Immunoelectron microscopic evidence that GLUT4 translocation explains the stimulation of glucose transport in isolated rat white adipose cells

QUICK SEARCH:

[advanced]

	Author:		Keyword(s):

Home Help Feedback Subscriptions Archive Search Table of Contents

This Article

	Summary
	Full Text (PDF)
	Alert me when this article is cited
	Alert me if a correction is posted

Services

	Email this article to a friend
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new issues of the journal
	Download to citation manager


Citing Articles

	Citing Articles via HighWire
	Citing Articles via Google Scholar

Google Scholar

	Articles by Malide, D.
	Articles by Slot, J. W.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Malide, D.
	Articles by Slot, J. W.


Social Bookmarking

	What's this?

Birnbaum, M. J (1992). The insulin-sensitive glucose transporter. Int. Rev. Cytol 137, 239-297.[Medline]

Calderhead, D. M., Kitagawa, K., Tanner, L. I., Holman, G. D. and Lienhard, G. E (1990). Insulin regulation of the two glucose transporters in 3T3-L1 adipocytes. J. Biol. Chem 265, 13801-13808.

El-Jack, A. K., Kandror, K. V. and Pilch, P. F (1999). The formation of an insulin-responsive vesicular cargo compartment is an early event in 3T3-L1 adipocyte differentiation. Mol. Biol. Cell 10, 1581-1594.[Abstract/Free Full Text]

Haney, P. M., Slot, J. W., Piper, R. C., James, D. E. and Mueckler, M (1991). Intracellular targeting of the insulin-regulatable glucose transporter (GLUT4) is isoform specific and independent of cell type. J.Cell Biol 114, 689-699.[Abstract/Free Full Text]

Herman, G. A., Bonzelius, F., Cieutat, A. M. and Kelly, R. B (1994). A distinct class of intracellular storage vesicles, identified by expression of the glucose transporter GLUT4. Proc. Natl. Acad. Sci. USA 91, 12750-12754.[Abstract/Free Full Text]

Holman, G. D., Kozka, I. J., Clark, A. E., Flower, C. J., Saltis, J., Habberfield, A. D., Simpson, I. A. and Cushman, S. W (1990). Cell-surface labeling of glucose transporter isoform GLUT4 by bis-mannose photolabel-correlation with stimulation of glucose transport in rat adipose cells by insulin and phorbol ester. J. Biol. Chem 265, 18172-18179.[Abstract/Free Full Text]

Holman, G. D. and Cushman, S. W (1994). Subcellular localization and trafficking of the GLUT4 glucose transporter isoform in insulin-responsive cells. BioEssays 16, 753-759.[Medline]

Holman, G. D., Leggio, L. L. and Cushman, S. W (1994). Insulin-stimulated GLUT4 glucose transporter recycling \320 a problem in membrane-protein subcellular trafficking through multiple pools. J. Biol. Chem 269, 17516-17524.[Abstract/Free Full Text]

Hudson, A. W., Ruiz, M. and Birnbaum, M. J (1992). Isoform-specific subcellular targeting of glucose transporters in mouse fibroblasts. J. Cell Biol 116, 785-797.[Abstract/Free Full Text]

Hudson, A. W., Fingar, D. C., Seidner, G. A., Griffiths, G., Burke, B. and Birnbaum, M. J (1993). Targeting of the \324insulin-responsive' glucose transporter (GLUT4) to the regulated secretory pathway in PC12 cells. J. Cell Biol 122, 579-588.[Abstract/Free Full Text]

Karnieli, E., Zarnowski, M. J., Hissin, P. J., Simpson, I. A., Salans, L. B. and Cushman, S. W (1981). Insulin-stimulated translocation of glucose transport systems in the isolated rat adipose cell. Time course, reversal, insulin concentration dependency, and relationship to glucose transport activity. J. Biol. Chem 256, 4772-4777.[Free Full Text]

Liou, W., Geuze, H. J. and Slot, J. W (1996). Improving structural integrity of cryosections for immunogold labeling. Histochem. Cell Biol 106, 41-58.[Medline]

Malide, D., Dwyer, N. K., Blanchette-Mackie, E. J. and Cushman, S. W (1997). Immunocytochemical evidence that GLUT4 resides in a specialized translocation post-endosomal VAMP2-positive compartment in rat adipose cells in the absence of insulin. J. Histochem. Cytochem 45, 1083-1096.[Abstract/Free Full Text]

Omatsu-Kanbe, M., Zarnowski, M. J. and Cushman, S. W (1996). Hormonal regulation of glucose transport in a brown adipose cell preparation isolated from rats that shows a large response to insulin. Biochem. J 315, 25-31.

Ploug, T., van Deurs, B., Ai, H., Cushman, S. W. and Ralston, E (1998). Analysis of GLUT4 distribution in whole skeletal muscle fibers: identification of distinct storage compartments that are recruited by insulin and muscle contractions. J. Cell Biol 142, 1429-1446.[Abstract/Free Full Text]

Rodnick, K. J., Slot, J. W., Studelska, D. R., Hanpeter, D. E., Robinson, L. J., Geuze, H. J. and James, D. E (1992). Immunocytochemical and biochemical studies of GLUT4 in rat skeletal muscle. J. Biol. Chem 267, 6278-6285.[Abstract/Free Full Text]

Satoh, S., Nishimura, H., Clark, A. E., Kozka, I. J., Vannucci, S. J., Simpson, I. A., Quon, M. J., Cushman, S. W. and Holman, G. D (1993). Use of bismannose photolabel to elucidate insulin-regulated GLUT4 subcellular trafficking kinetics in rat adipose cells \320 evidence that exocytosis is a critical site for hormone action. J. Biol.Chem 268, 17820-17829.[Abstract/Free Full Text]

Simpson, I. A., Yver, D. R., Hissin, P. J., Wardzala, L. J., Karnieli, E., Salans, L. B. and Cushman, S. W (1983). Insulin-stimulated translocation of glucose transporters in the isolated rat adipose cells: characterization of subcellular fractions. Biochim. Biophys. Acta 763, 393-407.[Medline]

Slot, J. W., Garruti, G., Martin, S., Oorschot, V., Posthuma, G., Kraegen, E. W., Laybutt, R., Thibault, G. and James, D. E (1997). Glucose transporter (GLUT-4) is targeted to secretory granules in rat atrial cardiomyocytes. J. Cell Biol 137, 1243-1254.[Abstract/Free Full Text]

Slot, J. W. and Geuze, H. J (1985). A new method of preparing gold probes for multiple-labeling cytochemistry. Eur. J. Cell Biol 38, 87-93.[Medline]

Slot, J. W., Geuze, H. J., Gigengack, S., Lienhard, G. E. and James, D. E (1991). Immuno-localization of the insulin regulatable glucose transporter in brown adipose tissue of the rat. J.Cell Biol 113, 123-135.[Abstract/Free Full Text]

Slot, J. W., Geuze, H. J., Gigengack, S., James, D. E. and Lienhard, G. E (1991). Translocation of the glucose transporter GLUT4 in cardiac myocytes of the rat. Proc. Natl. Acad. Sci. USA 88, 7815-7819.[Abstract/Free Full Text]

Slot, J. W., Moxley, R., Geuze, H. J. and James, D. E (1990). No evidence for expression of the insulin-regulatable glucose transporter in endothelial cells. Nature 346, 369-371.[Medline]

Smith, R. M., Charron, M. J., Shah, N., Lodish, H. F. and Jarett, L (1991). Immunoelectron microscopic demonstration of insulin-stimulated translocation of glucose transporters to the plasma membrane of isolated rat adipocytes and masking of the carboxyl-terminal epitope of intracellular GLUT4. Proc. Natl. Acad. Sci. USA 88, 6893-6897.[Abstract/Free Full Text]

Stephens, J. M. and Pilch, P. F (1995). The metabolic regulation and vesicular transport of GLUT4, the major insulin-responsive glucose transporter. Endocr. Rev 16, 529-546.[Abstract/Free Full Text]

Thorens, B. and Roth, J (1996). Intracellular targeting of GLUT4 in transfected insulinoma cells: evidence for association with constitutively recycling vesicles distinct from synaptophysin and insulin vesicles. J. Cell Sci 109, 1311-1323.[Abstract]

Wang, W., Hansen, P. A., Marshall, B. A., Holloszy, J. O. and Mueckler, M (1996). Insulin unmasks a COOH-terminal Glut4 epitope and increases glucose transport across T-tubules in skeletal muscle. J. Cell Biol 135, 415-430.[Abstract/Free Full Text]

CiteULike

Complore

Connotea

Del.icio.us Add to Digg

Digg

Technorati

Twitter What's this?

This article has been cited by other articles:

B. Scazzocchio, R. Vari, M. D'Archivio, C. Santangelo, C. Filesi, C. Giovannini, and R. Masella
Oxidized LDL impair adipocyte response to insulin by activating serine/threonine kinases
J. Lipid Res., May 1, 2009; 50(5): 832 - 845.
[Abstract] [Full Text] [PDF]

X. M. Song, R. C. Hresko, and M. Mueckler
Identification of Amino Acid Residues within the C Terminus of the Glut4 Glucose Transporter That Are Essential for Insulin-stimulated Redistribution to the Plasma Membrane
J. Biol. Chem., May 2, 2008; 283(18): 12571 - 12585.
[Abstract] [Full Text] [PDF]

M. Larance, G. Ramm, and D. E. James
The GLUT4 Code
Mol. Endocrinol., February 1, 2008; 22(2): 226 - 233.
[Abstract] [Full Text] [PDF]

Y. Bao, J. A. Lopez, D. E. James, and W. Hunziker
Snapin Interacts with the Exo70 Subunit of the Exocyst and Modulates GLUT4 Trafficking
J. Biol. Chem., January 4, 2008; 283(1): 324 - 331.
[Abstract] [Full Text] [PDF]

P. F. Pilch, R. P. Souto, L. Liu, M. P. Jedrychowski, E. A. Berg, C. E. Costello, and S. P. Gygi
Cellular spelunking: exploring adipocyte caveolae
J. Lipid Res., October 1, 2007; 48(10): 2103 - 2111.
[Abstract] [Full Text] [PDF]

J. Ye, Z. Gao, J. Yin, and Q. He
Hypoxia is a potential risk factor for chronic inflammation and adiponectin reduction in adipose tissue of ob/ob and dietary obese mice
Am J Physiol Endocrinol Metab, October 1, 2007; 293(4): E1118 - E1128.
[Abstract] [Full Text] [PDF]

L.-B. Liu, W. Omata, I. Kojima, and H. Shibata
The SUMO Conjugating Enzyme Ubc9 is a Regulator of GLUT4 Turnover and Targeting to the Insulin-Responsive Storage Compartment in 3T3-L1 Adipocytes
Diabetes, August 1, 2007; 56(8): 1977 - 1985.
[Abstract] [Full Text] [PDF]

J. Shi and K. V. Kandror
The Luminal Vps10p Domain of Sortilin Plays the Predominant Role in Targeting to Insulin-responsive Glut4-containing Vesicles
J. Biol. Chem., March 23, 2007; 282(12): 9008 - 9016.
[Abstract] [Full Text] [PDF]

M. Larance, G. Ramm, J. Stockli, E. M. van Dam, S. Winata, V. Wasinger, F. Simpson, M. Graham, J. R. Junutula, M. Guilhaus, et al.
Characterization of the Role of the Rab GTPase-activating Protein AS160 in Insulin-regulated GLUT4 Trafficking
J. Biol. Chem., November 11, 2005; 280(45): 37803 - 37813.
[Abstract] [Full Text] [PDF]

M. Ishiki, V. K. Randhawa, V. Poon, L. JeBailey, and A. Klip
Insulin Regulates the Membrane Arrival, Fusion, and C-terminal Unmasking of Glucose Transporter-4 via Distinct Phosphoinositides
J. Biol. Chem., August 5, 2005; 280(31): 28792 - 28802.
[Abstract] [Full Text] [PDF]

L. V. Li and K. V. Kandror
Golgi-Localized, {gamma}-Ear-Containing, Arf-Binding Protein Adaptors Mediate Insulin-Responsive Trafficking of Glucose Transporter 4 in 3T3-L1 Adipocytes
Mol. Endocrinol., August 1, 2005; 19(8): 2145 - 2153.
[Abstract] [Full Text] [PDF]

V. A. Lizunov, H. Matsumoto, J. Zimmerberg, S. W. Cushman, and V. A. Frolov
Insulin stimulates the halting, tethering, and fusion of mobile GLUT4 vesicles in rat adipose cells
J. Cell Biol., May 9, 2005; 169(3): 481 - 489.
[Abstract] [Full Text] [PDF]

M. Malikova, J. Shi, and K. V. Kandror
V-type ATPase is involved in biogenesis of GLUT4 vesicles
Am J Physiol Endocrinol Metab, September 1, 2004; 287(3): E547 - E552.
[Abstract] [Full Text] [PDF]

R. T. Watson, M. Kanzaki, and J. E. Pessin
Regulated Membrane Trafficking of the Insulin-Responsive Glucose Transporter 4 in Adipocytes
Endocr. Rev., April 1, 2004; 25(2): 177 - 204.
[Abstract] [Full Text] [PDF]

A. W. Cohen, T. P. Combs, P. E. Scherer, and M. P. Lisanti
Role of caveolin and caveolae in insulin signaling and diabetes
Am J Physiol Endocrinol Metab, December 1, 2003; 285(6): E1151 - E1160.
[Abstract] [Full Text] [PDF]

H. Ruan, M. J. Zarnowski, S. W. Cushman, and H. F. Lodish
Standard Isolation of Primary Adipose Cells from Mouse Epididymal Fat Pads Induces Inflammatory Mediators and Down-regulates Adipocyte Genes
J. Biol. Chem., November 28, 2003; 278(48): 47585 - 47593.
[Abstract] [Full Text] [PDF]

L.-B. Liu, W. Omata, I. Kojima, and H. Shibata
Insulin Recruits GLUT4 from Distinct Compartments via Distinct Traffic Pathways with Differential Microtubule Dependence in Rat Adipocytes
J. Biol. Chem., August 8, 2003; 278(32): 30157 - 30169.
[Abstract] [Full Text] [PDF]

C. A. Bertrand and R. A. Frizzell
The role of regulated CFTR trafficking in epithelial secretion
Am J Physiol Cell Physiol, July 1, 2003; 285(1): C1 - C18.
[Abstract] [Full Text] [PDF]

R. P. Souto, G. Vallega, J. Wharton, J. Vinten, J. Tranum-Jensen, and P. F. Pilch
Immunopurification and Characterization of Rat Adipocyte Caveolae Suggest Their Dissociation from Insulin Signaling
J. Biol. Chem., May 9, 2003; 278(20): 18321 - 18329.
[Abstract] [Full Text] [PDF]

R. Somwar, S. Koterski, G. Sweeney, R. Sciotti, S. Djuric, C. Berg, J. Trevillyan, P. E. Scherer, C. M. Rondinone, and A. Klip
A Dominant-negative p38 MAPK Mutant and Novel Selective Inhibitors of p38 MAPK Reduce Insulin-stimulated Glucose Uptake in 3T3-L1 Adipocytes without Affecting GLUT4 Translocation
J. Biol. Chem., December 20, 2002; 277(52): 50386 - 50395.
[Abstract] [Full Text] [PDF]

Z. Xu and K. V. Kandror
Translocation of Small Preformed Vesicles Is Responsible for the Insulin Activation of Glucose Transport in Adipose Cells. EVIDENCE FROM THE IN VITRO RECONSTITUTION ASSAY
J. Biol. Chem., December 6, 2002; 277(50): 47972 - 47975.
[Abstract] [Full Text] [PDF]

J. Yang, A. K. Gillingham, A. Hodel, F. Koumanov, B. Woodward, and G. D. Holman
Insulin-stimulated cytosol alkalinization facilitates optimal activation of glucose transport in cardiomyocytes
Am J Physiol Endocrinol Metab, December 1, 2002; 283(6): E1299 - E1307.
[Abstract] [Full Text] [PDF]

T. A. Kupriyanova, V. Kandror, and K. V. Kandror
Isolation and Characterization of the Two Major Intracellular Glut4 Storage Compartments
J. Biol. Chem., March 8, 2002; 277(11): 9133 - 9138.
[Abstract] [Full Text] [PDF]

P. E. Bickel
Lipid rafts and insulin signaling
Am J Physiol Endocrinol Metab, January 1, 2002; 282(1): E1 - E10.
[Abstract] [Full Text] [PDF]

R. Somwar, W. Niu, D. Y. Kim, G. Sweeney, V. K. Randhawa, C. Huang, T. Ramlal, and A. Klip
Differential Effects of Phosphatidylinositol 3-Kinase Inhibition on Intracellular Signals Regulating GLUT4 Translocation and Glucose Transport
J. Biol. Chem., November 30, 2001; 276(49): 46079 - 46087.
[Abstract] [Full Text] [PDF]

This Article

Summary

Full Text (PDF)

Alert me when this article is cited

Alert me if a correction is posted

Services

Email this article to a friend

Similar articles in this journal

Similar articles in PubMed

Alert me to new issues of the journal

Download to citation manager

Citing Articles

Citing Articles via HighWire

Citing Articles via Google Scholar

Google Scholar

Articles by Malide, D.

Articles by Slot, J. W.

Search for Related Content

PubMed

PubMed Citation

Articles by Malide, D.

Articles by Slot, J. W.

Social Bookmarking

What's this?

				X. M. Song, R. C. Hresko, and M. Mueckler Identification of Amino Acid Residues within the C Terminus of the Glut4 Glucose Transporter That Are Essential for Insulin-stimulated Redistribution to the Plasma Membrane J. Biol. Chem., May 2, 2008; 283(18): 12571 - 12585. [Abstract] [Full Text] [PDF]

				M. Larance, G. Ramm, and D. E. James The GLUT4 Code Mol. Endocrinol., February 1, 2008; 22(2): 226 - 233. [Abstract] [Full Text] [PDF]

				Y. Bao, J. A. Lopez, D. E. James, and W. Hunziker Snapin Interacts with the Exo70 Subunit of the Exocyst and Modulates GLUT4 Trafficking J. Biol. Chem., January 4, 2008; 283(1): 324 - 331. [Abstract] [Full Text] [PDF]

				P. F. Pilch, R. P. Souto, L. Liu, M. P. Jedrychowski, E. A. Berg, C. E. Costello, and S. P. Gygi Cellular spelunking: exploring adipocyte caveolae J. Lipid Res., October 1, 2007; 48(10): 2103 - 2111. [Abstract] [Full Text] [PDF]

				J. Ye, Z. Gao, J. Yin, and Q. He Hypoxia is a potential risk factor for chronic inflammation and adiponectin reduction in adipose tissue of ob/ob and dietary obese mice Am J Physiol Endocrinol Metab, October 1, 2007; 293(4): E1118 - E1128. [Abstract] [Full Text] [PDF]

				L.-B. Liu, W. Omata, I. Kojima, and H. Shibata The SUMO Conjugating Enzyme Ubc9 is a Regulator of GLUT4 Turnover and Targeting to the Insulin-Responsive Storage Compartment in 3T3-L1 Adipocytes Diabetes, August 1, 2007; 56(8): 1977 - 1985. [Abstract] [Full Text] [PDF]

				J. Shi and K. V. Kandror The Luminal Vps10p Domain of Sortilin Plays the Predominant Role in Targeting to Insulin-responsive Glut4-containing Vesicles J. Biol. Chem., March 23, 2007; 282(12): 9008 - 9016. [Abstract] [Full Text] [PDF]

				M. Larance, G. Ramm, J. Stockli, E. M. van Dam, S. Winata, V. Wasinger, F. Simpson, M. Graham, J. R. Junutula, M. Guilhaus, et al. Characterization of the Role of the Rab GTPase-activating Protein AS160 in Insulin-regulated GLUT4 Trafficking J. Biol. Chem., November 11, 2005; 280(45): 37803 - 37813. [Abstract] [Full Text] [PDF]

				M. Ishiki, V. K. Randhawa, V. Poon, L. JeBailey, and A. Klip Insulin Regulates the Membrane Arrival, Fusion, and C-terminal Unmasking of Glucose Transporter-4 via Distinct Phosphoinositides J. Biol. Chem., August 5, 2005; 280(31): 28792 - 28802. [Abstract] [Full Text] [PDF]

				L. V. Li and K. V. Kandror Golgi-Localized, {gamma}-Ear-Containing, Arf-Binding Protein Adaptors Mediate Insulin-Responsive Trafficking of Glucose Transporter 4 in 3T3-L1 Adipocytes Mol. Endocrinol., August 1, 2005; 19(8): 2145 - 2153. [Abstract] [Full Text] [PDF]

				V. A. Lizunov, H. Matsumoto, J. Zimmerberg, S. W. Cushman, and V. A. Frolov Insulin stimulates the halting, tethering, and fusion of mobile GLUT4 vesicles in rat adipose cells J. Cell Biol., May 9, 2005; 169(3): 481 - 489. [Abstract] [Full Text] [PDF]

				M. Malikova, J. Shi, and K. V. Kandror V-type ATPase is involved in biogenesis of GLUT4 vesicles Am J Physiol Endocrinol Metab, September 1, 2004; 287(3): E547 - E552. [Abstract] [Full Text] [PDF]

				R. T. Watson, M. Kanzaki, and J. E. Pessin Regulated Membrane Trafficking of the Insulin-Responsive Glucose Transporter 4 in Adipocytes Endocr. Rev., April 1, 2004; 25(2): 177 - 204. [Abstract] [Full Text] [PDF]

				A. W. Cohen, T. P. Combs, P. E. Scherer, and M. P. Lisanti Role of caveolin and caveolae in insulin signaling and diabetes Am J Physiol Endocrinol Metab, December 1, 2003; 285(6): E1151 - E1160. [Abstract] [Full Text] [PDF]

				H. Ruan, M. J. Zarnowski, S. W. Cushman, and H. F. Lodish Standard Isolation of Primary Adipose Cells from Mouse Epididymal Fat Pads Induces Inflammatory Mediators and Down-regulates Adipocyte Genes J. Biol. Chem., November 28, 2003; 278(48): 47585 - 47593. [Abstract] [Full Text] [PDF]

				C. A. Bertrand and R. A. Frizzell The role of regulated CFTR trafficking in epithelial secretion Am J Physiol Cell Physiol, July 1, 2003; 285(1): C1 - C18. [Abstract] [Full Text] [PDF]

				R. P. Souto, G. Vallega, J. Wharton, J. Vinten, J. Tranum-Jensen, and P. F. Pilch Immunopurification and Characterization of Rat Adipocyte Caveolae Suggest Their Dissociation from Insulin Signaling J. Biol. Chem., May 9, 2003; 278(20): 18321 - 18329. [Abstract] [Full Text] [PDF]

				R. Somwar, S. Koterski, G. Sweeney, R. Sciotti, S. Djuric, C. Berg, J. Trevillyan, P. E. Scherer, C. M. Rondinone, and A. Klip A Dominant-negative p38 MAPK Mutant and Novel Selective Inhibitors of p38 MAPK Reduce Insulin-stimulated Glucose Uptake in 3T3-L1 Adipocytes without Affecting GLUT4 Translocation J. Biol. Chem., December 20, 2002; 277(52): 50386 - 50395. [Abstract] [Full Text] [PDF]

				Z. Xu and K. V. Kandror Translocation of Small Preformed Vesicles Is Responsible for the Insulin Activation of Glucose Transport in Adipose Cells. EVIDENCE FROM THE IN VITRO RECONSTITUTION ASSAY J. Biol. Chem., December 6, 2002; 277(50): 47972 - 47975. [Abstract] [Full Text] [PDF]

				J. Yang, A. K. Gillingham, A. Hodel, F. Koumanov, B. Woodward, and G. D. Holman Insulin-stimulated cytosol alkalinization facilitates optimal activation of glucose transport in cardiomyocytes Am J Physiol Endocrinol Metab, December 1, 2002; 283(6): E1299 - E1307. [Abstract] [Full Text] [PDF]

				T. A. Kupriyanova, V. Kandror, and K. V. Kandror Isolation and Characterization of the Two Major Intracellular Glut4 Storage Compartments J. Biol. Chem., March 8, 2002; 277(11): 9133 - 9138. [Abstract] [Full Text] [PDF]

				P. E. Bickel Lipid rafts and insulin signaling Am J Physiol Endocrinol Metab, January 1, 2002; 282(1): E1 - E10. [Abstract] [Full Text] [PDF]

				R. Somwar, W. Niu, D. Y. Kim, G. Sweeney, V. K. Randhawa, C. Huang, T. Ramlal, and A. Klip Differential Effects of Phosphatidylinositol 3-Kinase Inhibition on Intracellular Signals Regulating GLUT4 Translocation and Glucose Transport J. Biol. Chem., November 30, 2001; 276(49): 46079 - 46087. [Abstract] [Full Text] [PDF]