c-Cbl localizes to actin lamellae and regulates lamellipodia formation and cell morphology

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Andoniou, C. E., Thien, C. B. F. and Langdon, W. Y (1994). Tumour induction by activated abl involves tyrosine phosphorylation of the product of the cbl oncogene. EMBO J 13, 4515-4523.[Medline]

Andoniou, C. E., Thien, C. B. F. and Langdon, W. Y (1996). The two major sites of cbl tyrosine phosphorylation in abl-transformed cells select the crkL SH2 domain. Oncogene 12, 1981-1989.[Medline]

Ben-Ze'ev, A (1997). Cytoskeletal and adhesion proteins as tumor suppressors. Curr. Opin. Cell Biol 9, 99-108.[Medline]

Blake, T. J., Shapiro, M., Morse, H. C., III and Langdon, W. Y (1991). The sequences of the human and mouse c- cbl proto-oncogenes show v- cbl was generated by a large truncation encompassing a proline-rich domain and a leucine zipper-like motif. Oncogene 6, 653-657.[Medline]

Blake, T. J., Heath, K. G. and Langdon, W. Y (1993). The truncation that generated the v- cbl oncogene reveals an ability for nuclear transport, DNA binding and acute transformation. EMBO J 12, 2017-2026.[Medline]

Bonita, D. P., Miyake, S., Lupher Jr, M. L., Langdon, W. Y. and Band, H (1997). Phosphotyrosine binding domain-dependent upregulation of the platelet-derived growth factor receptor a signaling cascade by transforming mutants of Cbl: implications for Cbl's function and oncogenicity. Mol. Cell. Biol 17, 4597-4610.[Abstract]

Boussiotis, V. A., Freeman, G. J., Berezovskaya, A., Barber, D. and Nadler, L. M (1997). Maintenance of human T-cell anergy: blocking of IL-2 gene transcription by activated rap1. Science 278, 124-128.[Abstract/Free Full Text]

Bowtell, D. D. L. and Langdon, W. Y (1995). The protein product of the c- cbl oncogene rapidly complexes with the EGF receptor and is tyrosine phosphorylated following EGF stimulation. Oncogene 11, 1561-1567.[Medline]

Dolfi, F., Garcia-Guzman, M., Ojaniemi, M., Nakamura, H., Matsuda, M. and Vuori, K (1998). The adaptor protein Crk connects multiple cellular stimuli to the JNK signaling pathway. Proc. Nat. Acad. Sci. USA 95, 15394-15399.[Abstract/Free Full Text]

Donovan, J. A., Ota, Y., Langdon, W. Y. and Samelson, L. E (1996). Regulation of the association of p120cbl with Grb2 in Jurkat T cells. J. Biol. Chem 271, 26369-26374.[Abstract/Free Full Text]

Feshchenko, E., Langdon, W. Y. and Tsygankov, A (1998). Fyn, Yes, and Syk phosphorylation sites in c-Cbl map to the same tyrosine residues that become phosphorylated in activated T cells. J. Biol. Chem 273, 8323-8331.[Abstract/Free Full Text]

Feshchenko, E., Shore, S. and Tsygankov, A (1999). Tyrosinephosphorylation of c-Cbl facilitates adhesion and spreading while suppressing anchorage-independent growth of v-Abl transformed NIH 3T3 fibroblasts. Oncogene 18, 3703-3715.[Medline]

Galisteo, M. L., Dikic, I., Batzer, A. G., Langdon, W. Y. and Schlessinger, J (1995). Tyrosine phosphorylation of the c- cbl proto-oncogene product and association with epidermal growth factor (EGF) receptor upon EGF stimulation. J. Biol. Chem 270, 20241-20245.

Hall, A (1998). Rho GTPases and the cytoskeleton. Science 279, 509-514.[Abstract/Free Full Text]

Kiyokawa, E., Hashimoto, Y., Kobayashi, S., Sugimura, H., Kurata, T. and Matsuda, M (1998). Activation of Rac1 by a Crk SH3-binding protein, DOCK180. Genes Dev 12, 3331-3336.[Abstract/Free Full Text]

Kiyokawa, E., Hashimoto, Y., Kurata, T., Sugimura, H. and Matsuda, M (1998). Evidence that DOCK180 up-regulates signals from the CrkII-p130(Cas) complex. J. Biol. Chem 273, 24479-24484.[Abstract/Free Full Text]

Klemke, R. L., Leng, J., Molander, R., Brooks, P. C., Vuori, K. and Cheresh, D. A (1998). Cas/Crk coupling serves as a \324molecular switch' for induction of cell migration. J. Cell. Biol 140, 961-972.[Abstract/Free Full Text]

Lamarche, N., Tapon, N., Stowers, L., Burbelo, P., Aspenstrom, P., Bridges, T., Chant, J. and Hall, A (1996). Rac and Cdc42 induce actin polymerization and G1cell cycle progression independently of p65PAK and the JNK/SAPK MAP kinase cascade. Cell 87, 519-529.[Medline]

Lauffenberger, D. and Horwitz, A. F (1996). Cell migration: a physically integrated molecular process. Cell 84, 359-369.[Medline]

Lee, P., Wang, Y., Dominguez, M., Yeung, Y.-G., Murphy, M., Bowtell, D. and Stanley, R (1999). The Cbl protooncogene stimulates CSF-1 receptor multiubiquitination and endocytosis, and attenuates macrophage proliferation. EMBO J 18, 3616-3628.[Medline]

Levkowitz, G., Waterman, H., Zamir, E., Kam, Z., Oved, S., Langdon, W. Y., Beguinot, L., Geiger, B. and Yarden, Y (1998). c-Cbl/Sli-1 regulates endocytic sorting and ubiquitination of the epidermal growth factor receptor. Genes Dev 12, 3663-3674.[Abstract/Free Full Text]

Liu, Y.-C. and Altman, A (1998). Cbl: complex formation and functional implications. Cell. Signalling 10, 377-385.[Medline]

Lupher, M. L., Jr, Reedquist, K. A., Miyake, S., Langdon, W. Y. and Band, H (1996). A novel PTB domain in the N-terminal transforming region of Cbl interacts directly and selectively wth ZAP-70 in T cells. J. Biol. Chem 271, 24063-24068.[Abstract/Free Full Text]

Lupher, M. L., Songyang, Z., Shoelson, S. E., Cantley, L. C. and Band, H (1997). The Cbl phosphotyrosine-binding domain selects a D(N/D)XpY motif and binds to the TyrP292 negative regulatory phosphorylation site of ZAP-70. J. Biol. Chem 272, 33140-33144.[Abstract/Free Full Text]

Lupher, M. L., Rao, N., Lill, N., Andoniou, C. E., Miyake, S., Clark, E., Druker, B. and Band, H (1998). Cbl-mediated negative regulation of the Syk tyrosine kinase. J. Biol. Chem 273, 35273-35281.[Abstract/Free Full Text]

Meng, F. and Lowell, C. A (1998). A1 integrin signaling pathway involving Src-family kinases, Cbl and PI 3-kinase is required for macrophage spreading and migration. EMBO J 17, 4391-4403.[Medline]

Meng, W., Sawasdikosol, S., Burakoff, S. and Eck, M (1999). Structure of the amino-terminal domain of Cbl complexed to its binding site on ZAP-70 kinase. Nature 398, 84-90.[Medline]

Mitchison, T. J. and Cramer, L. P (1996). Actin-based cell motility and cell locomotion. Cell 84, 371-379.[Medline]

Miyake, S., Luper, M. L., Andoniou, C., Lill, N. L., Ota, S., Douillard, P., Rao, N. and Band, H (1998). The cbl proto-oncogene product: from enigmatic oncogene to central stage of signal transduction. Crit. Rev. Oncogen 8, 189-218.

Miyake, S., Mullane-Robinson, K., Lill, N., Douillard, P. and Band, H (1999). Cbl-mediated negative regulation of platelet-derived growth factor receptor-dependent cell proliferation. J. Biol. Chem 274, 16619-16628.[Abstract/Free Full Text]

Murphy, M., Schnall, R., Venter, D., Bertoncello, I., Thien, C. B. F., Langdon, W. Y. and Bowtell, D. L (1998). Tissue hyperplasia and enhanced T cell signalling via ZAP-70 in c-Cbl deficient mice. Mol. Cell. Biol 18, 4872-4882.[Abstract/Free Full Text]

Naramura, M., Kole, H., Hu, R.-J. and Gu, H (1998). Altered thymic positive selection and intracellular signals in Cbl-deficient mice. Proc. Nat. Acad. Sci. USA 95, 15547-15552.[Abstract/Free Full Text]

Neudauer, C. L., Joberty, G., Tatsis, N. and Macara, I. G (1998). Distinct cellular effects and interactions of the Rho-family GTPase TC10. Curr. Biol 8, 1151-1160.[Medline]

Nobes, C. D., Hawkins, P., Stephens, L. and Hall, A (1995). Activation ofthe small GTP-binding proteins rho and rac by growth factor receptors. J. Cell Sci 108, 225-233.[Abstract]

Ojaniemi, M., Martin, S. S., Dolfi, F., Olefsky, J. M. and Vuori, K (1997). The proto-oncogene product p120 cbl links c-Src and phosphatidylinositol 3-kinase to the integrin signaling pathway. J. Biol. Chem 272, 3780-3787.[Abstract/Free Full Text]

Ota, Y. and Samelson, L. E (1997). The product of the proto-oncogene c-Cbl \320 a negative regulator of the Syk tyrosine kinase. Science 276, 418-420.[Abstract/Free Full Text]

Ribon, V., Herrera, R., Kay, B. K. and Saltiel, A. R (1998). A role for CAP, a novel, multifunctional src homology 3 domain-containing protein in formation of actin stress fibers and focal adhesions. J. Biol. Chem 273, 4073-4080.[Abstract/Free Full Text]

Ridley, A. and Hall, A (1992). The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors. Cell 70, 389-399.[Medline]

Rodriguez-Viciana, P., Warne, P. H., Kwaja, A., Marte, B. M., Pappin, D., Das, P., Waterfield, M., Ridley, A. and Downward, J (1997). Role of phosphoinositide 3-OH kinase in cell transformation and control of the actin cytoskeleton by ras. Cell 89, 457-467.[Medline]

Smit, L. and Borst, J (1997). The Cbl family of signal transduction molecules. Crit. Rev. Oncogen 8, 359-379.[Medline]

Tanaka, S., Amling, M., Neff, L., Peyman, A., Uhlmann, E., Levy, J. B.and Baron, R (1996). c-Cbl is downstream of c-Src in a signalling pathway necessary for bone resorption. Nature 383, 528-531.[Medline]

Thien, C. B. F. and Langdon, W. Y (1997). EGF receptor binding and transformation by v-cbl is ablated by the introduction of a loss-of-function mutation from the Caenorhabditis elegans sli-1 gene. Oncogene 14, 2239-2249.[Medline]

Thien, C. B. F. and Langdon, W. Y (1998). c-Cbl: a regulator of T cell receptor-mediated signalling. Immunol. Cell Biol 76, 473-482.[Medline]

Thien, C. B. F., Bowtell, D. and Langdon, W. Y (1999). Perturbed regulation of ZAP-70 and sustained tyrosine phosphorylatoin of LAT and SLP-76 in c-Cbl-deficient thymocytes. J. Immunol 162, 7133-7139.[Abstract/Free Full Text]

van Leeuwen, J., Paik, P. and Samelson, L (1999). Activation of nuclear factor of activated T cells-(NFAT) and activating protein 1 (AP-1) by oncogenic 70Z Cbl requires an intact phosphotyrosine binding domain but not Crk(L) or p85 phosphatidylinositol 3-kinase association. J. Biol. Chem 274, 5153-5162.[Abstract/Free Full Text]

Yoon, C. H., Lee, J., Jongeward, G. D. and Sternberg, P. W (1995). Similarity of sli-1 , a regulator of vulval development in C. elegans , to the mammalian proto-oncogene c- cbl. Science 269, 1102-1105.[Abstract/Free Full Text]

Zheng, Z., Elly, C., Altman, A. and Liu, Y.-C (1998). Dual regulation of T cell receptor-mediated signaling by oncogenic Cbl mutant 70Z. J. Biol. Chem 274, 4883-4889.[Abstract/Free Full Text]

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Articles by Scaife, R. M.

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				H. C. Lane, A. R. Anand, and R. K. Ganju Cbl and Akt regulate CXCL8-induced and CXCR1- and CXCR2-mediated chemotaxis Int. Immunol., August 1, 2006; 18(8): 1315 - 1325. [Abstract] [Full Text] [PDF]

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				R. M. Scaife, D. Job, and W. Y. Langdon Rapid Microtubule-dependent Induction of Neurite-like Extensions in NIH 3T3 Fibroblasts by Inhibition of ROCK and Cbl Mol. Biol. Cell, November 1, 2003; 14(11): 4605 - 4617. [Abstract] [Full Text] [PDF]

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				S. Lehtonen, F. Zhao, and E. Lehtonen CD2-associated protein directly interacts with the actin cytoskeleton Am J Physiol Renal Physiol, October 1, 2002; 283(4): F734 - F743. [Abstract] [Full Text] [PDF]

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