Normal membrane localization and actin association of the NF2 tumor suppressor protein are dependent on folding of its N-terminal domain

QUICK SEARCH:

[advanced]

	Author:		Keyword(s):

Home Help Feedback Subscriptions Archive Search Table of Contents

This Article

	Summary
	Full Text (PDF)
	Alert me when this article is cited
	Alert me if a correction is posted

Services

	Email this article to a friend
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new issues of the journal
	Download to citation manager


Citing Articles

	Citing Articles via HighWire
	Citing Articles via Google Scholar

Google Scholar

	Articles by Brault, E.
	Articles by Goutebroze, L.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Brault, E.
	Articles by Goutebroze, L.


Social Bookmarking

	What's this?

Algrain, M., Turunen, O., Vaheri, A., Louvard, D. and Arpin, M (1993). Ezrin contains cytoskeleton and membrane binding domains accounting for its proposed role as a membrane-cytoskeletal linker. J. Cell Biol 120, 129-139.[Abstract/Free Full Text]

Arakawa, H., Hayashi, N., Nagase, H., Ogawa, M. and Nakamura, Y (1994). Alternative splicing of the NF2 gene and its mutation analysis of breast and colorectal cancers. Hum. Mol. Genet 3, 565-568.[Abstract/Free Full Text]

Berryman, M., Franck, Z. and Bretscher, A (1993). Ezrin is concentrated in the apical microvilli of a wide variety of epithelial cells whereas moesin is found primarily in endothelial cells. J. Cell Sci 105, 1025-1043.[Abstract]

Bianchi, A. B., Hara, T., Ramesh, V., Gao, J., Klein-Szanto, A. J. P., Morin, F., Menon, A. G., Trofatter, J. A., Gusella, J. F., Seizinger, B. R. et al. ( (1994). Mutations in transcript isoforms of the neurofibromatosis 2 gene in multiple human tumour types. Nat. Genet 6, 185-192.[Medline]

Bretscher, A (1999). Regulation of cortical structure by the ezrin-radixin-moesin protein family. Curr. Opin. Cell Biol 11, 109-116.[Medline]

Chishti, A. H., Kim, A. C., Marfatia, S. M., Lutchman, M., Hanspal, M., Jindal, H., Liu, S. C., Low, P. S., Rouleau, G. A., Mohandas, N. et al. ( (1998). The FERM domain: a unique module involved in the linkage of cytoplasmic proteins to the membrane. Trends Biochem. Sci 23, 281-282.[Medline]

Deguen, B., Merel, P., Goutebroze, L., Giovannini, M., Reggio, H., Arpin, M. and Thomas, G (1998). Impaired interaction of naturally occurring mutant NF2 protein with actin-based cytoskeleton and membrane. Hum. Mol. Genet 7, 217-226.[Abstract/Free Full Text]

den Bakker, M. A., Riegman, P. H. J., Arnold, R., Hekman, C. P., Boersma, W., Janssen, P. J. A., van der Kwast, T. H. and Zwarthoff, E. C (1995). The product of the NF2 tumor suppressor gene localizes near the plasma membrane and is highly expressed in muscle cells. Oncogene, 10, 757-763.[Medline]

Evans, D. G., Huson, S. M., Donnai, D., Neary, W., Blair, V., Newton, V. and Harris, R (1992). A clinical study of type 2 neurofibromatosis. Q. J. Med 84, 603-618.[Abstract/Free Full Text]

Franck, Z., Gary, R. and Bretscher, A (1993). Moesin, like ezrin, colocalizes with actin in the cortical cytoskeleton in cultured cells, but its expression is more variable. J. Cell Sci 105, 219-231.[Abstract]

Girault, J. A., Labesse, G., Mornon, J. P. and Callebaut, I (1998). Januskinases and focal adhesion kinases play in the 4.1 band: a superfamily of band 4.1 domains important for cell structure and signal transduction. Mol. Med 4, 751-769.[Medline]

Girault, J. A., Labesse, G., Mornon, J. P. and Callebaut, I (1999). The N-termini of FAK and JAKs contain divergent band 4.1 domains. Trends Biochem. Sci 24, 54-57.[Medline]

Gonzalez-Agosti, C., Xu, L., Pinney, D., Beauchamp, R., Hobbs, W., Gusella, J. and Ramesh, V (1996). The merlin tumor suppressor localizes preferentially in membrane ruffles. Oncogene, 13, 1239-1247.[Medline]

Gonzalez-Agosti, C., Wiederhold, T., Herndon, M. E., Gusella, J. and Ramesh, V (1999). Interdomain interaction of merlin isoforms and its influence on intermolecular binding to NHE-RF. J. Biol. Chem 274, 34438-34442.[Abstract/Free Full Text]

Goutebroze, L., Brault, E., Muchardt, C., Camonis, J. and Thomas, G (2000). Cloning and characterization of SCHIP-1, a novel protein interacting specifically with spliced isoforms and naturally occurring mutant NF2 proteins. Mol. Cell. Biol 20, 1699-1712.[Abstract/Free Full Text]

Guex, N., Diemand, A. and Peitsch, M. C (1999). Protein modelling for all. Trends Biochem. Sci 24, 364-367.[Medline]

Gutmann, D. H., Geist, R. T., Xu, H.-M., Kim, J. S. and Saporito-Irwin, S (1998). Defects in neurofibromatosis 2 protein function can arise at multiple levels. Hum. Mol. Genet 7, 335-345.[Abstract/Free Full Text]

Gutmann, D. H., Haipek, C. A. and Hoang Lu, K (1999). Neurofibromatosis 2 tumor suppressor protein, merlin, forms two functionally important intramolecular associations. J. Neurosci. Res 58, 706-716.[Medline]

Hamada, K., Shimizu, T., Matsui, T., Tsukita, S. and Hakoshima, T (2000). Structural basis of the membrane-targeting and unmasking mechanisms of the radixin FERM domain. EMBO J 19, 4449-4462.[Medline]

Heiska, L., Alfthan, K., Gronholm, M., Vilja, P., Vaheri, A. and Carpen, O (1998). Association of ezrin with intercellular adhesion molecule-1 and-2 (ICAM-1 and ICAM-2). Regulation by phosphatidylinositol 4, 5-bisphosphate. J. Biol. Chem 273, 21893-21900.[Abstract/Free Full Text]

Hirao, M., Sato, N., Kondo, T., Yonemura, S., Monden, M., Sasaki, T., Takai, Y., Tsukita, S. and Tsukita, S (1996). Regulation mechanism of ERM (ezrin/radixin/moesin) protein/plasma membrane association: possible involvement of phosphatidylinositol turnover and Rho-dependent signaling pathway. J. Cell Biol 135, 37-51.[Abstract/Free Full Text]

Huang, L., Ichimaru, E., Pestonjamasp, K., Cui, X., Nakamura, H., Lo, G. Y., Lin, F. I., Luna, E. J. and Furthmayr, H (1998). Merlin differs from moesin in binding to F-actin and in its intra-and intermolecular interactions. Biochem. Biophys. Res. Commun 248, 548-553.[Medline]

Koga, H., Araki, N., Takeshima, H., Nishi, T., Hirota, T., Kimura, Y., Nakao, M. and Saya, H (1998). Impairment of cell adhesion by expression of the mutant neurofibromatosis type 2 (NF2) genes which lack exons in the ERM-homology domain. Oncogene, 17, 801-810.[Medline]

Martin, M., Roy, C., Montcourrier, P., Sahuquet, A. and Mangeat, P (1997). Three determinants in ezrin are responsible for cell extension activity. Mol. Biol. Cell 8, 1543-1557.[Abstract]

Matsui, T., Maeda, M., Doi, Y., Yonemura, S., Amano, M., Kaibuchi, K., Tsukita, S. and Tsukita, S (1998). Rho-kinase phosphorylates COOH-terminal threonines of ezrin/radixin/moesin (ERM) proteins and regulates their head-to-tail association. J. Cell Biol 140, 647-657.[Abstract/Free Full Text]

Murthy, A., Gonzalez-Agosti, C., Cordero, E., Pinney, D., Candia, C., Solomon, F., Gusella, J. and Ramesh, V (1998). NHE-RF, a regulatory cofactor for Na-H exchange, is a common interactor for merlin and ERM (MERM) proteins. J. Biol. Chem 273, 1273-1276.[Abstract/Free Full Text]

Nishi, T., Takeshima, H., Hamada, K., Yoshizato, K., Koga, H., Sato, K., Yamamoto, K., Kitamura, I., Kochi, M., Kuratsu, J.-I. et al. ( (1997). Neurofibromatosis 2 gene has novel alternative splicings which controls intracellular protein binding. Int. J. Onc 10, 1025-1029.

Pearson, M. A., Reczek, D., Bretscher, A. and Karplus, P. A (2000). Structure of the ERM protein moesin reveals the FERM domain fold masked by an extended actin binding tail domain. Cell, 101, 259-270.[Medline]

Pestonjamasp, K., Amieva, M. R., Strassel, C. P., Nauseef, W. M., Furthmayr, H. and Luna, E. J (1995). Moesin, ezrin, and p205 are actin-binding proteins associated with neutrophil plasma membranes. Mol. Biol. Cell 6, 247-259.[Abstract]

Pykett, M. J., Murphy, M., Harnish, P. R. and George, D. L (1994). The neurofibromatosis 2 (NF2) tumor suppressor gene encodes multiple alternatively spliced transcripts. Hum. Mol. Genet 3, 559-564.[Abstract/Free Full Text]

Rouleau, G. A., Merel, P., Lutchman, M., Sanson, M., Zucman, J.,Marineau, C., Hoang-Xuan, K., Demczuk, S., Desmaze, C., Plougastel, B. et al. ( (1993). Alteration in a new gene encoding a putative membrane-organizing protein causes neurofibromatosis type 2. Nature, 363, 515-521.[Medline]

Roy, C., Martin, M. and Mangeat, P (1997). A dual involvement of the amino-terminal domain of ezrin in F-and G-actin binding. J. Biol. Chem 272, 20088-20095.[Abstract/Free Full Text]

Sainio, M., Zhao, F., Heiska, L., Turunen, O., den Bakker, M., Zwarthoff, E., Lutchman, M., Rouleau, G. A., J\212\212skel\212inen, J., Vaheri, A. et al. ( (1997). Neurofibromatosis 2 tumor suppressor protein colocalizes with ezrin and CD44 and associates with actin-containing cytoskeleton. J. Cell Sci 110, 2249-2260.[Abstract]

Sato, N., Funayama, N., Nagafuchi, A., Yonemura, S., Tsukita, S. and Tsukita, S (1992). A gene family consisting of ezrin, radixin and moesin. Its specific localization at actin filament/plasma membrane association sites. J. Cell Sci 103, 131-143.[Abstract/Free Full Text]

Scoles, D. R., Huynh, D. P., Morcos, P. A., Coulsell, E. R., Robinson, N. G. G., Tamanoi, F. and Pulst, S. M (1998). Neurofibromatosis 2 tumour suppressor schwannomin interacts withII-spectrin. Nat. Genet 18, 354-359.[Medline]

Shaw, R. J., McClatchey, A. I. and Jacks, T (1998). Localization and functional domains of the neurofibromatosis type II tumor suppressor, merlin. Cell Growth Differ 9, 287-296.[Abstract]

Sherman, L., Xu, H.-M., Geist, R. T., Saporo-Irwin, S., Howells, N., Ponta,H., Herrlich, P. and Gutmann, D. H (1997). Interdomain binding mediates tumor growth suppression by the NF2 gene product. Oncogene, 15, 2505-2509.[Medline]

Takeshima, H., Izawa, I., Lee, P. S., Safdar, N., Levin, V. A. and Saya, H (1994). Detection of cellular proteins that interact with the NF2 tumor suppressor gene product. Oncogene, 9, 2135-2144.[Medline]

Takeuchi, K., Sato, N., Kasahara, H., Funayama, N., Nagafuchi, A., Yonemura, S., Tsukita, S. and Tsukita, S (1994). Perturbation of cell adhesion and microvilli formation by antisense oligonucleotides to ERM family members. J. Cell Biol 125, 1371-1384.[Abstract/Free Full Text]

Trofatter, J. A., MacCollin, M. M., Rutter, J. L., Murrell, J. R., Duyao, M. P., Parry, D. M., Eldridge, R., Kley, N., Menon, A. G., Pulaski, K. et al. ( (1993). A novel moesin-, ezrin-, radixin-like gene is a candidate for the neurofibromatosis 2 tumor suppressor. Cell, 72, 791-800.[Medline]

Turunen, O., Wahlstr\232m, T. and Vaheri, A (1994). Ezrin has a COOH-terminal actin-binding site that is conserved in the ezrin protein family. J. Cell Biol 126, 1445-1453.[Abstract/Free Full Text]

Turunen, O., Sainio, M., J\212\212skel\212inen, J., Carpen, O. and Vaheri, A (1998). Structure-function relationships in the ezrin family and the effect of tumor-associated point mutations in neurofibromatosis 2 protein. Biochim. Biophys. Acta, 1387, 1-16.[Medline]

Xu, H. M. and Gutmann, D. H (1998). Merlin differentially associates with the microtubule and actin cytoskeleton. J. Neurosci. Res 51, 403-415.[Medline]

CiteULike

Complore

Connotea

Del.icio.us Add to Digg

Digg

Technorati

Twitter What's this?

This article has been cited by other articles:

D. Lallemand, A. L. Saint-Amaux, and M. Giovannini
Tumor-suppression functions of merlin are independent of its role as an organizer of the actin cytoskeleton in Schwann cells
J. Cell Sci., November 15, 2009; 122(22): 4141 - 4149.
[Abstract] [Full Text] [PDF]

B. K. Cole, M. Curto, A. W. Chan, and A. I. McClatchey
Localization to the Cortical Cytoskeleton Is Necessary for Nf2/Merlin-Dependent Epidermal Growth Factor Receptor Silencing
Mol. Cell. Biol., February 15, 2008; 28(4): 1274 - 1284.
[Abstract] [Full Text] [PDF]

H. Lee, D. Kim, H. C. Dan, E. L. Wu, T. M. Gritsko, C. Cao, S. V. Nicosia, E. A. Golemis, W. Liu, D. Coppola, et al.
Identification and Characterization of Putative Tumor Suppressor NGB, a GTP-Binding Protein That Interacts with the Neurofibromatosis 2 Protein
Mol. Cell. Biol., March 15, 2007; 27(6): 2103 - 2119.
[Abstract] [Full Text] [PDF]

A. I. McClatchey and M. Giovannini
Membrane organization and tumorigenesis--the NF2 tumor suppressor, Merlin
Genes & Dev., October 1, 2005; 19(19): 2265 - 2277.
[Abstract] [Full Text] [PDF]

N. Manchanda, A. Lyubimova, H.-Y. H. Ho, M. F. James, J. F. Gusella, N. Ramesh, S. B. Snapper, and V. Ramesh
The NF2 Tumor Suppressor Merlin and the ERM Proteins Interact with N-WASP and Regulate Its Actin Polymerization Function
J. Biol. Chem., April 1, 2005; 280(13): 12517 - 12522.
[Abstract] [Full Text] [PDF]

A. Gautreau, B. T. Fievet, E. Brault, C. Antony, A. Houdusse, D. Louvard, and M. Arpin
Isolation and Characterization of an Aggresome Determinant in the NF2 Tumor Suppressor
J. Biol. Chem., February 14, 2003; 278(8): 6235 - 6242.
[Abstract] [Full Text] [PDF]

C.-X. Sun, C. Haipek, D. R. Scoles, S. M. Pulst, M. Giovannini, M. Komada, and D. H. Gutmann
Functional analysis of the relationship between the neurofibromatosis 2 tumor suppressor and its binding partner, hepatocyte growth factor-regulated tyrosine kinase substrate
Hum. Mol. Genet., December 1, 2002; 11(25): 3167 - 3178.
[Abstract] [Full Text] [PDF]

C.-X. Sun, V. A. Robb, and D. H. Gutmann
Protein 4.1 tumor suppressors: getting a FERM grip on growth regulation
J. Cell Sci., November 1, 2002; 115(21): 3991 - 4000.
[Abstract] [Full Text] [PDF]

M. Kressel and B. Schmucker
Nucleocytoplasmic transfer of the NF2 tumor suppressor protein merlin is regulated by exon 2 and a CRM1-dependent nuclear export signal in exon 15
Hum. Mol. Genet., September 15, 2002; 11(19): 2269 - 2278.
[Abstract] [Full Text] [PDF]

A. Gautreau, J. Manent, B. Fievet, D. Louvard, M. Giovannini, and M. Arpin
Mutant Products of the NF2 Tumor Suppressor Gene Are Degraded by the Ubiquitin-Proteasome Pathway
J. Biol. Chem., August 23, 2002; 277(35): 31279 - 31282.
[Abstract] [Full Text] [PDF]

T. Shimizu, A. Seto, N. Maita, K. Hamada, S. Tsukita, S. Tsukita, and T. Hakoshima
Structural Basis for Neurofibromatosis Type 2. CRYSTAL STRUCTURE OF THE MERLIN FERM DOMAIN
J. Biol. Chem., March 15, 2002; 277(12): 10332 - 10336.
[Abstract] [Full Text] [PDF]

M. Jannatipour, P. Dion, S. Khan, H. Jindal, X. Fan, J. Laganiere, A. H. Chishti, and G. A. Rouleau
Schwannomin Isoform-1 Interacts with Syntenin via PDZ Domains
J. Biol. Chem., August 24, 2001; 276(35): 33093 - 33100.
[Abstract] [Full Text] [PDF]

This Article

Summary

Full Text (PDF)

Alert me when this article is cited

Alert me if a correction is posted

Services

Email this article to a friend

Similar articles in this journal

Similar articles in PubMed

Alert me to new issues of the journal

Download to citation manager

Citing Articles

Citing Articles via HighWire

Citing Articles via Google Scholar

Google Scholar

Articles by Brault, E.

Articles by Goutebroze, L.

Search for Related Content

PubMed

PubMed Citation

Articles by Brault, E.

Articles by Goutebroze, L.

Social Bookmarking

What's this?

				B. K. Cole, M. Curto, A. W. Chan, and A. I. McClatchey Localization to the Cortical Cytoskeleton Is Necessary for Nf2/Merlin-Dependent Epidermal Growth Factor Receptor Silencing Mol. Cell. Biol., February 15, 2008; 28(4): 1274 - 1284. [Abstract] [Full Text] [PDF]

				H. Lee, D. Kim, H. C. Dan, E. L. Wu, T. M. Gritsko, C. Cao, S. V. Nicosia, E. A. Golemis, W. Liu, D. Coppola, et al. Identification and Characterization of Putative Tumor Suppressor NGB, a GTP-Binding Protein That Interacts with the Neurofibromatosis 2 Protein Mol. Cell. Biol., March 15, 2007; 27(6): 2103 - 2119. [Abstract] [Full Text] [PDF]

				A. I. McClatchey and M. Giovannini Membrane organization and tumorigenesis--the NF2 tumor suppressor, Merlin Genes & Dev., October 1, 2005; 19(19): 2265 - 2277. [Abstract] [Full Text] [PDF]

				N. Manchanda, A. Lyubimova, H.-Y. H. Ho, M. F. James, J. F. Gusella, N. Ramesh, S. B. Snapper, and V. Ramesh The NF2 Tumor Suppressor Merlin and the ERM Proteins Interact with N-WASP and Regulate Its Actin Polymerization Function J. Biol. Chem., April 1, 2005; 280(13): 12517 - 12522. [Abstract] [Full Text] [PDF]

				A. Gautreau, B. T. Fievet, E. Brault, C. Antony, A. Houdusse, D. Louvard, and M. Arpin Isolation and Characterization of an Aggresome Determinant in the NF2 Tumor Suppressor J. Biol. Chem., February 14, 2003; 278(8): 6235 - 6242. [Abstract] [Full Text] [PDF]

				C.-X. Sun, C. Haipek, D. R. Scoles, S. M. Pulst, M. Giovannini, M. Komada, and D. H. Gutmann Functional analysis of the relationship between the neurofibromatosis 2 tumor suppressor and its binding partner, hepatocyte growth factor-regulated tyrosine kinase substrate Hum. Mol. Genet., December 1, 2002; 11(25): 3167 - 3178. [Abstract] [Full Text] [PDF]

				C.-X. Sun, V. A. Robb, and D. H. Gutmann Protein 4.1 tumor suppressors: getting a FERM grip on growth regulation J. Cell Sci., November 1, 2002; 115(21): 3991 - 4000. [Abstract] [Full Text] [PDF]

				M. Kressel and B. Schmucker Nucleocytoplasmic transfer of the NF2 tumor suppressor protein merlin is regulated by exon 2 and a CRM1-dependent nuclear export signal in exon 15 Hum. Mol. Genet., September 15, 2002; 11(19): 2269 - 2278. [Abstract] [Full Text] [PDF]

				A. Gautreau, J. Manent, B. Fievet, D. Louvard, M. Giovannini, and M. Arpin Mutant Products of the NF2 Tumor Suppressor Gene Are Degraded by the Ubiquitin-Proteasome Pathway J. Biol. Chem., August 23, 2002; 277(35): 31279 - 31282. [Abstract] [Full Text] [PDF]

				T. Shimizu, A. Seto, N. Maita, K. Hamada, S. Tsukita, S. Tsukita, and T. Hakoshima Structural Basis for Neurofibromatosis Type 2. CRYSTAL STRUCTURE OF THE MERLIN FERM DOMAIN J. Biol. Chem., March 15, 2002; 277(12): 10332 - 10336. [Abstract] [Full Text] [PDF]

				M. Jannatipour, P. Dion, S. Khan, H. Jindal, X. Fan, J. Laganiere, A. H. Chishti, and G. A. Rouleau Schwannomin Isoform-1 Interacts with Syntenin via PDZ Domains J. Biol. Chem., August 24, 2001; 276(35): 33093 - 33100. [Abstract] [Full Text] [PDF]