation and maintenance of epithelial cell polarity. Curr. Opin. Cell Biol 2, 881-887.[Medline]

Gumbiner, B., Lowenkopf, T. and Apatira., D (1991). Identification of a 160-kDa polypeptide that binds to the tight junctional protein ZO-1. Proc. Nat. Acad. Sci. USA 88, 3460-34.[Abstract/Free Full Text]

Haskins, J., Gu, L., Wittchen, E. S., Hibbard, J. and Stevenson, B (1998). ZO-3, a novel member of the MAGUK protein family found at the tight junction, interacts with ZO-1 and occludin. J. Cell Biol 141, 199-208.[Abstract/Free Full Text]

Hecht, G., Robinson, B. and Koutsouris, A (1994). Reversible disassembly of an intestinal epithelial monolayer by prolonged exposure to phorbol ester. Am. J. Physiol 266, 214-.

Hull, R. N., Cherry, W. R. and Weaver, G. W (1976). The origin and characteristics of a pig kidney cell strain, LLC-PK1. In Vitro 12, 670-677.[Medline]

Itoh, M., Nagafuchi, A., Moroi, S. and Tsukita, S (1997). Involvement of ZO-1 in cadherin-based cell adhesion through its direct binding to a catenin and actin filaments. J. Cell Biol 138, 181-192.[Abstract/Free Full Text]

Itoh, M., Morita, K. and Tsukita, S (1999). Characterization of ZO-2 as a MAGUK family member associated with tight and adherens junctions with a binding affinity to occludin and a catenin. J. Biol. Chem 274, 5981-5986.[Abstract/Free Full Text]

Izumi, Y., Hirose, T., Tamai, Y., Hirai, S., Nagashima, Y., Fujimoto, T., Tabuse, Y., Kemphues, K. J. and Ohno, S (1998). An atypical PKC directly associates and colocalizes at the epithelial tight junction with ASIP, a mammalian homologue of Caenorhaditis elegans polarity protein PAR-3. J. Cell Biol 143, 95-106.[Abstract/Free Full Text]

Jesaitis, L. A. and Goodenough, D. A (1994). Molecular characterization and tissue distribution of ZO-2 a tight junction protein homologous to ZO-1 and the Drosophila Discs-large tumor suppressor protein. J. Cell Biol 124, 949-961.[Abstract/Free Full Text]

Keon, B. H., Schafer, S., Kuhn, C., Grund, C. and Francke, W. W (1996). Symplekin, a novel tight junction plaque protein. J. Cell Biol 134, 1003-1018.[Abstract/Free Full Text]

Laemmli, U. K (1970). Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227, 680-685.[Medline]

Li, D. and Mrsny, R (2000). Oncogenic Raf-1 disrupts epithelial tight junctions via downregulation of occludin. J. Cell Biol 148, 791-800.[Abstract/Free Full Text]

Lum, H. and Malik, A. B (1994). Regulation of vascular endothelial barrier function. Am. J. Physiol 267, 223-241.

Madara, J. L (1987). Intestinal absorptive cell tight junctions are linked to the cytoskeleton. Am. J. Physiol 253, 171-.

Madara, J. L (1988). Tight junction dynamics: is paracellular transport regulated?. Cell 53, 497-498.[Medline]

Madara, J. L., Stafford, J., Barenberg, D. and Carlson, S (1988). Functional coupling of tight junctions and microfilaments in T84 monolayers. Am. J. Physiol 254, 416-.

Madara, J. L. and J. Stafford, J (1989). Interferon-gamma directly affects barrier function of cultured intestinal epithelial monolayers. J. Clin. Invest 83, 724-727.

Madara, J. L., Parkos, C., Colgan, S., Nusrat, A., Atisook, K. and Kautzani, P (1992). The movement of solutes and cells across tight junctions. Ann. NY Acad. Sci 664, 47-60.[Abstract]

Marano, C. W., Lewis, S. A., Garulacan, L. A., Soler, A. P. and Mullin, J. M (1998). Tumor necrosis factor-increases sodium and chloride conductance across the tight junction of Caco-2 BBE, a human intestinal epithelial cell line. J. Membr. Biol 161, 263-274.[Medline]

Martinez-Palomo, A., Meza, I., Beaty, G. and Cereijido, M (1980). Experimental modulation of occluding junctions in a cultured transporting epithelium. J. Cell Biol 87, 736-745.[Abstract/Free Full Text]

McCarthy, K. M., Skare, I. B., Stankewich, M. C., Furuse, M., Tsukita, S., Rogers, R. A., Lynch, R. D. and Schneeeberger, E. E (1996). Occludin is a functional component of the tight junction. J. Cell Sci 109, 2287-2298.[Abstract]

Moore, R., Pothoulakis, C., LaMont, J. T., Carlson, S. and Madara, J. L (1990). C. difficile toxin A increases intestinal permeability and induces Clsecretion. Am. J. Physiol 259, 165-.

Morita, K., Furuse, M., Fujimoto, K. and Tsukita, S (1999). Claudin multigene family encoding four transmembrane domain protein components of tight junction strands. Proc. Nat. Acad. Sci. USA 96, 511-516.[Abstract/Free Full Text]

Moroi, S., Saitou, M., Fujimoto, K., Sakakibara, A., Furuse, M., Yoshida, O. and Tsukita, S (1998). Occludin is concentrated at tight junctions of mouse/rat but not human/guinea pig Sertoli cells in testes. Am. J. Physiol 274, 1708-.

Mullin, J. M. and O'Brien, T. G (1986). Effect of tumor promoters on LLC-PK1 renal epithelial tight junctions and transepithelial fluxes. Am. J. Physiol 251, 597-.

Mullin, J. M and McGinn, M. T (1988). Effects of diacylglycerols on LLC-PK1 renal epithelia: similarity to phorbol ester tumor promoters. J. Cell. Physiology 134, 357-366.[Medline]

Mullin, J. M. and Snock, K. V (1990). Effect of tumor necrosis factor on epithelial tight junctions and transepithelial permeability. Cancer Res 50, 2172-2176.[Abstract/Free Full Text]

Mullin, J. M., McGinn, M. T., Snock, K. V. and Imaizumi, S (1990). The effects of teleocidin and aplysiatoxin tumor promoters on epithelial tight junctions and transepithelial permeability: comparision to phorbol esters. Carcinogenesis 11, 377-385.[Abstract/Free Full Text]

Mullin, J. M, Snock, K. V., Shurina, R. D., Noe, J., George, K., Misner, L., Maizumi, S. and O'Brien, T. G (1992). Effects of acute vs. chronic phorbol ester exposure on transepithelial permeability and epithelial morphology. J. Cell. Physiol 152, 35-47.[Medline]

Mullin, J. M, Soler, A. P., Laughlin, K. V., Kampherstein, J. A., Russo, L. M., Saladik, D. T., Shurina, R. D. and O'Brien, T. G (1996). Chronic exposure of LLC-PK1 epithelia to the phorbol ester TPA produces polyp-likefoci with leaky tight junctions and altered protein kinase C-expression and localization. Exp. Cell Res 227, 12-22.[Medline]

Mullin, J. M., Kampherstein, J. A., Laughlin, K. V., Saladik, D. T. and Peralta Soler, A (1997). Transepithelial paracellular leakiness induced by chronic phorbol ester exposure correlates with polyp-like foci and redistribution of protein kinase C-. Carcinogenesis 18, 2339-2345.[Abstract/Free Full Text]

Mullin, J. M., Marano, C. W., Laughlin, K. V., Nuciglio, M., Stevenson, B. R. and Soler, A. P (1997). Different size limintations for increased transepithelial paracellular solute flux across phorbol ester and TNF-treated epithelial cell sheets. J. Cell Physiol 171, 226-233.[Medline]

Muresan, Z., Paul, D. L. and Goodenough, D. A (2000). Occludin 1B, a varient of the tight junction protein occludin. Mol. Biol. Cell 11, 627-634.[Abstract/Free Full Text]

Nigam, S. K., Denisenko, N., Rodriguez, E. and Citi, S (1991). The role of phosphorylation in development of tight junctions in cultured renal epithelial (MDCK) cells. Biochem. Biophys. Res. Commun 181, 548-553.[Medline]

Ojakian, G. K (1981). Tumor promoter-induced changes in the permeability of epithelial cell tight junctions. Cell 23, 95-103.[Medline]

Saitou, M., Ando-Akatsuka, Y., Itoh, M., Furuse, M., Inazawa, J., Fujimoto, K. and Tsukita, S (1997). Mammalian occludin in epithelial cells: its expression and subcellular distribution. Eur. J. Cell Biol 73, 222-231.

Sakakibara, A., Furuse, M., Saitou, M., Ando-Akatsuka, Y. and Tsukita, S (1997). Possible involvemnt of phosphorylation of occludin in tight junction formation. J. Cell Biol 137, 1393-1401.[Abstract/Free Full Text]

Saxon, M. L., Zhao, X. and Black., J. D (1994). Activation of protein kinase C isozymes is associated with post-mitotic events in intestinal epithelial cells in situ. J. Cell Biol 126, 747-763.[Abstract/Free Full Text]

Schneeberger, E. E. and Lynch, R. D (1992). Structure, function, and regulation of cellular tight junctions. Am J. Physiol 262, 647-.

Staddon, J. M., Herrenknecht, K., Smales, C. and Rubin, L. L (1995). Evidence that tyrosine phosphorylation may increase tight junction permeability. J. Cell Sci 108, 609-619.[Abstract]

Stenson, W. F., Easom, R. A., Riehl, T. E. and Turk, J (1993). Regulation of paracellular permeability in Caco-2 cell monolayers by protein kinase C. Am. J. Physiol 265, 955-.

Stevenson, B. R., Siliciano, J. D., Mooseker, M. S. and Goodenough, D. A (1986). Identification of ZO-1: a high molecular weight polypeptide associated with the tight junction (zonula occludens) in a variety of epithelia. J. Cell Biol 103, 755-766.[Abstract/Free Full Text]

Stuart, R. O. and Nigam, S. K (1995). Regulated assembly of tight junctions by protein kinase C. Proc. Nat. Acad. Sci USA 92, 6072-6076.[Abstract/Free Full Text]

Takeda, H. and Tsukita, S (1995). Effects of tyrosine phosphorylation on tight junctions in temperature-sensitive v-src-transfected MDCK cells. Cell Struct. Funct 20, 387-393.[Medline]

Tsukamoto, T. and Nigam, S (1999). Role of tyrosine phosphorylation in the reassembly of occludin and other tight junction proteins. Am. J. Physiol 276, 737-.

Tsukita, S., Itoh, M., Nagafuchi, A., Yonemure, S. and Tsukita, S (1993). Submembranous junctional plaque proteins include potential tumor suppressor molecules. J. Cell Biol 123, 1049-1053.[Free Full Text]

Weber, E., Berta, G., Tousson, A., St. John, P., Green, M. W., Gopalokrishnan, U., Jilling, T., Sorscher, E. J., Elton, T. S., Abrahamson, D. R. and Kirk, K. L (1994). Expression and polarized targeting of a rab3 isoform in epithelia cells. J. Cell Biol 125, 583-594.[Abstract/Free Full Text]

Wittchen, E. S., Haskins, J. and Stevenson, B. R (1999). Protein interactions at the tight junction: Actin has multiple binding partners, and ZO-1 forms independent complexes with ZO-2 and ZO-3. J. Biol. Chem 274, 35179-35185.[Abstract/Free Full Text]

Wong, V (1997). Phosphorylation of occludin correlates with occludin localization and function at the tight junction. Am. J. Physiol 273, 1859-.

Wong, V. and Gumbiner, B. M (1997). A synthetic peptide corresponding to the extracellular domain of occludin perturbs the tight junction permeability barrier. J. Cell Biol 136, 399-409.[Abstract/Free Full Text]

Zahraoui, A., Joberty, G., Arpin, M., Fontaine, J., Hellio, R., Tavitian, A. and Louvard, D (1994). A small rab GTPase is distributed in cytoplasmic vesicles in non polarized cells but colocalizes with the tight junction marler ZO-1 in polarized epithelial cells. J. Cell Biol 124, 101-115.[Abstract/Free Full Text]

Zhong, Y., Saitoh, T., Minase, N., Sawanda, N., Enomoto, K. and Mori, M (1993). Monoclonal antibody 7H6 reacts with a novel tight junction-associated protein distinct fro ZO-1, cingulin and ZO-2. J. Cell Biol 120, 477-483.[Abstract/Free Full Text]

This article has been cited by other articles:

K. Dokladny, D. Ye, J. C. Kennedy, P. L. Moseley, and T. Y. Ma
Cellular and Molecular Mechanisms of Heat Stress-Induced Up-Regulation of Occludin Protein Expression: Regulatory Role of Heat Shock Factor-1
Am. J. Pathol., March 1, 2008; 172(3): 659 - 670.
[Abstract] [Full Text] [PDF]

T. Suzuki, A. Seth, and R. Rao
Role of Phospholipase C{gamma}-induced Activation of Protein Kinase C{epsilon} (PKC{epsilon}) and PKC{beta}I in Epidermal Growth Factor-mediated Protection of Tight Junctions from Acetaldehyde in Caco-2 Cell Monolayers
J. Biol. Chem., February 8, 2008; 283(6): 3574 - 3583.
[Abstract] [Full Text] [PDF]

K. Kimura, S. Teranishi, K. Fukuda, K. Kawamoto, and T. Nishida
Delayed Disruption of Barrier Function in Cultured Human Corneal Epithelial Cells Induced by Tumor Necrosis Factor-{alpha} in a Manner Dependent on NF-{kappa}B
Invest. Ophthalmol. Vis. Sci., February 1, 2008; 49(2): 565 - 571.
[Abstract] [Full Text] [PDF]

P. Sheth, N. Delos Santos, A. Seth, N. F. LaRusso, and R. K. Rao
Lipopolysaccharide disrupts tight junctions in cholangiocyte monolayers by a c-Src-, TLR4-, and LBP-dependent mechanism
Am J Physiol Gastrointest Liver Physiol, July 1, 2007; 293(1): G308 - G318.
[Abstract] [Full Text] [PDF]

A. Seth, P. Sheth, B. C. Elias, and R. Rao
Protein Phosphatases 2A and 1 Interact with Occludin and Negatively Regulate the Assembly of Tight Junctions in the CACO-2 Cell Monolayer
J. Biol. Chem., April 13, 2007; 282(15): 11487 - 11498.
[Abstract] [Full Text] [PDF]

G. I. Gorodeski
Estrogen Decrease in Tight Junctional Resistance Involves Matrix-Metalloproteinase-7-Mediated Remodeling of Occludin
Endocrinology, January 1, 2007; 148(1): 218 - 231.
[Abstract] [Full Text] [PDF]

K. B. Sotiropoulos, A. Clermont, Y. Yasuda, C. Rask-Madsen, M. Mastumoto, J. Takahashi, K. Della Vecchia, T. Kondo, L. P. Aiello, and G. L. King
Adipose-specific effect of rosiglitazone on vascular permeability and protein kinase C activation: novel mechanism for PPAR{gamma} agonist's effects on edema and weight gain
FASEB J, June 1, 2006; 20(8): 1203 - 1205.
[Abstract] [Full Text] [PDF]

S. M. Stamatovic, O. B. Dimitrijevic, R. F. Keep, and A. V. Andjelkovic
Protein Kinase C{alpha}-RhoA Cross-talk in CCL2-induced Alterations in Brain Endothelial Permeability
J. Biol. Chem., March 31, 2006; 281(13): 8379 - 8388.
[Abstract] [Full Text] [PDF]

D. Mehta and A. B. Malik
Signaling Mechanisms Regulating Endothelial Permeability
Physiol Rev, January 1, 2006; 86(1): 279 - 367.
[Abstract] [Full Text] [PDF]

B. T. Hawkins and T. P. Davis
The Blood-Brain Barrier/Neurovascular Unit in Health and Disease
Pharmacol. Rev., June 1, 2005; 57(2): 173 - 185.
[Abstract] [Full Text] [PDF]

R. Zeng, X. Li, and G. I. Gorodeski
Estrogen Abrogates Transcervical Tight Junctional Resistance by Acceleration of Occludin Modulation
J. Clin. Endocrinol. Metab., October 1, 2004; 89(10): 5145 - 5155.
[Abstract] [Full Text] [PDF]

M. Cereijido, R. G. Contreras, and L. Shoshani
Cell Adhesion, Polarity, and Epithelia in the Dawn of Metazoans
Physiol Rev, October 1, 2004; 84(4): 1229 - 1262.
[Abstract] [Full Text] [PDF]

L. S. Bertelsen, G. Paesold, S. L. Marcus, B. B. Finlay, L. Eckmann, and K. E. Barrett
Modulation of chloride secretory responses and barrier function of intestinal epithelial cells by the Salmonella effector protein SigD
Am J Physiol Cell Physiol, October 1, 2004; 287(4): C939 - C948.
[Abstract] [Full Text] [PDF]

K. A. Witt, K. S. Mark, S. Hom, and T. P. Davis
Effects of hypoxia-reoxygenation on rat blood-brain barrier permeability and tight junctional protein expression
Am J Physiol Heart Circ Physiol, December 1, 2003; 285(6): H2820 - H2831.
[Abstract] [Full Text] [PDF]

J. Yoo, A. Nichols, J. Mammen, I. Calvo, J. C. Song, R. T. Worrell, K. Matlin, and J. B. Matthews
Bryostatin-1 enhances barrier function in T84 epithelia through PKC-dependent regulation of tight junction proteins
Am J Physiol Cell Physiol, August 1, 2003; 285(2): C300 - C309.
[Abstract] [Full Text] [PDF]

J. Yoo, A. Nichols, J. C. Song, J. Mammen, I. Calvo, R. T. Worrell, J. Cuppoletti, K. Matlin, and J. B. Matthews
Bryostatin-1 attenuates TNF-induced epithelial barrier dysfunction: role of novel PKC isozymes
Am J Physiol Gastrointest Liver Physiol, April 1, 2003; 284(4): G703 - G712.
[Abstract] [Full Text] [PDF]

G. Deschenes, E. Feraille, and A. Doucet
Mechanisms of oedema in nephrotic syndrome: old theories and new ideas
Nephrol. Dial. Transplant., March 1, 2003; 18(3): 454 - 456.
[Full Text] [PDF]

A. Siflinger-Birnboim and A. Johnson
Protein kinase C modulates pulmonary endothelial permeability: a paradigm for acute lung injury
Am J Physiol Lung Cell Mol Physiol, March 1, 2003; 284(3): L435 - L451.
[Abstract] [Full Text] [PDF]

V. Nunbhakdi-Craig, T. Machleidt, E. Ogris, D. Bellotto, C. L. White III, and E. Sontag
Protein phosphatase 2A associates with and regulates atypical PKC and the epithelial tight junction complex
J. Cell Biol., September 3, 2002; 158(5): 967 - 978.
[Abstract] [Full Text] [PDF]

H. A. Edens, B. P. Levi, D. L. Jaye, S. Walsh, T. A. Reaves, J. R. Turner, A. Nusrat, and C. A. Parkos
Neutrophil Transepithelial Migration: Evidence for Sequential, Contact-Dependent Signaling Events and Enhanced Paracellular Permeability Independent of Transjunctional Migration
J. Immunol., July 1, 2002; 169(1): 476 - 486.
[Abstract] [Full Text] [PDF]

Y.-H. Chen, Q. Lu, D. A. Goodenough, and B. Jeansonne
Nonreceptor Tyrosine Kinase c-Yes Interacts with Occludin during Tight Junction Formation in Canine Kidney Epithelial Cells
Mol. Biol. Cell, April 1, 2002; 13(4): 1227 - 1237.
[Abstract] [Full Text] [PDF]

M. L. Chen, C. Pothoulakis, and J. T. LaMont
Protein Kinase C Signaling Regulates ZO-1 Translocation and Increased Paracellular Flux of T84 Colonocytes Exposed to Clostridium difficile Toxin A
J. Biol. Chem., February 1, 2002; 277(6): 4247 - 4254.
[Abstract] [Full Text] [PDF]

A. Y. Andreeva, E. Krause, E.-C. Muller, I. E. Blasig, and D. I. Utepbergenov
Protein Kinase C Regulates the Phosphorylation and Cellular Localization of Occludin
J. Biol. Chem., October 12, 2001; 276(42): 38480 - 38486.
[Abstract] [Full Text] [PDF]

This Article

Summary

Full Text (PDF)

Alert me when this article is cited

Alert me if a correction is posted

Services

Email this article to a friend

Similar articles in this journal

Similar articles in PubMed

Alert me to new issues of the journal

Download to citation manager

Citing Articles

Citing Articles via HighWire

Citing Articles via Google Scholar

Google Scholar

Articles by Clarke, H.

Articles by Mullin, J. M.

Search for Related Content

PubMed

PubMed Citation

Articles by Clarke, H.

Articles by Mullin, J. M.

				T. Suzuki, A. Seth, and R. Rao Role of Phospholipase C{gamma}-induced Activation of Protein Kinase C{epsilon} (PKC{epsilon}) and PKC{beta}I in Epidermal Growth Factor-mediated Protection of Tight Junctions from Acetaldehyde in Caco-2 Cell Monolayers J. Biol. Chem., February 8, 2008; 283(6): 3574 - 3583. [Abstract] [Full Text] [PDF]

				K. Kimura, S. Teranishi, K. Fukuda, K. Kawamoto, and T. Nishida Delayed Disruption of Barrier Function in Cultured Human Corneal Epithelial Cells Induced by Tumor Necrosis Factor-{alpha} in a Manner Dependent on NF-{kappa}B Invest. Ophthalmol. Vis. Sci., February 1, 2008; 49(2): 565 - 571. [Abstract] [Full Text] [PDF]

				P. Sheth, N. Delos Santos, A. Seth, N. F. LaRusso, and R. K. Rao Lipopolysaccharide disrupts tight junctions in cholangiocyte monolayers by a c-Src-, TLR4-, and LBP-dependent mechanism Am J Physiol Gastrointest Liver Physiol, July 1, 2007; 293(1): G308 - G318. [Abstract] [Full Text] [PDF]

				A. Seth, P. Sheth, B. C. Elias, and R. Rao Protein Phosphatases 2A and 1 Interact with Occludin and Negatively Regulate the Assembly of Tight Junctions in the CACO-2 Cell Monolayer J. Biol. Chem., April 13, 2007; 282(15): 11487 - 11498. [Abstract] [Full Text] [PDF]

				G. I. Gorodeski Estrogen Decrease in Tight Junctional Resistance Involves Matrix-Metalloproteinase-7-Mediated Remodeling of Occludin Endocrinology, January 1, 2007; 148(1): 218 - 231. [Abstract] [Full Text] [PDF]

				K. B. Sotiropoulos, A. Clermont, Y. Yasuda, C. Rask-Madsen, M. Mastumoto, J. Takahashi, K. Della Vecchia, T. Kondo, L. P. Aiello, and G. L. King Adipose-specific effect of rosiglitazone on vascular permeability and protein kinase C activation: novel mechanism for PPAR{gamma} agonist's effects on edema and weight gain FASEB J, June 1, 2006; 20(8): 1203 - 1205. [Abstract] [Full Text] [PDF]

				S. M. Stamatovic, O. B. Dimitrijevic, R. F. Keep, and A. V. Andjelkovic Protein Kinase C{alpha}-RhoA Cross-talk in CCL2-induced Alterations in Brain Endothelial Permeability J. Biol. Chem., March 31, 2006; 281(13): 8379 - 8388. [Abstract] [Full Text] [PDF]

				D. Mehta and A. B. Malik Signaling Mechanisms Regulating Endothelial Permeability Physiol Rev, January 1, 2006; 86(1): 279 - 367. [Abstract] [Full Text] [PDF]

				B. T. Hawkins and T. P. Davis The Blood-Brain Barrier/Neurovascular Unit in Health and Disease Pharmacol. Rev., June 1, 2005; 57(2): 173 - 185. [Abstract] [Full Text] [PDF]

				R. Zeng, X. Li, and G. I. Gorodeski Estrogen Abrogates Transcervical Tight Junctional Resistance by Acceleration of Occludin Modulation J. Clin. Endocrinol. Metab., October 1, 2004; 89(10): 5145 - 5155. [Abstract] [Full Text] [PDF]

				M. Cereijido, R. G. Contreras, and L. Shoshani Cell Adhesion, Polarity, and Epithelia in the Dawn of Metazoans Physiol Rev, October 1, 2004; 84(4): 1229 - 1262. [Abstract] [Full Text] [PDF]

				L. S. Bertelsen, G. Paesold, S. L. Marcus, B. B. Finlay, L. Eckmann, and K. E. Barrett Modulation of chloride secretory responses and barrier function of intestinal epithelial cells by the Salmonella effector protein SigD Am J Physiol Cell Physiol, October 1, 2004; 287(4): C939 - C948. [Abstract] [Full Text] [PDF]

				K. A. Witt, K. S. Mark, S. Hom, and T. P. Davis Effects of hypoxia-reoxygenation on rat blood-brain barrier permeability and tight junctional protein expression Am J Physiol Heart Circ Physiol, December 1, 2003; 285(6): H2820 - H2831. [Abstract] [Full Text] [PDF]

				J. Yoo, A. Nichols, J. Mammen, I. Calvo, J. C. Song, R. T. Worrell, K. Matlin, and J. B. Matthews Bryostatin-1 enhances barrier function in T84 epithelia through PKC-dependent regulation of tight junction proteins Am J Physiol Cell Physiol, August 1, 2003; 285(2): C300 - C309. [Abstract] [Full Text] [PDF]

				J. Yoo, A. Nichols, J. C. Song, J. Mammen, I. Calvo, R. T. Worrell, J. Cuppoletti, K. Matlin, and J. B. Matthews Bryostatin-1 attenuates TNF-induced epithelial barrier dysfunction: role of novel PKC isozymes Am J Physiol Gastrointest Liver Physiol, April 1, 2003; 284(4): G703 - G712. [Abstract] [Full Text] [PDF]

				G. Deschenes, E. Feraille, and A. Doucet Mechanisms of oedema in nephrotic syndrome: old theories and new ideas Nephrol. Dial. Transplant., March 1, 2003; 18(3): 454 - 456. [Full Text] [PDF]

				A. Siflinger-Birnboim and A. Johnson Protein kinase C modulates pulmonary endothelial permeability: a paradigm for acute lung injury Am J Physiol Lung Cell Mol Physiol, March 1, 2003; 284(3): L435 - L451. [Abstract] [Full Text] [PDF]

				V. Nunbhakdi-Craig, T. Machleidt, E. Ogris, D. Bellotto, C. L. White III, and E. Sontag Protein phosphatase 2A associates with and regulates atypical PKC and the epithelial tight junction complex J. Cell Biol., September 3, 2002; 158(5): 967 - 978. [Abstract] [Full Text] [PDF]

				H. A. Edens, B. P. Levi, D. L. Jaye, S. Walsh, T. A. Reaves, J. R. Turner, A. Nusrat, and C. A. Parkos Neutrophil Transepithelial Migration: Evidence for Sequential, Contact-Dependent Signaling Events and Enhanced Paracellular Permeability Independent of Transjunctional Migration J. Immunol., July 1, 2002; 169(1): 476 - 486. [Abstract] [Full Text] [PDF]

				Y.-H. Chen, Q. Lu, D. A. Goodenough, and B. Jeansonne Nonreceptor Tyrosine Kinase c-Yes Interacts with Occludin during Tight Junction Formation in Canine Kidney Epithelial Cells Mol. Biol. Cell, April 1, 2002; 13(4): 1227 - 1237. [Abstract] [Full Text] [PDF]

				M. L. Chen, C. Pothoulakis, and J. T. LaMont Protein Kinase C Signaling Regulates ZO-1 Translocation and Increased Paracellular Flux of T84 Colonocytes Exposed to Clostridium difficile Toxin A J. Biol. Chem., February 1, 2002; 277(6): 4247 - 4254. [Abstract] [Full Text] [PDF]

				A. Y. Andreeva, E. Krause, E.-C. Muller, I. E. Blasig, and D. I. Utepbergenov Protein Kinase C Regulates the Phosphorylation and Cellular Localization of Occludin J. Biol. Chem., October 12, 2001; 276(42): 38480 - 38486. [Abstract] [Full Text] [PDF]