The PI 3-kinase isoforms p110(alpha) and p110(beta) have differential roles in PDGF- and insulin-mediated signaling

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Antonetti, D. A., Algenstaedt, P. and Kahn, C. R (1996). Insulin receptor substrate 1 binds two novel splice variants of the regulatory subunit of phosphatidylinositol 3-kinase in muscle and brain. Mol. Cell Biol 16, 2195-2203.[Abstract]

Ayscough, K. R (1998). In vivo functions of actin-binding proteins. Curr. Opin. Cell Biol 10, 102-111.[Medline]

Cantrell, D (1998). Lymphocyte signalling: a coordinating role for Vav?. Curr. Biol 8, 535-538.

Carpenter, C. L., Auger, K. R., Chanudhuri, M., Yoakim, M., Schaffhausen, B., Shoelson, S. and Cantley, L. C (1993). Phosphoinositide 3-kinase is activated by phosphopeptides that bind to the SH2 domains of the 85-kDa subunit. J. Biol. Chem 268, 9478-9483.[Abstract/Free Full Text]

Cheatham, B., Vlahos, C. J., Cheatham, L., Wang, L., Blenis, J. and Kahn, C. R (1994). Phosphatidylinositol 3-kinase activation is required for insulin stimulation of pp70 S6 kinase, DNA synthesis, and glucose transporter translocation. Mol. Cell Biol 14, 4902-4911.[Abstract/Free Full Text]

Chinkers, M., McKanna, J. A. and Cohen, S (1979). Rapid induction of morphological changes in human carcinoma cells A-431 by epidermal growth factors. J. Cell Biol 83, 260-265.[Abstract/Free Full Text]

Claesson-Welsh, L (1994). Platelet-derived growth factor receptor signals. J. Biol. Chem 269, 32023-6.[Free Full Text]

Cohen, G. B., Ren, R. and Baltimore, D (1995). Modular binding domains in signal transduction proteins. Cell 80, 237-248.[Medline]

Deora, A. A., Win, T., Vanhaesebroeck, B. and Lander, H. M (1998). A Redox-triggered Ras-Effector Interaction. Recruitment of phosphatidylinositol 3-kinase to ras by redox stress. J. Biol. Chem 273, 29923-29928.[Abstract/Free Full Text]

Fantl, W. J., Escobedo, J. A., Martin, G. A., Turck, C. W., del Rosario, M., McCormick, F. and Williams, L. T (1992). Distinct phosphotyrosines on a growth factor receptor bind to specific molecules that mediate different signaling pathways. Cell 69, 413-423.[Medline]

Frevert, E. U. and Kahn, B. B (1997). Differential effects of constitutively active phosphatidylinositol 3-kinase on glucose transport, glycogen synthase activity, and DNA synthesis in 3T3-L1 adipocytes. Mol. Cell Biol 17, 190-198.[Abstract]

Fry, M. J (1994). Structure, regulation and function of phosphoinositide 3-kinases. Biochim. Biophys. Acta 1226, 237-268.[Medline]

Goldschmidt-Clermont, P. J., Machesky, L. M., Baldassare, J. J. andPollard, T. D (1990). The actin-binding protein profilin binds to PIP2 and inhibits its hydrolysis by phospholipase C. Science 247, 1575-1578.[Abstract/Free Full Text]

Goldschmidt-Clermont, P. J., Kim, J. W., Machesky, L. M., Rhee, S. G. and Pollard, T. D (1991). Regulation of phospholipase C-gamma 1 by profilin and tyrosine phosphorylation. Science 251, 1231-1233.[Abstract/Free Full Text]

Guinebault, C., Payrastre, B., Racaud-Sultan, C., Mazarguil, H., Breton, M., Mauco, G., Plantavid, M. and Chap, H (1995). Integrin-dependent translocation of phosphoinositide 3-kinase to the cytoskeleton of thrombin-activated platelets involves specific interactions of p85with actin filaments and focal adhesion kinase. J. Cell Biol 129, 831-842.[Abstract/Free Full Text]

Hartwig, J. H., Bokoch, G. M., Carpenter, C. L., Janmey, P. A., Taylor, L. A., Toker, A. and Stossel, T. P (1995). Thrombin receptor ligation and activated Rac uncap actin filament barbed ends through phosphoinositide synthesis in permeabilized human platelets. Cell 82, 643-653.[Medline]

Heldin, C. H., \205stman, A. and R\232nnstrand, L (1998). Signal transduction via platelet-derived growth factor receptors. Biochim. Biophys. Acta 1378, 79-113.

Hiles, I. D., Otsu, M., Volinia, S., Fry, M. J., Gout, I., Dhand, R., Panayotou, G., Ruiz-Larrea, F., Thompson, A., Totty, N. F., Hsuan, J. J., Courtneidge, S. A., Parker, P. J. and Waterfield, M. D (1992). Phosphatidylinositol 3-kinase: structure and expression of the 110 kd catalytic subunit. Cell 70, 419-429.[Medline]

H\232glund, A. S., Karlsson, R., Arro, E., Fredriksson, B. A. and Lindberg, U (1980). Visualization of the peripheral weave of microfilaments in glia cells. J. Muscle Res. Cell Motil 1, 127-146.[Medline]

Hooshmand-Rad, R., Claesson-Welsh, L., Wennstr\232m, S., Yokote, K., Siegbahn, A. and Heldin, C. H (1997). Involvement of phosphatidylinositide 3-kinase and Rac in platelet-derived growth factor-induced actin reorganization and chemotaxis. Exp. Cell Res 234, 434-441.[Medline]

Hu, P., Mondino, A., Skolnik, E. Y. and Schlessinger, J (1993). Cloning of a novel, ubiquitously expressed human phosphatidylinositol 3-kinase and identification of its binding site on p85. Mol. Cell Biol 13, 7677-7688.[Abstract/Free Full Text]

Hunter, S., Koch, B. L. and Anderson, S. M (1997). Phosphorylation of cbl after stimulation of Nb2 cells with prolactin and its association with phosphatidylinositol 3-kinase. Mol. Endocrinol 11, 1213-1222.[Abstract/Free Full Text]

Inukai, K., Funaki, M., Ogihara, T., Katagiri, H., Kanda, A., Anai, M., Fukushima, Y., Hosaka, T., Suzuki, M., Shin, B. C., Takata, K., Yazaki, Y., Kikuchi, M., Oka, Y. and Asano, T (1997). p85gene generates three isoforms of regulatory subunit for phosphatidylinositol 3-kinase (PI 3-Kinase), p50 , p55, and p85 , with different PI3-kinase activity elevating responses to insulin. J. Biol. Chem 272, 7873-7882.[Abstract/Free Full Text]

Jhun, B. H., Rose, D. W., Seely, B. L., Rameh, L., Cantley, L., Saltiel, A. R. and Olefsky, J. M (1994). Microinjection of the SH2 domain of the 85-kilodalton subunit of phosphatidylinositol 3-kinase inhibits insulin-induced DNA synthesis and c-fos expression. Mol. Cell Biol 14, 7466-7475.[Abstract/Free Full Text]

Kaliman, P., Canicio, J., Shepherd, P. R., Beeton, C. A., Testar, X., Palacin, M. and Zorzano, A (1998). Insulin-like growth factors require phosphatidylinositol 3-kinase to signal myogenesis: dominant negative p85 expression blocks differentiation of L6E9 muscle cells. Mol. Endocrinol 12, 66-77.[Abstract/Free Full Text]

Kazlauskas, A., Kashishian, A., Cooper, J. A. and Valius, M (1992). GTPase-activating protein and phosphatidylinositol 3-kinase bind to distinct regions of the platelet-derived growth factor receptor beta subunit. Mol. Cell Biol 12, 2534-2544.[Abstract/Free Full Text]

Kerouz, N. J., Horsch, D., Pons, S. and Kahn, C. R (1997). Differential regulation of insulin receptor substrates-1 and-2 (IRS-1 and IRS-2) and phosphatidylinositol 3-kinase isoforms in liver and muscle of the obese diabetic (ob/ob) mouse. J. Clin. Invest 100, 3164-3172.[Medline]

Klippel, A., Escobedo, J. A., Hirano, M. and Williams, L. T (1994). The interaction of small domains between the subunits of phosphatidylinositol 3-kinase determines enzyme activity. Mol. Cell Biol 14, 2675-2685.[Abstract/Free Full Text]

Kotani, K., Yonezawa, K., Hara, K., Ueda, H., Kitamura, Y., Sakaue, H., Ando, A., Chavanieu, A., Calas, B., Grigorescu, F., Nishiyama, M., Waterfield, M. D. and Kasuga, M (1994). Involvement of phosphoinositide 3-kinase in insulin-or IGF-induced membrane ruffling. EMBO J 13, 2313-2321.[Medline]

Kundra, V., Escobedo, J. A., Kazlauskas, A., Kim, H. K., Rhee, S. G., Williams, L. T. and Zetter, B. R (1994). Regulation of chemotaxis by the platelet-derived growth factor receptor-beta. Nature 367, 474-476.[Medline]

Kurosu, H., Maehama, T., Okada, T., Yamamoto, T., Hoshino, S., Fukui, Y., Ui, M., Hazeki, O. and Katada, T (1997). Heterodimeric phosphoinositide 3-kinase consisting of p85 and p110is synergistically activated by the subunits of G proteins and phosphotyrosyl peptide. J. Biol. Chem 272, 24252-24256.[Abstract/Free Full Text]

Lassing, I. and Lindberg, U (1985). Specific interaction between phosphatidylinositol 4, 5-bisphosphate and profilactin. Nature 314, 472-474.[Medline]

Liu, X., Marengere, L. E., Koch, C. A. and Pawson, T (1993). The v-Src SH3 domain binds phosphatidylinositol 3-kinase. Mol. Cell Biol 13, 5225-5232.[Abstract/Free Full Text]

Lu, P. J., Shieh, W. R., Rhee, S. G., Yin, H. L. and Chen, C. S (1996). Lipid products of phosphoinositide 3-kinase bind human profilin with high affinity. Biochemistry 35, 14027-14034.[Medline]

McIlroy, J., Chen, D., Wjasow, C., Michaeli, T. and Backer, J. M (1997). Specific activation of p85-p110 phosphatidylinositol 3-kinase stimulates DNA synthesis by ras-and p70 S6 kinase-dependent pathways. Mol. Cell Biol 17, 248-255.[Abstract]

Mellstr\232m, K., H\232glund, A. S., Nister, M., Heldin, C. H., Westermark, B. and Lindberg, U (1983). the effect of platelet-derived growth factor on morphology and motility of human glial cells. J. Muscle Res. Cell Motil 4, 589-609.[Medline]

Nave, B. T., Haigh, R. J., Hayward, A. C., Siddle, K. and Shepherd, P. R (1996). Compartment-specific regulation of phosphoinositide 3-kinase by platelet-derived growth factor and insulin in 3T3-L1 adipocytes. Biochem. J 318, 55-60.

Nobes, C. D., Hawkins, P., Stephens, L. and Hall, A (1995). Activation of the small GTP-binding proteins rho and rac by growth factor receptors. J. Cell Sci 108, 225-233.[Abstract]

Pleiman, C. M., Hertz, W. M. and Cambier, J. C (1994). Activation of phosphatidylinositol-3kinase by Src-family kinase SH3 binding to the p85 subunit. Science 263, 1609-1612.[Abstract/Free Full Text]

Roche, S., Koegl, M. and Courtneidge, S. A (1994). The phosphatidylinositol 3-kinaseis required for DNA synthesis induced by some, but not all, growth factors. Proc. Nat. Acad. Sci. USA 91, 9185-9189.[Abstract/Free Full Text]

Roche, S., Downward, J., Raynal, P. and Courtneidge, S. A (1998). A function for phosphatidylinositol 3-kinase beta (p85-p110 ) in fibroblasts during mitogenesis: requirement for insulin-and lysophosphatidic acid-mediated signal transduction. Mol. Cell Biol 18, 7119-7129.[Abstract/Free Full Text]

Shepherd, P. R., Nave, B. T., Rincon, J., Nolte, L. A., Bevan, A. P., Siddle, K., Zierath, J. R. and Wallberg-Henriksson, H (1997). Differential regulation of phosphoinositide 3-kinase adapter subunit variants by insulin in human skeletal muscle. J. Biol. Chem 272, 19000-19007.[Abstract/Free Full Text]

Shibasaki, F., Fukami, K., Fukui, Y. and Takenawa, T (1994). Phosphatidylinositol 3-kinase binds to-actinin through the p85 subunit. Biochem. J 302, 551-557.

Siddhanta, U., McIlroy, J., Shah, A., Zhang, Y. and Backer, J. M (1998). Distinct roles for the p110and hVPS34 phosphatidylinositol 3 -kinases in vesicular trafficking, regulation of the actin cytoskeleton, and mitogenesis. J. Cell Biol 143, 1647-1659.[Abstract/Free Full Text]

Singh, S. S., Chauhan, A., Murakami, N. and Chauhan, V. P (1996). Profilin and gelsolin stimulate phosphatidylinositol 3-kinase activity. Biochemistry 35, 16544-16549.[Medline]

Small, J. V (1981). Organization of actin in the leading edge of cultured cells: influence of osmium tetroxide and dehydration on the ultrastructure of actin meshworks. J. Cell Biol 91, 695-705.[Abstract/Free Full Text]

Small, J. V., Rottner, K. and Kaverina, I (1999). Functional design in the actin cytoskeleton. Curr. Opin. Cell Biol 11, 54-60.[Medline]

Stephens, L. R., Jackson, T. R. and Hawkins, P. T (1993). Agonist-stimulated synthesis of phosphatidylinositol(3,4,5)-trisphosphate: a new intracellular signalling system?. Biochim. Biophys. Acta 1179, 27-75.[Medline]

Stephens, L., Smrcka, A., Cooke, F. T., Jackson, T. R., Sternweis, P. C. and Hawkins, P. T (1994). A novel phosphoinositide 3 kinase activity in myeloid-derived cells is activated by G proteinsubunits. Cell 77, 83-93.[Medline]

Stoyanov, B., Volinia, S., Hanck, T., Rubio, I., Loubtchenkov, M., Malek, D., Stoyanova, S., Vanhaesebroeck, B., Dhand, R., Nurnberg, B., Gierschik, P., Seedorf, K., Hsuan, J. J., Waterfield, M. D. and Wetzker, R (1995). Cloning and characterization of a G protein-activated human phosphoinositide-3 kinase. Science 269, 690-693.[Abstract/Free Full Text]

Tomiyama, K., Nakata, H., Sasa, H., Arimura, S., Nishio, E. and Watanabe, Y (1995). Wortmannin, a specific phosphatidylinositol 3-kinase inhibitor, inhibits adipocytic differentiation of 3T3-L1 cells. Biochem. Biophys Res. Commun 212, 263-269.[Medline]

Vanhaesebroeck, B., Leevers, S. J., Panayotou, G. and Waterfield, M. D (1997). Phosphoinositide 3-kinases: a conserved family of signal transducers. Trends Biochem. Sci 22, 267-272.[Medline]

Vanhaesebroeck, B., Welham, M. J., Kotani, K., Stein, R., Warne, P. H., Zvelebil, M. J., Higashi, K., Volinia, S., Downward, J. and Waterfield, M. D (1997). P110, a novel phosphoinositide 3-kinase in leukocytes. Proc. Nat. Acad. Sci. USA 94, 4330-4335.[Abstract/Free Full Text]

Vanhaesebroeck, B., Higashi, K., Raven, C., Welham, M., Anderson, S., Brennan, P., Ward, S. G. and Waterfield, M. D (1999). Autophosphorylation of p110phosphoinositide 3-kinase: a new paradigm for the regulation of lipid kinases in vitro and in vivo. EMBO J 18, 1292-1302.[Medline]

Wang, J., Auger, K. R., Jarvis, L., Shi, Y. and Roberts, T. M (1995). Direct association of Grb2 with the p85 subunit of phosphatidylinositol 3-kinase. J. Biol. Chem 270, 12774-12780.[Abstract/Free Full Text]

Wang, Q., Bilan, P. J., Tsakiridis, T., Hinek, A. and Klip, A (1998). Actin filaments participate in the relocalization of phosphatidylinositol 3-kinase to glucose transporter-containing compartments and in the stimulation of glucose uptake in 3T3-L1 adipocytes. Biochem. J 331, 917-928.

Wennstr\232m, S., Hawkins, P., Cooke, F., Hara, K., Yonezawa, K., Kasuga, M., Jackson, T., Claesson-Welsh, L. and Stephens, L (1994). Activation of phosphoinositide 3-kinase is required for PDGF-stimulated membrane ruffling. Curr. Biol 4, 385-393.[Medline]

Wennstr\232m, S., Siegbahn, A., Yokote, K., Arvidsson, A. K., Heldin, C. H., Mori, S. and Claesson-Welsh, L (1994). Membrane ruffling and chemotaxis transduced by the PDGF-receptor require the binding site for phosphatidylinositol 3 kinase. Oncogene 9, 651-660.[Medline]

Yao, R. and Cooper, G. M (1995). Requirement for phosphatidylinositol-3 kinase in the prevention of apoptosis by nerve growth factor. Science 267, 2003-2006.[Abstract/Free Full Text]

Yuan, Z. M., Utsugisawa, T., Huang, Y., Ishiko, T., Nakada, S., Kharbanda, S., Weichselbaum, R. and Kufe, D (1997). Inhibition of phosphatidylinositol 3-kinase by c-Abl in the genotoxic stress response. J. Biol. Chem 272, 23485-23488.[Abstract/Free Full Text]

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				N. T. Ihle, G. Paine-Murrieta, M. I. Berggren, A. Baker, W. R. Tate, P. Wipf, R. T. Abraham, D. L. Kirkpatrick, and G. Powis The phosphatidylinositol-3-kinase inhibitor PX-866 overcomes resistance to the epidermal growth factor receptor inhibitor gefitinib in A-549 human non-small cell lung cancer xenografts Mol. Cancer Ther., September 1, 2005; 4(9): 1349 - 1357. [Abstract] [Full Text] [PDF]

				V. Munugalavadla, J. Borneo, D. A. Ingram, and R. Kapur p85{alpha} subunit of class IA PI-3 kinase is crucial for macrophage growth and migration Blood, July 1, 2005; 106(1): 103 - 109. [Abstract] [Full Text] [PDF]

				D. Torok, N. Patel, L. JeBailey, F. S. L. Thong, V. K. Randhawa, A. Klip, and A. Rudich Insulin but not PDGF relies on actin remodeling and on VAMP2 for GLUT4 translocation in myoblasts J. Cell Sci., October 15, 2004; 117(22): 5447 - 5455. [Abstract] [Full Text] [PDF]

				M. Campbell, W. E. Allen, C. Sawyer, B. Vanhaesebroeck, and E. R. Trimble Glucose-Potentiated Chemotaxis in Human Vascular Smooth Muscle Is Dependent on Cross-Talk Between the PI3K and MAPK Signaling Pathways Circ. Res., August 20, 2004; 95(4): 380 - 388. [Abstract] [Full Text] [PDF]

				Y. Leverrier, K. Okkenhaug, C. Sawyer, A. Bilancio, B. Vanhaesebroeck, and A. J. Ridley Class I Phosphoinositide 3-Kinase p110{beta} Is Required for Apoptotic Cell and Fc{gamma} Receptor-mediated Phagocytosis by Macrophages J. Biol. Chem., October 3, 2003; 278(40): 38437 - 38442. [Abstract] [Full Text] [PDF]

				C. S. Park, I. C. Schneider, and J. M. Haugh Kinetic Analysis of Platelet-derived Growth Factor Receptor/Phosphoinositide 3-Kinase/Akt Signaling in Fibroblasts J. Biol. Chem., September 26, 2003; 278(39): 37064 - 37072. [Abstract] [Full Text] [PDF]

				A. M. Woolsey, L. Sunwoo, C. A. Petersen, S. M. Brachmann, L. C. Cantley, and B. A. Burleigh Novel PI 3-kinase-dependent mechanisms of trypanosome invasion and vacuole maturation J. Cell Sci., September 1, 2003; 116(17): 3611 - 3622. [Abstract] [Full Text] [PDF]

				N. Patel, A. Rudich, Z. A. Khayat, R. Garg, and A. Klip Intracellular Segregation of Phosphatidylinositol-3,4,5-Trisphosphate by Insulin-Dependent Actin Remodeling in L6 Skeletal Muscle Cells Mol. Cell. Biol., July 1, 2003; 23(13): 4611 - 4626. [Abstract] [Full Text] [PDF]

				A. P. Curnock, Y. Sotsios, K. L. Wright, and S. G. Ward Optimal Chemotactic Responses of Leukemic T Cells to Stromal Cell-Derived Factor-1 Requires the Activation of Both Class IA and IB Phosphoinositide 3-Kinases J. Immunol., April 15, 2003; 170(8): 4021 - 4030. [Abstract] [Full Text] [PDF]

				C. Sawyer, J. Sturge, D. C. Bennett, M. J. O'Hare, W. E. Allen, J. Bain, G. E. Jones, and B. Vanhaesebroeck Regulation of Breast Cancer Cell Chemotaxis by the Phosphoinositide 3-Kinase p110{delta} Cancer Res., April 1, 2003; 63(7): 1667 - 1675. [Abstract] [Full Text] [PDF]

				D. Cantrell Phosphoinositide 3-kinase signalling pathways J. Cell Sci., January 4, 2001; 114(8): 1439 - 1445. [Abstract] [PDF]

				C. Jimenez, R. A. Portela, M. Mellado, J. M. Rodriguez-Frade, J. Collard, A. Serrano, C. Martinez-A, J. Avila, and A. C. Carrera Role of the PI3K Regulatory Subunit in the Control of Actin Organization and Cell Migration J. Cell Biol., October 18, 2000; 151(2): 249 - 262. [Abstract] [Full Text] [PDF]

				M. Vandromme, A. Rochat, R. Meier, G. Carnac, D. Besser, B. A. Hemmings, A. Fernandez, and N. J. C. Lamb Protein Kinase B beta /Akt2 Plays a Specific Role in Muscle Differentiation J. Biol. Chem., March 9, 2001; 276(11): 8173 - 8179. [Abstract] [Full Text] [PDF]

				K. M. Hill, Y. Huang, S.-C. Yip, J. Yu, J. E. Segall, and J. M. Backer N-terminal Domains of the Class IA Phosphoinositide 3-Kinase Regulatory Subunit Play a Role in Cytoskeletal but Not Mitogenic Signaling J. Biol. Chem., May 4, 2001; 276(19): 16374 - 16378. [Abstract] [Full Text] [PDF]

				A. J. Smith, Z. Surviladze, E. A. Gaudet, J. M. Backer, C. A. Mitchell, and B. S. Wilson p110beta and p110delta Phosphatidylinositol 3-Kinases Up-regulate Fcepsilon RI-activated Ca2+ Influx by Enhancing Inositol 1,4,5-Trisphosphate Production J. Biol. Chem., May 11, 2001; 276(20): 17213 - 17220. [Abstract] [Full Text] [PDF]

				J.-F. Quignard, J. Mironneau, V. Carricaburu, B. Fournier, A. Babich, B. Nurnberg, C. Mironneau, and N. Macrez Phosphoinositide 3-Kinase gamma Mediates Angiotensin II-induced Stimulation of L-type Calcium Channels in Vascular Myocytes J. Biol. Chem., August 24, 2001; 276(35): 32545 - 32551. [Abstract] [Full Text] [PDF]

				T. Asano, A. Kanda, H. Katagiri, M. Nawano, T. Ogihara, K. Inukai, M. Anai, Y. Fukushima, Y. Yazaki, M. Kikuchi, et al. p110beta Is Up-regulated during Differentiation of 3T3-L1 Cells and Contributes to the Highly Insulin-responsive Glucose Transport Activity J. Biol. Chem., June 2, 2000; 275(23): 17671 - 17676. [Abstract] [Full Text] [PDF]

				N. Macrez, C. Mironneau, V. Carricaburu, J.-F. Quignard, A. Babich, C. Czupalla, B. Nurnberg, and J. Mironneau Phosphoinositide 3-Kinase Isoforms Selectively Couple Receptors to Vascular L-Type Ca2+ Channels Circ. Res., October 12, 2001; 89(8): 692 - 699. [Abstract] [Full Text] [PDF]