ID helix-loop-helix proteins in cell growth, differentiation and tumorigenesis

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L. M. Gronning, R. Tingsabadh, K. Hardy, K. T. Dalen, P. S. Jat, L. Gnudi, and P. R. Shepherd
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J. Lee, K. Kim, J. H. Kim, H. M. Jin, H. K. Choi, S.-H. Lee, H. Kook, K. K. Kim, Y. Yokota, S. Y. Lee, et al.
Id helix-loop-helix proteins negatively regulate TRANCE-mediated osteoclast differentiation
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A. Nakashima, T. Katagiri, and M. Tamura
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P. M. Siu and S. E. Alway
Subcellular responses of p53 and Id2 in fast and slow skeletal muscle in response to stretch-induced overload
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D. Reynaud, E. Ravet, M. Titeux, F. Mazurier, L. Renia, A. Dubart-Kupperschmitt, P.-H. Romeo, and F. Pflumio
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S. Gokhan, M. Marin-Husstege, S. Y. Yung, D. Fontanez, P. Casaccia-Bonnefil, and M. F. Mehler
Combinatorial Profiles of Oligodendrocyte-Selective Classes of Transcriptional Regulators Differentially Modulate Myelin Basic Protein Gene Expression
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W. Leeanansaksiri, H. Wang, J. M. Gooya, K. Renn, M. Abshari, S. Tsai, and J. R. Keller
IL-3 Induces Inhibitor of DNA-Binding Protein-1 in Hemopoietic Progenitor Cells and Promotes Myeloid Cell Development
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Differential regulation of granulopoiesis by the basic helix-loop-helix transcriptional inhibitors Id1 and Id2
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J. Chaudhary, I. Sadler-Riggleman, J. M. Ague, and M. K. Skinner
The Helix-Loop-Helix Inhibitor of Differentiation (ID) Proteins Induce Post-Mitotic Terminally Differentiated Sertoli Cells to Re-Enter the Cell Cycle and Proliferate
Biol Reprod, May 1, 2005; 72(5): 1205 - 1217.
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S. Baghdoyan, J. Lamartine, D. Castel, A. Pitaval, Y. Roupioz, N. Franco, M. Duarte, M. T. Martin, and X. Gidrol
Id2 Reverses Cell Cycle Arrest Induced by {gamma}-Irradiation in Human HaCaT Keratinocytes
J. Biol. Chem., April 22, 2005; 280(16): 15836 - 15841.
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W. Light, A. E. Vernon, A. Lasorella, A. Iavarone, and C. LaBonne
Xenopus Id3 is required downstream of Myc for the formation of multipotent neural crest progenitor cells
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Y. Kee and M. Bronner-Fraser
To proliferate or to die: role of Id3 in cell cycle progression and survival of neural crest progenitors
Genes & Dev., March 15, 2005; 19(6): 744 - 755.
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H. Kurooka and Y. Yokota
Nucleo-cytoplasmic Shuttling of Id2, a Negative Regulator of Basic Helix-Loop-Helix Transcription Factors
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S.-K. Lee, B. Lee, E. C. Ruiz, and S. L. Pfaff
Olig2 and Ngn2 function in opposition to modulate gene expression in motor neuron progenitor cells
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R. Christine, R. Sylvie, B. Erik, P. Genevieve, R. Amelie, R. Gerard, B. Marc, G. Christian, and A. Samir
Implication of STAT3 Signaling in Human Colonic Cancer Cells during Intestinal Trefoil Factor 3 (TFF3) - and Vascular Endothelial Growth Factor-Mediated Cellular Invasion and Tumor Growth
Cancer Res., January 1, 2005; 65(1): 195 - 202.
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S. Forrest and C. McNamara
Id Family of Transcription Factors and Vascular Lesion Formation
Arterioscler Thromb Vasc Biol, November 1, 2004; 24(11): 2014 - 2020.
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K. Yun, A. Mantani, S. Garel, J. Rubenstein, and M. A. Israel
Id4 regulates neural progenitor proliferation and differentiation in vivo
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L. Wine-Lee, K. J. Ahn, R. D. Richardson, Y. Mishina, K. M. Lyons, and E. B. Crenshaw III
Signaling through BMP type 1 receptors is required for development of interneuron cell types in the dorsal spinal cord
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F. Vinals and F. Ventura
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J. A. Nilsson, L. M. Nilsson, U. Keller, Y. Yokota, K. Boyd, and J. L. Cleveland
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J. Zhang, S. Hu, D. E. Schofield, P. H. B. Sorensen, and T. J. Triche
Selective Usage of D-Type Cyclins by Ewing's Tumors and Rhabdomyosarcomas
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K. Hata, T. Yoshimoto, and J. Mizuguchi
CD40 Ligand Rescues Inhibitor of Differentiation 3-Mediated G1 Arrest Induced by Anti-IgM in WEHI-231 B Lymphoma Cells
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Y. Peng, Q. Kang, Q. Luo, W. Jiang, W. Si, B. A. Liu, H. H. Luu, J. K. Park, X. Li, J. Luo, et al.
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W. Zheng, H. Wang, L. Xue, Z. Zhang, and T. Tong
Regulation of Cellular Senescence and p16INK4a Expression by Id1 and E47 Proteins in Human Diploid Fibroblast
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U. Gurok, C. Steinhoff, B. Lipkowitz, H.-H. Ropers, C. Scharff, and U. A. Nuber
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H. W. Cheung, M.-t. Ling, S. W. Tsao, Y.C. Wong, and X. Wang
Id-1-induced Raf/MEK pathway activation is essential for its protective role against taxol-induced apoptosis in nasopharyngeal carcinoma cells
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M. J. Scobey, C. A. Fix, and W. H. Walker
The Id2 Transcriptional Repressor Is Induced by Follicle-stimulating Hormone and cAMP
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Y. Liu, M. Encinas, J. X. Comella, M. Aldea, and C. Gallego
Basic Helix-Loop-Helix Proteins Bind to TrkB and p21Cip1 Promoters Linking Differentiation and Cell Cycle Arrest in Neuroblastoma Cells
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J.-Y. Kim, K. Chu, H.-J. Kim, H.-A Seong, K.-C. Park, S. Sanyal, J. Takeda, H. Ha, M. Shong, M.-J. Tsai, et al.
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J.-P. Coppe, Y. Itahana, D. H. Moore, J. L. Bennington, and P.-Y. Desprez
Id-1 and Id-2 Proteins as Molecular Markers for Human Prostate Cancer Progression
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D. J. Murphy, L. B. Swigart, M. A. Israel, and G. I. Evan
Id2 Is Dispensable for Myc-Induced Epidermal Neoplasia
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M.-C. Delfini and D. Duprez
Ectopic Myf5 or MyoD prevents the neuronal differentiation program in addition to inducing skeletal muscle differentiation, in the chick neural tube
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M. Garcia-Dominguez, C. Poquet, S. Garel, and P. Charnay
Ebf gene function is required for coupling neuronal differentiation and cell cycle exit
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L. Shan, M. Yu, C. Qiu, and E. G. Snyderwine
Id4 Regulates Mammary Epithelial Cell Growth and Differentiation and Is Overexpressed in Rat Mammary Gland Carcinomas
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H. Zhang and I. Rosdahl
Ultraviolet A and B differently induce intracellular protein expression in human skin melanocytes--a speculation of separate pathways in initiation of melanoma
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Q.-G. V. Nguyen, J. N. Buskin, C. L. Himeda, M. A. Shield, and S. D. Hauschka
Differences in the Function of Three Conserved E-boxes of the Muscle Creatine Kinase Gene in Cultured Myocytes and in Transgenic Mouse Skeletal and Cardiac Muscle
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P. J. O'Toole, T. Inoue, L. Emerson, I. E. G. Morrison, A. R. Mackie, R. J. Cherry, and J. D. Norton
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S. Fong, Y. Itahana, T. Sumida, J. Singh, J.-P. Coppe, Y. Liu, P. C. Richards, J. L. Bennington, N. M. Lee, R. J. Debs, et al.
Id-1 as a molecular target in therapy for breast cancer cell invasion and metastasis
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Y. Itahana, J. Singh, T. Sumida, J.-P. Coppe, S. Parrinello, J. L. Bennington, and P.-Y. Desprez
Role of Id-2 in the Maintenance of a Differentiated and Noninvasive Phenotype in Breast Cancer Cells
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T. K.-W. Lee, K. Man, M.-T. Ling, X.-H. Wang, Y.-C. Wong, C.-M. Lo, R. T.-P. Poon, I. O.-L. Ng, and S.-T. Fan
Over-expression of Id-1 induces cell proliferation in hepatocellular carcinoma through inactivation of p16INK4a/RB pathway
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P. M. Siegel, W. Shu, and J. Massague
Mad Upregulation and Id2 Repression Accompany Transforming Growth Factor (TGF)-{beta}-mediated Epithelial Cell Growth Suppression
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J. J. Buzzard, N. G. Wreford, and J. R. Morrison
Thyroid Hormone, Retinoic Acid, and Testosterone Suppress Proliferation and Induce Markers of Differentiation in Cultured Rat Sertoli Cells
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J. Stinson, T. Inoue, P. Yates, A. Clancy, J. D. Norton, and A. D. Sharrocks
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T. G. Shepherd and M. W. Nachtigal
Identification of a Putative Autocrine Bone Morphogenetic Protein-Signaling Pathway in Human Ovarian Surface Epithelium and Ovarian Cancer Cells
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J. Tang, G. M. Gordon, M. G. Muller, M. Dahiya, and K. E. Foreman
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S. Miyake, Y. Yanagisawa, and Y. Yuasa
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S. E. Alway, J. K. Martyn, J. Ouyang, A. Chaudhrai, and Z. S. Murlasits
Id2 expression during apoptosis and satellite cell activation in unloaded and loaded quail skeletal muscles
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Cell Cycle Blockade and Differentiation of Ovarian Cancer Cells by the Histone Deacetylase Inhibitor Trichostatin A Are Associated with Changes in p21, Rb, and Id Proteins
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A. K. Gupta and B. C. Kone
USF-1 and USF-2 trans-repress IL-1beta -induced iNOS transcription in mesangial cells
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G. Lopez-Carballo, L. Moreno, S. Masia, P. Perez, and D. Barettino
Activation of the Phosphatidylinositol 3-Kinase/Akt Signaling Pathway by Retinoic Acid Is Required for Neural Differentiation of SH-SY5Y Human Neuroblastoma Cells
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[Abstract] [Full Text] [PDF]

S. E. Alway, H. Degens, G. Krishnamurthy, and C. A. Smith
Potential role for Id myogenic repressors in apoptosis and attenuation of hypertrophy in muscles of aged rats
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D A Mann and D E Smart
Transcriptional regulation of hepatic stellate cell activation
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X. S. Ouyang, X. Wang, M.-T. Ling, H. L. Wong, S. W. Tsao, and Y.C. Wong
Id-1 stimulates serum independent prostate cancer cell proliferation through inactivation of p16INK4a/pRB pathway
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[Abstract] [Full Text] [PDF]

A. Jogi, P. Persson, A. Grynfeld, S. Pahlman, and H. Axelson
Modulation of Basic Helix-Loop-Helix Transcription Complex Formation by Id Proteins during Neuronal Differentiation
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[Abstract] [Full Text] [PDF]

O. Korchynskyi and P. ten Dijke
Identification and Functional Characterization of Distinct Critically Important Bone Morphogenetic Protein-specific Response Elements in the Id1 Promoter
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[Abstract] [Full Text] [PDF]

T. Lopez-Rovira, E. Chalaux, J. Massague, J. L. Rosa, and F. Ventura
Direct Binding of Smad1 and Smad4 to Two Distinct Motifs Mediates Bone Morphogenetic Protein-specific Transcriptional Activation of Id1 Gene
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[Abstract] [Full Text] [PDF]

A. Lasorella, R. Boldrini, C. Dominici, A. Donfrancesco, Y. Yokota, A. Inserra, and A. Iavarone
Id2 Is Critical for Cellular Proliferation and Is the Oncogenic Effector of N-Myc in Human Neuroblastoma
Cancer Res., January 1, 2002; 62(1): 301 - 306.
[Abstract] [Full Text] [PDF]

J. W. Wilson, R. W. Deed, T. Inoue, M. Balzi, A. Becciolini, P. Faraoni, C. S. Potten, and J. D. Norton
Expression of Id Helix-Loop-Helix Proteins in Colorectal Adenocarcinoma Correlates with p53 Expression and Mitotic Index
Cancer Res., December 1, 2001; 61(24): 8803 - 8810.
[Abstract] [Full Text] [PDF]

P. Oettgen
Transcriptional Regulation of Vascular Development
Circ. Res., August 31, 2001; 89(5): 380 - 388.
[Abstract] [Full Text] [PDF]

D. Polsky, A. Z. Young, K. J. Busam, and R. M. Alani
The Transcriptional Repressor of p16/Ink4a, Id1, Is Up-Regulated in Early Melanomas
Cancer Res., August 1, 2001; 61(16): 6008 - 6011.
[Abstract] [Full Text] [PDF]

R. M. Alani, A. Z. Young, and C. B. Shifflett
Id1 regulation of cellular senescence through transcriptional repression of p16/Ink4a
PNAS, June 20, 2001; (2001) 141235398.
[Abstract] [Full Text] [PDF]

B. A. Christy
A Role for an Alternatively Spliced Id3 Isoform in Vascular Lesions?
Arterioscler Thromb Vasc Biol, May 1, 2001; 21(5): 727 - 728.
[Full Text] [PDF]

E. C. Roberts, R. W. Deed, T. Inoue, J. D. Norton, and A. D. Sharrocks
Id Helix-Loop-Helix Proteins Antagonize Pax Transcription Factor Activity by Inhibiting DNA Binding
Mol. Cell. Biol., January 15, 2001; 21(2): 524 - 533.
[Abstract] [Full Text]

S. E. Bell, A. Mavila, R. Salazar, K. J. Bayless, S. Kanagala, S. A. Maxwell, and G. E. Davis
Differential gene expression during capillary morphogenesis in 3D collagen matrices: regulated expression of genes involved in basement membrane matrix assembly, cell cycle progression, cellular differentiation and G-protein signaling
J. Cell Sci., January 8, 2001; 114(15): 2755 - 2773.
[Abstract] [Full Text] [PDF]

S. P. Rockman, S. A. Currie, M. Ciavarella, E. Vincan, C. Dow, R. J. S. Thomas, and W. A. Phillips
Id2 Is a Target of the beta -Catenin/T Cell Factor Pathway in Colon Carcinoma
J. Biol. Chem., November 21, 2001; 276(48): 45113 - 45119.
[Abstract] [Full Text] [PDF]

R. M. Alani, A. Z. Young, and C. B. Shifflett
Id1 regulation of cellular senescence through transcriptional repression of p16/Ink4a
PNAS, July 3, 2001; 98(14): 7812 - 7816.
[Abstract] [Full Text] [PDF]

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				Y. Qian and X. Chen ID1, Inhibitor of Differentiation/DNA Binding, Is an Effector of the p53-dependent DNA Damage Response Pathway J. Biol. Chem., August 15, 2008; 283(33): 22410 - 22416. [Abstract] [Full Text] [PDF]

				M. Ji, H. Li, H. C. Suh, K. D. Klarmann, Y. Yokota, and J. R. Keller Id2 intrinsically regulates lymphoid and erythroid development via interaction with different target proteins Blood, August 15, 2008; 112(4): 1068 - 1077. [Abstract] [Full Text] [PDF]

				B. Eun, Y. Lee, S. Hong, J. Kim, H.-W. Lee, K. Kim, W. Sun, and H. Kim Hes6 Controls Cell Proliferation via Interaction with cAMP-response Element-binding Protein-binding Protein in the Promyelocytic Leukemia Nuclear Body J. Biol. Chem., February 29, 2008; 283(9): 5939 - 5949. [Abstract] [Full Text] [PDF]

				R. Tsunedomi, N. Iizuka, T. Tamesa, K. Sakamoto, T. Hamaguchi, H. Somura, M. Yamada, and M. Oka Decreased ID2 Promotes Metastatic Potentials of Hepatocellular Carcinoma by Altering Secretion of Vascular Endothelial Growth Factor Clin. Cancer Res., February 15, 2008; 14(4): 1025 - 1031. [Abstract] [Full Text] [PDF]

				X. Zhang, M.-T. Ling, Q. Wang, C.-K. Lau, S. C. L. Leung, T. K. Lee, A. L. M. Cheung, Y.-C. Wong, and X. Wang Identification of a Novel Inhibitor of Differentiation-1 (ID-1) Binding Partner, Caveolin-1, and Its Role in Epithelial-Mesenchymal Transition and Resistance to Apoptosis in Prostate Cancer Cells J. Biol. Chem., November 16, 2007; 282(46): 33284 - 33294. [Abstract] [Full Text] [PDF]

				S. S. Perry, Y. Zhao, L. Nie, S. W. Cochrane, Z. Huang, and X.-H. Sun Id1, but not Id3, directs long-term repopulating hematopoietic stem-cell maintenance Blood, October 1, 2007; 110(7): 2351 - 2360. [Abstract] [Full Text] [PDF]

				B. Tang, N. Yoo, M. Vu, M. Mamura, J.-S. Nam, A. Ooshima, Z. Du, P.-Y. Desprez, M. R. Anver, A. M. Michalowska, et al. Transforming Growth Factor-{beta} Can Suppress Tumorigenesis through Effects on the Putative Cancer Stem or Early Progenitor Cell and Committed Progeny in a Breast Cancer Xenograft Model Cancer Res., September 15, 2007; 67(18): 8643 - 8652. [Abstract] [Full Text] [PDF]

				R. J. Wordinger and A. F. Clark Bone Morphogenetic Proteins and Their Receptors in the Eye Experimental Biology and Medicine, September 1, 2007; 232(8): 979 - 992. [Abstract] [Full Text] [PDF]

				K. U. Birkenkamp, A. Essafi, K. E. van der Vos, M. da Costa, R. C.-Y. Hui, F. Holstege, L. Koenderman, E. W.-F. Lam, and P. J. Coffer FOXO3a Induces Differentiation of Bcr-Abl-transformed Cells through Transcriptional Down-regulation of Id1 J. Biol. Chem., January 26, 2007; 282(4): 2211 - 2220. [Abstract] [Full Text] [PDF]

				V. Jankovic, A. Ciarrocchi, P. Boccuni, T. DeBlasio, R. Benezra, and S. D. Nimer Id1 restrains myeloid commitment, maintaining the self-renewal capacity of hematopoietic stem cells PNAS, January 23, 2007; 104(4): 1260 - 1265. [Abstract] [Full Text] [PDF]

				R. Morosetti, M. Mirabella, C. Gliubizzi, A. Broccolini, L. De Angelis, E. Tagliafico, M. Sampaolesi, T. Gidaro, M. Papacci, E. Roncaglia, et al. MyoD expression restores defective myogenic differentiation of human mesoangioblasts from inclusion-body myositis muscle PNAS, November 7, 2006; 103(45): 16995 - 17000. [Abstract] [Full Text] [PDF]

				Y. Zhao, C. Johansson, T. Tran, R. Bettencourt, Y. Itahana, P.-Y. Desprez, and S. F. Konieczny Identification of a Basic Helix-Loop-Helix Transcription Factor Expressed in Mammary Gland Alveolar Cells and Required for Maintenance of the Differentiated State Mol. Endocrinol., September 1, 2006; 20(9): 2187 - 2198. [Abstract] [Full Text] [PDF]

				G. Pache, C. Schafer, S. Wiesemann, E. Springer, M. Liebau, H. C. Reinhardt, C. August, H. Pavenstadt, and M. J. Bek Upregulation of Id-1 via BMP-2 receptors induces reactive oxygen species in podocytes Am J Physiol Renal Physiol, September 1, 2006; 291(3): F654 - F662. [Abstract] [Full Text] [PDF]

				S. Peddada, D. H. Yasui, and J. M. LaSalle Inhibitors of differentiation (ID1, ID2, ID3 and ID4) genes are neuronal targets of MeCP2 that are elevated in Rett syndrome Hum. Mol. Genet., June 15, 2006; 15(12): 2003 - 2014. [Abstract] [Full Text] [PDF]

				H. Hua, Y.-Q. Zhang, S. Dabernat, M. Kritzik, D. Dietz, L. Sterling, and N. Sarvetnick BMP4 Regulates Pancreatic Progenitor Cell Expansion through Id2 J. Biol. Chem., May 12, 2006; 281(19): 13574 - 13580. [Abstract] [Full Text] [PDF]

				L. M. Gronning, R. Tingsabadh, K. Hardy, K. T. Dalen, P. S. Jat, L. Gnudi, and P. R. Shepherd Glucose induces increases in levels of the transcriptional repressor Id2 via the hexosamine pathway Am J Physiol Endocrinol Metab, April 1, 2006; 290(4): E599 - E606. [Abstract] [Full Text] [PDF]

				J. Lee, K. Kim, J. H. Kim, H. M. Jin, H. K. Choi, S.-H. Lee, H. Kook, K. K. Kim, Y. Yokota, S. Y. Lee, et al. Id helix-loop-helix proteins negatively regulate TRANCE-mediated osteoclast differentiation Blood, April 1, 2006; 107(7): 2686 - 2693. [Abstract] [Full Text] [PDF]

				A. Lasorella and A. Iavarone The protein ENH is a cytoplasmic sequestration factor for Id2 in normal and tumor cells from the nervous system PNAS, March 28, 2006; 103(13): 4976 - 4981. [Abstract] [Full Text] [PDF]

				P. M. Siu, E. E. Pistilli, Z. Murlasits, and S. E. Alway Hindlimb unloading increases muscle content of cytosolic but not nuclear Id2 and p53 proteins in young adult and aged rats J Appl Physiol, March 1, 2006; 100(3): 907 - 916. [Abstract] [Full Text] [PDF]