Phosphorylation of neurofilament heavy chain side-arms by stress activated protein kinase-1b/Jun N-terminal kinase-3

QUICK SEARCH:

[advanced]

	Author:		Keyword(s):

Home Help Feedback Subscriptions Archive Search Table of Contents

This Article

	Summary
	Full Text (PDF)
	Alert me when this article is cited
	Alert me if a correction is posted

Services

	Email this article to a friend
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new issues of the journal
	Download to citation manager


Citing Articles

	Citing Articles via HighWire
	Citing Articles via Google Scholar

Google Scholar

	Articles by Brownlees, J.
	Articles by Miller, C. C.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Brownlees, J.
	Articles by Miller, C. C.

Archer, D. R., Watson, D. F. and Griffin, J. W (1994). Phosphorylation-dependent immunoreactivity of neurofilaments and the rate of slow axonal transport in the central and peripheral axons of the rat dorsal root ganglia. J. Neurochem 62, 1119-1125.[Medline]

Bajaj, N. P. and Miller, C. C. J (1997). Phosphorylation of neurofilament heavy-chain side-arm fragments by cyclin-dependent kinase-5 and glycogen synthase kinase-3a in transfected cells. J. Neurochem 69, 737-743.[Medline]

Beaudette, K. N., Lew, J. and Wang, J. H (1993). Substrate specificity characterization of a cdc2-like protein kinase purified from bovine brain. J. Biol. Chem 268, 20825-20830.[Abstract/Free Full Text]

Brownlees, J., Irving, N. G., Brion, J.-P., Gibb, B. J. M., Wagner, U., Woodgett, J. and Miller, C. C. J (1997). Tau phosphorylation in transgenic mice expressing glycogen synthase kinase-3transgenes. Neuroreport 8, 3251-3255.[Medline]

Carboni, L., Tacconi, S., Carletti, R., Bettini, E. and Ferraguti, F (1997). Localization of the messenger RNA for the c-Jun NH2-terminal kinase kinase in the adult and developing rat brain: An in situ hybridization study. Neuroscience 80, 147-160.[Medline]

Carden, M. J., Schlaepfer, W. W. and Lee, V. M.-Y (1985). The structure, biochemical properties, and immunogenicity of neurofilament peripheral regions are determined by phosphorylation state. J. Biol. Chem 260, 9805-9817.[Abstract/Free Full Text]

Cheng, B., Goodman, Y., Begley, J. G. and Mattson, M. P (1994). Neurotrophin-4/5 protects hippocampal and cortical neurons against energy deprivation-and excitatory amino acid-induced injury. Brain Res 650, 331-335.[Medline]

Chin, S. S. M. and Liem, R. K. H (1990). Transfected rat high-molecular-weight neurofilament (NF-H) coassembles with vimentin in a predominantly nonphosphorylated form. J. Neurosci 10, 3714-3726.[Abstract]

Clark, E. A. and Lee, V. M.-Y (1991). Dynamics of mammalian high-molecular-weight neurofilament subunit phosphorylation in cultured rat sympathetic neurons. J. Neurosci. Res 30, 116-123.[Medline]

Davis, D. R., Brion, J.-P., Couck, A.-M., Gallo, J.-M., Hanger, D. P., Ladhani, K., Lewis, C., Miller, C. C. J., Rupniak, T., Smith, C. andAnderton, B. H (1995). The phosphorylation state of the microtubule-associated protein tau as affected by glutamate, colchicineand-amyloid in primary rat cortical neuronal cultures. Biochem. J 309, 941-949.

Elhanany, E., Jaffe, H., Link, W. T., Sheeley, D. M., Gainer, H. and Pant, H. C (1994). Identification of endogenously phosphorylated KSP sites in the high-molecular-weight rat neurofilament protein. J. Neurochem 63, 2324-2335.[Medline]

Fernyhough, P., Gallagher, A., Averill, S. A., Priestley, J. V., Hounsom, L., Patel, J. and Tomlinson, D. R (1999). Aberrant neurofilament phosphorylation in sensory neurons of rats with diabetic neuropathy. Diabetes 48, 881-889.[Abstract]

Giasson, B. I. and Mushynski, W. E (1996). Aberrant stress-induced phosphorylation of perikaryal neurofilaments. J. Biol. Chem 271, 30404-30409.[Abstract/Free Full Text]

Giasson, B. I. and Mushynski, W. E (1997). Study of proline-directed kinases involved in phosphorylation of the heavy neurofilament subunit. J. Neurosci 17, 9466-9472.[Abstract/Free Full Text]

Guan, R. J., Khatra, B. S. and Cohlberg, J. A (1991). Phosphorylation of bovine neurofilament proteins by protein kinase FA(Glycogen synthase kinase 3). J. Biol. Chem 266, 8262-8267.[Abstract/Free Full Text]

Guidato, S., Tsai, L.-H., Woodgett, J. and Miller, C. C. J (1996). Differential cellular phosphorylation of neurofilament heavy side-arms by glycogen synthase kinase-3 and cyclin-dependent kinase-5. J. Neurochem 66, 1698-1706.[Medline]

He, X., Saint-Jeannet, J.-P., Woodgett, J. R., Varmus, H. E. and Dawid, I. B (1995). Glycogen synthase kinase-3 and dorsoventral patterning in Xenopus embryos. Nature 374, 617-622.[Medline]

Hirano, A (1991). Cytopathology of amyotrophic lateral sclerosis. Adv. Neurol 56, 91-102.[Medline]

Hirokawa, N (1982). The crosslinker system between neurofilaments, microtubules and membranous organelles revealed by quick freeze, freeze-fracture, deep-etching method. J. Cell Biol 94, 129-142.[Abstract/Free Full Text]

Hisanaga, S., Ishiguro, K., Uchida, T., Okumura, E., Okano, T. and Kishimoto, T (1993). Tau protein kinase II has a similar characteristic to cdc2 kinase for phosphorylating neurofilament proteins. J. Biol. Chem 268, 15056-15060.[Abstract/Free Full Text]

Hong, M., Chen, D. C. R., Klein, P. S. and Lee, V. M. Y (1997). Lithium reduces tau phosphorylation by inhibition of glycogen synthase kinase-3. J. Biol. Chem 272, 25326-25332.[Abstract/Free Full Text]

Julien, J.-P., Cote, F., Beaudet, L., Sidky, M., Flavell, D., Grosveld, F. and Mushynski, W (1988). Sequence and structure of the mouse gene coding for the largest neurofilament subunit. Gene 68, 307-314.[Medline]

Kawasaki, H., Morooka, T., Shimohama, S., Kimura, J., Hirano, T., Gotoh, Y. and Nishida, E (1997). Activation and involvement of p38 mitogen-activated protein kinase in glutamate-induced apoptosis in rat cerebellar granule cells. J. Biol. Chem 272, 18518-18521.[Abstract/Free Full Text]

Kyriakis, J. M., Banerjee, P., Nikolakaki, E., Dai, T., Rubie, E. A., Ahmad, M. F., Avruch, J. and Woodgett, J. R (1994). The stress-activated protein kinase subfamily of c-Jun kinases. Nature 369, 156-160.[Medline]

Lee, M. K. and Cleveland, D. W (1996). Neuronal intermediate filaments. Annu. Rev. Neurosci 19, 187-217.[Medline]

Lee, V. M.-Y., Carden, M. J., Schlaepfer, W. W. and Trojanowski, J. Q (1987). Monoclonal antibodies distinguish several differently phosphorylated states of the two largest rat neurofilament subunits (NF-H and NF-M) and demonstrate their existence in the normal nervous system of rats. J. Neurosci 7, 3474-3488.[Abstract]

Lee, V. M.-Y., Otvos, L., Carden, M. J., Hollosi, M., Deitzschold, B. and Lazzarini, R. A (1988). Identification of the major multiphosphorylation site in mammalian neurofilaments. Proc. Nat. Acad. Sci. USA 85, 1998-2002.[Abstract/Free Full Text]

Lees, J. F., Schneidman, P. S., Skuntz, S. F., Carden, M. J. and Lazzarinin, R. A (1988). The structure and organization of the human heavy neurofilament subunit (NF-H) and the gene encoding it. EMBO J 7, 1947-1955.[Medline]

Leigh, P. N. and Meldrum, B. S (1996). Excitotoxicity in ALS. Neurology 47, 221-.

Lew, J., Winkfein, R. J., Paudel, H. K. and Wang, J. H (1992). Brain proline-directed protein kinase is a neurofilament kinase which displays high sequence homology to p34cdc2. J. Biol. Chem 267, 25922-25926.[Abstract/Free Full Text]

Lin, C.-L. G., Bristol, L. A., Jin, L., Dykes-Hoberg, M., Crawford, T., Clawson, L. and Rothstein, J. D (1998). Aberrant RNA processing in a neurodegenerative disease: the cause of absent EAAT2, a glutamatetransporter, in Amyotrophic Lateral Sclerosis. Neuron 20, 589-602.[Medline]

Lovestone, S., Reynolds, C. H., Latimer, D., Davis, D. R., Anderton, B. H., Gallo, J.-M., Hanger, D., Mulot, S., Marquardt, B., Stabel, S., Woodgett, J. R. and Miller, C. C. J (1994). Alzheimer's disease-like phosphorylation of the microtubule-associated protein tau by glycogen synthase kinase-3 in transfected mammalian cells. Curr. Biol 4, 1077-1086.[Medline]

Lovestone, S., Davis, D. R., Webster, M. T., Kaech, S., Brion, J. P., Matus, A. and Anderton, B. H (1999). Lithium reduces tau phosphorylation: Effects in living cells and in neurons at therapeutic concentrations. Biol. Psychiatry 45, 995-1003.[Medline]

Marszalek, J. R., Williamson, T. L., Lee, M. K., Xu, Z. S., Hoffman, P. N., Becher, M. W., Crawford, T. O. and Cleveland, D. W (1996). Neurofilament subunit NF-H modulates axonal diameter by selectively slowing neurofilament transport. J. Cell Biol 135, 711-724.[Abstract/Free Full Text]

Merritt, S. E., Matas, M., Nihalani, D., Zhu, X. and Holzman, L. B (1999). The mixed lineage kinase DLK utilizes MKK7 and not MKK4 as substrate. J. Biol. Chem 274, 10195-10202.[Abstract/Free Full Text]

Miller, C. C. J., Brion, J. P., Calvert, R., Chin, T. K., Eagles, P. A. M., Downes, M. J., Haugh, M., Kahn, J., Probst, A., Ulrich, J. and Anderton, B. H (1986). Alzheimer's paired helical filaments share epitopes with neurofilament side arms. EMBO J 5, 269-276.[Medline]

Miyasaka, H., Okabe, S., Ishiguro, K., Uchida, T. and Hirokawa, N (1993). Interaction of the tail domain of high molecular weight subunits of neurofilaments with the COOH-terminal region of tubulin and its regulation byprotein kinase II. J. Biol. Chem 268, 22695-22702.[Abstract/Free Full Text]

Mohit, A. A., Martin, J. H. and Miller, C. A (1995). p493F12kinase: A novel MAP kinase expressed in a subset of neurones in the human nervous system. Neuron 14, 67-78.[Medline]

Mu\226oz-Monta\226o, J. R., Moreno, F. J., Avila, J. and D\222az-Nido, J (1997). Lithium inhibits Alzheimer's disease-like tau protein phosphorylation in neurons. FEBS Lett 411, 183-188.[Medline]

Nixon, R. A., Lewis, S. E., Mercken, M. and Sihag, R. K (1994). Orthophosphate and methionine label separate pools of neurofilaments with markedly different axonal transport kinetics. Neurochem. Res 19, 1445-1453.[Medline]

Nixon, R. A., Paskevich, P. A., Sihag, RK. and Thayer, C (1994). Phosphorylation on carboxy terminus domains of neurofilament proteins in retinal ganglion cell neurons in vivo: Influences on regional neurofilament spacing, and axon caliber. J. Cell Biol 126, 1031-1046.[Abstract/Free Full Text]

Nixon, R. A (1998). The slow axonal transport of cytoskeletal proteins. Curr. Opin. Cell Biol 10, 87-92.[Medline]

Reynolds, C. H., Utton, M. A., Gibb, G. A., Yates, A. and Anderton, B. H (1997). Stress-activated protein kinase/c-Jun N-terminal kinase phosphorylatesprotein. J. Neurochem 68, 1736-1744.[Medline]

Rothstein, J. D., Tsai, G., Kuncl, R. W., Clawson, L., Cornblath, D. R., Drachman, D. B., Pestronk, A., Stauch, B. L. and Coyle, J. T (1990). Abnormal excitatory amino acid metabolism in amyotrophic lateral sclerosis. Ann. Neurol 28, 18-25.[Medline]

Rothstein, J. D (1996). Excitotoxicity hypothesis. Neurology 47, 19-.

Roy, J., Minotti, S., Dong, L. C., Figlewicz, D. A. and Durham, H. D (1998). Glutamate potentiates the toxicity of mutant Cu/Zn-superoxide dismutase in motor neurons by postsynaptic calcium-dependent mechanisms. J. Neurosci 18, 9673-9684.[Abstract/Free Full Text]

Schwarzschild, M. A., Cole, R. L. and Hyman, S. E (1997). Glutamate, but not dopamine, stimulates stress-activated protein kinase and AP-1-mediated transcription in striatal neurons. J. Neurosci 17, 3455-3466.[Abstract/Free Full Text]

Schwarzchild, M. A., Cole, R. L., Meyers, M. A. and Hyman, S. E (1999). Contrasting calcium dependencies of SAPK and ERK activations by glutamate in cultured striatal neurons. J. Neurochem 72, 2248-2255.[Medline]

Shaw, P. J (1994). Excitotoxicity and motor neurone disease: a review of the evidence. J. Neurol. Sci 124, 6-13.

Shetty, K. T., Link, W. T. and Pant, H. C (1993). cdc2-like kinase from rat spinal cord specifically phosphorylates KSPXK motifs in neurofilament proteins: Isolation and characterization. Proc. Nat. Acad. Sci. USA 90, 6844-6848.[Abstract/Free Full Text]

Sternberger, L. A. and Sternberger, N. H (1983). Monoclonal antibodies distinguish phosphorylated and nonphosphorylated forms of neurofilaments. Proc. Nat. Acad. Sci. USA 80, 6126-6130.[Abstract/Free Full Text]

Sun, D., Leung, C. L. and Liem, R. K. H (1996). Phosphorylation of the high molecular weight neurofilament protein (NF-H) by cdk-5 and p35. J. Biol. Chem 271, 14245-14251.[Abstract/Free Full Text]

Veeranna, Amin, N. D., Ahn, N. G., Jaffe, H., Winters, C. A., Grant, P. and Pant, H. C (1998). Mitogen-activated protein kinases (Erk1, 2) phosphorylate Lys-Ser-Pro (KSP) repeats in neurofilament proteins NF-H and NF-M. J. Neurosci 18, 4008-4021.[Abstract/Free Full Text]

Wagner, U., Utton, M., Gallo, J.-M. and Miller, C. C. J (1996). Cellular phosphorylation of tau by GSK-3influences tau binding to microtubules and microtubule organisation. J. Cell Sci 109, 1537-1543.[Abstract]

Watson, A., Eilers, A., Lallemand, D., Kyriakis, J., Rubin, L. L. and Ham, J (1998). Survival signal withdrawal in cerebellar granule neurons. J. Neurosci 18, 751-762.[Abstract/Free Full Text]

Watson, D. F., Fittro, K. P., Hoffman, P. N. and Griffin, J. W (1991). Phosphorylation-related immunoreactivity and the rate of transport of neurofilaments in chronic 2, 5-hexanedione intoxication. Brain Res 539, 103-109.[Medline]

Yang, D. D., Kuan, C.-Y., Whitmarsh, A. J., Rincon, M., Zheng, T. S., Davis, R. J., Rakic, P. and Flavell, R. A (1997). Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene. Nature 389, 865-870.[Medline]

This article has been cited by other articles:

A. Zamoner, K. P. Barreto, D. W. Filho, F. Sell, V. M. Woehl, F. C. R. Guma, R. Pessoa-Pureur, and F. R. M. B. Silva
Propylthiouracil-induced congenital hypothyroidism upregulates vimentin phosphorylation and depletes antioxidant defenses in immature rat testis
J. Mol. Endocrinol., March 1, 2008; 40(3): 125 - 135.
[Abstract] [Full Text] [PDF]

S. Kesavapany, V. Patel, Y.-L. Zheng, T. K. Pareek, M. Bjelogrlic, W. Albers, N. Amin, H. Jaffe, J. S. Gutkind, M. J. Strong, et al.
Inhibition of Pin1 Reduces Glutamate-induced Perikaryal Accumulation of Phosphorylated Neurofilament-H in Neurons
Mol. Biol. Cell, September 1, 2007; 18(9): 3645 - 3655.
[Abstract] [Full Text] [PDF]

E. L. Tudor, M. S. Perkinton, A. Schmidt, S. Ackerley, J. Brownlees, N. J. O. Jacobsen, H. L. Byers, M. Ward, A. Hall, P. N. Leigh, et al.
ALS2/Alsin Regulates Rac-PAK Signaling and Neurite Outgrowth
J. Biol. Chem., October 14, 2005; 280(41): 34735 - 34740.
[Abstract] [Full Text] [PDF]

P. G. Bannerman, A. Hahn, S. Ramirez, M. Morley, C. Bonnemann, S. Yu, G.-X. Zhang, A. Rostami, and D. Pleasure
Motor neuron pathology in experimental autoimmune encephalomyelitis: studies in THY1-YFP transgenic mice
Brain, August 1, 2005; 128(8): 1877 - 1886.
[Abstract] [Full Text] [PDF]

A Petzold, M J Eikelenboom, G Keir, D Grant, R H C Lazeron, C H Polman, B M J Uitdehaag, E J Thompson, and G Giovannoni
Axonal damage accumulates in the progressive phase of multiple sclerosis: three year follow up study
J. Neurol. Neurosurg. Psychiatry, February 1, 2005; 76(2): 206 - 211.
[Abstract] [Full Text] [PDF]

W. K.-H. Chan, A. Dickerson, D. Ortiz, A. F. Pimenta, C. M. Moran, J. Motil, S. J. Snyder, K. Malik, H. C. Pant, and T. B. Shea
Mitogen-activated protein kinase regulates neurofilament axonal transport
J. Cell Sci., September 15, 2004; 117(20): 4629 - 4642.
[Abstract] [Full Text] [PDF]

J. L. Hallows, K. Chen, R. A. DePinho, and I. Vincent
Decreased Cyclin-Dependent Kinase 5 (cdk5) Activity Is Accompanied by Redistribution of cdk5 and Cytoskeletal Proteins and Increased Cytoskeletal Protein Phosphorylation in p35 Null Mice
J. Neurosci., November 19, 2003; 23(33): 10633 - 10644.
[Abstract] [Full Text] [PDF]

A. Middlemas, J.-D. Delcroix, N. M. Sayers, D. R. Tomlinson, and P. Fernyhough
Enhanced activation of axonally transported stress-activated protein kinases in peripheral nerve in diabetic neuropathy is prevented by neurotrophin-3
Brain, July 1, 2003; 126(7): 1671 - 1682.
[Abstract] [Full Text] [PDF]

S. Kesavapany, K.-F. Lau, S. Ackerley, S. J. Banner, S. J. A. Shemilt, J. D. Cooper, P. N. Leigh, C. E. Shaw, D. M. McLoughlin, and C. C. J. Miller
Identification of a Novel, Membrane-Associated Neuronal Kinase, Cyclin-Dependent Kinase 5/p35-Regulated Kinase
J. Neurosci., June 15, 2003; 23(12): 4975 - 4983.
[Abstract] [Full Text] [PDF]

S. Ackerley, P. Thornhill, A. J. Grierson, J. Brownlees, B. H. Anderton, P. N. Leigh, C. E. Shaw, and C. C.J. Miller
Neurofilament heavy chain side arm phosphorylation regulates axonal transport of neurofilaments
J. Cell Biol., May 12, 2003; 161(3): 489 - 495.
[Abstract] [Full Text] [PDF]

S.-Y. Han, S.-H. Kim, and L. E. Heasley
Differential Gene Regulation by Specific Gain-of-function JNK1 Proteins Expressed in Swiss 3T3 Fibroblasts
J. Biol. Chem., November 27, 2002; 277(49): 47167 - 47174.
[Abstract] [Full Text] [PDF]

S. Ackerley, A. J. Grierson, J. Brownlees, P. Thornhill, B. H. Anderton, P. N. Leigh, C. E. Shaw, and C. C.J. Miller
Glutamate Slows Axonal Transport of Neurofilaments in Transfected Neurons
J. Cell Biol., July 11, 2000; 150(1): 165 - 176.
[Abstract] [Full Text] [PDF]

D. M. McLoughlin, C. L. Standen, K.-F. Lau, S. Ackerley, T. P. Bartnikas, J. D. Gitlin, and C. C. J. Miller
The Neuronal Adaptor Protein X11alpha Interacts with the Copper Chaperone for SOD1 and Regulates SOD1 Activity
J. Biol. Chem., March 16, 2001; 276(12): 9303 - 9307.
[Abstract] [Full Text] [PDF]

This Article

Summary

Full Text (PDF)

Alert me when this article is cited

Alert me if a correction is posted

Services

Email this article to a friend

Similar articles in this journal

Similar articles in PubMed

Alert me to new issues of the journal

Download to citation manager

Citing Articles

Citing Articles via HighWire

Citing Articles via Google Scholar

Google Scholar

Articles by Brownlees, J.

Articles by Miller, C. C.

Search for Related Content

PubMed

PubMed Citation

Articles by Brownlees, J.

Articles by Miller, C. C.

				S. Kesavapany, V. Patel, Y.-L. Zheng, T. K. Pareek, M. Bjelogrlic, W. Albers, N. Amin, H. Jaffe, J. S. Gutkind, M. J. Strong, et al. Inhibition of Pin1 Reduces Glutamate-induced Perikaryal Accumulation of Phosphorylated Neurofilament-H in Neurons Mol. Biol. Cell, September 1, 2007; 18(9): 3645 - 3655. [Abstract] [Full Text] [PDF]

				E. L. Tudor, M. S. Perkinton, A. Schmidt, S. Ackerley, J. Brownlees, N. J. O. Jacobsen, H. L. Byers, M. Ward, A. Hall, P. N. Leigh, et al. ALS2/Alsin Regulates Rac-PAK Signaling and Neurite Outgrowth J. Biol. Chem., October 14, 2005; 280(41): 34735 - 34740. [Abstract] [Full Text] [PDF]

				P. G. Bannerman, A. Hahn, S. Ramirez, M. Morley, C. Bonnemann, S. Yu, G.-X. Zhang, A. Rostami, and D. Pleasure Motor neuron pathology in experimental autoimmune encephalomyelitis: studies in THY1-YFP transgenic mice Brain, August 1, 2005; 128(8): 1877 - 1886. [Abstract] [Full Text] [PDF]

				A Petzold, M J Eikelenboom, G Keir, D Grant, R H C Lazeron, C H Polman, B M J Uitdehaag, E J Thompson, and G Giovannoni Axonal damage accumulates in the progressive phase of multiple sclerosis: three year follow up study J. Neurol. Neurosurg. Psychiatry, February 1, 2005; 76(2): 206 - 211. [Abstract] [Full Text] [PDF]

				W. K.-H. Chan, A. Dickerson, D. Ortiz, A. F. Pimenta, C. M. Moran, J. Motil, S. J. Snyder, K. Malik, H. C. Pant, and T. B. Shea Mitogen-activated protein kinase regulates neurofilament axonal transport J. Cell Sci., September 15, 2004; 117(20): 4629 - 4642. [Abstract] [Full Text] [PDF]

				J. L. Hallows, K. Chen, R. A. DePinho, and I. Vincent Decreased Cyclin-Dependent Kinase 5 (cdk5) Activity Is Accompanied by Redistribution of cdk5 and Cytoskeletal Proteins and Increased Cytoskeletal Protein Phosphorylation in p35 Null Mice J. Neurosci., November 19, 2003; 23(33): 10633 - 10644. [Abstract] [Full Text] [PDF]

				A. Middlemas, J.-D. Delcroix, N. M. Sayers, D. R. Tomlinson, and P. Fernyhough Enhanced activation of axonally transported stress-activated protein kinases in peripheral nerve in diabetic neuropathy is prevented by neurotrophin-3 Brain, July 1, 2003; 126(7): 1671 - 1682. [Abstract] [Full Text] [PDF]

				S. Kesavapany, K.-F. Lau, S. Ackerley, S. J. Banner, S. J. A. Shemilt, J. D. Cooper, P. N. Leigh, C. E. Shaw, D. M. McLoughlin, and C. C. J. Miller Identification of a Novel, Membrane-Associated Neuronal Kinase, Cyclin-Dependent Kinase 5/p35-Regulated Kinase J. Neurosci., June 15, 2003; 23(12): 4975 - 4983. [Abstract] [Full Text] [PDF]

				S. Ackerley, P. Thornhill, A. J. Grierson, J. Brownlees, B. H. Anderton, P. N. Leigh, C. E. Shaw, and C. C.J. Miller Neurofilament heavy chain side arm phosphorylation regulates axonal transport of neurofilaments J. Cell Biol., May 12, 2003; 161(3): 489 - 495. [Abstract] [Full Text] [PDF]

				S.-Y. Han, S.-H. Kim, and L. E. Heasley Differential Gene Regulation by Specific Gain-of-function JNK1 Proteins Expressed in Swiss 3T3 Fibroblasts J. Biol. Chem., November 27, 2002; 277(49): 47167 - 47174. [Abstract] [Full Text] [PDF]

				S. Ackerley, A. J. Grierson, J. Brownlees, P. Thornhill, B. H. Anderton, P. N. Leigh, C. E. Shaw, and C. C.J. Miller Glutamate Slows Axonal Transport of Neurofilaments in Transfected Neurons J. Cell Biol., July 11, 2000; 150(1): 165 - 176. [Abstract] [Full Text] [PDF]

				D. M. McLoughlin, C. L. Standen, K.-F. Lau, S. Ackerley, T. P. Bartnikas, J. D. Gitlin, and C. C. J. Miller The Neuronal Adaptor Protein X11alpha Interacts with the Copper Chaperone for SOD1 and Regulates SOD1 Activity J. Biol. Chem., March 16, 2001; 276(12): 9303 - 9307. [Abstract] [Full Text] [PDF]