Expression-site-associated gene 8 (ESAG8) of Trypanosoma brucei is apparently essential and accumulates in the nucleolus

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Aarts, M. M., Rix, A., Guo, J., Bringhurst, R. and Henderson,J. E (1999). The nucleolar targeting signal (NTS) of parathyroid hormone related protein mediates endocytosis and nucleolar translocation. J. Bone Miner. Res 14, 1493-1503.[Medline]

Allis, C. D., Ziegler, Y. S., Gorovsky, M. A. and Olmsted,J. B (1982). A conserved histone variant enriched in nucleoli of mammalian cells. Cell 31, 131-136.[Medline]

Annilo, T., Karis, A., Hoth, S., Rikk, T., Kruppa, J. and Metspalu,A (1998). Nuclear import and nucleolar accumulation of the human ribosomal protein S7 depends on both a minimal nuclear localization sequence and an adjacent basic region. Biochem. Biophys. Res. Commun 249, 759-766.[Medline]

Ansorge, I., Steverding, D., Melville, S., Hartmann, C. and Clayton,C (1999). Transcription of \324inactive' expression sites in African trypanosomes leads to expression of multiple transferrin receptor RNAs in bloodstream forms. Mol. Biochem. Parasitol 101, 81-94.[Medline]

Berberof, M., Vanhamme, L., Alexandre, S., Lips, S., Tebabi, P. and Pays, E (2000). A single-stranded DNA-binding protein shared by telomeric repeats, the variant surface glycoprotein transcription promoter and the procyclin transcription terminator of Trypanosoma brucei. Nucl. Acids Res 28, 597-604.[Abstract/Free Full Text]

Bhatnagar, Y. M., McCullar, M. K. and Chronister,R. B (1984). Immunocytochemical localization of a histone H2A variant in the mammalian nucleolar chromatin. Cell. Biol. Int. Rep 8, 971-979.[Medline]

Borden, K. L (2000). RING Domains: Master Builders of Molecular Scaffolds?. J. Mol. Biol 295, 1103-1112.[Medline]

Borst, P., Bitter, W., Blundell, P. A., Chaves, I., Cross, M., Gerrits, H., van Leeuwen, F., McCulloch, R., Taylor, M. and Rudenko,G (1998). Control of VSG gene expression sites in Trypanosoma brucei. Mol. Biochem. Parasitol 91, 67-76.[Medline]

Borst, P. and Chaves,I (1999). Mono-allelic expression of genes in simple eukaryotes. Trends Genet 15, 95-96.

Carruthers, V. B., Navarro, M. and Cross,G. A. M (1996). Targeted disruption of expression-site-associated gene-1 in bloodstream-form Trypanosoma brucei. Mol. Biochem. Parasitol 81, 65-79.[Medline]

Carruthers, V. B., van der Ploeg, L. H. T. and Cross,G. A. M (1993). DNA-mediated transformation of bloodstream-form Trypanosoma brucei. Nucl. Acids Res 21, 2537-2538.[Free Full Text]

Chaves, I., Rudenko, G., Dirks-Mulder, A., Cross M., and Borst,P (1999). Control of variant surface glycoprotein gene-expression sites in Trypanosoma brucei. EMBO J 18, 4846-4855.[Medline]

Chaves, I., Zomerdijk, J., Dirks-Mulder, A., Dirks, R. W., Raap, A. K. and Borst,P (1998). Subnuclear localization of the active variant surface glycoprotein gene expression site in Trypanosoma brucei. Proc. Natl. Acad. Sci. USA 95, 12328-12333.[Abstract/Free Full Text]

Cross, G. A. M (1996). Antigenic variation in trypanosomes: secrets surface slowly. BioEssays 18, 283-291.[Medline]

Cross, G. A. M., Wirtz, L. E. and Navarro,M (1998). Regulation of vsg expression site transcription and switching in Trypanosoma brucei. Mol. Biochem. Parasitol 91, 77-91.[Medline]

Cross, M., Kieft, R., Sabatini, R., Wilm, M., de Kort, M., van der Marel, G. A., van Boom, J. H., van Leeuwen, F. and Borst,P (1999). The modified base J is the target for a novel DNA-binding protein in kinetoplastid protozoans. EMBO J 18, 6573-6581.[Medline]

Das, A., Park, J. H., Hagen, C. B. and Parsons,M (1998). Distinct domains of a nucleolar protein mediate protein kinase binding, interaction with nucleic acids and nucleolar localization. J. Cell Sci 111, 2615-2623.[Abstract]

Davies, K. P., Carruthers, V. B. and Cross,G. A. M (1997). Manipulation of the vsg co-transposed region increases expression-site switching in Trypanosoma brucei. Mol. Biochem. Parasitol 86, 163-177.[Medline]

Ersfeld, K. and Gull,K (1997). Partitioning of large and minichromosomes in Trypanosoma brucei. Science 276, 611-614.[Abstract/Free Full Text]

Gommers-Ampt, J. H., van Leeuwen, F., de Beer, A. L. J., Vliegenthart, J. F. G., Dizdaroglu, M., Kowalak, J. A., Crain, P. F. and Borst,P (1993). -D-glucosyl-hydroxymethyluracil: a novel modified base present in the DNA of the parasitic protozoan T. brucei. Cell 75, 1129-1136.[Medline]

Haas, J., Park, E. C. and Seed,B (1996). Codon usage limitation in the expression of HIV-1 envelope glycoprotein. Curr. Biol 6, 315-324.[Medline]

Hirumi, H. and Hirumi,K (1989). Continuous cultivation of Trypanosoma brucei bloodstream forms in a medium containing a low concentration of serum protein without feeder cell layers. J. Parasitol 75, 985-989.[Medline]

Hofer, L., Weichselbraun, I., Quick, S., Farrington, G. K., Bohnlein, E.and Hauber,J (1991). Mutational analysis of the human T-cell leukemia virus type I trans-acting rex gene product. J. Virol 65, 3379-3383.[Abstract/Free Full Text]

Horn, D. and Cross,G. A. M (1995). A developmentally regulated position effect at a telomeric locus in Trypanosoma brucei. Cell 83, 555-561.[Medline]

Horn, D. and Cross,G. A. M (1997). Analysis of Trypanosoma bruceivsg expression site switching in vitro. Mol. Biochem. Parasitol 84, 189-201.[Medline]

Kobe, B. and Deisenhofer,J (1994). The leucine-rich repeat: a versatile binding motif. Trends Biochem. Sci 19, 415-421.[Medline]

Kohler, S (1999). Trypanosoma brucei : improved detection of nuclear transcripts reveals a genomic position effect on nuclearly accumulating NEO RNAs visualized in stably transformed cells. Exp. Parasitol 92, 249-262.[Medline]

Kubota, S., Copeland, T. D. and Pomerantz,R. J (1999). Nuclear and nucleolar targeting of human ribosomal protein S25: common features shared with HIV-1 regulatory proteins. Oncogene 18, 1503-1514.[Medline]

Kubota, S., Siomi, H., Satoh, T., Endo, S., Maki, M. and Hatanaka,M (1989). Functional similarity of HIV-I rev and HTLV-I rex proteins: identification of a new nucleolar-targeting signal in rev protein. Biochem. Biophys. Res. Commun 162, 963-970.[Medline]

Lamont, G. S., Tucker, R. S. and Cross,G. A. M (1986). Analysis of antigen switching rates in Trypanosoma brucei. Parasitology 92, 355-367.

Lee, M. G. S. and van der Ploeg,L. H. T (1997). Transcription of protein-coding genes in trypanosomes by RNA Polymerase I. Annu. Rev. Microbiol 51, 463-489.[Medline]

Lips, S., Geuskens, M., Paturiaux-Hanocq, F., Hanocq-Quertier, J. and Pays,E (1996). The esag 8 gene of Trypanosoma brucei encodes a nuclear protein. Mol. Biochem. Parasitol 79, 113-117.[Medline]

Lips, S., Revelard, P. and Pays,E (1993). Identification of a new expression site-associated gene in the complete 30.5 kb sequence from the AnTat 1.3A variant surface protein gene expression site of Trypanosoma brucei. Mol. Biochem. Parasitol 62, 135-138.[Medline]

Marchetti, M. A., Tschudi, C., Kwon, H, Wolin, S. L. and Ullu,E (2000). Import of proteins into the trypanosome nucleus and their distribution at karyokinesis. J. Cell Sci 113, 899-906.[Abstract]

Navarro, M. and Cross,G. A. M (1998). In situ analysis of a variant surface glycoprotein expression-site promoter region in Trypanosoma brucei. Mol. Biochem. Parasitol 94, 53-66.[Medline]

Navarro, M., Cross, G. A. M. and Wirtz,E (1999). Trypanosoma brucei variant surface glycoprotein regulation involves coupled activation/ inactivation and chromatin remodeling of expression sites. EMBO J 18, 2265-2272.[Medline]

Pederson, T (1998). The plurifunctional nucleolus. Nucl. Acids Res 26, 3871-6.[Abstract/Free Full Text]

Perez-Morga, D. and Pays,E (1999). A protein linked to mitochondrion development in Trypanosoma brucei. Mol. Biochem. Parasitol 101, 161-172.[Medline]

Pham, V. P., Qi, C. C. and Gottesdiener,K. M (1996). A detailed mutational analysis of the VSG gene expression site promoter. Mol. Biochem. Parasitol 75, 241-254.[Medline]

Pham, V. P., Rothman, P. B. and Gottesdiener,K. M (1997). Binding of trans -acting factors to the double-stranded variant surface glycoprotein (VSG) expression site promoter of Trypanosoma brucei. Mol. Biochem. Parasitol 89, 11-23.[Medline]

Qi, C. C., Urmenyi, T. and Gottesdiener,K. M (1996). Analysis of a hybrid PARP/VSG ES promoter in procyclic trypanosomes. Mol. Biochem. Parasitol 77, 147-159.[Medline]

Revelard, P., Lips, S. and Pays,E (1990). A gene from the VSG expression site of Trypanosoma brucei encodes a protein with both leucine-rich repeats and a putative zinc finger. Nucl. Acids Res 18, 7299-7303.[Abstract/Free Full Text]

Robbins, J., Dilworth, S. M., Laskey, R. A. and Dingwall,C (1991). Two interdependent basic domains in nucleoplasmin nuclear targeting sequence: identification of a class of bipartite nuclear targeting sequence. Cell 64, 615-623.[Medline]

Robinson, N. P., Burman, N., Melville, S. E. and Barry,J. D (1999). Predominance of duplicative VSG gene conversion in antigenic variation in African trypanosomes. Mol. Cell. Biol 19, 5839-5846.[Abstract/Free Full Text]

Rosorius, O., Fries, B., Stauber, R. H., Hirschmann, N., Bevec, D. and Hauber,J (2000). Human ribosomal protein L5 contains defined nuclear localization and export signals. J. Biol. Chem 275, 12061-12068.[Abstract/Free Full Text]

Rudenko, G., Blundell, P. A., Dirks-Mulder, A., Kieft, R. and Borst,P (1995). A ribosomal DNA promoter replacing the promoter of a telomeric VSG gene expression site can be efficiently switched on and off in T. brucei. Cell 83, 547-553.[Medline]

Rudenko, G., Chung, H.-M. M., Pham, V. P. and van der Ploeg,L. H. T (1991). RNA polymerase I can mediate expression of CAT and neo protein-coding genes in Trypanosoma brucei. EMBO J 10, 3387-3397.[Medline]

Rudenko, G., Cross, M. and Borst,P (1998). Changing the end: antigenic variation orchestrated at the telomeres of African trypanosomes. Trends Microbiol 6, 113-116.[Medline]

Scheer, U. and Hock,R (1999). Structure and function of the nucleolus. Curr. Opin. Cell Biol 11, 385-390.[Medline]

Schmidt-Zachmann, M. S. and Nigg,E. A (1993). Protein localization to the nucleolus: a search for targeting domains in nucleolin. J. Cell Sci 105, 799-806.[Abstract]

Schneiter, R., Kadowaki, T. and Tartakoff,A. M (1995). mRNA transport in yeast: time to reinvestigate the functions of the nucleus. Mol. Biol. Cell 6, 357-370.[Abstract]

Shou, W. Y., Seol, J. H., Shevchenko, A., Baskerville, C., Moazed, D., Chen, Z. W. S., Jang, J., Charbonneau, H. and Deshaies,R. J (1999). Exit from mitosis is triggered by Tem1-dependent release of the protein phosphatase Cdc14 from nucleolar RENT complex. Cell 97, 233-244.[Medline]

Stauber, R. H. and Pavlakis,G. N (1998). Intracellular trafficking and interactions of the HIV-1 Tat protein. Virology 252, 126-136.[Medline]

Straight, A. F., Shou, W. Y., Dowd, G. J., Turck, C. W., Deshaies, R. J., Johnson, A. D. and Moazed,D (1999). Net1, a Sir2-associated nucleolar protein required for rDNA silencing and nucleolar integrity. Cell 97, 245-256.[Medline]

Tanaka, I., Akahori, Y., Gomi, K., Suzuki, T. and Ueda,K (1999). A novel histone variant localized in nucleoli of higher plant cells. Chromosoma 108, 190-199.[Medline]

Ueki, N., Kondo, M., Seki, N., Yano, K., Oda, T., Masuho, Y. and Muramatsu,M (1998). NOLP: identification of a novel human nucleolarprotein and determination of sequence requirements for its nucleolar localization. Biochem. Biophys. Res. Commun 252, 97-102.[Medline]

van Leeuwen, F., Dirks-Mulder, A., Dirks, R. W., Borst, P. and Gibson,W (1998). The modified DNA base-D-glucosyl-hydroxymethyluracil is not found in the tsetse fly stages of Trypanosoma brucei. Mol. Biochem. Parasitol 94, 127-130.[Medline]

van Leeuwen, F., Wijsman, E. R., Kieft, R., van der Marel, G. A., van Boom, J. H. and Borst,P (1997). Localization of the modified base J in telomeric VSG gene expression sites of Trypanosoma brucei. Genes Dev 11, 3232-3241.[Abstract/Free Full Text]

van Xong, H., Vanhamme, L., Chamekh, M., Chimfwembe, C. E., van den Abbeele, J., Pays, A., van Meirvenne, N. Hamers, R., de Baetselier, P. and Pays,E (1998). A VSG expression-site-associated gene confers resistance to human serum in Trypanosoma rhodesiense. Cell 95, 839-846.[Medline]

Vanhamme, L., Pays, A., Tebabi, P., Alexandre, S. and Pays, E (1995). Specific binding of proteins to the noncoding strand of a crucial element of the variant surface glycoprotein, procyclin, and ribosomal promoters of Trypanosoma brucei. Mol. Cell. Biol 15, 5598-5606.[Abstract]

Vanhamme, L. and Pays,E (1998). Controls of the expression of the Vsg in Trypanosoma brucei. Mol. Biochem. Parasitol 91, 107-116.[Medline]

Vanhamme, L., Postiaux, S., Poelvoorde, P. and Pays,E (1999). Differential regulation of ESAG transcripts in Trypanosoma brucei. Mol. Biochem. Parasitol 102, 35-42.[Medline]

Wirtz, E., Hoek, M. and Cross,G. A. M (1998). Regulated processive transcription of chromatin by T7 RNA polymerase in Trypanosoma brucei. Nucl. Acids Res 26, 4626-4634.[Abstract/Free Full Text]

Zhang, B., Gallegos, M., Puoti, A., Durkin, E., Fields, S., Kimble, J. and Wickens,M. P (1997). A conserved RNA-binding protein that regulates sexual fates in the C. elegans hermaphrodite germ line. Nature 390, 477-484.[Medline]

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				N. Boucher, D. Dacheux, C. Giroud, and T. Baltz An Essential Cell Cycle-regulated Nucleolar Protein Relocates to the Mitotic Spindle Where It Is Involved in Mitotic Progression in Trypanosoma brucei J. Biol. Chem., May 4, 2007; 282(18): 13780 - 13790. [Abstract] [Full Text] [PDF]