Senescence-associated (beta)-galactosidase reflects an increase in lysosomal mass during replicative ageing of human endothelial cells

QUICK SEARCH:

[advanced]

	Author:		Keyword(s):

Home Help Feedback Subscriptions Archive Search Table of Contents

This Article

	Summary
	Full Text (PDF)
	Alert me when this article is cited
	Alert me if a correction is posted

Services

	Email this article to a friend
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new issues of the journal
	Download to citation manager


Citing Articles

	Citing Articles via HighWire
	Citing Articles via Google Scholar

Google Scholar

	Articles by Kurz, D. J.
	Articles by Erusalimsky, J. D.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Kurz, D. J.
	Articles by Erusalimsky, J. D.

Atherton, A. J., O'Hare, M. J., Buluwela, L., Titley, J., Monaghan, P., Paterson, H. F., Warburton, M. J. and Gusterson, B. A (1994). Ectoenzyme regulation by phenotypically distinct fibroblast sub-populations isolated from the human mammary gland. J. Cell Sci 107, 2931-2939.[Abstract]

Ben-Yosseph, Y., Shapira, E., Edelmann, E., Burton, B. K. and Nadler, H. L (1977). Purification and properties of neutral-galactosidase from human liver. Arch. Biochem. Biophys 184, 373-380.[Medline]

Bodnar, A. G., Ouellette, M., Frolkis, M., Holt, S. E., Chiu, C., Morin, G. B., Harley, C. B., Shay, J. W., Lichtsteiner, S. and Wright, W. E (1998). Extension of life-span by introduction of telomerase into normal human cells. Science 279, 349-352.[Abstract/Free Full Text]

Bosmann, H. B., Gutheil, R. L. and Case, K. R (1976). Loss of critical neutral protease in ageing WI-38 cells. Nature 261, 499-501.[Medline]

Brunk, U. T., Ericsson. J. L. E., Ponten, J. and Westermark, B (1973). Residual bodies and \324aging' in cultured human glia cells. Exp. Cell Res 79, 1-14.[Medline]

Campisi, J (1996). Replicative senescence: an old lives' tale?. Cell 84, 497-500.[Medline]

Cristofalo, V. J. and Kabakjian, J (1975). Lysosomal enzymes and aging in vitro: subcellular enzyme distribution and effect of hydrocortisone on cell life-span. Mech. Ageing Dev 4, 19-28.[Medline]

d'Azzo, A., Hoogeveen, A. T., Reuser, A. J. J., Robinson, D. and Galjaard, H (1982). Molecular defect in combined-galactosidase and neuraminidase deficiency in man. Proc. Natl. Acad. Sci. USA 79, 4535-4539.[Abstract/Free Full Text]

Devarakonda, R. K., Sperker, B., Fritz, P. and Klotz, U (1999). Does pH 6-galactosidase activity indicate cell senescence?. Mech. Ageing Dev 109, 113-123.[Medline]

Dimri, G. P., Lee, X., Basile, G., Acosta, M., Scott, G., Roskelly, C., Medrano, E. E., Linskens, M., Rubelj, I., Pereira-Smith, O., Peacocke, M. and Campisi, J (1995). A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc. Natl. Acad. Sci. USA 92, 9363-9367.[Abstract/Free Full Text]

Escobales, N., Longo, E., Cragoe, E. J., Danthuluri, N. R. and Brock, T. A (1990). Osmotic activation of Na+-H+exchange in human endothelial cells. Am. J. Physiol 259, 640-.

Fiering, S. N, Roederer, M., Nolan, G. P., Micklem, D. R., Parks, D. R. and Herzenberg, L. A (1991). Improved FACS-Gal: Flow cytometric analysis and sorting of viable eukaryotic cells expressing reporter gene constructs. Cytometry 12, 291-301.[Medline]

Goldstein, S. and Harley, C. B (1979). In vitro studies of age-associated diseases. Fed. Proc 38, 1862-1867.[Medline]

Hartz, P. A. and Wilson, P. D (1997). Functional defects in lysosomal enzymes in autosomal dominant polycystic kidney disease (ADPKD): abnormalities in synthesis, molecular processing, polarity, and secretion. Biochem. Mol. Med 60, 8-26.[Medline]

Hayflick, L. and Moorhead, P. S (1961). The serial cultivation of human diploid cell strains. Exp. Cell Res 25, 585-621.

Hayflick, L (1965). The limited in vitro life time of human diploid cell strains. Exp. Cell Res 37, 614-636.[Medline]

Hayflick, L (1980). Cell Aging. Ann. Rev. Gerontol. Geriatr 1, 26-67.

Ho, M. W., Cheetham P. and Robinson D (1973). Hydrolysis of GM1-ganglioside by human liver-galactosidase isoenzymes. Biochem. J 136, 351-359.[Medline]

Hoogeveen, A. T., Verheijen, F. W. and Galjaard, H (1983). The relation between human lysosomal-galactosidase and its protective protein. J. Biol. Chem 258, 12143-12146.[Abstract/Free Full Text]

Matsunaga, H., Handa, J. T., Aotaki-Keen, A., Sherwood, W., West, M. D. and Hjelmeland, L. M (1999). -galactosidase histochemistry and telomere loss in senescent retinal pigment epithelial cells. Invest. Ophthalmol. Vis. Sci 40, 197-202.[Abstract/Free Full Text]

Meisler, M. and Rattazzi, M. C (1974). Immunological studies of-galactosidase in normal human liver and in GM1 gangliosidosis. Am. J. Hum. Genet 26, 683-691.[Medline]

Mishima, K., Handa, J. T., Aotaki-Keen, A., Lutty, G. A., Morse, L. S. andHjelmeland, L. M (1999). Senescence-associated-galactosidase histochemistry for the primate eye. Invest. Ophthalmol. Vis. Sci 40, 1590-1593.[Abstract/Free Full Text]

Morreau, H., Galjart, N. J., Gillemans, N., Willemsen, R., van der Horst, G. T. J. and d'Azzo, A (1989). Alternative splicing of-galactosidase mRNA generates the classic lysosomal enzyme and a -galactosidase-related protein. J. Biol. Chem 264, 20655-20663.[Abstract/Free Full Text]

Negulescu, P. A. and Machen, T. E (1990). Intracellular ion activities and membrane transport in parietal cells measured with fluorescent dyes. Methods Enzymol 192, 38-81.[Medline]

Norden, A. G., Tennant, L. L. and O'Brien, J. S (1974). GM1ganglioside-galactosidase. A. Purification and studies of the enzyme from human liver. J. Biol. Chem 249, 7969-7976.[Abstract/Free Full Text]

Reznikoff, C. A., Yaeger, T. R., Belair, C. D., Saveliena, E., Phthenveettil, J. A. and Stadler, W. M (1996). Elevated p16 at senescence and loss of p16 at immortalization in human papillomavirus 16 E6, but not E7, transformed human uroepithelial cells. Cancer Res 56, 2886-2990.[Abstract/Free Full Text]

Robbins, E., Levine, E. M. and Eagle, H (1970). Morphologic changes accompanying senescence of cultured human diploid cells. J. Exp. Med 131, 1211-1222.[Abstract]

Rudolph, K. L., Chang, S., Millard, M., Schreiber-Agus, N. and DePinho, R. A (2000). Inhibition of experimental liver cirrhosis in mice by telomerase gene delivery. Science 287, 1253-1258.[Abstract/Free Full Text]

Serrano, M., Lin, A. W., McCurrach, M. E., Beach, D. and Lowe, S. W (1997). Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a. Cell 88, 593-602.[Medline]

Sigal, S. H., Rajvinshi, P., Gorla, G. R., Sokhi, R. P., Saxena, R., Gebhard, Jr., D. R., Reid, L. M. and Gupta, S (1999). Partial hepatectomy-inducedpolyploidy attenuates hepatocyte replication and activates cell aging events. Am. J. Physiol 276, 1260-.

Smith, J. R. and Pereira-Smith, O. M (1996). Replicative senescence: implications for in vivo aging and tumor suppression. Science 273, 63-67.[Abstract]

Tsukamoto, A., Kaneko, Y., Yoshida, T., Han, K., Ichinose, M. and Kimura, S (1998). 2-Methoxyestradiol, and endogenous metabolite of estrogen, enhances apoptosis and-galactosidase expression in vascular endothelial cells. Biochem. Biophys. Res. Commun 248, 9-12.[Medline]

Turk, B. and Milo, G. E (1974). An in vitro study of senescent events of human embryonic lung (WI-38) cells. Arch. Biochem. Biophys 161, 46-53.

van der Loo, B., Fenton, M. J. and Erusalimsky, J. D (1998). Cytochemical detection of a senescence-associated-galactosidase in endothelial and smooth muscle cells from human and rabbit blood vessels. Exp. Cell Res 241, 309-315.[Medline]

Yegorov, Y., Akimov, S. S., Hass, R., Zelenin, A. V. and Prudovsky, I. A (1998). Endogenous-galactosidase acitivity in continuously nonproliferating cells. Exp. Cell Res 243, 207-211.[Medline]

Yin, D (1996). Biochemical basis of lipofuscin, ceroid, and age pigment-like fluorophores. Free Rad. Biol. Med 21, 871-888.[Medline]

Yoshimori, T., Yamamoto, A., Moriyama, Y., Futai, M. and Tashiro, Y (1991). Bafilomycin A1, a specific inhibitor of vacuolar-type H+-ATPase, inhibits acidification and protein degredation in lysosomes of cultured cells. J. Biol. Chem 266, 17707-17712.[Abstract/Free Full Text]

This article has been cited by other articles:

S. Patschan, J. Chen, A. Polotskaia, N. Mendelev, J. Cheng, D. Patschan, and M. S. Goligorsky
Lipid mediators of autophagy in stress-induced premature senescence of endothelial cells
Am J Physiol Heart Circ Physiol, March 1, 2008; 294(3): H1119 - H1129.
[Abstract] [Full Text] [PDF]

L. Xue, H. Nolla, A. Suzuki, T. W. Mak, and A. Winoto
Normal development is an integral part of tumorigenesis in T cell-specific PTEN-deficient mice
PNAS, February 12, 2008; 105(6): 2022 - 2027.
[Abstract] [Full Text] [PDF]

S. Patschan, J. Chen, O. Gealekman, K. Krupincza, M. Wang, L. Shu, J. A. Shayman, and M. S. Goligorsky
Mapping mechanisms and charting the time course of premature cell senescence and apoptosis: lysosomal dysfunction and ganglioside accumulation in endothelial cells
Am J Physiol Renal Physiol, January 1, 2008; 294(1): F100 - F109.
[Abstract] [Full Text] [PDF]

Q. Shi, G. B. Hubbard, R. S. Kushwaha, D. Rainwater, C. A. Thomas III, M. M. Leland, J. L. VandeBerg, and X. L. Wang
Endothelial senescence after high-cholesterol, high-fat diet challenge in baboons
Am J Physiol Heart Circ Physiol, June 1, 2007; 292(6): H2913 - H2920.
[Abstract] [Full Text] [PDF]

K. Johung, E. C. Goodwin, and D. DiMaio
Human Papillomavirus E7 Repression in Cervical Carcinoma Cells Initiates a Transcriptional Cascade Driven by the Retinoblastoma Family, Resulting in Senescence
J. Virol., March 1, 2007; 81(5): 2102 - 2116.
[Abstract] [Full Text] [PDF]

T. Hatanaka, Y. Hatanaka, J.-i. Tsuchida, V. Ganapathy, and M. Setou
Amino Acid Transporter ATA2 Is Stored at the trans-Golgi Network and Released by Insulin Stimulus in Adipocytes
J. Biol. Chem., December 22, 2006; 281(51): 39273 - 39284.
[Abstract] [Full Text] [PDF]

T. Nyunoya, M. M. Monick, A. Klingelhutz, T. O. Yarovinsky, J. R. Cagley, and G. W. Hunninghake
Cigarette Smoke Induces Cellular Senescence
Am. J. Respir. Cell Mol. Biol., December 1, 2006; 35(6): 681 - 688.
[Abstract] [Full Text] [PDF]

I. Gorenne, M. Kavurma, S. Scott, and M. Bennett
Vascular smooth muscle cell senescence in atherosclerosis
Cardiovasc Res, October 1, 2006; 72(1): 9 - 17.
[Abstract] [Full Text] [PDF]

C. Matthews, I. Gorenne, S. Scott, N. Figg, P. Kirkpatrick, A. Ritchie, M. Goddard, and M. Bennett
Vascular Smooth Muscle Cells Undergo Telomere-Based Senescence in Human Atherosclerosis: Effects of Telomerase and Oxidative Stress
Circ. Res., July 21, 2006; 99(2): 156 - 164.
[Abstract] [Full Text] [PDF]

T. Mimura and N. C. Joyce
Replication competence and senescence in central and peripheral human corneal endothelium.
Invest. Ophthalmol. Vis. Sci., April 1, 2006; 47(4): 1387 - 1396.
[Abstract] [Full Text] [PDF]

T. Chernova, P. Nicotera, and A. G. Smith
Heme Deficiency Is Associated with Senescence and Causes Suppression of N-Methyl-D-aspartate Receptor Subunits Expression in Primary Cortical Neurons
Mol. Pharmacol., March 1, 2006; 69(3): 697 - 705.
[Abstract] [Full Text] [PDF]

T. Tsuji, K. Aoshiba, and A. Nagai
Cigarette Smoke Induces Senescence in Alveolar Epithelial Cells
Am. J. Respir. Cell Mol. Biol., December 1, 2004; 31(6): 643 - 649.
[Abstract] [Full Text] [PDF]

E. TRIVIER, D. J. KURZ, Y. HONG, H.-L. HUANG, and J. D. ERUSALIMSKY
Differential Regulation of Telomerase in Endothelial Cells by Fibroblast Growth Factor-2 and Vascular Endothelial Growth Factor-A: Association with Replicative Life Span
Ann. N.Y. Acad. Sci., June 1, 2004; 1019(1): 111 - 115.
[Abstract] [Full Text] [PDF]

D. J. Kurz, S. Decary, Y. Hong, E. Trivier, A. Akhmedov, and J. D. Erusalimsky
Chronic oxidative stress compromises telomere integrity and accelerates the onset of senescence in human endothelial cells
J. Cell Sci., May 1, 2004; 117(11): 2417 - 2426.
[Abstract] [Full Text] [PDF]

A. Melk
Senescence of renal cells: molecular basis and clinical implications
Nephrol. Dial. Transplant., December 1, 2003; 18(12): 2474 - 2478.
[Full Text] [PDF]

A. Ruiz-Torres, R. Lozano, J. Melon, and R. Carraro
Age-Dependent Decline of In Vitro Migration (Basal and Stimulated by IGF-1 or Insulin) of Human Vascular Smooth Muscle Cells
J. Gerontol. A Biol. Sci. Med. Sci., December 1, 2003; 58(12): B1074 - 1077.
[Abstract] [Full Text] [PDF]

K. Aoshiba, T. Tsuji, and A. Nagai
Bleomycin induces cellular senescence in alveolar epithelial cells
Eur. Respir. J., September 1, 2003; 22(3): 436 - 443.
[Abstract] [Full Text] [PDF]

I. B. Roninson
Tumor Cell Senescence in Cancer Treatment
Cancer Res., June 1, 2003; 63(11): 2705 - 2715.
[Abstract] [Full Text] [PDF]

D. J. Kurz, Y. Hong, E. Trivier, H.-L. Huang, S. Decary, G. H. Zang, T. F. Luscher, and J. D. Erusalimsky
Fibroblast Growth Factor-2, But Not Vascular Endothelial Growth Factor, Upregulates Telomerase Activity in Human Endothelial Cells
Arterioscler. Thromb. Vasc. Biol., May 1, 2003; 23(5): 748 - 754.
[Abstract] [Full Text] [PDF]

S. A. Joosten, V. van Ham, C. E. Nolan, M. C. Borrias, A. G. Jardine, P. G. Shiels, C. van Kooten, and L. C. Paul
Telomere Shortening and Cellular Senescence in a Model of Chronic Renal Allograft Rejection
Am. J. Pathol., April 1, 2003; 162(4): 1305 - 1312.
[Abstract] [Full Text] [PDF]

K. Ono, S. O. Kim, and J. Han
Susceptibility of Lysosomes to Rupture Is a Determinant for Plasma Membrane Disruption in Tumor Necrosis Factor Alpha-Induced Cell Death
Mol. Cell. Biol., January 15, 2003; 23(2): 665 - 676.
[Abstract] [Full Text] [PDF]

S. S. Deshpande, B. Qi, Y. C. Park, and K. Irani
Constitutive Activation of rac1 Results in Mitochondrial Oxidative Stress and Induces Premature Endothelial Cell Senescence
Arterioscler. Thromb. Vasc. Biol., January 1, 2003; 23(1): e1 - 6.
[Abstract] [Full Text] [PDF]

J. D. Erusalimsky, M. Fenton, T. Minamino, H. Miyauchi, T. Yoshida, I. Komuro, Y. Ishida, and H. Yoshida
Further In Vivo Evidence That Cellular Senescence Is Implicated in Vascular Pathophysiology * Response
Circulation, November 12, 2002; 106 (20): e144 - e144.
[Full Text] [PDF]

M. Fenton, S. Barker, D. J. Kurz, and J. D. Erusalimsky
Cellular Senescence After Single and Repeated Balloon Catheter Denudations of Rabbit Carotid Arteries
Arterioscler. Thromb. Vasc. Biol., February 1, 2001; 21(2): 220 - 226.
[Abstract] [Full Text] [PDF]

This Article

Summary

Full Text (PDF)

Alert me when this article is cited

Alert me if a correction is posted

Services

Email this article to a friend

Similar articles in this journal

Similar articles in PubMed

Alert me to new issues of the journal

Download to citation manager

Citing Articles

Citing Articles via HighWire

Citing Articles via Google Scholar

Google Scholar

Articles by Kurz, D. J.

Articles by Erusalimsky, J. D.

Search for Related Content

PubMed

PubMed Citation

Articles by Kurz, D. J.

Articles by Erusalimsky, J. D.

				L. Xue, H. Nolla, A. Suzuki, T. W. Mak, and A. Winoto Normal development is an integral part of tumorigenesis in T cell-specific PTEN-deficient mice PNAS, February 12, 2008; 105(6): 2022 - 2027. [Abstract] [Full Text] [PDF]

				S. Patschan, J. Chen, O. Gealekman, K. Krupincza, M. Wang, L. Shu, J. A. Shayman, and M. S. Goligorsky Mapping mechanisms and charting the time course of premature cell senescence and apoptosis: lysosomal dysfunction and ganglioside accumulation in endothelial cells Am J Physiol Renal Physiol, January 1, 2008; 294(1): F100 - F109. [Abstract] [Full Text] [PDF]

				Q. Shi, G. B. Hubbard, R. S. Kushwaha, D. Rainwater, C. A. Thomas III, M. M. Leland, J. L. VandeBerg, and X. L. Wang Endothelial senescence after high-cholesterol, high-fat diet challenge in baboons Am J Physiol Heart Circ Physiol, June 1, 2007; 292(6): H2913 - H2920. [Abstract] [Full Text] [PDF]

				K. Johung, E. C. Goodwin, and D. DiMaio Human Papillomavirus E7 Repression in Cervical Carcinoma Cells Initiates a Transcriptional Cascade Driven by the Retinoblastoma Family, Resulting in Senescence J. Virol., March 1, 2007; 81(5): 2102 - 2116. [Abstract] [Full Text] [PDF]

				T. Hatanaka, Y. Hatanaka, J.-i. Tsuchida, V. Ganapathy, and M. Setou Amino Acid Transporter ATA2 Is Stored at the trans-Golgi Network and Released by Insulin Stimulus in Adipocytes J. Biol. Chem., December 22, 2006; 281(51): 39273 - 39284. [Abstract] [Full Text] [PDF]

				T. Nyunoya, M. M. Monick, A. Klingelhutz, T. O. Yarovinsky, J. R. Cagley, and G. W. Hunninghake Cigarette Smoke Induces Cellular Senescence Am. J. Respir. Cell Mol. Biol., December 1, 2006; 35(6): 681 - 688. [Abstract] [Full Text] [PDF]

				I. Gorenne, M. Kavurma, S. Scott, and M. Bennett Vascular smooth muscle cell senescence in atherosclerosis Cardiovasc Res, October 1, 2006; 72(1): 9 - 17. [Abstract] [Full Text] [PDF]

				C. Matthews, I. Gorenne, S. Scott, N. Figg, P. Kirkpatrick, A. Ritchie, M. Goddard, and M. Bennett Vascular Smooth Muscle Cells Undergo Telomere-Based Senescence in Human Atherosclerosis: Effects of Telomerase and Oxidative Stress Circ. Res., July 21, 2006; 99(2): 156 - 164. [Abstract] [Full Text] [PDF]

				T. Mimura and N. C. Joyce Replication competence and senescence in central and peripheral human corneal endothelium. Invest. Ophthalmol. Vis. Sci., April 1, 2006; 47(4): 1387 - 1396. [Abstract] [Full Text] [PDF]

				T. Chernova, P. Nicotera, and A. G. Smith Heme Deficiency Is Associated with Senescence and Causes Suppression of N-Methyl-D-aspartate Receptor Subunits Expression in Primary Cortical Neurons Mol. Pharmacol., March 1, 2006; 69(3): 697 - 705. [Abstract] [Full Text] [PDF]

				T. Tsuji, K. Aoshiba, and A. Nagai Cigarette Smoke Induces Senescence in Alveolar Epithelial Cells Am. J. Respir. Cell Mol. Biol., December 1, 2004; 31(6): 643 - 649. [Abstract] [Full Text] [PDF]

				E. TRIVIER, D. J. KURZ, Y. HONG, H.-L. HUANG, and J. D. ERUSALIMSKY Differential Regulation of Telomerase in Endothelial Cells by Fibroblast Growth Factor-2 and Vascular Endothelial Growth Factor-A: Association with Replicative Life Span Ann. N.Y. Acad. Sci., June 1, 2004; 1019(1): 111 - 115. [Abstract] [Full Text] [PDF]

				D. J. Kurz, S. Decary, Y. Hong, E. Trivier, A. Akhmedov, and J. D. Erusalimsky Chronic oxidative stress compromises telomere integrity and accelerates the onset of senescence in human endothelial cells J. Cell Sci., May 1, 2004; 117(11): 2417 - 2426. [Abstract] [Full Text] [PDF]

				A. Melk Senescence of renal cells: molecular basis and clinical implications Nephrol. Dial. Transplant., December 1, 2003; 18(12): 2474 - 2478. [Full Text] [PDF]

				A. Ruiz-Torres, R. Lozano, J. Melon, and R. Carraro Age-Dependent Decline of In Vitro Migration (Basal and Stimulated by IGF-1 or Insulin) of Human Vascular Smooth Muscle Cells J. Gerontol. A Biol. Sci. Med. Sci., December 1, 2003; 58(12): B1074 - 1077. [Abstract] [Full Text] [PDF]

				K. Aoshiba, T. Tsuji, and A. Nagai Bleomycin induces cellular senescence in alveolar epithelial cells Eur. Respir. J., September 1, 2003; 22(3): 436 - 443. [Abstract] [Full Text] [PDF]

				I. B. Roninson Tumor Cell Senescence in Cancer Treatment Cancer Res., June 1, 2003; 63(11): 2705 - 2715. [Abstract] [Full Text] [PDF]

				D. J. Kurz, Y. Hong, E. Trivier, H.-L. Huang, S. Decary, G. H. Zang, T. F. Luscher, and J. D. Erusalimsky Fibroblast Growth Factor-2, But Not Vascular Endothelial Growth Factor, Upregulates Telomerase Activity in Human Endothelial Cells Arterioscler. Thromb. Vasc. Biol., May 1, 2003; 23(5): 748 - 754. [Abstract] [Full Text] [PDF]

				S. A. Joosten, V. van Ham, C. E. Nolan, M. C. Borrias, A. G. Jardine, P. G. Shiels, C. van Kooten, and L. C. Paul Telomere Shortening and Cellular Senescence in a Model of Chronic Renal Allograft Rejection Am. J. Pathol., April 1, 2003; 162(4): 1305 - 1312. [Abstract] [Full Text] [PDF]

				K. Ono, S. O. Kim, and J. Han Susceptibility of Lysosomes to Rupture Is a Determinant for Plasma Membrane Disruption in Tumor Necrosis Factor Alpha-Induced Cell Death Mol. Cell. Biol., January 15, 2003; 23(2): 665 - 676. [Abstract] [Full Text] [PDF]

				S. S. Deshpande, B. Qi, Y. C. Park, and K. Irani Constitutive Activation of rac1 Results in Mitochondrial Oxidative Stress and Induces Premature Endothelial Cell Senescence Arterioscler. Thromb. Vasc. Biol., January 1, 2003; 23(1): e1 - 6. [Abstract] [Full Text] [PDF]

				J. D. Erusalimsky, M. Fenton, T. Minamino, H. Miyauchi, T. Yoshida, I. Komuro, Y. Ishida, and H. Yoshida *Further In Vivo Evidence That Cellular Senescence Is Implicated in Vascular Pathophysiology Response** Circulation, November 12, 2002; 106 (20): e144 - e144. [Full Text] [PDF]

				M. Fenton, S. Barker, D. J. Kurz, and J. D. Erusalimsky Cellular Senescence After Single and Repeated Balloon Catheter Denudations of Rabbit Carotid Arteries Arterioscler. Thromb. Vasc. Biol., February 1, 2001; 21(2): 220 - 226. [Abstract] [Full Text] [PDF]