Exosome: from internal vesicle of the multivesicular body to intercellular signaling device

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A. Islam, X. Shen, T. Hiroi, J. Moss, M. Vaughan, and S. J. Levine
The Brefeldin A-inhibited Guanine Nucleotide-exchange Protein, BIG2, Regulates the Constitutive Release of TNFR1 Exosome-like Vesicles
J. Biol. Chem., March 30, 2007; 282(13): 9591 - 9599.
[Abstract] [Full Text] [PDF]

A. Calzolari, C. Raggi, S. Deaglio, N. M. Sposi, M. Stafsnes, K. Fecchi, I. Parolini, F. Malavasi, C. Peschle, M. Sargiacomo, et al.
TfR2 localizes in lipid raft domains and is released in exosomes to activate signal transduction along the MAPK pathway
J. Cell Sci., November 1, 2006; 119(21): 4486 - 4498.
[Abstract] [Full Text] [PDF]

E. Chertova, O. Chertov, L. V. Coren, J. D. Roser, C. M. Trubey, J. W. Bess Jr., R. C. Sowder II, E. Barsov, B. L. Hood, R. J. Fisher, et al.
Proteomic and biochemical analysis of purified human immunodeficiency virus type 1 produced from infected monocyte-derived macrophages.
J. Virol., September 1, 2006; 80(18): 9039 - 9052.
[Abstract] [Full Text] [PDF]

C. Robertson, S. A. Booth, D. R. Beniac, M. B. Coulthart, T. F. Booth, and A. McNicol
Cellular prion protein is released on exosomes from activated platelets
Blood, May 15, 2006; 107(10): 3907 - 3911.
[Abstract] [Full Text] [PDF]

X. Yu, S. L. Harris, and A. J. Levine
The Regulation of Exosome Secretion: a Novel Function of the p53 Protein.
Cancer Res., May 1, 2006; 66(9): 4795 - 4801.
[Abstract] [Full Text] [PDF]

A. M. Megiovanni, F. Sanchez, M. Robledo-Sarmiento, C. Morel, J. C. Gluckman, and S. Boudaly
Polymorphonuclear neutrophils deliver activation signals and antigenic molecules to dendritic cells: a new link between leukocytes upstream of T lymphocytes
J. Leukoc. Biol., May 1, 2006; 79(5): 977 - 988.
[Abstract] [Full Text] [PDF]

L. Mincheva-Nilsson, O. Nagaeva, T. Chen, U. Stendahl, J. Antsiferova, I. Mogren, J. Hernestal, and V. Baranov
Placenta-Derived Soluble MHC Class I Chain-Related Molecules Down-Regulate NKG2D Receptor on Peripheral Blood Mononuclear Cells during Human Pregnancy: A Possible Novel Immune Escape Mechanism for Fetal Survival
J. Immunol., March 15, 2006; 176(6): 3585 - 3592.
[Abstract] [Full Text] [PDF]

A. M. Booth, Y. Fang, J. K. Fallon, J.-M. Yang, J. E.K. Hildreth, and S. J. Gould
Exosomes and HIV Gag bud from endosome-like domains of the T cell plasma membrane.
J. Cell Biol., March 13, 2006; 172(6): 923 - 935.
[Abstract] [Full Text] [PDF]

A. Islam, B. Adamik, F. I. Hawari, G. Ma, F. N. Rouhani, J. Zhang, and S. J. Levine
Extracellular TNFR1 Release Requires the Calcium-dependent Formation of a Nucleobindin 2-ARTS-1 Complex
J. Biol. Chem., March 10, 2006; 281(10): 6860 - 6873.
[Abstract] [Full Text] [PDF]

G. S. Baron, A. C. Magalhaes, M. A. M. Prado, and B. Caughey
Mouse-Adapted Scrapie Infection of SN56 Cells: Greater Efficiency with Microsome-Associated versus Purified PrP-res
J. Virol., March 1, 2006; 80(5): 2106 - 2117.
[Abstract] [Full Text] [PDF]

K. Kolegraff, P. Bostik, and A. A. Ansari
Characterization and role of lentivirus-associated host proteins.
Experimental Biology and Medicine, March 1, 2006; 231(3): 252 - 263.
[Abstract] [Full Text] [PDF]

J. D. Johnson and M. Fleshner
Releasing signals, secretory pathways, and immune function of endogenous extracellular heat shock protein 72
J. Leukoc. Biol., March 1, 2006; 79(3): 425 - 434.
[Abstract] [Full Text] [PDF]

J. L. Spees, S. D. Olson, M. J. Whitney, and D. J. Prockop
Mitochondrial transfer between cells can rescue aerobic respiration
PNAS, January 31, 2006; 103(5): 1283 - 1288.
[Abstract] [Full Text] [PDF]

W. L. Beatty
Trafficking from CD63-positive late endocytic multivesicular bodies is essential for intracellular development of Chlamydia trachomatis
J. Cell Sci., January 15, 2006; 119(2): 350 - 359.
[Abstract] [Full Text] [PDF]

P. S. Haddad, G. A. Azar, S. Groom, and M. Boivin
Natural Health Products, Modulation of Immune Function and Prevention of Chronic Diseases
Evid. Based Complement. Altern. Med., December 1, 2005; 2(4): 513 - 520.
[Abstract] [Full Text] [PDF]

K. M. Hardy, E. A. Hoffman, P. Gonzalez, B. S. McKay, and W. D. Stamer
Extracellular Trafficking of Myocilin in Human Trabecular Meshwork Cells
J. Biol. Chem., August 12, 2005; 280(32): 28917 - 28926.
[Abstract] [Full Text] [PDF]

S. J. Levine, B. Adamik, F. I. Hawari, A. Islam, Z.-X. Yu, D.-W. Liao, J. Zhang, X. Cui, and F. N. Rouhani
Proteasome inhibition induces TNFR1 shedding from human airway epithelial (NCI-H292) cells
Am J Physiol Lung Cell Mol Physiol, August 1, 2005; 289(2): L233 - L243.
[Abstract] [Full Text] [PDF]

M.-P. Caby, D. Lankar, C. Vincendeau-Scherrer, G. Raposo, and C. Bonnerot
Exosomal-like vesicles are present in human blood plasma
Int. Immunol., July 1, 2005; 17(7): 879 - 887.
[Abstract] [Full Text] [PDF]

G. I. Lancaster and M. A. Febbraio
Exosome-dependent Trafficking of HSP70: A NOVEL SECRETORY PATHWAY FOR CELLULAR STRESS PROTEINS
J. Biol. Chem., June 17, 2005; 280(24): 23349 - 23355.
[Abstract] [Full Text] [PDF]

R. Gastpar, M. Gehrmann, M. A. Bausero, A. Asea, C. Gross, J. A. Schroeder, and G. Multhoff
Heat Shock Protein 70 Surface-Positive Tumor Exosomes Stimulate Migratory and Cytolytic Activity of Natural Killer Cells
Cancer Res., June 15, 2005; 65(12): 5238 - 5247.
[Abstract] [Full Text] [PDF]

S.-H. Kim, E. R. Lechman, N. Bianco, R. Menon, A. Keravala, J. Nash, Z. Mi, S. C. Watkins, A. Gambotto, and P. D. Robbins
Exosomes Derived from IL-10-Treated Dendritic Cells Can Suppress Inflammation and Collagen-Induced Arthritis
J. Immunol., May 15, 2005; 174(10): 6440 - 6448.
[Abstract] [Full Text] [PDF]

R. Mortarini, A. Scarito, D. Nonaka, M. Zanon, I. Bersani, E. Montaldi, E. Pennacchioli, R. Patuzzo, M. Santinami, and A. Anichini
Constitutive Expression and Costimulatory Function of LIGHT/TNFSF14 on Human Melanoma Cells and Melanoma-Derived Microvesicles
Cancer Res., April 15, 2005; 65(8): 3428 - 3436.
[Abstract] [Full Text] [PDF]

A. K. Satoh, J. E. O'Tousa, K. Ozaki, and D. F. Ready
Rab11 mediates post-Golgi trafficking of rhodopsin to the photosensitive apical membrane of Drosophila photoreceptors
Development, April 1, 2005; 132(7): 1487 - 1497.
[Abstract] [Full Text] [PDF]

H. B. Rind, R. Butowt, and C. S. von Bartheld
Synaptic Targeting of Retrogradely Transported Trophic Factors in Motoneurons: Comparison of Glial Cell Line-Derived Neurotrophic Factor, Brain-Derived Neurotrophic Factor, and Cardiotrophin-1 with Tetanus Toxin
J. Neurosci., January 19, 2005; 25(3): 539 - 549.
[Abstract] [Full Text] [PDF]

L. Frangsmyr, V. Baranov, O. Nagaeva, U. Stendahl, L. Kjellberg, and L. Mincheva-Nilsson
Cytoplasmic microvesicular form of Fas ligand in human early placenta: switching the tissue immune privilege hypothesis from cellular to vesicular level
Mol. Hum. Reprod., January 1, 2005; 11(1): 35 - 41.
[Abstract] [Full Text] [PDF]

A. Llorente, M. C. de Marco, and M. A. Alonso
Caveolin-1 and MAL are located on prostasomes secreted by the prostate cancer PC-3 cell line
J. Cell Sci., October 15, 2004; 117(22): 5343 - 5351.
[Abstract] [Full Text] [PDF]

M. D. Stuchell, J. E. Garrus, B. Muller, K. M. Stray, S. Ghaffarian, R. McKinnon, H.-G. Krausslich, S. G. Morham, and W. I. Sundquist
The Human Endosomal Sorting Complex Required for Transport (ESCRT-I) and Its Role in HIV-1 Budding
J. Biol. Chem., August 20, 2004; 279(34): 36059 - 36071.
[Abstract] [Full Text] [PDF]

C. Karacsonyi, R. Knorr, A. Fulbier, and R. Lindner
Association of Major Histocompatibility Complex II with Cholesterol- and Sphingolipid-rich Membranes Precedes Peptide Loading
J. Biol. Chem., August 13, 2004; 279(33): 34818 - 34826.
[Abstract] [Full Text] [PDF]

J. Dong, W. Chen, A. Welford, and A. Wandinger-Ness
The Proteasome {alpha}-Subunit XAPC7 Interacts Specifically with Rab7 and Late Endosomes
J. Biol. Chem., May 14, 2004; 279(20): 21334 - 21342.
[Abstract] [Full Text] [PDF]

M. Iwamoto and R. D. Allen
Uptake and Rapid Transfer of Fluorescent Ceramide Analogues to Acidosomes (Late Endosomes) in Paramecium
J. Histochem. Cytochem., May 1, 2004; 52(5): 557 - 566.
[Abstract] [Full Text] [PDF]

				C.-F. Cheng, J. Fan, M. Fedesco, S. Guan, Y. Li, B. Bandyopadhyay, A. M. Bright, D. Yerushalmi, M. Liang, M. Chen, et al. Transforming Growth Factor {alpha} (TGF{alpha})-Stimulated Secretion of HSP90{alpha}: Using the Receptor LRP-1/CD91 To Promote Human Skin Cell Migration against a TGF{beta}-Rich Environment during Wound Healing Mol. Cell. Biol., May 15, 2008; 28(10): 3344 - 3358. [Abstract] [Full Text] [PDF]

				D. L. Sprague, B. D. Elzey, S. A. Crist, T. J. Waldschmidt, R. J. Jensen, and T. L. Ratliff Platelet-mediated modulation of adaptive immunity: unique delivery of CD154 signal by platelet-derived membrane vesicles Blood, May 15, 2008; 111(10): 5028 - 5036. [Abstract] [Full Text] [PDF]

				A. Montecalvo, W. J. Shufesky, D. Beer Stolz, M. G. Sullivan, Z. Wang, S. J. Divito, G. D. Papworth, S. C. Watkins, P. D. Robbins, A. T. Larregina, et al. Exosomes As a Short-Range Mechanism to Spread Alloantigen between Dendritic Cells during T Cell Allorecognition J. Immunol., March 1, 2008; 180(5): 3081 - 3090. [Abstract] [Full Text] [PDF]

				S. Bhatnagar, K. Shinagawa, F. J. Castellino, and J. S. Schorey Exosomes released from macrophages infected with intracellular pathogens stimulate a proinflammatory response in vitro and in vivo Blood, November 1, 2007; 110(9): 3234 - 3244. [Abstract] [Full Text] [PDF]

				S. Hao, J. Yuan, and J. Xiang Nonspecific CD4+ T cells with uptake of antigen-specific dendritic cell-released exosomes stimulate antigen-specific CD8+ CTL responses and long-term T cell memory J. Leukoc. Biol., October 1, 2007; 82(4): 829 - 838. [Abstract] [Full Text] [PDF]

				G. Hundorfean, K.-P. Zimmer, S. Strobel, A. Gebert, D. Ludwig, and J. Buning Luminal antigens access late endosomes of intestinal epithelial cells enriched in MHC I and MHC II molecules: in vivo study in Crohn's ileitis Am J Physiol Gastrointest Liver Physiol, October 1, 2007; 293(4): G798 - G808. [Abstract] [Full Text] [PDF]

				S. Hao, Y. Liu, J. Yuan, X. Zhang, T. He, X. Wu, Y. Wei, D. Sun, and J. Xiang Novel Exosome-Targeted CD4+ T Cell Vaccine Counteracting CD4+25+ Regulatory T Cell-Mediated Immune Suppression and Stimulating Efficient Central Memory CD8+ CTL Responses J. Immunol., September 1, 2007; 179(5): 2731 - 2740. [Abstract] [Full Text] [PDF]

				S. Bhatnagar and J. S. Schorey Exosomes Released from Infected Macrophages Contain Mycobacterium avium Glycopeptidolipids and Are Proinflammatory J. Biol. Chem., August 31, 2007; 282(35): 25779 - 25789. [Abstract] [Full Text] [PDF]

				A. Mendoza-Naranjo, P. J. Saez, C. C. Johansson, M. Ramirez, D. Mandakovic, C. Pereda, M. N. Lopez, R. Kiessling, J. C. Saez, and F. Salazar-Onfray Functional Gap Junctions Facilitate Melanoma Antigen Transfer and Cross-Presentation between Human Dendritic Cells J. Immunol., June 1, 2007; 178(11): 6949 - 6957. [Abstract] [Full Text] [PDF]

				A. Islam, X. Shen, T. Hiroi, J. Moss, M. Vaughan, and S. J. Levine The Brefeldin A-inhibited Guanine Nucleotide-exchange Protein, BIG2, Regulates the Constitutive Release of TNFR1 Exosome-like Vesicles J. Biol. Chem., March 30, 2007; 282(13): 9591 - 9599. [Abstract] [Full Text] [PDF]

				A. Calzolari, C. Raggi, S. Deaglio, N. M. Sposi, M. Stafsnes, K. Fecchi, I. Parolini, F. Malavasi, C. Peschle, M. Sargiacomo, et al. TfR2 localizes in lipid raft domains and is released in exosomes to activate signal transduction along the MAPK pathway J. Cell Sci., November 1, 2006; 119(21): 4486 - 4498. [Abstract] [Full Text] [PDF]

				E. Chertova, O. Chertov, L. V. Coren, J. D. Roser, C. M. Trubey, J. W. Bess Jr., R. C. Sowder II, E. Barsov, B. L. Hood, R. J. Fisher, et al. Proteomic and biochemical analysis of purified human immunodeficiency virus type 1 produced from infected monocyte-derived macrophages. J. Virol., September 1, 2006; 80(18): 9039 - 9052. [Abstract] [Full Text] [PDF]

				C. Robertson, S. A. Booth, D. R. Beniac, M. B. Coulthart, T. F. Booth, and A. McNicol Cellular prion protein is released on exosomes from activated platelets Blood, May 15, 2006; 107(10): 3907 - 3911. [Abstract] [Full Text] [PDF]

				X. Yu, S. L. Harris, and A. J. Levine The Regulation of Exosome Secretion: a Novel Function of the p53 Protein. Cancer Res., May 1, 2006; 66(9): 4795 - 4801. [Abstract] [Full Text] [PDF]

				A. M. Megiovanni, F. Sanchez, M. Robledo-Sarmiento, C. Morel, J. C. Gluckman, and S. Boudaly Polymorphonuclear neutrophils deliver activation signals and antigenic molecules to dendritic cells: a new link between leukocytes upstream of T lymphocytes J. Leukoc. Biol., May 1, 2006; 79(5): 977 - 988. [Abstract] [Full Text] [PDF]

				L. Mincheva-Nilsson, O. Nagaeva, T. Chen, U. Stendahl, J. Antsiferova, I. Mogren, J. Hernestal, and V. Baranov Placenta-Derived Soluble MHC Class I Chain-Related Molecules Down-Regulate NKG2D Receptor on Peripheral Blood Mononuclear Cells during Human Pregnancy: A Possible Novel Immune Escape Mechanism for Fetal Survival J. Immunol., March 15, 2006; 176(6): 3585 - 3592. [Abstract] [Full Text] [PDF]

				A. M. Booth, Y. Fang, J. K. Fallon, J.-M. Yang, J. E.K. Hildreth, and S. J. Gould Exosomes and HIV Gag bud from endosome-like domains of the T cell plasma membrane. J. Cell Biol., March 13, 2006; 172(6): 923 - 935. [Abstract] [Full Text] [PDF]

				A. Islam, B. Adamik, F. I. Hawari, G. Ma, F. N. Rouhani, J. Zhang, and S. J. Levine Extracellular TNFR1 Release Requires the Calcium-dependent Formation of a Nucleobindin 2-ARTS-1 Complex J. Biol. Chem., March 10, 2006; 281(10): 6860 - 6873. [Abstract] [Full Text] [PDF]

				G. S. Baron, A. C. Magalhaes, M. A. M. Prado, and B. Caughey Mouse-Adapted Scrapie Infection of SN56 Cells: Greater Efficiency with Microsome-Associated versus Purified PrP-res J. Virol., March 1, 2006; 80(5): 2106 - 2117. [Abstract] [Full Text] [PDF]

				K. Kolegraff, P. Bostik, and A. A. Ansari Characterization and role of lentivirus-associated host proteins. Experimental Biology and Medicine, March 1, 2006; 231(3): 252 - 263. [Abstract] [Full Text] [PDF]

				J. D. Johnson and M. Fleshner Releasing signals, secretory pathways, and immune function of endogenous extracellular heat shock protein 72 J. Leukoc. Biol., March 1, 2006; 79(3): 425 - 434. [Abstract] [Full Text] [PDF]

				J. L. Spees, S. D. Olson, M. J. Whitney, and D. J. Prockop Mitochondrial transfer between cells can rescue aerobic respiration PNAS, January 31, 2006; 103(5): 1283 - 1288. [Abstract] [Full Text] [PDF]

				W. L. Beatty Trafficking from CD63-positive late endocytic multivesicular bodies is essential for intracellular development of Chlamydia trachomatis J. Cell Sci., January 15, 2006; 119(2): 350 - 359. [Abstract] [Full Text] [PDF]

				P. S. Haddad, G. A. Azar, S. Groom, and M. Boivin Natural Health Products, Modulation of Immune Function and Prevention of Chronic Diseases Evid. Based Complement. Altern. Med., December 1, 2005; 2(4): 513 - 520. [Abstract] [Full Text] [PDF]

				K. M. Hardy, E. A. Hoffman, P. Gonzalez, B. S. McKay, and W. D. Stamer Extracellular Trafficking of Myocilin in Human Trabecular Meshwork Cells J. Biol. Chem., August 12, 2005; 280(32): 28917 - 28926. [Abstract] [Full Text] [PDF]

				S. J. Levine, B. Adamik, F. I. Hawari, A. Islam, Z.-X. Yu, D.-W. Liao, J. Zhang, X. Cui, and F. N. Rouhani Proteasome inhibition induces TNFR1 shedding from human airway epithelial (NCI-H292) cells Am J Physiol Lung Cell Mol Physiol, August 1, 2005; 289(2): L233 - L243. [Abstract] [Full Text] [PDF]

				M.-P. Caby, D. Lankar, C. Vincendeau-Scherrer, G. Raposo, and C. Bonnerot Exosomal-like vesicles are present in human blood plasma Int. Immunol., July 1, 2005; 17(7): 879 - 887. [Abstract] [Full Text] [PDF]

				G. I. Lancaster and M. A. Febbraio Exosome-dependent Trafficking of HSP70: A NOVEL SECRETORY PATHWAY FOR CELLULAR STRESS PROTEINS J. Biol. Chem., June 17, 2005; 280(24): 23349 - 23355. [Abstract] [Full Text] [PDF]

				R. Gastpar, M. Gehrmann, M. A. Bausero, A. Asea, C. Gross, J. A. Schroeder, and G. Multhoff Heat Shock Protein 70 Surface-Positive Tumor Exosomes Stimulate Migratory and Cytolytic Activity of Natural Killer Cells Cancer Res., June 15, 2005; 65(12): 5238 - 5247. [Abstract] [Full Text] [PDF]

				S.-H. Kim, E. R. Lechman, N. Bianco, R. Menon, A. Keravala, J. Nash, Z. Mi, S. C. Watkins, A. Gambotto, and P. D. Robbins Exosomes Derived from IL-10-Treated Dendritic Cells Can Suppress Inflammation and Collagen-Induced Arthritis J. Immunol., May 15, 2005; 174(10): 6440 - 6448. [Abstract] [Full Text] [PDF]