Hairless is translocated to the nucleus via a novel bipartite nuclear localization signal and is associated with the nuclear matrix

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Ahmad, W., Faiyaz ul Haque, M., Brancolini, V., Tsou, H. C., ul Haque, S., Lam, H., Aita, V. M., Owen, J., deBlaquiere, M., Frank, J. et al (1998). Alopecia universalis associated with a mutation in the human hairless gene. Science 279, 720-724.[Abstract/Free Full Text]

Ahmad, W., Irvine, A. D., Lam, H., Buckley, C., Bingham, E. A., Panteleyev, A. A., Ahmad, M., McGrath, J. A. and Christiano, A. M (1998). A missense mutation in the zinc-finger domain of the human hairless gene underlies congenital atrichia in a family of Irish travellers. Am. J. Hum. Genet 63, 984-991.[Medline]

Ahmad, W., Panteleyev, A. A., Henson-Apollonio, V., Sundberg, J. P. and Christiano, A. M (1998). Molecular basis of a novel rhino (hr(rhChr)) phenotype: a nonsense mutation in the mouse hairless gene. Exp. Dermatol 7, 298-301.[Medline]

Ahmad, W., Nomura, K., McGrath, J. A., Hashimoto, I. and Christiano, A. M (1999). A homozygous nonsense mutation in the zinc-finger domain of the human hairless gene underlies congenital atrichia [letter]. J. Invest. Dermatol 113, 281-283.[Medline]

Ahmad, W., Zlotogorski, A., Panteleyev, A. A., Lam, H., Ahmad, M., ul Haque, M. F., Abdallah, H. M., Dragan, L. and Christiano, A. M (1999). Genomic organization of the human hairless gene (HR) and identification of a mutation underlying congenital atrichia in an Arab Palestinian family. Genomics 56, 141-148.[Medline]

Aita, V. M., Ahmad, W., Panteleyev, A. A., Kozlowska, U., Kozlowska, A., Gilliam, T. C., Jablonska, S. and Christiano, A. M (2000). A novel missense mutation (C622G) in the zinc-finger domain of the human hairless gene associated with congenital atrichia with papular lesions. Exp. Dermatol 9, 157-162.[Medline]

Arceci, R. J., King, A. A., Simon, M. C., Orkin, S. H. and Wilson, D. B (1993). Mouse GATA-4: a retinoic acid-inducible GATA-binding transcription factor expressed in endodermally derived tissues and heart. Mol. Cell Biol 13, 2235-2246.[Abstract/Free Full Text]

Bairoch, A. and Apweiler, R (1999). The SWISS-PROT protein sequence data bank and its supplement TrEMBL in 1999. Nucl. Acids Res 27, 49-54.[Abstract/Free Full Text]

Baker, S. J., Markowitz, S., Fearon, E. R., Willson, J. K. and Vogelstein, B (1990). Suppression of human colorectal carcinoma cell growth by wild-type p53. Science 249, 912-915.[Abstract/Free Full Text]

Barettino, D., Vivianco Ruiz, M. M. and Stunnenberg, H. G (1994). Characterization of the ligand-dependent transactivation domain of thyroid hormone receptor. EMBO J 13, 3039-3049.[Medline]

Barrett, T. J. and Spelsberg, T. C (1999). Nuclear matrix and steroid hormone action. Vitam. Horm 55, 127-163.[Medline]

Brooke, H. C (1926). Hairless mice. J. Hered 17, 173-174.[Free Full Text]

Brown, K (1999). Nuclear structure, gene expression and development. Crit. Rev. Eukaryot. Gene Expr 9, 203-212.[Medline]

Cachon-Gonzalez, M. B., Fenner, S., Coffin, J. M., Moran, C., Best, S. and Stoye, J. P (1994). Structure and expression of the hairless gene of mice. Proc. Nat. Acad. Sci. USA 91, 7717-7721.[Abstract/Free Full Text]

Cachon-Gonzalez, M. B., San-Jose, I., Cano, A., Vega, J. A., Garcia, N., Freeman, T., Schimmang, T. and Stoye, J. P (1999). The hairless gene of the mouse: relationship of phenotypic effects with expression profile and genotype. Dev. Dynam 216, 113-126.[Medline]

Damste, J. and Prakken, J. R (1954). Atrichia with papular lesions: a variant of congenital ectodermal dysplasias. Dermatologica 108, 114-117.[Medline]

Danielian, P. S., White, R., Lees, J. A. and Parker, M. G (1992). Identification of a conserved region required for hormone dependent transcriptional activation by streroid hormone receptors. EMBO J 11, 1025-1033.[Medline]

Darimont, B. D., Wagner, R. L., Apriletti, J. W., Stallcup, M. R., Kushner, P. J., Baxter, J. D., Fletterick, R. J. and Yamamoto, K. R (1998). Structure and specificity of nuclear receptor-coactivator interactions. Genes Dev 12, 3343-3356.[Abstract/Free Full Text]

Dingwall, C. and Laskey, R. A (1991). Nuclear targeting sequences \320 a consensus?. Trends Biochem. Sci 16, 478-481.[Medline]

Djabali, K., Portier, M.-M., Gros, F., Blobel, G. and Georgatos, S. D (1991). Network antibodies identify nuclear lamin B as a physiological attachment site for peripherin intermediate filaments. Cell 64, 109-121.[Medline]

Durand, B., Saunders, M., Gaudon, C., Roy, B., Losson, R. and Chambon, P (1994). Activation function 2 (AF-2) of retinoic acid receptor and 9-cis retinoic acid receptor: presence of a conserved autonomous constitutive activating domain and influence of the nature of the response element on AF-2 activity. EMBO J 13, 5370-5382.[Medline]

Evans, R. M. and Hollenberg, S. M (1998). Zinc fingers: gilt by association. Cell 52, 1-3.

Fredrich, H. C (1950). Zur kenntnis der kongenitale hypotrichosis. Dermatol. Wochenschr 121, 408-410.

Glass, C. K., Rose, D. W. and Rosenfeld, M. G (1997). Nuclear receptor coactivators. Curr. Opin. Cell Biol 9, 222-232.[Medline]

Gorlich, D. and Mattaj, I. W (1996). Nucleocytoplasmic transport. Science 271, 1513-1518.[Abstract]

He, D., Nickerson, A. N. and Penman, S (1990). Core filaments of the nuclear matrix. J. Cell Biol 110, 569-580.[Abstract/Free Full Text]

Hochberg, Z., Benderli, A., Levy, J., Vardi, P., Weisman, Y., Chen, T. and Feldman, D (1984). 1,25-Dihydroxyvitamin D resistance, rickets, and alopecia. Am. J. Med 77, 805-811.[Medline]

Kato, S., Takeyama, K., Kitanaka, S., Murayama, A., Sekine, K. and Yoshizawa, T (1999). In vivo function of VDR in gene expression-VDR knock-out mice. J. Steroid Biochem. Mol. Biol 69, 247-251.[Medline]

Ko, L. J. and Engel, J. D (1993). DNA-binding specificities of the GATA transcription factor family. Mol. Cell Biol 13, 4011-4022.[Abstract/Free Full Text]

Kruse, R., Cichon, S., Anker, M., Hillmer, A. M., Barros-Nunez, P., Cantu, J. M., Leal, E., Weinlich, G., Schmuth, M., Fritsch, P. et al. ( (1999). Novel Hairless mutations in two kindreds with autosomal recessive papular atrichia. J. Invest. Dermatol 113, 954-959.[Medline]

LeDouarin, B., Nielsen, A. L., Garnier, J. M., Ichinose, H., Jeanmougin, F., Losson, R. and Chambon, P (1996). A possible involvement of TIF1and TIF1 in the epigenetic control of transcription by nuclear receptors. EMBO J 15, 6701-6715.[Medline]

Lowenthal, L. J. A. and Prakken, J (1961). Atrichia with papular lesions. Dermatologica 122, 85-87.[Medline]

Mangelsdorf, D. J. and Evans, R. M (1995). The RXR heterodimers and orphan receptors. Cell 83, 841-850.[Medline]

Mattaj, I. W. and Englmeier, L (1998). Nucleocytoplasmic transport: the soluble phase. Annu. Rev. Biochem 67, 265-306.[Medline]

McInerney, E. M., Rose, D. W., Flynn, S. E., Westin, S., Mullen, T. M., Krones, A., Inostroza, J., Torchia, J., Nolte, R. T., Assa-Munt, N. et al. ( (1998). Determinants of coactivator LXXLL motif specificity in nuclear receptor transcriptional activation. Genes Dev 12, 3357-3368.[Abstract/Free Full Text]

Nangia, A. K., Butcher, J. L., Konety, B. R., Vietmeier, B. N. and Getzenberg, R. H (1998). Association of vitamin D receptors with the nuclear matrix of human and rat genitourinary tissues. J. Steroid Biochem. Mol. Biol 66, 241-246.[Medline]

Panteleyev, A. A., Ahmad, W., Malashenko, A. M., Ignatieva, E. L., Paus, R., Sundberg, J. P. and Christiano, A. M (1998). Molecular basis for the rhino Yurlovo (hr(rhY)) phenotype: severe skin abnormalities and female reproductive defects associated with an insertion in the hairless gene. Exp. Dermatol 7, 281-288.[Medline]

Panteleyev, A. A., Botchkareva, N. V., van der Veen, C., Christiano, A. M. and Aus, R (1998). Pathology of the hairless phenotype: dysregulation of the hair follicle apoptosis and topobiology during the initiation of follicle cycling. J. Invest. Dermatol 110, 577-.

Panteleyev, A. A., Paus, R., Ahmad, W., Sundberg, J. P. and Christiano,A. M (1998). Molecular and functional aspects of the hairless (hr) gene in laboratory rodents and humans. Exp. Dermatol 7, 249-267.[Medline]

Panteleyev, A. A., Botchkareva, N. V., Sundberg, J. P., Christiano, A. M. and Paus, R (1999). The role of the hairless (hr) gene in the regulation of hair follicle catagen transformation. Am. J. Pathol 155, 159-171.[Abstract/Free Full Text]

Panteleyev, A. A., Paus, R. and Christiano, A. M (2000). Patterns of Hairless (hr) gene expression in mouse hair follicle morphogenesis and cycling. Am. J. Path 157, 1071-1079.[Abstract/Free Full Text]

Pederson, T (1998). Thinking about a nuclear matrix. J. Mol. Biol 277, 147-159.[Medline]

Pederson, T (2000). Half a century of \324the nuclear matrix'. Mol. Biol. Cell 11, 799-805.[Abstract/Free Full Text]

Rachez, C. and Freedman, L. P (2000). Mechanisms of gene regulation by vitamin D(3) receptor: a network of coactivator interactions. Gene 246, 9-21.[Medline]

Sakai, Y. and Demay, M. B (2000). Evaluation of keratinocyte proliferation and differentiation in vitamin D receptor knockout mice. Endocrinology 141, 2043-2049.[Abstract/Free Full Text]

Siomi, H. and Dreyfuss, G (1995). A nuclear localization domain in the hnRNP A1 protein. J. Cell Biol 129, 551-560.[Abstract/Free Full Text]

Sprecher, E., Bergman, R., Szargel, R., Friedman-Birnbaum, R. and Cohen, N (1999). Identification of a genetic defect in the hairless gene in atrichia with papular lesions: evidence for phenotypic heterogeneity among inherited atrichias. Am. J. Hum. Genet 64, 1323-1329.[Medline]

Stein, G. S., van Wijnen, A. J., Stein, J. L., Lian, J. B., Pockwinse, S. and McNeil, S (1998). Interrelationships of nuclear structure and transcriptional control: functional consequences of being in the right place at the right time. J. Cell Biochem 70, 200-712.[Medline]

Stenoien, D., Sharp, Z. D., Smith, C. L. and Mancini, M. A (1998). Functional subnuclear partitioning of transcription factors. J. Cell Biochem 70, 213-221.[Medline]

Summer, F. B (1924). Hairless mice. J. Hered 15, 475-.[Free Full Text]

Thompson, C (1996). Thyroid hormone-responsive genes in developing cerebellum include a novel synaptotagmin and a hairless homolog. J. Neurosci 16, 7832-7840.[Abstract/Free Full Text]

Thompson, C. C. and Bottcher, M (1997). The product of a thyroid hormone-responsive gene interacts with thyroid hormone receptors. Proc. Nat. Acad. Sci. USA 94, 8527-8532.[Abstract/Free Full Text]

Voegel, J. J., Heine, M. J. S., Tini, M., Vivat, V., Chambon, P. andGronemeyer, H (1998). The coactivator of TIF2 contains three nuclear receptor-bindingmotifs and mediates transactivation through CBPbinding-dependent andindependent pathways. EMBO J 17, 507-519.[Medline]

Weiss, M. J. and Orkin, S. H (1995). GATA transcription factors: key regulators of hematopoiesis. Exp. Hematol 23, 99-107.[Medline]

Zlotogorski, A., Ahmad, W. and Christiano, A. M (1998). Congenital atrichia in five Arab Palestinian families resulting from a deletion mutation in the human hairless gene. Hum. Genet 103, 400-404.[Medline]

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				P. J. Malloy, J. Wang, K. Jensen, and D. Feldman Modulation of Vitamin D Receptor Activity by the Corepressor Hairless: Differential Effects of Hairless Isoforms Endocrinology, November 1, 2009; 150(11): 4950 - 4957. [Abstract] [Full Text] [PDF]

				Z. Xie, S. Chang, Y. Oda, and D. D. Bikle Hairless Suppresses Vitamin D Receptor Transactivation in Human Keratinocytes Endocrinology, January 1, 2006; 147(1): 314 - 323. [Abstract] [Full Text] [PDF]

				A. C. Maiyar, M. L.L. Leong, and G. L. Firestone Importin-alpha Mediates the Regulated Nuclear Targeting of Serum- and Glucocorticoid-inducible Protein Kinase (Sgk) by Recognition of a Nuclear Localization Signal in the Kinase Central Domain Mol. Biol. Cell, March 1, 2003; 14(3): 1221 - 1239. [Abstract] [Full Text] [PDF]