Programmed cell death of keratinocytes culminates in apoptotic secretion of a humectant upon secretagogue action of acetylcholine

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Bignold, L. P. and Ferrante, A (1988). Effects of cytochalasin B, N-formyl peptide and plasma on polarisation, zeiosis (blebbing) and degranulation of polymorphonuclear leukocytes in suspension. Cell Biol Int. Rep 12, 195-203.[Medline]

Boess, F. G., Balasubramanian, M. K., Brammer, M. J. and Campbell, I. C (1990). Stimulation of muscarinic acetylcholine receptors increases synaptosomal free calcium concentration by protein kinase-dependent opening of L-type calcium channels. J. Neurochem 55, 230-236.[Medline]

Brody, I (1960). The ultrastructure of the tonofibrils in the keratinization process of normal human epidermis. J. Ultrastruct. Res 4, 264-297.

Brown, M. R. and Chew, C. S (1989). Carbachol-induced protein phosphorylation in parietal cells: Regulation by intracellular calcium concentration. Am J. Physiol 257, 99-.

Burgoyne, R. D., Handel, S. E., Morgan, A., Rennison, M. E., Turner, M. D. and Wilde, C. J (1991). Calcium the cytoskeleton and calpactin annexin II in exocytotic secretion from adrenal chromaffin and mammary epithelial cells. Biochem. Soc. Trans 19, 1085-1090.[Medline]

Caulfield, M. P (1993). Muscarinic receptors characterization coupling and function. Pharmacol. Ther 58, 319-379.[Medline]

Chomczynski, P. and Sacchi, N (1987). Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem 162, 156-159.[Medline]

Dale, B. A., Presland, R. B., Lewis, S. P., Underwood, R. A. and Fleckman, P (1997). Transient expression of epidermal filaggrin in cultured cells causes collapse of intermediate filament networks with alteration of cell shape and nuclear integrity. J. Invest. Dermatol 108, 179-187.[Medline]

Delbono, O., Gopalakrishnan, M., Renganathan, M., Monteggia, L. M., Messi, M. L. and Sullivan, J. P (1997). Activation of the recombinant human7 nicotinic acetylcholine receptor significantly raises intracellular free calcium. J. Pharmacol. Exp. Ther 280, 428-438.[Abstract/Free Full Text]

Derkach, V. A., Kurenny, D. E., Melishchuk, A. I., Selyanko, A. A. and Skok, V. I (1991). Role of disulfide bonds in burst-like activity of nicotinic acetylcholine receptor channels in rat sympathetic neurons. J. Physiol 440, 1-16.

Dolezal, V., Lisa, V. and Tucek, S (1997). Differential effects of the M-1-M-5 muscarinic acetylcholine receptor subtypes on intracellular calcium and on the incorporation of choline into membrane lipids in genetically modified Chinese hamster ovary cell lines. Brain Res. Bull 42, 71-78.[Medline]

Eglen, R. M., Reddy, H. and Watson, N (1994). Selective inactivation of muscarinic receptor subtypes. Int. J. Biochem 26, 1357-1368.[Medline]

Elgoyhen, A. B., Johnson, D. S., Boulter, J., Vetter, D. E. and Heinemann, S (1994). 9: An acetylcholine receptor with novel pharmacological properties expressed in rat cochlear hair cells. Cell 79, 705-715.[Medline]

Elias, P. M (1996). Stratum corneum architecture, metabolic activity and interactivity with subjacent cell layers. Exp. Dermatol 5, 191-201.[Medline]

Fleckman, P., Dale, B. A. and Holbrook, K. A (1985). Profilaggrin, a high-molecular-weight precursor of filaggrin in human epidermis and cultured keratinocytes. J. Invest. Dermatol 85, 507-512.[Medline]

Gandarillas, A., Goldsmith, L. A., Gschmeissner, S., Leigh, I. M. and Watt, F. M (1999). Evidence that apoptosis and terminal differentiation of epidermal keratinocytes are distinct processes. Exp. Dermatol 8, 71-79.[Medline]

Godman, G. C., Miranda, A. F., Deitch, A. D. and Tanenbaum, S. W (1975). Action of cytochalasin D on cells of established lines. III. Zeiosis and movements at the cell surface. J. Cell Biol 64, 644-667.[Abstract/Free Full Text]

Grando, S. A., Cabrera, R., Hostager, B. S., Bigliardi, P. L., Blake, J. S., Herron, M. J., Dahl, M. V. and Nelson, R. D (1993). Computerized microassay of keratinocyte cell-plastic attachment and proliferation for assessing net stimulatory inhibitory and toxic effects of compounds on nonimmortalized cell lines. Skin Pharmacol 6, 135-147.[Medline]

Grando, S. A., Kist, D. A., Qi, M. and Dahl, M. V (1993). Human keratinocytes synthesize, secrete and degrade acetylcholine. J. Invest. Dermatol 101, 32-36.[Medline]

Grando, S. A., Horton, R. M., Pereira, E. F. R., Diethelm-Okita, B. M., George, P. M., Albuquerque, E. X. and Conti-Fine, B. M (1995). A nicotinic acetylcholine receptor regulating cell adhesion and motility is expressed in human keratinocytes. J. Invest. Dermatol 105, 774-781.[Medline]

Grando, S. A., Zelickson, B. D., Kist, D. A., Weinshenker, D., Bigliardi, P. L., Wendelschafer-Crabb, G., Kennedy, W. R. and Dahl, M. V (1995). Keratinocyte muscarinic acetylcholine receptors: immunolocalization and partial characterization. J. Invest. Dermatol 104, 95-100.[Medline]

Grando, S. A., Horton, R. M., Mauro, T. M., Kist, D. A., Lee, T. X. and Dahl, M. V (1996). Activation of keratinocyte nicotinic cholinergic receptors stimulates calcium influx and enhances cell differentiation. J. Invest. Dermatol 107, 412-418.[Medline]

Grando, S. A., Schofield, O. M. V., Skubitz, A. P. N., Kist, D. A., Zelickson, B. D. and Zachary, C. B (1996). Nodular basal cell carcinoma in vivo vs in vitro: Establishment of pure cell cultures, cytomorphologic characteristics, ultrastructure, immunophenotype, biosynthetic activities, and generation of antisera. Arch. Dermatol 132, 1185-1193.[Abstract]

Grynkiewicz, G., Poenie, M. and Tsien, R. Y (1985). A new generation of Ca2+indicators with greatly improved fluorescence properties. J. Biol. Chem 260, 3440-3450.[Abstract/Free Full Text]

Haake, A. R. and Polakowska, R. R (1993). Cell death by apoptosis in epidermal biology. J. Invest. Dermatol 101, 107-112.[Medline]

Hall, L. L., Bicknell, G. R., Primrose, L., Pringle, J. H., Shaw, J. A. and Furness, P. N (1998). Reproducibility in the quantification of mRNA levels by RT-PCR-ELISA and RT competitive PCR-ELISA. Biotechniques 24, 652-656.[Medline]

Ikeda, K., Ishigaki, M., Wu, D., Sunose, H., Suzuki, M., Ishitani, K. and Takasaka, T (1995). Intracellular Ca2+responses induced by acetylcholine in the submucosal nasal gland acinar cells in guinea pigs. Am. J. Physiol 268, 361-.

Ishida-Yamamoto, A., Takahashi, H., Presland, R. B., Dale, B. A. and Iizuka, H (1998). Translocation of profilaggrin N-terminal domain into keratinocyte nuclei with fragmented DNA in normal human skin and loricrin keratoderma. Lab. Invest 78, 1245-1253.[Medline]

Jagger, D. J., Griesinger, C. B., Rivolta, M. N., Holley, M. C. and Ashmore, J. F (2000). Calcium signalling mediated by the 9 acetylcholine receptor in a cochlear cell line from the Immortomouse. J. Physiol 527, 49-54.

Jewell, S. A., Bellomo, G., Thor, H., Orrenius, S. and Smith, M (1982). Bleb formation in hepatocytes during drug metabolism is caused by disturbances in thiol and calcium ion homeostasis. Science 217, 1257-1259.[Abstract/Free Full Text]

Jones, S. V. P (1993). Muscarinic receptor subtypes modulation of ion channels. Life Sci 52, 457-464.[Medline]

Kerr, J. F., Wyllie, A. H. and Currie, A. R (1972). Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br. J. Cancer 26, 239-257.[Medline]

Krawczyk, W. S. and Wilgram, G. F (1973). Hemidesmosome and desmosome morphogenesis during epidermal wound healing. J. Ultrastruct. Res 45, 93-101.[Medline]

Kurosumi, K. and Kawabata, I (1976). Transmission and scanning electron microscopy of the human ceruminous apocrine gland. I. Secretory glandular cells. Arch. Histol. Jpn 39, 207-229.[Medline]

Lavker, R. M. and Matoltsy, A. G (1970). Formation of horny cells: the fate of cell organelles and differentiation products in ruminal epithelium. J. Cell Biol 44, 501-512.[Abstract/Free Full Text]

Lazareno, S. and Birdsall, N. J (1993). Pharmacological characterization of acetylcholine-stimulated [35S]-GTP gamma S binding mediated by human muscarinic m1-m4 receptors: antagonist studies. Br. J. Pharmacol 109, 1120-1127.[Medline]

Lee, Y.-S., Yuspa, S. H. and Dlugosz, A. A (1998). Differentiation of cultured human epidermal keratinocytes at high cell densities is mediated by endogenous activation of the protein kinase C signaling pathway. J. Invest. Dermatol 11, 762-766.

LeSage, G., Alvaro, D., Benedetti, A., Glaser, S., Marucci, L., Baiocchi, L., Eisel, W., Caligiuri, A., Phinizy, J. L., Rodgers, R. et al. ( (1999). Cholinergic system modulates growth, apoptosis, and secretion of cholangiocytes from bile duct-ligated rats. Gastroenterology 117, 191-199.[Medline]

Lewis, J. E., Jensen, P. J. and Wheelock, M. J (1994). Cadherin function is required for human keratinocytes to assemble desmosomes and stratify in response to calcium. J. Invest. Dermatol 102, 870-877.[Medline]

Li, L., Tucker, R. W., Hennings, H. and Yuspa, S. H (1995). Chelation of intracellular Ca2+inhibits murine keratinocyte differentiation in vitro. J. Cell Physiol 163, 105-114.[Medline]

Majno, G. and Joris, I (1995). Apoptosis, oncosis, and necrosis: An overview of cell death. Am. J. Pathol 146, 3-15.[Abstract]

Matoltsy, A. G (1966). Membrane-coating granules of the epidermis. J. Ultrastruct. Res 15, 510-515.[Medline]

Mauro, T., Bench, G., Sidderas-Haddad, E., Feingold, K., Elias, P. and Cullander, C (1998). Acute barrier perturbation abolishes the Ca2+and K+gradients in murine epidermis: quantitative measurement using PIXE. J. Invest. Dermatol 111, 1198-1201.[Medline]

McCall, C. A. and Cohen, J. J (1991). Programmed cell death in terminally differentiating keratinocytes: role of endogenous endonuclease. J. Invest. Dermatol 97, 111-114.[Medline]

Menon, G. K., Brown, B. E. and Elias, P. M (1986). Avian epidermal differentiation: Role of lipids in permeability barrier formation. Tissue & Cell 18, 71-82.[Medline]

Menon, G. K., Elias, P. M., Lee, S. H. and Feingold, K. R (1992). Localization of calcium in murine epidermis following disruption and repair of the permeability barrier. Cell Tiss. Res 270, 503-512.[Medline]

Menon, G. K., Price, L. F., Bommannan, B., Elias, P. M. and Feingold, K. R (1994). Selective obliteration of the epidermal calcium gradient leads to enhanced lamellar body secretion. J. Invest. Dermatol 102, 789-795.[Medline]

Meyer, J., Alvares, O. F. and Barrington, E. P (1970). Volume and dry weight of cells in the epithelium of rat cheek and palate. Growth 34, 57-73.[Medline]

Ndoye, A., Buchli, R., Greenberg, B., Nguyen, V. T., Zia, S., Rodriguez, J. G., Webber, R. J., Lawry, M. A. and Grando, S. A (1998). Identification and mapping of keratinocyte muscarinic acetylcholine receptor subtypes in human epidermis. J. Invest. Dermatol 111, 100-106.

Nguyen, V. T., Lee, T. X., Ndoye, A., Shultz, L. D., Pittelkow, M. R., Dahl, M. V., Lynch, P. J. and Grando, S. A (1998). The pathophysiological significance of non-desmoglein targets of pemphigus autoimmunity. Pemphigus vulgaris and foliaceus patients develop antibodies against keratinocyte cholinergic receptors. Arch. Dermatol 134, 971-980.[Abstract/Free Full Text]

Nguyen, V. T., Hall, L. L., Gallacher, G., Ndoye, A., Jolkovsky, D. L., Webber, R. J., Buchli, R. and Grando, S. A (2000). Choline acetyltransferase, acetylcholinesterase, and nicotinic acetylcholine receptors of human gingival and esophageal epithelia. J. Dental Res 79, 939-949.[Abstract/Free Full Text]

Nguyen, V. T., Ndoye, A. and Grando, S. A (2000). Novel human9 acetylcholine receptor regulating keratinocyte adhesion is targeted by pemphigus vulgaris autoimmunity. Am. J. Pathol 157, 1377-1391.[Abstract/Free Full Text]

Odland, G. P. and Holbrook, K (1987). The lamellar granules of the epidermis. Curr. Probl. Dermatol 9, 29-49.

Perrin, D., Moeller, K., Hanke, K. and Soling, H. D (1992). cAMP and calcium-mediated secretion in parotid acinar cells is associated with reversible changes in the organization of the cytoskeleton. J. Cell Biol 116, 127-134.[Abstract/Free Full Text]

Puchelle, E., Beorchia, A., Menager, M., Zahm, J. M. and Ploton, D (1991). Three-dimensional imaging of the mucus secretory process in the cryofixed frog respiratory epithelium. Biol. Cell 72, 159-166.[Medline]

Rawlings, A. V., Scott, I. R., Harding, C. R. and Bowser, P. A (1994). Stratum corneum moisturization at the molecular level. J. Invest. Dermatol 103, 731-741.[Medline]

Rinner, I., Globerson, A., Kawashima, K., Korsatko, W. and Schauenstein, K (1999). A possible role for acetylcholine in the dialogue between thymocytes and thymic stroma. Neuroimmunomodulation 6, 51-55.[Medline]

Sastry, B. V. and Sadavongvivad, C (1978). Cholinergic systems in non-nervous tissues. Pharmacol. Rev 30, 65-132.[Medline]

Scott, I. R. and Harding, C. R (1981). Studies on the synthesis and degradation of a high molecular weight, histidine-rich phosphoprotein from mammalian epidermis. Biochim. Biophys. Acta 669, 65-78.[Medline]

Scott, I. R. and Harding, C. R (1986). Filaggrin breakdown to water binding compounds during development of the rat stratum corneum is controlled by the water activity of the environment. Dev. Biol 115, 84-92.[Medline]

Seguela, P., Wadiche, J., Dineley-Miller, K., Dani, J. A. and Patrick, J. W (1993). Molecular cloning, functional properties, and distribution of rat brain7: a nicotinic cation channel highly permeable to calcium. J. Neurosci 13, 596-604.[Abstract]

Sharpe, G. R., Fisher, C., Gillespie, J. I. and Greenwell, J. R (1993). Growth and differentiation stimuli induce different and distinct increases in intracellular free calcium in human keratinocytes. Arch Dermatol. Res 284, 445-450.[Medline]

Smith, J. B. and Fenske, N. A (1996). Cutaneous manifestations and consequences of smoking. J. Am. Acad. Dermatol 34, 717-732.[Medline]

Soltoff, S. P. and Toker, A (1995). Carbachol, substance P, and phorbol ester promote the tyrosine phosphorylation of protein kinase C delta in salivary gland epithelial cells. J. Biol. Chem 270, 13490-13495.[Abstract/Free Full Text]

Theilig, C., Bernd, A., Ramirez-Bosca, A., Gormar, F. F., Bereiter-Hahn, J., Keller-Stanislawski, B., Sewell, A. C., Rietbrock, N. and Holzmann, H (1994). Reactions of human keratinocytes in vitro after application of nicotine. Skin Pharmacol 7, 307-315.[Medline]

Thody, A. J. and Shuster, S (1989). Control and function of sebaceous glands. Physiol. Rev 69, 383-416.[Abstract/Free Full Text]

Verbitsky, M., Rothlin, C. V., Katz, E. and Belen Elgoyhen, A (2000). Mixed nicotinic-muscarinic properties of the9 nicotinic cholinergic receptor. Neuropharmacology 39, 2515-2524.[Medline]

Wessler, I., Kirkpatrick, C. J. and Racke, K (1998). Non-neuronal acetylcholine, a locally acting molecule, widely distributed in biological systems: expression and function in humans. Pharmacol. Ther 77, 59-79.[Medline]

Wessler, I., Kirkpatrick, C. J. and Racke, K (1999). The cholinergic \324pitfall': acetylcholine, a universal cell molecule in biological systems, including humans. Clin. Exp. Pharmacol. Physiol 26, 198-205.[Medline]

Wikstrom, M. A., Lawoko, G. and Heilbronn, E (1998). Cholinergic modulation of extracellular ATP-induced cytoplasmic calcium concentrations in cochlear outer hair cells. J. Physiol. Paris 92, 345-349.[Medline]

Williams, A. C., Cornwell, P. A. and Barry, B. W (1992). On the non-Gaussian distribution of human skin permeabilities. Int. J. Pharm 86, 69-77.

Wolff, K. and Schreiner, E (1968). An electron microscopic study on the extraneous coat of keratinocytes and the intercellular space of the epidermis. J. Invest. Dermatol 51, 418-430.[Medline]

Yan, G.-M., Lin, S.-Z., Irwin, R. P. and Paul, S. M (1995). Activation of muscarinic cholinergic receptors blocks apoptosis of cultured cerebellar granule neurons. Mol. Pharmacol 47, 248-257.[Abstract]

Yang, X. and Buccafusco, J. J (1994). Effect of chronic central treatment with the acetylcholine analog methylcarbamylcholine on cortical nicotinic receptors: Correlation between receptor changes and behavioral function. J. Pharmacol. Exp. Ther 271, 651-659.[Abstract/Free Full Text]

Zia, S., Ndoye, A., Nguyen, V. T. and Grando, S. A (1997). Nicotine enhances expression of the3, 4,5, and 7 nicotinic receptors modulating calcium metabolism and regulating adhesion and motility of respiratory epithelial cells. Res. Commun. Mol. Pathol. Pharmacol 97, 243-262.[Medline]

Zia, S., Ndoye, A., Lee, T. X., Webber, R. J. and Grando, S. A (2000). Receptor-mediated inhibition of keratinocyte migration by nicotine involves modulations of calcium influx and intracellular concentration. J. Pharm. Exp. Ther 293, 973-981.[Abstract/Free Full Text]

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				A. I. Chernyavsky, J. Arredondo, E. Karlsson, I. Wessler, and S. A. Grando The Ras/Raf-1/MEK1/ERK Signaling Pathway Coupled to Integrin Expression Mediates Cholinergic Regulation of Keratinocyte Directional Migration J. Biol. Chem., November 25, 2005; 280(47): 39220 - 39228. [Abstract] [Full Text] [PDF]

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				A. I. Chernyavsky, J. Arredondo, J. Wess, E. Karlsson, and S. A. Grando Novel signaling pathways mediating reciprocal control of keratinocyte migration and wound epithelialization through M3 and M4 muscarinic receptors J. Cell Biol., July 19, 2004; 166(2): 261 - 272. [Abstract] [Full Text] [PDF]

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