ID helix-loop-helix proteins in cell growth, differentiation and tumorigenesis

QUICK SEARCH:

[advanced]

	Author:		Keyword(s):

Home Help Feedback Subscriptions Archive Search Table of Contents

This Article

	Summary
	Full Text (PDF)
	Alert me when this article is cited
	Alert me if a correction is posted

Services

	Email this article to a friend
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new issues of the journal
	Download to citation manager


Citing Articles

	Citing Articles via HighWire
	Citing Articles via Google Scholar

Google Scholar

	Articles by Norton, J. D.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Norton, J. D.

Alani, R., Hasskarl, J., Grace, M., Hernandez, M-C., Israel, M. and Munger, K (1999). Immortalisation of primary human keratinocytes by the helix-loop-helix protein, ID1. Proc. Natl. Acad. Sci. USA 96, 9637-9641.[Abstract/Free Full Text]

Andres-Barquin, P. J., Hernandez, M. C., Hayes, T. E., McKay, R. D. G. and Israel, M. A (1997). Id genes encoding inhibitors of transcription are expressed during in vitro astrocyte differentiation and in cell lines derived from astrocytic tumours. Cancer Res 57, 215-220.[Abstract/Free Full Text]

Andres-Barquin, P. J., Hernandez, M. C. and Israel, M. A (1999). Id4 expression induces apoptosis in astrocytic cultures and is down-regulated by activation of the cAMP-dependent signal transduction pathway. Exp. Cell Res 247, 347-355.[Medline]

Andres-Barquin, P.J., Hernandez, M. C. and Israel, M. A (2000). Id genes in nervous system development. Histol. Histopathol 15, 603-618.[Medline]

Artavanis Tsakonas, S., Rand, M. D. and Lake, R. J (1999). Notch signalling: cell fate control and signal integration in development. Science 284, 770-776.[Abstract/Free Full Text]

Atherton, G., Travers, H., Deed, R. and Norton, J. D (1996). Regulation of cell differentiation in C2C12 myoblasts by the ID3 helix-loop-helix protein. Cell Growth Diff 7, 1059-1066.[Abstract]

Bain, G., Quong, M. W., Soloff, R. S., Hedrick, S. M. and Murre, C (1999). Thymocyte maturation is regulated by the activity of the helix-loop-helix protein, E47. J. Exp. Med 190, 1605-1616.[Abstract/Free Full Text]

Baonza, A., de Celis, J. F. and Garcia-Bellido, A (2000). Relationships between extramacrochaetae and Notch signalling in Drosophila wing development. Development 127, 2383-2393.[Abstract]

Barone, M. V., Pepperkok, R., Peverali, F. A. and Philipson, L (1994). ID proteins control growth induction in mammalian cells. Proc. Natl. Acad. Sci. USA 91, 4985-4988.[Abstract/Free Full Text]

Benezra, R., Davis, R., Lockshon, D., Turner, D and Weintraub, H (1990). The protein ID \320 a negative regulator of helix-loop-helix DNA binding proteins. Cell 61, 49-59.[Medline]

Biggs, J., Murphy, E. V. and Israel, M. A (1992). A human ID-like helix-loop-helix protein expressed during early development. Proc. Natl. Acad. Sci. USA 89, 1512-1516.[Abstract/Free Full Text]

Blom, B., Heemskerk, M. H. M., Verschuren, M. C. M., van Dongen, J. J. M., Stegmann, A. P. A., Bakker, A. Q., Couwenberg, F., Res, P. C. M. and Spits, H (1999). Disruption ofbut not T cell development by overexpression of the helix-loop-helix protein ID3 in committed T cell progenitors. EMBO J 18, 2793-2802.[Medline]

Bounpheng, M. A., Dimas, J. J., Dodds, S. G. and Christy, B. A (1999). Degradation of ID proteins by the ubiquitin-proteasome pathway. FASEB J 13, 2257-2264.[Abstract/Free Full Text]

Bounpheng, M. A., Melnikova, I. N., Dimas, J. J. and Christy, B. A (1999). Identification of a novel transcriptional activity of mammalian ID proteins. Nucleic Acids Res 27, 1740-1746.[Abstract/Free Full Text]

Christy, B. A., Sanders, L. K., Lau, L. F., Copeland, N. G., Jenkins, N. A. and Nathans, D (1991). An ID-related helix-loop-helix protein encoded by a growth factor inducible gene. Proc. Natl. Acad. Sci. USA 88, 1815-1819.[Abstract/Free Full Text]

Cooper, C. L. and Newburger, P. E (1998). Differential expression of Id genes in multipotent myeloid progenitor cells: Id1 is induced by early and late-acting cytokines while Id2 is selectively induced by cytokines that drive terminal granulocytic differentiation. J. Cell. Biochem 71, 277-285.[Medline]

Deed, R. W., Armitage, S. and Norton, J. D (1996). Nuclear localisation of ID protein through an E protein-mediated chaperone mechanisms. J Biol. Chem 271, 23603-23606.[Abstract/Free Full Text]

Deed, R. W., Bianchi, S. M., Atherton, G. T., Johnston, D., Santibanez-Koref, M., Murphy, J. J. and Norton, J. D (1993). An immediate early human gene encodes an ID-like helix-loop-helix protein and is regulated by protein kinase C activation in diverse cell types. Oncogene 8, 599-607.[Medline]

Deed, R. W., Hara, E., Atherton, G. T., Peters, G. and Norton, J. D (1997). Regulation of ID3 cell cycle function by Cdk2-dependent phosphorylation. Mol. Cell Biol 17, 6815-6821.[Abstract]

Deed, R. W., Hirose, T., Mitchell, E. L. D., Santibanez-Koref, M. F. and Norton, J. D (1994). Structural organisation and chromosomal mapping of the human Id3 gene. Gene 151, 309-314.[Medline]

Deed, R. W., Jasiok, M. and Norton, J. D (1998). Lymphoid-specific expression of the Id3 gene in hematopoietic cells: selective antagonism of E2A basic helix-loop-helix protein associated with Id3-induced differentiation of erythroleukaemia cells. J. Biol. Chem 273, 8278-8286.[Abstract/Free Full Text]

Desprez, P. Y., Hara, E., Bissell, M. J. and Campisi, J (1995). Suppression of mammary epithelial cell differentiation by the helix-loop-helix protein, ID1. Mol. Cell Biol 15, 3398-3404.[Abstract]

Desprez, P-Y., Lin, C. Q., Thomasset, N., Sympson, C. J., Bissell, M. J. and Campisi, J (1998). A novel pathway for mammary epithelial cell invasion induced by the helix-loop-helix protein, ID1. Mol. Cell Biol 18, 4577-4588.[Abstract/Free Full Text]

Ellis, H. M., Spann, D. R. and Posakony, J. W (1990). Extramacrochaetae , a negative regulator of sensory organ development in Drosophila , defines a new class of helix-loop-helix proteins. Cell 61, 27-37.[Medline]

Engel, I. and Murre, C (1999). Ectopic expression of E47 or E12 promotes the cell death of E2A-deficient lymphomas. Proc. Nat. Acad. Sci. USA 96, 996-1001.[Abstract/Free Full Text]

Florio, M., Hernandez, M. C., Yang, H., Shu, H-K., Cleveland, J. L. and Israel, M. A (1998). ID2 promotes apoptosis by a novel mechanism independent of dimerisation to basic helix-loop-helix factors. Mol. Cell Biol 18, 2371-2381.[Abstract/Free Full Text]

Garrell, J. and Modolel, J (1990). The Drosophila extramacrochaetae locus, an antogonist of pro-neural genes that like these genes encodes a helix-loop-helix protein. Cell 61, 39-48.[Medline]

Hara, E., Hall, M. and Peters, G (1997). Cdk2-dependent phosphorylation of ID2 modulates activity of E2A-related transcription factors. EMBO J 16, 101-110.

Hara, E., Yamaguchi, T., Nojima, H., Ide, T., Campisi, J., Okayama, H. and Oda, K (1994). Id -related genes encoding HLH proteins are required for G1 progression and are repressed in senescent human fibroblasts. J. Biol. Chem 269, 2139-2145.[Abstract/Free Full Text]

Heemskerk, M. H. M., Blom, B., Nolan, G., Stegmann, A. P. A., Bakker, A. Q., Wejer, K., Res, P. C. M. and Spits, H (1997). Inhibition of T celland promotion of natural killer cell development by the dominant negative helix-loop-helix factor, ID3. J. Exp. Med 186, 1597-1602.[Abstract/Free Full Text]

Holmes, M. L., Haley, J. D., Cerruti, L., Zhou, W. L., Smith, D. E., Cunningham, J. M. and Jane, S. M (1999). Identification of ID2 as a globin regulatory protein by representational difference analysis of K562 cells induced to express gamma-globin with a fungal compound. Mol. Cell Biol 19, 4182-4190.[Abstract/Free Full Text]

Iavarone, A., Garg, P., Lasorella, A., Hsu, J. and Israel, M. A (1994). The helix-loop-helix protein ID2 enhances cell proliferation and binds to the Retinoblastoma protein. Genes and Dev 8, 1270-1284.[Abstract/Free Full Text]

Inoue, T., Shoji, W. and Obinata, M (1999). MIDA1, an ID-associated protein, has two distinct DNA binding activities that are converted by the association with Id1: a novel function of Id protein. Biochem. Biophys. Res. Commun 266, 147-151.[Medline]

Ishiguro, A., Konstantin, S., Spirin, M. S., Tobler, A., Gombart, A., Israel, M., Norton, J. D. and Keoffler, H. P (1996). Id2 expression increases with differentiation of human myeloid cells. Blood 87, 5225-5231.[Abstract/Free Full Text]

Israel, M. A., Hernandez, M-C., Florio, M., Andres-Barquin, P., Mantani, A., Carter, J. H. and Julin, C. M (1999). Id gene expression as a key mediator of tumour cell biology. Cancer Res 59, 1726-1730.

Jaleco, A. C., Stegmann, A. P. A., Heemskerk, M. H. M., Couwenberg, F., Bakker, A. Q., Weijer, K. and Spits, H (1999). Genetic modification of human B cell development: B cell development is inhibited by the dominant negative helix-loop-helix factor, ID3. Blood 8, 2637-2646.

Jan, Y. N. and Jan, L. Y (1993). HLH proteins, fly neurogenesis and vertebrate myogenesis. Cell 75, 827-830.[Medline]

Jen, Y., Weintraub, H. and Benezra, R (1992). Overexpression of ID protein inhibits the muscle differentiation programme: in vivo association of ID with E2A proteins. Genes Dev 6, 1466-1479.[Abstract/Free Full Text]

Kim, D., Peng, X. C. and Sun, X-H (1999). Massive apoptosis of thymocytes in T cell deficient Id1 transgenic mice. Mol. Cell Biol 19, 8240-8253.[Abstract/Free Full Text]

Kleef, J., Ishiwata, T., Friess, H., Buchler, M. W., Israel, M. A. and Korc, M (1998). The helix-loop-helix protein, ID2, is overexpressed in human pancreatic cancer. Cancer Res 58, 3769-3772.[Abstract/Free Full Text]

Kondo, T. and Raff, M (2000). The ID4 HLH protein and the timing of oligodendrocyte differentiation. EMBO J 19, 1998-2007.[Medline]

Langlands, K., Yin, X., Anand, G. and Prochownik, E. V (1997). Differential interactions of ID proteins with basic helix-loop-helix transcription factors. J. Biol. Chem 272, 19785-19793.[Abstract/Free Full Text]

Lasorella, A., Iavarone, A. and Israel, M. A (1996). ID2 specifically alters regulation of the cell cycle by tumour suppressor proteins. Mol. Cell Biol 16, 2570-2578.[Abstract]

Lin, C. Q., Singh, J., Murata, K., Itahana, Y., Parrinello, S., Liang, S. H., Gillet, C. E., Campisi, J. and Desprez, P-Y (2000). A role for ID1 in the aggressive phenotype and steroid response of human breast cancer cells. Cancer Res 60, 1332-1340.[Abstract/Free Full Text]

Littlewood, T. D. and Evan, G. I (1995). Helix-loop-helix proteins. Protein Profile 2, 621-702.[Medline]

Lyden, D., Young, A. Z., Zagzag, D., Yan, W., Gerald, W., O'Reilly, R., Bader, B. L., Hynes, R. O., Zhuang, Y., Manova, K. and Benezra, R (1999). Id1 and Id3 are required for neurogenesis, angiogenesis and vascularisation of tumour xenografts. Nature 401, 670-677.[Medline]

Martinez, C., Modolell., J and Garrell, J (1993). Regulation of the proneural gene achaete by helix-loop-helix proteins. Mol. Cell Biol 13, 3514-3521.[Abstract/Free Full Text]

Martinsen, B. J. and Bronner-Fraser, M (1998). Neural crest specification regulated by the helix-loop-helix repressor, ID2. Science 281, 988-991.[Abstract/Free Full Text]

Maruyama, H., Kleef, J., Wildi, S., Friess, H., Buchler, M. W., Israel, M. A. and Korc, M (1999). Id1 and Id2 are overexpressed in pancreatic cancer and in dysplastic lesions in chronic pancreatitis. Am. J. Pathol 155, 815-822.[Abstract/Free Full Text]

Massari, M. E. and Murre, (2000). Helix-loop-helix proteins: regulators of transcription in eukaryotic organisms. Mol. Cell Biol 20, 429-440.[Free Full Text]

Melnikova, I. N., Bounpheng, M., Schatteman, G. C., Gilliam, D. and Christy, B. A (1999). Differential biological activities of mammalian ID proteins in muscle cells. Exp. Cell Res 247, 94-104.[Medline]

Moldes, M., Boizard, M., leLiepvre, X., Feve, B., Dugail, I and Pairault, J (1999). Functional antagonism between inhibitor of DNA binding (ID) and adipocyte determination and differentiation factor 1/sterol regulatoryelement-binding protein-1c (ADD1/SREBP-1c) trans-factors for the regulation of fatty acid synthase promoter in adipocytes. Biochem. J 344, 873-880.

Morrow, M. A., Mayer, E. W., Perez, C. A., Adlam, M. and Siu, G (1999). Overexpression of the helix-loop-helix inhibitor protein, ID2, blocks T cell development at multiple stages. Mol. Immunol 36, 491-503.[Medline]

Nakajima, T., Yageta, M., Shiotsu, K., Morita, K., Akashi, N., Suzuki, M. and Oda, K (1998). Co-expression of adenovirus E1A and ID proteins indices apoptosis in rat cells carrying p53 mutation. Proc. Natl. Acad. Sci. USA 95, 10590-10595.[Abstract/Free Full Text]

Norton, J. D. and Atherton, G. T (1998). Coupling of cell growth control and apoptosis functions of ID proteins. Mol. Cell Biol 18, 2371-2381.

Pan, L., Sato, S., Frederick, J. P., Sun, X-H. and Zhuang, Y (1999). Impaired immune responses and B cell proliferation in mice lacking the Id3 gene. Mol. Cell Biol 19, 5969-5980.[Abstract/Free Full Text]

Park, S. T., Nolan, G. P. and Sun, X-H (1999). Growth inhibition and apoptosis due to restoration of E2A activity in T cell acute lymphoblastic leukaemia cells. J. Exp. Med 189, 501-508.[Abstract/Free Full Text]

Peverali, F., Ramqvist, T., Saffrich, R., Pepperkok, R., Barone, M. and Philipson, L (1994). Regulation of G1 progression by E2A and ID helix-loop-helix proteins. EMBO J 13, 4291-4301.[Medline]

Prabhu, S., Ignatova, A., Park, S. T. and Sun, X-H (1997). Regulation of expression of the cyclin dependent kinase inhibitor p21 by E2A and ID proteins. Mol. Cell Biol 17, 5888-5896.[Abstract]

Quong, M. W., Harris, D. P., Swain, S. L. and Murre, C (1999). E2A activity is induced during B cell activation to promote immunoglobulin class switch recombination. EMBO J 18, 6307-6318.[Medline]

Riechmann, V., van Cruchten, I. and Sablitzky, F (1994). The expression pattern of Id4 , a novel dominant negative helix-loop-helix protein is distinct from Id1 , Id2 and Id3. Nucleic Acids Res 22, 749-755.[Abstract/Free Full Text]

Rivera, R. R., Johns, C. P., Quan, J., Johnson, R. S. and Murre, C (2000). Thymocyte selection is regulated by the helix-loop-helix inhibitor, ID3. Immunity 12, 17-26.[Medline]

Sablitzky, F., Moore, A., Bromley, M., Deed, R. W., Newton, J. S. and Norton, J. D (1998). Stage-and subcellular-specific expression of ID proteins in male germ and sertoli cells implicates distinct regulatory roles for ID proteins during meiosis, spermatogenesis and sertoli cell differentiation. Cell Growth Diff 9, 1015-1024.[Abstract]

Sherr, C. J. and Roberts, J. M (1999). CDK inhibitors: positive and negative regulators of G1-phase progression. Genes Dev 13, 1501-1512.[Free Full Text]

Shoji, W., Inoue, T., Yamamoto, T. and Obinata, M (1995). MIDA1, a protein associated with ID regulates cell growth. J. Biol. Chem 270, 24818-24825.[Abstract/Free Full Text]

Sun, X-H (1994). Constitutive expression of the Id1 gene impairs mouse B cell development. Cell 79, 893-900.[Medline]

Sun, X-H., Copeland, N. G., Jenkins, N.. and Baltimore, D (1991). ID proteins, ID1 and ID2 selectively inhibit DNA binding by one class of helix-loop-helix proteins. Mol. Cell Biol 11, 5603-5611.[Abstract/Free Full Text]

Tanaka, K., Pracyk, J. B., Takeda, K., Yu, Z-X., Ferrans, V. J., Deshpande, S. S., Ozaki, M., Hwang, P. M., Lowenstein, C. J., Irani, K. and Finkel, T (1998). Expression of Id1 results in apoptosis of cardiac myocytes through a redox-dependent mechanism. J. Biol. Chem 273, 25922-25928.[Abstract/Free Full Text]

Tournay, O. and Benezra, R (1996). Transcription of the dominant negative helix-loop-helix protein ID1 is regulated by a protein complex containing the immediate early response gene, Egr-1. Mol. Cell Biol 16, 2418-2430.[Abstract]

Wice, B. M. and Gordon, J. I (1998). Forced expression of Id1 in the adult mouse small intestineal epithelium is associated with development of adenomas. J. Biol. Chem 273, 25310-25319.[Abstract/Free Full Text]

Yan, W., Young, A. Z., Soares, V. C., Kelley, R., Benezra, R. and Zhuang, Y (1997). High incidence of T cell tumours in E2A-null mice and E2A/Id1 double knock-out mice. Mol. Cell Biol 17, 7317-7327.[Abstract]

Yokota, Y., Mansouri, A., Mori, S., Sugawara, S., Adachi, S., Nishikawa, S.-I. and Gruss, P (1999). Development of peripheral lymphoid organs and natural killer cells depends on the helix-loop-helix inhibitor, ID2. Nature 397, 702-706.[Medline]

This article has been cited by other articles:

K. Harada, A. Ogai, T. Takahashi, M. Kitakaze, H. Matsubara, and H. Oh
Crossveinless-2 Controls Bone Morphogenetic Protein Signaling during Early Cardiomyocyte Differentiation in P19 Cells
J. Biol. Chem., September 26, 2008; 283(39): 26705 - 26713.
[Abstract] [Full Text] [PDF]

Y. Qian and X. Chen
ID1, Inhibitor of Differentiation/DNA Binding, Is an Effector of the p53-dependent DNA Damage Response Pathway
J. Biol. Chem., August 15, 2008; 283(33): 22410 - 22416.
[Abstract] [Full Text] [PDF]

M. Ji, H. Li, H. C. Suh, K. D. Klarmann, Y. Yokota, and J. R. Keller
Id2 intrinsically regulates lymphoid and erythroid development via interaction with different target proteins
Blood, August 15, 2008; 112(4): 1068 - 1077.
[Abstract] [Full Text] [PDF]

B. Eun, Y. Lee, S. Hong, J. Kim, H.-W. Lee, K. Kim, W. Sun, and H. Kim
Hes6 Controls Cell Proliferation via Interaction with cAMP-response Element-binding Protein-binding Protein in the Promyelocytic Leukemia Nuclear Body
J. Biol. Chem., February 29, 2008; 283(9): 5939 - 5949.
[Abstract] [Full Text] [PDF]

R. Tsunedomi, N. Iizuka, T. Tamesa, K. Sakamoto, T. Hamaguchi, H. Somura, M. Yamada, and M. Oka
Decreased ID2 Promotes Metastatic Potentials of Hepatocellular Carcinoma by Altering Secretion of Vascular Endothelial Growth Factor
Clin. Cancer Res., February 15, 2008; 14(4): 1025 - 1031.
[Abstract] [Full Text] [PDF]

X. Zhang, M.-T. Ling, Q. Wang, C.-K. Lau, S. C. L. Leung, T. K. Lee, A. L. M. Cheung, Y.-C. Wong, and X. Wang
Identification of a Novel Inhibitor of Differentiation-1 (ID-1) Binding Partner, Caveolin-1, and Its Role in Epithelial-Mesenchymal Transition and Resistance to Apoptosis in Prostate Cancer Cells
J. Biol. Chem., November 16, 2007; 282(46): 33284 - 33294.
[Abstract] [Full Text] [PDF]

S. S. Perry, Y. Zhao, L. Nie, S. W. Cochrane, Z. Huang, and X.-H. Sun
Id1, but not Id3, directs long-term repopulating hematopoietic stem-cell maintenance
Blood, October 1, 2007; 110(7): 2351 - 2360.
[Abstract] [Full Text] [PDF]

B. Tang, N. Yoo, M. Vu, M. Mamura, J.-S. Nam, A. Ooshima, Z. Du, P.-Y. Desprez, M. R. Anver, A. M. Michalowska, et al.
Transforming Growth Factor-{beta} Can Suppress Tumorigenesis through Effects on the Putative Cancer Stem or Early Progenitor Cell and Committed Progeny in a Breast Cancer Xenograft Model
Cancer Res., September 15, 2007; 67(18): 8643 - 8652.
[Abstract] [Full Text] [PDF]

R. J. Wordinger and A. F. Clark
Bone Morphogenetic Proteins and Their Receptors in the Eye
Experimental Biology and Medicine, September 1, 2007; 232(8): 979 - 992.
[Abstract] [Full Text] [PDF]

K. U. Birkenkamp, A. Essafi, K. E. van der Vos, M. da Costa, R. C.-Y. Hui, F. Holstege, L. Koenderman, E. W.-F. Lam, and P. J. Coffer
FOXO3a Induces Differentiation of Bcr-Abl-transformed Cells through Transcriptional Down-regulation of Id1
J. Biol. Chem., January 26, 2007; 282(4): 2211 - 2220.
[Abstract] [Full Text] [PDF]

V. Jankovic, A. Ciarrocchi, P. Boccuni, T. DeBlasio, R. Benezra, and S. D. Nimer
Id1 restrains myeloid commitment, maintaining the self-renewal capacity of hematopoietic stem cells
PNAS, January 23, 2007; 104(4): 1260 - 1265.
[Abstract] [Full Text] [PDF]

R. Morosetti, M. Mirabella, C. Gliubizzi, A. Broccolini, L. De Angelis, E. Tagliafico, M. Sampaolesi, T. Gidaro, M. Papacci, E. Roncaglia, et al.
MyoD expression restores defective myogenic differentiation of human mesoangioblasts from inclusion-body myositis muscle
PNAS, November 7, 2006; 103(45): 16995 - 17000.
[Abstract] [Full Text] [PDF]

Y. Zhao, C. Johansson, T. Tran, R. Bettencourt, Y. Itahana, P.-Y. Desprez, and S. F. Konieczny
Identification of a Basic Helix-Loop-Helix Transcription Factor Expressed in Mammary Gland Alveolar Cells and Required for Maintenance of the Differentiated State
Mol. Endocrinol., September 1, 2006; 20(9): 2187 - 2198.
[Abstract] [Full Text] [PDF]

G. Pache, C. Schafer, S. Wiesemann, E. Springer, M. Liebau, H. C. Reinhardt, C. August, H. Pavenstadt, and M. J. Bek
Upregulation of Id-1 via BMP-2 receptors induces reactive oxygen species in podocytes
Am J Physiol Renal Physiol, September 1, 2006; 291(3): F654 - F662.
[Abstract] [Full Text] [PDF]

S. Peddada, D. H. Yasui, and J. M. LaSalle
Inhibitors of differentiation (ID1, ID2, ID3 and ID4) genes are neuronal targets of MeCP2 that are elevated in Rett syndrome
Hum. Mol. Genet., June 15, 2006; 15(12): 2003 - 2014.
[Abstract] [Full Text] [PDF]

H. Hua, Y.-Q. Zhang, S. Dabernat, M. Kritzik, D. Dietz, L. Sterling, and N. Sarvetnick
BMP4 Regulates Pancreatic Progenitor Cell Expansion through Id2
J. Biol. Chem., May 12, 2006; 281(19): 13574 - 13580.
[Abstract] [Full Text] [PDF]

L. M. Gronning, R. Tingsabadh, K. Hardy, K. T. Dalen, P. S. Jat, L. Gnudi, and P. R. Shepherd
Glucose induces increases in levels of the transcriptional repressor Id2 via the hexosamine pathway
Am J Physiol Endocrinol Metab, April 1, 2006; 290(4): E599 - E606.
[Abstract] [Full Text] [PDF]

J. Lee, K. Kim, J. H. Kim, H. M. Jin, H. K. Choi, S.-H. Lee, H. Kook, K. K. Kim, Y. Yokota, S. Y. Lee, et al.
Id helix-loop-helix proteins negatively regulate TRANCE-mediated osteoclast differentiation
Blood, April 1, 2006; 107(7): 2686 - 2693.
[Abstract] [Full Text] [PDF]

A. Lasorella and A. Iavarone
The protein ENH is a cytoplasmic sequestration factor for Id2 in normal and tumor cells from the nervous system
PNAS, March 28, 2006; 103(13): 4976 - 4981.
[Abstract] [Full Text] [PDF]

P. M. Siu, E. E. Pistilli, Z. Murlasits, and S. E. Alway
Hindlimb unloading increases muscle content of cytosolic but not nuclear Id2 and p53 proteins in young adult and aged rats
J Appl Physiol, March 1, 2006; 100(3): 907 - 916.
[Abstract] [Full Text] [PDF]

A. Nakashima, T. Katagiri, and M. Tamura
Cross-talk between Wnt and Bone Morphogenetic Protein 2 (BMP-2) Signaling in Differentiation Pathway of C2C12 Myoblasts
J. Biol. Chem., November 11, 2005; 280(45): 37660 - 37668.
[Abstract] [Full Text] [PDF]

P. M. Siu and S. E. Alway
Subcellular responses of p53 and Id2 in fast and slow skeletal muscle in response to stretch-induced overload
J Appl Physiol, November 1, 2005; 99(5): 1897 - 1904.
[Abstract] [Full Text] [PDF]

D. Reynaud, E. Ravet, M. Titeux, F. Mazurier, L. Renia, A. Dubart-Kupperschmitt, P.-H. Romeo, and F. Pflumio
SCL/TAL1 expression level regulates human hematopoietic stem cell self-renewal and engraftment
Blood, October 1, 2005; 106(7): 2318 - 2328.
[Abstract] [Full Text] [PDF]

S. Gokhan, M. Marin-Husstege, S. Y. Yung, D. Fontanez, P. Casaccia-Bonnefil, and M. F. Mehler
Combinatorial Profiles of Oligodendrocyte-Selective Classes of Transcriptional Regulators Differentially Modulate Myelin Basic Protein Gene Expression
J. Neurosci., September 7, 2005; 25(36): 8311 - 8321.
[Abstract] [Full Text] [PDF]

W. Leeanansaksiri, H. Wang, J. M. Gooya, K. Renn, M. Abshari, S. Tsai, and J. R. Keller
IL-3 Induces Inhibitor of DNA-Binding Protein-1 in Hemopoietic Progenitor Cells and Promotes Myeloid Cell Development
J. Immunol., June 1, 2005; 174(11): 7014 - 7021.
[Abstract] [Full Text] [PDF]

M. Buitenhuis, H. W. M. van Deutekom, L. P. Verhagen, A. Castor, S. E. W. Jacobsen, J.-W. J. Lammers, L. Koenderman, and P. J. Coffer
Differential regulation of granulopoiesis by the basic helix-loop-helix transcriptional inhibitors Id1 and Id2
Blood, June 1, 2005; 105(11): 4272 - 4281.
[Abstract] [Full Text] [PDF]

J. Chaudhary, I. Sadler-Riggleman, J. M. Ague, and M. K. Skinner
The Helix-Loop-Helix Inhibitor of Differentiation (ID) Proteins Induce Post-Mitotic Terminally Differentiated Sertoli Cells to Re-Enter the Cell Cycle and Proliferate
Biol Reprod, May 1, 2005; 72(5): 1205 - 1217.
[Abstract] [Full Text] [PDF]

S. Baghdoyan, J. Lamartine, D. Castel, A. Pitaval, Y. Roupioz, N. Franco, M. Duarte, M. T. Martin, and X. Gidrol
Id2 Reverses Cell Cycle Arrest Induced by {gamma}-Irradiation in Human HaCaT Keratinocytes
J. Biol. Chem., April 22, 2005; 280(16): 15836 - 15841.
[Abstract] [Full Text] [PDF]

W. Light, A. E. Vernon, A. Lasorella, A. Iavarone, and C. LaBonne
Xenopus Id3 is required downstream of Myc for the formation of multipotent neural crest progenitor cells
Development, April 15, 2005; 132(8): 1831 - 1841.
[Abstract] [Full Text] [PDF]

Y. Kee and M. Bronner-Fraser
To proliferate or to die: role of Id3 in cell cycle progression and survival of neural crest progenitors
Genes & Dev., March 15, 2005; 19(6): 744 - 755.
[Abstract] [Full Text] [PDF]

H. Kurooka and Y. Yokota
Nucleo-cytoplasmic Shuttling of Id2, a Negative Regulator of Basic Helix-Loop-Helix Transcription Factors
J. Biol. Chem., February 11, 2005; 280(6): 4313 - 4320.
[Abstract] [Full Text] [PDF]

S.-K. Lee, B. Lee, E. C. Ruiz, and S. L. Pfaff
Olig2 and Ngn2 function in opposition to modulate gene expression in motor neuron progenitor cells
Genes & Dev., January 15, 2005; 19(2): 282 - 294.
[Abstract] [Full Text] [PDF]

R. Christine, R. Sylvie, B. Erik, P. Genevieve, R. Amelie, R. Gerard, B. Marc, G. Christian, and A. Samir
Implication of STAT3 Signaling in Human Colonic Cancer Cells during Intestinal Trefoil Factor 3 (TFF3) - and Vascular Endothelial Growth Factor-Mediated Cellular Invasion and Tumor Growth
Cancer Res., January 1, 2005; 65(1): 195 - 202.
[Abstract] [Full Text] [PDF]

S. Forrest and C. McNamara
Id Family of Transcription Factors and Vascular Lesion Formation
Arterioscler. Thromb. Vasc. Biol., November 1, 2004; 24(11): 2014 - 2020.
[Abstract] [Full Text] [PDF]

K. Yun, A. Mantani, S. Garel, J. Rubenstein, and M. A. Israel
Id4 regulates neural progenitor proliferation and differentiation in vivo
Development, November 1, 2004; 131(21): 5441 - 5448.
[Abstract] [Full Text] [PDF]

L. Wine-Lee, K. J. Ahn, R. D. Richardson, Y. Mishina, K. M. Lyons, and E. B. Crenshaw III
Signaling through BMP type 1 receptors is required for development of interneuron cell types in the dorsal spinal cord
Development, November 1, 2004; 131(21): 5393 - 5403.
[Abstract] [Full Text] [PDF]

F. Vinals and F. Ventura
Myogenin Protein Stability Is Decreased by BMP-2 through a Mechanism Implicating Id1
J. Biol. Chem., October 29, 2004; 279(44): 45766 - 45772.
[Abstract] [Full Text] [PDF]

J. A. Nilsson, L. M. Nilsson, U. Keller, Y. Yokota, K. Boyd, and J. L. Cleveland
Id2 Is Dispensable for Myc-Induced Lymphomagenesis
Cancer Res., October 15, 2004; 64(20): 7296 - 7301.
[Abstract] [Full Text] [PDF]

J. Zhang, S. Hu, D. E. Schofield, P. H. B. Sorensen, and T. J. Triche
Selective Usage of D-Type Cyclins by Ewing's Tumors and Rhabdomyosarcomas
Cancer Res., September 1, 2004; 64(17): 6026 - 6034.
[Abstract] [Full Text] [PDF]

K. Hata, T. Yoshimoto, and J. Mizuguchi
CD40 Ligand Rescues Inhibitor of Differentiation 3-Mediated G1 Arrest Induced by Anti-IgM in WEHI-231 B Lymphoma Cells
J. Immunol., August 15, 2004; 173(4): 2453 - 2461.
[Abstract] [Full Text] [PDF]

Y. Peng, Q. Kang, Q. Luo, W. Jiang, W. Si, B. A. Liu, H. H. Luu, J. K. Park, X. Li, J. Luo, et al.
Inhibitor of DNA Binding/Differentiation Helix-Loop-Helix Proteins Mediate Bone Morphogenetic Protein-induced Osteoblast Differentiation of Mesenchymal Stem Cells
J. Biol. Chem., July 30, 2004; 279(31): 32941 - 32949.
[Abstract] [Full Text] [PDF]

W. Zheng, H. Wang, L. Xue, Z. Zhang, and T. Tong
Regulation of Cellular Senescence and p16INK4a Expression by Id1 and E47 Proteins in Human Diploid Fibroblast
J. Biol. Chem., July 23, 2004; 279(30): 31524 - 31532.
[Abstract] [Full Text] [PDF]

U. Gurok, C. Steinhoff, B. Lipkowitz, H.-H. Ropers, C. Scharff, and U. A. Nuber
Gene Expression Changes in the Course of Neural Progenitor Cell Differentiation
J. Neurosci., June 30, 2004; 24(26): 5982 - 6002.
[Abstract] [Full Text] [PDF]

H. W. Cheung, M.-t. Ling, S. W. Tsao, Y.C. Wong, and X. Wang
Id-1-induced Raf/MEK pathway activation is essential for its protective role against taxol-induced apoptosis in nasopharyngeal carcinoma cells
Carcinogenesis, June 1, 2004; 25(6): 881 - 887.
[Abstract] [Full Text] [PDF]

M. J. Scobey, C. A. Fix, and W. H. Walker
The Id2 Transcriptional Repressor Is Induced by Follicle-stimulating Hormone and cAMP
J. Biol. Chem., April 16, 2004; 279(16): 16064 - 16070.
[Abstract] [Full Text] [PDF]

Y. Liu, M. Encinas, J. X. Comella, M. Aldea, and C. Gallego
Basic Helix-Loop-Helix Proteins Bind to TrkB and p21Cip1 Promoters Linking Differentiation and Cell Cycle Arrest in Neuroblastoma Cells
Mol. Cell. Biol., April 1, 2004; 24(7): 2662 - 2672.
[Abstract] [Full Text] [PDF]

J.-Y. Kim, K. Chu, H.-J. Kim, H.-A Seong, K.-C. Park, S. Sanyal, J. Takeda, H. Ha, M. Shong, M.-J. Tsai, et al.
Orphan Nuclear Receptor Small Heterodimer Partner, a Novel Corepressor for a Basic Helix-Loop-Helix Transcription Factor BETA2/NeuroD
Mol. Endocrinol., April 1, 2004; 18(4): 776 - 790.
[Abstract]

				Y. Qian and X. Chen ID1, Inhibitor of Differentiation/DNA Binding, Is an Effector of the p53-dependent DNA Damage Response Pathway J. Biol. Chem., August 15, 2008; 283(33): 22410 - 22416. [Abstract] [Full Text] [PDF]

				M. Ji, H. Li, H. C. Suh, K. D. Klarmann, Y. Yokota, and J. R. Keller Id2 intrinsically regulates lymphoid and erythroid development via interaction with different target proteins Blood, August 15, 2008; 112(4): 1068 - 1077. [Abstract] [Full Text] [PDF]

				B. Eun, Y. Lee, S. Hong, J. Kim, H.-W. Lee, K. Kim, W. Sun, and H. Kim Hes6 Controls Cell Proliferation via Interaction with cAMP-response Element-binding Protein-binding Protein in the Promyelocytic Leukemia Nuclear Body J. Biol. Chem., February 29, 2008; 283(9): 5939 - 5949. [Abstract] [Full Text] [PDF]

				R. Tsunedomi, N. Iizuka, T. Tamesa, K. Sakamoto, T. Hamaguchi, H. Somura, M. Yamada, and M. Oka Decreased ID2 Promotes Metastatic Potentials of Hepatocellular Carcinoma by Altering Secretion of Vascular Endothelial Growth Factor Clin. Cancer Res., February 15, 2008; 14(4): 1025 - 1031. [Abstract] [Full Text] [PDF]

				X. Zhang, M.-T. Ling, Q. Wang, C.-K. Lau, S. C. L. Leung, T. K. Lee, A. L. M. Cheung, Y.-C. Wong, and X. Wang Identification of a Novel Inhibitor of Differentiation-1 (ID-1) Binding Partner, Caveolin-1, and Its Role in Epithelial-Mesenchymal Transition and Resistance to Apoptosis in Prostate Cancer Cells J. Biol. Chem., November 16, 2007; 282(46): 33284 - 33294. [Abstract] [Full Text] [PDF]

				S. S. Perry, Y. Zhao, L. Nie, S. W. Cochrane, Z. Huang, and X.-H. Sun Id1, but not Id3, directs long-term repopulating hematopoietic stem-cell maintenance Blood, October 1, 2007; 110(7): 2351 - 2360. [Abstract] [Full Text] [PDF]

				B. Tang, N. Yoo, M. Vu, M. Mamura, J.-S. Nam, A. Ooshima, Z. Du, P.-Y. Desprez, M. R. Anver, A. M. Michalowska, et al. Transforming Growth Factor-{beta} Can Suppress Tumorigenesis through Effects on the Putative Cancer Stem or Early Progenitor Cell and Committed Progeny in a Breast Cancer Xenograft Model Cancer Res., September 15, 2007; 67(18): 8643 - 8652. [Abstract] [Full Text] [PDF]

				R. J. Wordinger and A. F. Clark Bone Morphogenetic Proteins and Their Receptors in the Eye Experimental Biology and Medicine, September 1, 2007; 232(8): 979 - 992. [Abstract] [Full Text] [PDF]

				K. U. Birkenkamp, A. Essafi, K. E. van der Vos, M. da Costa, R. C.-Y. Hui, F. Holstege, L. Koenderman, E. W.-F. Lam, and P. J. Coffer FOXO3a Induces Differentiation of Bcr-Abl-transformed Cells through Transcriptional Down-regulation of Id1 J. Biol. Chem., January 26, 2007; 282(4): 2211 - 2220. [Abstract] [Full Text] [PDF]

				V. Jankovic, A. Ciarrocchi, P. Boccuni, T. DeBlasio, R. Benezra, and S. D. Nimer Id1 restrains myeloid commitment, maintaining the self-renewal capacity of hematopoietic stem cells PNAS, January 23, 2007; 104(4): 1260 - 1265. [Abstract] [Full Text] [PDF]

				R. Morosetti, M. Mirabella, C. Gliubizzi, A. Broccolini, L. De Angelis, E. Tagliafico, M. Sampaolesi, T. Gidaro, M. Papacci, E. Roncaglia, et al. MyoD expression restores defective myogenic differentiation of human mesoangioblasts from inclusion-body myositis muscle PNAS, November 7, 2006; 103(45): 16995 - 17000. [Abstract] [Full Text] [PDF]

				Y. Zhao, C. Johansson, T. Tran, R. Bettencourt, Y. Itahana, P.-Y. Desprez, and S. F. Konieczny Identification of a Basic Helix-Loop-Helix Transcription Factor Expressed in Mammary Gland Alveolar Cells and Required for Maintenance of the Differentiated State Mol. Endocrinol., September 1, 2006; 20(9): 2187 - 2198. [Abstract] [Full Text] [PDF]

				G. Pache, C. Schafer, S. Wiesemann, E. Springer, M. Liebau, H. C. Reinhardt, C. August, H. Pavenstadt, and M. J. Bek Upregulation of Id-1 via BMP-2 receptors induces reactive oxygen species in podocytes Am J Physiol Renal Physiol, September 1, 2006; 291(3): F654 - F662. [Abstract] [Full Text] [PDF]

				S. Peddada, D. H. Yasui, and J. M. LaSalle Inhibitors of differentiation (ID1, ID2, ID3 and ID4) genes are neuronal targets of MeCP2 that are elevated in Rett syndrome Hum. Mol. Genet., June 15, 2006; 15(12): 2003 - 2014. [Abstract] [Full Text] [PDF]

				H. Hua, Y.-Q. Zhang, S. Dabernat, M. Kritzik, D. Dietz, L. Sterling, and N. Sarvetnick BMP4 Regulates Pancreatic Progenitor Cell Expansion through Id2 J. Biol. Chem., May 12, 2006; 281(19): 13574 - 13580. [Abstract] [Full Text] [PDF]

				L. M. Gronning, R. Tingsabadh, K. Hardy, K. T. Dalen, P. S. Jat, L. Gnudi, and P. R. Shepherd Glucose induces increases in levels of the transcriptional repressor Id2 via the hexosamine pathway Am J Physiol Endocrinol Metab, April 1, 2006; 290(4): E599 - E606. [Abstract] [Full Text] [PDF]

				J. Lee, K. Kim, J. H. Kim, H. M. Jin, H. K. Choi, S.-H. Lee, H. Kook, K. K. Kim, Y. Yokota, S. Y. Lee, et al. Id helix-loop-helix proteins negatively regulate TRANCE-mediated osteoclast differentiation Blood, April 1, 2006; 107(7): 2686 - 2693. [Abstract] [Full Text] [PDF]

				A. Lasorella and A. Iavarone The protein ENH is a cytoplasmic sequestration factor for Id2 in normal and tumor cells from the nervous system PNAS, March 28, 2006; 103(13): 4976 - 4981. [Abstract] [Full Text] [PDF]

				P. M. Siu, E. E. Pistilli, Z. Murlasits, and S. E. Alway Hindlimb unloading increases muscle content of cytosolic but not nuclear Id2 and p53 proteins in young adult and aged rats J Appl Physiol, March 1, 2006; 100(3): 907 - 916. [Abstract] [Full Text] [PDF]

				A. Nakashima, T. Katagiri, and M. Tamura Cross-talk between Wnt and Bone Morphogenetic Protein 2 (BMP-2) Signaling in Differentiation Pathway of C2C12 Myoblasts J. Biol. Chem., November 11, 2005; 280(45): 37660 - 37668. [Abstract] [Full Text] [PDF]

				P. M. Siu and S. E. Alway Subcellular responses of p53 and Id2 in fast and slow skeletal muscle in response to stretch-induced overload J Appl Physiol, November 1, 2005; 99(5): 1897 - 1904. [Abstract] [Full Text] [PDF]

				D. Reynaud, E. Ravet, M. Titeux, F. Mazurier, L. Renia, A. Dubart-Kupperschmitt, P.-H. Romeo, and F. Pflumio SCL/TAL1 expression level regulates human hematopoietic stem cell self-renewal and engraftment Blood, October 1, 2005; 106(7): 2318 - 2328. [Abstract] [Full Text] [PDF]

				S. Gokhan, M. Marin-Husstege, S. Y. Yung, D. Fontanez, P. Casaccia-Bonnefil, and M. F. Mehler Combinatorial Profiles of Oligodendrocyte-Selective Classes of Transcriptional Regulators Differentially Modulate Myelin Basic Protein Gene Expression J. Neurosci., September 7, 2005; 25(36): 8311 - 8321. [Abstract] [Full Text] [PDF]

				W. Leeanansaksiri, H. Wang, J. M. Gooya, K. Renn, M. Abshari, S. Tsai, and J. R. Keller IL-3 Induces Inhibitor of DNA-Binding Protein-1 in Hemopoietic Progenitor Cells and Promotes Myeloid Cell Development J. Immunol., June 1, 2005; 174(11): 7014 - 7021. [Abstract] [Full Text] [PDF]

				M. Buitenhuis, H. W. M. van Deutekom, L. P. Verhagen, A. Castor, S. E. W. Jacobsen, J.-W. J. Lammers, L. Koenderman, and P. J. Coffer Differential regulation of granulopoiesis by the basic helix-loop-helix transcriptional inhibitors Id1 and Id2 Blood, June 1, 2005; 105(11): 4272 - 4281. [Abstract] [Full Text] [PDF]

				J. Chaudhary, I. Sadler-Riggleman, J. M. Ague, and M. K. Skinner The Helix-Loop-Helix Inhibitor of Differentiation (ID) Proteins Induce Post-Mitotic Terminally Differentiated Sertoli Cells to Re-Enter the Cell Cycle and Proliferate Biol Reprod, May 1, 2005; 72(5): 1205 - 1217. [Abstract] [Full Text] [PDF]

				S. Baghdoyan, J. Lamartine, D. Castel, A. Pitaval, Y. Roupioz, N. Franco, M. Duarte, M. T. Martin, and X. Gidrol Id2 Reverses Cell Cycle Arrest Induced by {gamma}-Irradiation in Human HaCaT Keratinocytes J. Biol. Chem., April 22, 2005; 280(16): 15836 - 15841. [Abstract] [Full Text] [PDF]

				W. Light, A. E. Vernon, A. Lasorella, A. Iavarone, and C. LaBonne Xenopus Id3 is required downstream of Myc for the formation of multipotent neural crest progenitor cells Development, April 15, 2005; 132(8): 1831 - 1841. [Abstract] [Full Text] [PDF]

				Y. Kee and M. Bronner-Fraser To proliferate or to die: role of Id3 in cell cycle progression and survival of neural crest progenitors Genes & Dev., March 15, 2005; 19(6): 744 - 755. [Abstract] [Full Text] [PDF]

				H. Kurooka and Y. Yokota Nucleo-cytoplasmic Shuttling of Id2, a Negative Regulator of Basic Helix-Loop-Helix Transcription Factors J. Biol. Chem., February 11, 2005; 280(6): 4313 - 4320. [Abstract] [Full Text] [PDF]