Immobilization of Notch ligand, Delta-1, is required for induction of notch signaling

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Rand, M. D., Grimm, L. M., Artavanis-Tsakonas, S., Patriub, V., Blacklow, S. C., Sklar, J. and Aster, J. C (2000). Calcium depletion dissociates and activates heterodimeric Notch receptors. Mol. Cell Biol 20, 1825-1835.[Abstract/Free Full Text]

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				B. Varnum-Finney, M. H. Dallas, K. Kato, and I. D. Bernstein Notch target Hes5 ensures appropriate Notch induced T- versus B-cell choices in the thymus Blood, March 1, 2008; 111(5): 2615 - 2620. [Abstract] [Full Text] [PDF]

				J. B.-D. Ponio, C. Wright-Crosnier, M.-T. Groyer-Picard, C. Driancourt, I. Beau, M. Hadchouel, and M. Meunier-Rotival Biological function of mutant forms of JAGGED1 proteins in Alagille syndrome: inhibitory effect on Notch signaling Hum. Mol. Genet., November 15, 2007; 16(22): 2683 - 2692. [Abstract] [Full Text] [PDF]

				K. Aoyama, C. Delaney, B. Varnum-Finney, A. D. Kohn, R. T. Moon, and I. D. Bernstein The Interaction of the Wnt and Notch Pathways Modulates Natural Killer Versus T Cell Differentiation Stem Cells, October 1, 2007; 25(10): 2488 - 2497. [Abstract] [Full Text] [PDF]

				P. S. Hodkinson, Paul. A. Elliott, Y. Lad, B. J. McHugh, A. C. MacKinnon, C. Haslett, and T. Sethi Mammalian NOTCH-1 Activates beta1 Integrins via the Small GTPase R-Ras J. Biol. Chem., September 28, 2007; 282(39): 28991 - 29001. [Abstract] [Full Text] [PDF]

				M. A. Santos, L. M. Sarmento, M. Rebelo, A. A. Doce, I. Maillard, A. Dumortier, H. Neves, F. Radtke, W. S. Pear, L. Parreira, et al. Notch1 engagement by Delta-like-1 promotes differentiation of B lymphocytes to antibody-secreting cells PNAS, September 25, 2007; 104(39): 15454 - 15459. [Abstract] [Full Text] [PDF]

				M. H. Dallas, B. Varnum-Finney, P. J. Martin, and I. D. Bernstein Enhanced T-cell reconstitution by hematopoietic progenitors expanded ex vivo using the Notch ligand Delta1 Blood, April 15, 2007; 109(8): 3579 - 3587. [Abstract] [Full Text] [PDF]

				J. T. Nichols, A. Miyamoto, S. L. Olsen, B. D'Souza, C. Yao, and G. Weinmaster DSL ligand endocytosis physically dissociates Notch1 heterodimers before activating proteolysis can occur J. Cell Biol., February 12, 2007; 176(4): 445 - 458. [Abstract] [Full Text] [PDF]

				N. Chadwick, M. C. Nostro, M. Baron, R. Mottram, G. Brady, and A.-M. Buckle Notch Signaling Induces Apoptosis in Primary Human CD34+ Hematopoietic Progenitor Cells Stem Cells, January 1, 2007; 25(1): 203 - 210. [Abstract] [Full Text] [PDF]

				T. Suzuki, Y. Yokoyama, K. Kumano, M. Takanashi, S. Kozuma, T. Takato, T. Nakahata, M. Nishikawa, S. Sakano, M. Kurokawa, et al. Highly Efficient Ex Vivo Expansion of Human Hematopoietic Stem Cells Using Delta1-Fc Chimeric Protein Stem Cells, November 1, 2006; 24(11): 2456 - 2465. [Abstract] [Full Text] [PDF]

				L. X. Heinz, B. Platzer, P. M. Reisner, A. Jorgl, S. Taschner, F. Gobel, and H. Strobl Differential involvement of PU.1 and Id2 downstream of TGF-beta1 during Langerhans-cell commitment Blood, February 15, 2006; 107(4): 1445 - 1453. [Abstract] [Full Text] [PDF]

				J. Huang, K. P. Garrett, R. Pelayo, J. C. Zuniga-Pflucker, H. T. Petrie, and P. W. Kincade Propensity of Adult Lymphoid Progenitors to Progress to DN2/3 Stage Thymocytes with Notch Receptor Ligation J. Immunol., October 15, 2005; 175(8): 4858 - 4865. [Abstract] [Full Text] [PDF]

				C. Delaney, B. Varnum-Finney, K. Aoyama, C. Brashem-Stein, and I. D. Bernstein Dose-dependent effects of the Notch ligand Delta1 on ex vivo differentiation and in vivo marrow repopulating ability of cord blood cells Blood, October 15, 2005; 106(8): 2693 - 2699. [Abstract] [Full Text] [PDF]

				E. M. K. Smith, P. Akerblad, T. Kadesch, H. Axelson, and M. Sigvardsson Inhibition of EBF function by active Notch signaling reveals a novel regulatory pathway in early B-cell development Blood, September 15, 2005; 106(6): 1995 - 2001. [Abstract] [Full Text] [PDF]

				S. K. Nilsson, H. M. Johnston, G. A. Whitty, B. Williams, R. J. Webb, D. T. Denhardt, I. Bertoncello, L. J. Bendall, P. J. Simmons, and D. N. Haylock Osteopontin, a key component of the hematopoietic stem cell niche and regulator of primitive hematopoietic progenitor cells Blood, August 15, 2005; 106(4): 1232 - 1239. [Abstract] [Full Text] [PDF]

				L. C. Nehring, A. Miyamoto, P. W. Hein, G. Weinmaster, and J. M. Shipley The Extracellular Matrix Protein MAGP-2 Interacts with Jagged1 and Induces Its Shedding from the Cell Surface J. Biol. Chem., May 27, 2005; 280(21): 20349 - 20355. [Abstract] [Full Text] [PDF]

				M. H. Dallas, B. Varnum-Finney, C. Delaney, K. Kato, and I. D. Bernstein Density of the Notch ligand Delta1 determines generation of B and T cell precursors from hematopoietic stem cells J. Exp. Med., May 2, 2005; 201(9): 1361 - 1366. [Abstract] [Full Text] [PDF]

				R. Le Borgne, A. Bardin, and F. Schweisguth The roles of receptor and ligand endocytosis in regulating Notch signaling Development, April 15, 2005; 132(8): 1751 - 1762. [Abstract] [Full Text] [PDF]

				A. Proweller, W. S. Pear, and M. S. Parmacek Notch Signaling Represses Myocardin-induced Smooth Muscle Cell Differentiation J. Biol. Chem., March 11, 2005; 280(10): 8994 - 9004. [Abstract] [Full Text] [PDF]

				L.-T. Yang, J. T. Nichols, C. Yao, J. O. Manilay, E. A. Robey, and G. Weinmaster Fringe Glycosyltransferases Differentially Modulate Notch1 Proteolysis Induced by Delta1 and Jagged1 Mol. Biol. Cell, February 1, 2005; 16(2): 927 - 942. [Abstract] [Full Text] [PDF]

				D. A. Ross, P. K. Rao, and T. Kadesch Dual Roles for the Notch Target Gene Hes-1 in the Differentiation of 3T3-L1 Preadipocytes Mol. Cell. Biol., April 15, 2004; 24(8): 3505 - 3513. [Abstract] [Full Text] [PDF]

				R. Trifonova, D. Small, D. Kacer, D. Kovalenko, V. Kolev, A. Mandinova, R. Soldi, L. Liaw, I. Prudovsky, and T. Maciag The non-transmembrane form of Delta1 but not of jagged1 Induces normal migratory behavior accompanied by FGF receptor 1-dependent transformation J. Biol. Chem., February 9, 2004; (2004) 300564200. [Abstract] [PDF]

				V. Vas, L. Szilagyi, K. Paloczi, and F. Uher Soluble Jagged-1 is able to inhibit the function of its multivalent form to induce hematopoietic stem cell self-renewal in a surrogate in vitro assay J. Leukoc. Biol., April 1, 2004; 75(4): 714 - 720. [Abstract] [Full Text] [PDF]

				M. J. LaVoie and D. J. Selkoe The Notch Ligands, Jagged and Delta, Are Sequentially Processed by {alpha}-Secretase and Presenilin/{gamma}-Secretase and Release Signaling Fragments J. Biol. Chem., September 5, 2003; 278(36): 34427 - 34437. [Abstract] [Full Text] [PDF]

				D. Small, D. Kovalenko, R. Soldi, A. Mandinova, V. Kolev, R. Trifonova, C. Bagala, D. Kacer, C. Battelli, L. Liaw, et al. Notch Activation Suppresses Fibroblast Growth Factor-dependent Cellular Transformation J. Biol. Chem., April 25, 2003; 278(18): 16405 - 16413. [Abstract] [Full Text] [PDF]

				C. E. Bland, P. Kimberly, and M. D. Rand Notch-induced Proteolysis and Nuclear Localization of the Delta Ligand J. Biol. Chem., April 11, 2003; 278(16): 13607 - 13610. [Abstract] [Full Text] [PDF]

				T. Yamada, H. Yamazaki, T. Yamane, M. Yoshino, H. Okuyama, M. Tsuneto, T. Kurino, S.-I. Hayashi, and S. Sakano Regulation of osteoclast development by Notch signaling directed to osteoclast precursors and through stromal cells Blood, March 15, 2003; 101(6): 2227 - 2234. [Abstract] [Full Text] [PDF]

				B. Varnum-Finney, C. Brashem-Stein, and I. D. Bernstein Combined effects of Notch signaling and cytokines induce a multiple log increase in precursors with lymphoid and myeloid reconstituting ability Blood, March 1, 2003; 101(5): 1784 - 1789. [Abstract] [Full Text] [PDF]

				L. Wu, T. Sun, K. Kobayashi, P. Gao, and J. D. Griffin Identification of a Family of Mastermind-Like Transcriptional Coactivators for Mammalian Notch Receptors Mol. Cell. Biol., November 1, 2002; 22(21): 7688 - 7700. [Abstract] [Full Text] [PDF]

				K. Mishra-Gorur, M. D. Rand, B. Perez-Villamil, and S. Artavanis-Tsakonas Down-regulation of Delta by proteolytic processing J. Cell Biol., October 28, 2002; 159(2): 313 - 324. [Abstract] [Full Text] [PDF]

				B. S. Johnson, L. Mueller, J. Si, and S. J. Collins The cytokines IL-3 and GM-CSF regulate the transcriptional activity of retinoic acid receptors in different in vitro models of myeloid differentiation Blood, February 1, 2002; 99(3): 746 - 753. [Abstract] [Full Text] [PDF]