TrioGEF1 controls Rac- and Cdc42-dependent cell structures through the direct activation of rhoG

QUICK SEARCH:

[advanced]

	Author:		Keyword(s):

Home Help Feedback Subscriptions Archive Search Table of Contents

This Article

	Summary
	Full Text (PDF)
	Alert me when this article is cited
	Alert me if a correction is posted

Services

	Email this article to a friend
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new issues of the journal
	Download to citation manager


Citing Articles

	Citing Articles via HighWire
	Citing Articles via Google Scholar

Google Scholar

	Articles by Blangy, A.
	Articles by Fort, P.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Blangy, A.
	Articles by Fort, P.

Aronheim, A., Broder, Y. C., Cohen, A., Fritsch, A., Belisle, B. and Abo, A (1998). Chp, a homologue of the GTPase Cdc42Hs, activates the JNK pathway and is implicated in reorganizing the actin cytoskeleton. Curr. Biol 8, 1125-1128.[Medline]

Bellanger, J. M., Lazaro, J. B., Diriong, S., Fernandez, A., Lamb, N. and Debant, A (1998). The two guanine nucleotide exchange factor domains of Trio link the Rac1 and the RhoA pathways in vivo. Oncogene 16, 147-152.[Medline]

Boguski, M. S. and McCormick, F (1993). Proteins regulating Ras and its relatives. Nature 366, 643-654.[Medline]

Bourne, H. R., Sanders, D. A. and McCormick, F (1991). The GTPase superfamily: conserved structure and molecular mechanism. Nature 349, 117-127.[Medline]

Brunk, U., Collins, V. P. and Arro, E (1981). The fixation, dehydration, drying and coating of cultured cells for SEM. J. Microsc 123, 121-131.[Medline]

Cerione, R. A. and Zheng, Y (1996). The Dbl family of oncogenes. Curr. Opin. Cell Biol 8, 216-222.[Medline]

Chardin, P., Boquet, P., Madaule, P., Popoff, M. R., Rubin, E. J. and Gill, D. M (1989). The mammalian G protein rhoC is ADP-ribosylated by Clostridium botulinum exoenzyme C3 and affects actin microfilaments in Vero cells. EMBO J 8, 1087-1092.[Medline]

Chardin, P., Camonis, J. H., Gale, N. W., van Aelst, L., Schlessinger, J., Wigler, M. H. and Bar-Sagi, D (1993). Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2. Science 260, 1338-1343.[Abstract/Free Full Text]

Chuang, T. H., Xu, X., Kaartinen, V., Heisterkamp, N., Groffen, J. and Bokoch, G. M (1995). Abr and Bcr are multifunctional regulators of the Rho GTP-binding protein family. Proc. Natl. Acad. Sci. USA 92, 10282-10286.[Abstract/Free Full Text]

Chung, D., Amar, S., Glozman, A., Chen, J. M., Friedman, F. K., Robinson, R., Monaco, R., Brandt-Rauf, P., Yamaizumi, Z. and Pincus, M. R (1997). Inhibition of oncogenic and activated wild-type ras-p21 protein-induced oocyte maturation by peptides from the ras-binding domain of the raf-p74 protein, identified from molecular dynamics calculations. J. Protein Chem 16, 631-635.[Medline]

Colomer, V., Engelender, S., Sharp, A. H., Duan, K., Cooper, J. K., Lanahan, A., Lyford, G., Worley, P. and Ross, C. A (1997). Huntingtin-associated protein 1 (HAP1) binds to a Trio-like polypeptide, with a rac1 guanine nucleotide exchange factor domain. Hum. Mol. Genet 6, 1519-1525.[Abstract/Free Full Text]

de Rooij, J. and Bos, J. L (1997). Minimal Ras-binding domain of Raf1 can be used as an activation-specific probe for Ras. Oncogene 14, 623-625.[Medline]

Debant, A., Serra-Pages, C., Seipel, K., O'Brien, S., Tang, M., Park, S. H. and Streuli, M (1996). The multidomain protein Trio binds the LAR transmembrane tyrosine phosphatase, contains a protein kinase domain, andhas separate rac-specific and rho-specific guanine nucleotide exchange factor domains. Proc. Natl. Acad. Sci. USA 93, 5466-5471.[Abstract/Free Full Text]

Feig, L. and Cooper, G. M (1988). Inhibition of NIH 3T3 cell proliferation by a mutant ras protein with preferential affinity for GDP. Mol. Cell. Biol 8, 3235-3243.[Abstract/Free Full Text]

Gallo, G. and Letourneau, P. C (1998). Axon guidance: GTPases help axons reach their targets. Curr. Biol 8, 80-82.

Gauthier-Rouviere, C., Vignal, E., Meriane, M., Roux, P., Montcourier, P. and Fort, P (1998). RhoG GTPase controls a pathway that independently activates Rac1 and Cdc42Hs. Mol. Biol. Cell 9, 1379-1394.[Abstract/Free Full Text]

Glaven, J. A., Whitehead, I. P., Nomanbhoy, T., Kay, R. and Cerione, R. A (1996). Lfc and Lsc oncoproteins represent two new guanine nucleotide exchange factors for the Rho GTP-binding protein. J. Biol. Chem 271, 27374-27381.[Abstract/Free Full Text]

Hall, A (1998). Rho GTPases and the actin cytoskeleton. Science 279, 509-514.[Abstract/Free Full Text]

Hardt, W. D., Chen, L. M., Schuebel, K. E., Bustelo, X. R. and Galan, J. E (1998). S. typhimurium encodes an activator of Rho GTPases that induces membrane ruffling and nuclear responses in host cells. Cell 93, 815-826.[Medline]

Horii, Y., Beeler, J. F., Sakaguchi, K., Tachibana, M. and Miki, T (1994). A novel oncogene, ost, encodes a guanine nucleotide exchange factor that potentially links Rho and Rac signaling pathways. EMBO J 13, 4776-4786.[Medline]

Kozma, R., Ahmed, S., Best, A. and Lim, L (1995). The Ras-related protein Cdc42Hs and bradykinin promote formation of peripheral actin microspikes and filopodia in Swiss 3T3 fibroblasts. Mol. Cell Biol 15, 1942-1952.[Abstract]

Krueger, N. X., Van Vactor, D., Wan, H. I., Gelbart, W. M., Goodman, C. S. and Saito, H (1996). The transmembrane tyrosine phosphatase DLAR controls motor axon guidance in Drosophila. Cell 84, 611-622.[Medline]

Lamarche, N., Tapon, N., Stowers, L., Burbelo, P. D., Aspenstr\232m, P., Bridges, T., Chant, J. and Hall, A (1996). Rac and Cdc42 induce actin polymerization and G1 cell cycle progression independently of p65PAK and the JNK/SAPK MAP kinase cascade. Cell 87, 519-529.[Medline]

Li, R. and Zheng, Y (1997). Residues of the Rho family GTPases Rho and Cdc42 that specify sensitivity to Dbl-like guanine nucleotide exchange factors. J. Biol. Chem 272, 4671-4679.[Abstract/Free Full Text]

Luo, L., Jan, L. and Jan, Y. N (1996). Small GTPases in axon outgrowth. Perspect. Dev. Neurobiol 4, 199-204.[Medline]

Michiels, F., Habets, G. G., Stam, J. C., van der Kammen, R. A. and Collard, J. G (1995). A role for Rac in Tiam1-induced membrane ruffling and invasion. Nature 375, 338-340.[Medline]

Miki, T., Smith, C. L., Long, J. E., Eva, A. and Fleming, T. P (1993). Oncogene ect2 is related to regulators of small GTP-binding proteins. Nature 362, 462-465.[Medline]

Moorman, J. P., Luu, D., Wickham, J., Bobak, D. A. and Hahn, C. S (1999). A balance of signaling by Rho family small GTPases RhoA, Rac1 and Cdc42 coordinates cytoskeletal morphology but not cell survival. Oncogene 18, 47-57.[Medline]

Neudauer, C. L., Joberty, G., Tatsis, N. and Macara, I. G (1998). Distinct cellular effects and interactions of the Rho-family GTPase TC10. Curr. Biol 8, 1151-1160.[Medline]

Nobes, C. D. and Hall, A (1995). Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia. Cell 81, 53-62.[Medline]

Olson, M. F (1996). Guanine nucleotide exchange factors for the Rho GTPases: a role in human disease?. J. Mol. Med 74, 563-571.[Medline]

Quilliam, L. A., Khosravi-Far, R., Huff, S. Y. and Der, C. J (1995). Guanine nucleotide exchange factors: activators of the Ras superfamily of proteins. BioEssays 17, 395-404.[Medline]

Ratovitski, E. A., Alam, M. R., Quick, R. A., McMillan, A., Bao, C., Kozlovsky, C., Hand, T. A., Johnson, R. C., Mains, R. E., Eipper, B. A. et al (1999). Kalirin inhibition of inducible nitric-oxide synthase. J. Biol. Chem 274, 993-999.[Abstract/Free Full Text]

Ren, Y., Li, R., Zheng, Y. and Busch, H (1998). Cloning and characterization of GEF-H1, a microtubule-associated guanine nucleotide exchange factor for Rac and Rho GTPases. J. Biol. Chem 273, 34954-34960.[Abstract/Free Full Text]

Ridley, A. J. and Hall, A (1992). The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors. Cell 70, 389-399.[Medline]

Ridley, A. J., Paterson, H. F., Johnston, C. L., Diekmann, D. and Hall, A (1992). The small GTP-binding protein rac regulates growth factor-induced membrane ruffling. Cell 70, 401-410.[Medline]

Rose, M. and Botstein, D (1983). Structure and function of the yeast URA3 gene. Differentially regulated expression of hybrid beta-galactosidase from overlapping coding sequences in yeast. J. Mol. Biol 170, 883-904.[Medline]

Roux, P., Gauthier-Rouviere, C., Doucet-Brutin, S. and Fort, P (1997). The small GTPases Cdc42Hs, Rac1 and RhoG delineate Raf-independent pathways that cooperate to transform NIH3T3 cells. Curr. Biol 7, 629-637.[Medline]

Schuebel, K. E., Movilla, N., Rosa, J. L. and Bustelo, X. R (1998). Phosphorylation-dependent and constitutive activation of Rho proteins by wild-type and oncogenic Vav-2. EMBO J 17, 6608-6621.[Medline]

Self, A. J. and Hall, A (1995). Purification of recombinant Rho/Rac/G25K from Escherichia coli. Meth. Enzymol 256, 3-10.[Medline]

Steven, R., Kubiseski, T. J., Zheng, H., Kulkarni, S., Mancillas, J., Ruiz Morales, A., Hogue, C. W., Pawson, T. and Culotti, J (1998). UNC-73 activates the Rac GTPase and is required for cell and growth cone migrations in C. elegans. Cell 92, 785-795.[Medline]

Taba, M. R., Muroff, I., Lydall, D., Tebb, G. and Nasmyth, K (1991). Changes in a SWI4,6-DNA-binding complex occur at the time of HO gene activation in yeast. Genes Dev 5, 2000-2013.[Abstract/Free Full Text]

Tapon, N. and Hall, A (1997). Rho, Rac and Cdc42 GTPases regulate the organization of the actin cytoskeleton. Curr. Opin. Cell Biol 9, 86-92.[Medline]

Van Aelst, L. and D'Souza-Schorey, C (1997). Rho GTPases and signaling networks. Genes Dev 11, 2295-2322.[Free Full Text]

van den Berghe, N., Cool, R. H., Horn, G. and Wittinghofer, A (1997). Biochemical characterization of C3G: an exchange factor that discriminates between Rap1 and Rap2 and is not inhibited by Rap1A(S17N). Oncogene 15, 845-850.[Medline]

Vojtek, A. B., Hollenberg, S. M. and Cooper, J. A (1993). Mammalian Ras interacts directly with the serine/threonine kinase Raf. Cell 74, 205-214.[Medline]

Waterman-Storer, C. M. and Salmon, E (1999). Positive feedback interactions between microtubule and actin dynamics during cell motility. Curr. Opin. Cell Biol 11, 61-67.[Medline]

Westwick, J. K., Lambert, Q. T., Clark, G. J., Symons, M., Van Aelst, L., Pestell, R. G. and Der, C. J (1997). Rac regulation of transformation, gene expression, and actin organization by multiple, PAK-independent pathways. Mol. Cell. Biol 17, 1324-1335.[Abstract]

White, M. A., Nicolette, C., Minden, A., Polverino, A., Van Aelst, L., Karin, M. and Wigler, M. H (1995). Multiple Ras functions can contribute to mammalian cell transformation. Cell 80, 533-541.[Medline]

Whitehead, I. P., Campbell, S., Rossman, K. L. and Der, C. J (1997). Dbl family proteins. Biochim. Biophys. Acta 1332, 1-23.

Yaffe, M. P. and Schatz, G (1984). Two nuclear mutations that block mitochondrial protein import in yeast. Proc. Natl. Acad. Sci. USA 81, 4819-4823.[Abstract/Free Full Text]

Yeo, T. T., Yang, T., Massa, S. M., Zhang, J. S., Honkaniemi, J., Butcher, L. L. and Longo, F. M (1997). Deficient LAR expression decreases basal forebrain cholinergic neuronal size and hippocampal cholinergic innervation. J. Neurosci. Res 47, 348-360.[Medline]

Zhang, J. S., Honkaniemi, J., Yang, T., Yeo, T. T. and Longo, F. M (1998). LAR tyrosine phosphatase receptor: a developmental isoform is present in neurites and growth cones and its expression is regional and cell-specific. Mol. Cell. Neurosci 10, 271-286.

Zheng, Y., Olson, M. F., Hall, A., Cerione, R. A. and Toksoz, D (1995). Direct involvement of the small GTP-binding protein Rho in lbc oncogene function. J. Biol. Chem 270, 9031-9034.[Abstract/Free Full Text]

Ziman, M. and Johnson, D. I (1994). Genetic evidence for a functional interaction between Saccharomyces cerevisiae CDC24 and CDC42. Yeast 10, 463-474.[Medline]

This article has been cited by other articles:

J. Meller, L. Vidali, and M. A. Schwartz
Endogenous RhoG is dispensable for integrin-mediated cell spreading but contributes to Rac-independent migration
J. Cell Sci., June 15, 2008; 121(12): 1981 - 1989.
[Abstract] [Full Text] [PDF]

A. Briancon-Marjollet, A. Ghogha, H. Nawabi, I. Triki, C. Auziol, S. Fromont, C. Piche, H. Enslen, K. Chebli, J.-F. Cloutier, et al.
Trio Mediates Netrin-1-Induced Rac1 Activation in Axon Outgrowth and Guidance
Mol. Cell. Biol., April 1, 2008; 28(7): 2314 - 2323.
[Abstract] [Full Text] [PDF]

R. D'Angelo, S. Aresta, A. Blangy, L. Del Maestro, D. Louvard, and M. Arpin
Interaction of Ezrin with the Novel Guanine Nucleotide Exchange Factor PLEKHG6 Promotes RhoG-dependent Apical Cytoskeleton Rearrangements in Epithelial Cells
Mol. Biol. Cell, December 1, 2007; 18(12): 4780 - 4793.
[Abstract] [Full Text] [PDF]

F. Ferraro, X.-M. Ma, J. A. Sobota, B. A. Eipper, and R. E. Mains
Kalirin/Trio Rho Guanine Nucleotide Exchange Factors Regulate a Novel Step in Secretory Granule Maturation
Mol. Biol. Cell, December 1, 2007; 18(12): 4813 - 4825.
[Abstract] [Full Text] [PDF]

S. Charrasse, F. Comunale, M. Fortier, E. Portales-Casamar, A. Debant, and C. Gauthier-Rouviere
M-Cadherin Activates Rac1 GTPase through the Rho-GEF Trio during Myoblast Fusion
Mol. Biol. Cell, May 1, 2007; 18(5): 1734 - 1743.
[Abstract] [Full Text] [PDF]

S. E. Siegrist and C. Q. Doe
Microtubule-induced cortical cell polarity
Genes & Dev., March 1, 2007; 21(5): 483 - 496.
[Abstract] [Full Text] [PDF]

C. M. Grimsley, M. Lu, L. B. Haney, J. M. Kinchen, and K. S. Ravichandran
Characterization of a Novel Interaction between ELMO1 and ERM Proteins
J. Biol. Chem., March 3, 2006; 281(9): 5928 - 5937.
[Abstract] [Full Text] [PDF]

H. Katoh, K. Hiramoto, and M. Negishi
Activation of Rac1 by RhoG regulates cell migration
J. Cell Sci., January 1, 2006; 119(1): 56 - 65.
[Abstract] [Full Text] [PDF]

E. Dransart, A. Morin, J. Cherfils, and B. Olofsson
Uncoupling of Inhibitory and Shuttling Functions of Rho GDP Dissociation Inhibitors
J. Biol. Chem., February 11, 2005; 280(6): 4674 - 4683.
[Abstract] [Full Text] [PDF]

X. Xin, F. Ferraro, N. Back, B. A. Eipper, and R. E. Mains
Cdk5 and Trio modulate endocrine cell exocytosis
J. Cell Sci., September 15, 2004; 117(20): 4739 - 4748.
[Abstract] [Full Text] [PDF]

K. R. Skowronek, F. Guo, Y. Zheng, and N. Nassar
The C-terminal Basic Tail of RhoG Assists the Guanine Nucleotide Exchange Factor Trio in Binding to Phospholipids
J. Biol. Chem., September 3, 2004; 279(36): 37895 - 37907.
[Abstract] [Full Text] [PDF]

F. Causeret, M. Hidalgo-Sanchez, P. Fort, S. Backer, M.-R. Popoff, C. Gauthier-Rouviere, and E. Bloch-Gallego
Distinct roles of Rac1/Cdc42 and Rho/Rock for axon outgrowth and nucleokinesis of precerebellar neurons toward netrin 1
Development, June 15, 2004; 131(12): 2841 - 2852.
[Abstract] [Full Text] [PDF]

E. Vigorito, S. Bell, B. J. Hebeis, H. Reynolds, S. McAdam, P. C. Emson, A. McKenzie, and M. Turner
Immunological Function in Mice Lacking the Rac-Related GTPase RhoG
Mol. Cell. Biol., January 15, 2004; 24(2): 719 - 729.
[Abstract] [Full Text] [PDF]

R. M. Prieto-Sanchez and X. R. Bustelo
Structural Basis for the Signaling Specificity of RhoG and Rac1 GTPases
J. Biol. Chem., September 26, 2003; 278(39): 37916 - 37925.
[Abstract] [Full Text] [PDF]

A. K. Criss and J. E. Casanova
Coordinate Regulation of Salmonella enterica Serovar Typhimurium Invasion of Epithelial Cells by the Arp2/3 Complex and Rho GTPases
Infect. Immun., May 1, 2003; 71(5): 2885 - 2891.
[Abstract] [Full Text] [PDF]

Q. G. Medley, E. G. Buchbinder, K. Tachibana, H. Ngo, C. Serra-Pages, and M. Streuli
Signaling between Focal Adhesion Kinase and Trio
J. Biol. Chem., April 4, 2003; 278(15): 13265 - 13270.
[Abstract] [Full Text] [PDF]

K. Wennerberg, S. M. Ellerbroek, R.-Y. Liu, A. E. Karnoub, K. Burridge, and C. J. Der
RhoG Signals in Parallel with Rac1 and Cdc42
J. Biol. Chem., November 27, 2002; 277(49): 47810 - 47817.
[Abstract] [Full Text] [PDF]

K. Hattula, J. Furuhjelm, A. Arffman, and J. Peranen
A Rab8-specific GDP/GTP Exchange Factor Is Involved in Actin Remodeling and Polarized Membrane Transport
Mol. Biol. Cell, September 1, 2002; 13(9): 3268 - 3280.
[Abstract] [Full Text] [PDF]

F. Rashid-Doubell, I. McKinnell, A. R. Aricescu, G. Sajnani, and A. Stoker
Chick PTPsigma Regulates the Targeting of Retinal Axons within the Optic Tectum
J. Neurosci., June 15, 2002; 22(12): 5024 - 5033.
[Abstract] [Full Text] [PDF]

E. Vignal, A. Blangy, M. Martin, C. Gauthier-Rouviere, and P. Fort
Kinectin Is a Key Effector of RhoG Microtubule-Dependent Cellular Activity
Mol. Cell. Biol., December 1, 2001; 21(23): 8022 - 8034.
[Abstract] [Full Text] [PDF]

C.-G. Koh, E. Manser, Z.-S. Zhao, C.-P. Ng, and L. Lim
{beta}1PIX, the PAK-interacting exchange factor, requires localization via a coiled-coil region to promote microvillus-like structures and membrane ruffles
J. Cell Sci., January 12, 2001; 114(23): 4239 - 4251.
[Abstract] [Full Text] [PDF]

T. Wittmann and C. M. Waterman-Storer
Cell motility: can Rho GTPases and microtubules point the way?
J. Cell Sci., January 11, 2001; 114(21): 3795 - 3803.
[Abstract] [Full Text] [PDF]

J. Bateman and D. Van Vactor
The Trio family of guanine-nucleotide-exchange factors: regulators of axon guidance
J. Cell Sci., January 6, 2001; 114(11): 1973 - 1980.
[Abstract] [Full Text] [PDF]

K Seipel, S. O'Brien, E Iannotti, Q. Medley, and M Streuli
Tara, a novel F-actin binding protein, associates with the Trio guanine nucleotide exchange factor and regulates actin cytoskeletal organization
J. Cell Sci., January 1, 2001; 114(2): 389 - 399.
[Abstract] [PDF]

S. P. O'Brien, K. Seipel, Q. G. Medley, R. Bronson, R. Segal, and M. Streuli
Skeletal muscle deformity and neuronal disorder in Trio exchange factor-deficient mouse embryos
PNAS, October 24, 2000; 97(22): 12074 - 12078.
[Abstract] [Full Text] [PDF]

H. Katoh, H. Yasui, Y. Yamaguchi, J. Aoki, H. Fujita, K. Mori, and M. Negishi
Small GTPase RhoG Is a Key Regulator for Neurite Outgrowth in PC12 Cells
Mol. Cell. Biol., October 1, 2000; 20(19): 7378 - 7387.
[Abstract] [Full Text]

E. Vignal, M. De Toledo, F. Comunale, A. Ladopoulou, C. Gauthier-Rouviere, A. Blangy, and P. Fort
Characterization of TCL, a New GTPase of the Rho Family related to TC10 and Cdc42
J. Biol. Chem., November 10, 2000; 275(46): 36457 - 36464.
[Abstract] [Full Text] [PDF]

Q. G. Medley, C. Serra-Pages, E. Iannotti, K. Seipel, M. Tang, S. P. O'Brien, and M. Streuli
The Trio Guanine Nucleotide Exchange Factor Is a RhoA Target. BINDING OF RhoA TO THE TRIO IMMUNOGLOBULIN-LIKE DOMAIN
J. Biol. Chem., November 10, 2000; 275(46): 36116 - 36123.
[Abstract] [Full Text] [PDF]

S. Taya, N. Inagaki, H. Sengiku, H. Makino, A. Iwamatsu, I. Urakawa, K. Nagao, S. Kataoka, and K. Kaibuchi
Direct interaction of insulin-like growth factor-1 receptor with leukemia-associated RhoGEF
J. Cell Biol., November 26, 2001; 155(5): 809 - 820.
[Abstract] [Full Text] [PDF]

Q. Wei and R. S. Adelstein
Pitx2a Expression Alters Actin-Myosin Cytoskeleton and Migration of HeLa Cells through Rho GTPase Signaling
Mol. Biol. Cell, February 1, 2002; 13(2): 683 - 697.
[Abstract] [Full Text] [PDF]

This Article

Summary

Full Text (PDF)

Alert me when this article is cited

Alert me if a correction is posted

Services

Email this article to a friend

Similar articles in this journal

Similar articles in PubMed

Alert me to new issues of the journal

Download to citation manager

Citing Articles

Citing Articles via HighWire

Citing Articles via Google Scholar

Google Scholar

Articles by Blangy, A.

Articles by Fort, P.

Search for Related Content

PubMed

PubMed Citation

Articles by Blangy, A.

Articles by Fort, P.

				A. Briancon-Marjollet, A. Ghogha, H. Nawabi, I. Triki, C. Auziol, S. Fromont, C. Piche, H. Enslen, K. Chebli, J.-F. Cloutier, et al. Trio Mediates Netrin-1-Induced Rac1 Activation in Axon Outgrowth and Guidance Mol. Cell. Biol., April 1, 2008; 28(7): 2314 - 2323. [Abstract] [Full Text] [PDF]

				R. D'Angelo, S. Aresta, A. Blangy, L. Del Maestro, D. Louvard, and M. Arpin Interaction of Ezrin with the Novel Guanine Nucleotide Exchange Factor PLEKHG6 Promotes RhoG-dependent Apical Cytoskeleton Rearrangements in Epithelial Cells Mol. Biol. Cell, December 1, 2007; 18(12): 4780 - 4793. [Abstract] [Full Text] [PDF]

				F. Ferraro, X.-M. Ma, J. A. Sobota, B. A. Eipper, and R. E. Mains Kalirin/Trio Rho Guanine Nucleotide Exchange Factors Regulate a Novel Step in Secretory Granule Maturation Mol. Biol. Cell, December 1, 2007; 18(12): 4813 - 4825. [Abstract] [Full Text] [PDF]

				S. Charrasse, F. Comunale, M. Fortier, E. Portales-Casamar, A. Debant, and C. Gauthier-Rouviere M-Cadherin Activates Rac1 GTPase through the Rho-GEF Trio during Myoblast Fusion Mol. Biol. Cell, May 1, 2007; 18(5): 1734 - 1743. [Abstract] [Full Text] [PDF]

				S. E. Siegrist and C. Q. Doe Microtubule-induced cortical cell polarity Genes & Dev., March 1, 2007; 21(5): 483 - 496. [Abstract] [Full Text] [PDF]

				C. M. Grimsley, M. Lu, L. B. Haney, J. M. Kinchen, and K. S. Ravichandran Characterization of a Novel Interaction between ELMO1 and ERM Proteins J. Biol. Chem., March 3, 2006; 281(9): 5928 - 5937. [Abstract] [Full Text] [PDF]

				H. Katoh, K. Hiramoto, and M. Negishi Activation of Rac1 by RhoG regulates cell migration J. Cell Sci., January 1, 2006; 119(1): 56 - 65. [Abstract] [Full Text] [PDF]

				E. Dransart, A. Morin, J. Cherfils, and B. Olofsson Uncoupling of Inhibitory and Shuttling Functions of Rho GDP Dissociation Inhibitors J. Biol. Chem., February 11, 2005; 280(6): 4674 - 4683. [Abstract] [Full Text] [PDF]

				X. Xin, F. Ferraro, N. Back, B. A. Eipper, and R. E. Mains Cdk5 and Trio modulate endocrine cell exocytosis J. Cell Sci., September 15, 2004; 117(20): 4739 - 4748. [Abstract] [Full Text] [PDF]

				K. R. Skowronek, F. Guo, Y. Zheng, and N. Nassar The C-terminal Basic Tail of RhoG Assists the Guanine Nucleotide Exchange Factor Trio in Binding to Phospholipids J. Biol. Chem., September 3, 2004; 279(36): 37895 - 37907. [Abstract] [Full Text] [PDF]

				F. Causeret, M. Hidalgo-Sanchez, P. Fort, S. Backer, M.-R. Popoff, C. Gauthier-Rouviere, and E. Bloch-Gallego Distinct roles of Rac1/Cdc42 and Rho/Rock for axon outgrowth and nucleokinesis of precerebellar neurons toward netrin 1 Development, June 15, 2004; 131(12): 2841 - 2852. [Abstract] [Full Text] [PDF]

				E. Vigorito, S. Bell, B. J. Hebeis, H. Reynolds, S. McAdam, P. C. Emson, A. McKenzie, and M. Turner Immunological Function in Mice Lacking the Rac-Related GTPase RhoG Mol. Cell. Biol., January 15, 2004; 24(2): 719 - 729. [Abstract] [Full Text] [PDF]

				R. M. Prieto-Sanchez and X. R. Bustelo Structural Basis for the Signaling Specificity of RhoG and Rac1 GTPases J. Biol. Chem., September 26, 2003; 278(39): 37916 - 37925. [Abstract] [Full Text] [PDF]

				A. K. Criss and J. E. Casanova Coordinate Regulation of Salmonella enterica Serovar Typhimurium Invasion of Epithelial Cells by the Arp2/3 Complex and Rho GTPases Infect. Immun., May 1, 2003; 71(5): 2885 - 2891. [Abstract] [Full Text] [PDF]

				Q. G. Medley, E. G. Buchbinder, K. Tachibana, H. Ngo, C. Serra-Pages, and M. Streuli Signaling between Focal Adhesion Kinase and Trio J. Biol. Chem., April 4, 2003; 278(15): 13265 - 13270. [Abstract] [Full Text] [PDF]

				K. Wennerberg, S. M. Ellerbroek, R.-Y. Liu, A. E. Karnoub, K. Burridge, and C. J. Der RhoG Signals in Parallel with Rac1 and Cdc42 J. Biol. Chem., November 27, 2002; 277(49): 47810 - 47817. [Abstract] [Full Text] [PDF]

				K. Hattula, J. Furuhjelm, A. Arffman, and J. Peranen A Rab8-specific GDP/GTP Exchange Factor Is Involved in Actin Remodeling and Polarized Membrane Transport Mol. Biol. Cell, September 1, 2002; 13(9): 3268 - 3280. [Abstract] [Full Text] [PDF]

				F. Rashid-Doubell, I. McKinnell, A. R. Aricescu, G. Sajnani, and A. Stoker Chick PTPsigma Regulates the Targeting of Retinal Axons within the Optic Tectum J. Neurosci., June 15, 2002; 22(12): 5024 - 5033. [Abstract] [Full Text] [PDF]

				E. Vignal, A. Blangy, M. Martin, C. Gauthier-Rouviere, and P. Fort Kinectin Is a Key Effector of RhoG Microtubule-Dependent Cellular Activity Mol. Cell. Biol., December 1, 2001; 21(23): 8022 - 8034. [Abstract] [Full Text] [PDF]

				C.-G. Koh, E. Manser, Z.-S. Zhao, C.-P. Ng, and L. Lim {beta}1PIX, the PAK-interacting exchange factor, requires localization via a coiled-coil region to promote microvillus-like structures and membrane ruffles J. Cell Sci., January 12, 2001; 114(23): 4239 - 4251. [Abstract] [Full Text] [PDF]

				T. Wittmann and C. M. Waterman-Storer Cell motility: can Rho GTPases and microtubules point the way? J. Cell Sci., January 11, 2001; 114(21): 3795 - 3803. [Abstract] [Full Text] [PDF]

				J. Bateman and D. Van Vactor The Trio family of guanine-nucleotide-exchange factors: regulators of axon guidance J. Cell Sci., January 6, 2001; 114(11): 1973 - 1980. [Abstract] [Full Text] [PDF]

				K Seipel, S. O'Brien, E Iannotti, Q. Medley, and M Streuli Tara, a novel F-actin binding protein, associates with the Trio guanine nucleotide exchange factor and regulates actin cytoskeletal organization J. Cell Sci., January 1, 2001; 114(2): 389 - 399. [Abstract] [PDF]

				S. P. O'Brien, K. Seipel, Q. G. Medley, R. Bronson, R. Segal, and M. Streuli Skeletal muscle deformity and neuronal disorder in Trio exchange factor-deficient mouse embryos PNAS, October 24, 2000; 97(22): 12074 - 12078. [Abstract] [Full Text] [PDF]

				H. Katoh, H. Yasui, Y. Yamaguchi, J. Aoki, H. Fujita, K. Mori, and M. Negishi Small GTPase RhoG Is a Key Regulator for Neurite Outgrowth in PC12 Cells Mol. Cell. Biol., October 1, 2000; 20(19): 7378 - 7387. [Abstract] [Full Text]

				E. Vignal, M. De Toledo, F. Comunale, A. Ladopoulou, C. Gauthier-Rouviere, A. Blangy, and P. Fort Characterization of TCL, a New GTPase of the Rho Family related to TC10 and Cdc42 J. Biol. Chem., November 10, 2000; 275(46): 36457 - 36464. [Abstract] [Full Text] [PDF]

				Q. G. Medley, C. Serra-Pages, E. Iannotti, K. Seipel, M. Tang, S. P. O'Brien, and M. Streuli The Trio Guanine Nucleotide Exchange Factor Is a RhoA Target. BINDING OF RhoA TO THE TRIO IMMUNOGLOBULIN-LIKE DOMAIN J. Biol. Chem., November 10, 2000; 275(46): 36116 - 36123. [Abstract] [Full Text] [PDF]

				S. Taya, N. Inagaki, H. Sengiku, H. Makino, A. Iwamatsu, I. Urakawa, K. Nagao, S. Kataoka, and K. Kaibuchi Direct interaction of insulin-like growth factor-1 receptor with leukemia-associated RhoGEF J. Cell Biol., November 26, 2001; 155(5): 809 - 820. [Abstract] [Full Text] [PDF]

				Q. Wei and R. S. Adelstein Pitx2a Expression Alters Actin-Myosin Cytoskeleton and Migration of HeLa Cells through Rho GTPase Signaling Mol. Biol. Cell, February 1, 2002; 13(2): 683 - 697. [Abstract] [Full Text] [PDF]