Mutant cadherin affects epithelial morphogenesis and invasion, but not transformation

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Aberle, H., Butz, S., Stappert, J., Weissig, H., Kemler, R. and Hoschuetzky, H (1994). Assembly of the cadherin-catenin complex in vitro with recombinant proteins. J. Cell Sci 107, 3665-3663.

Barth, A. I. M., Stewart, D. B. and Nelson, W. J (1999). T cell factor-activated transcription is not sufficient to induce anchorage-independent growth of epithelial cells expressing mutant-catenin. Proc. Natl. Acad. Sci. USA 96, 4947-4952.[Abstract/Free Full Text]

Becker, K.-F., Atkinson, M. J., Reich, U., Becker, I., Nekarda, H., Siewert, J. R. and H\232fler, H (1994). E-cadherin gene mutation provide clues to diffuse type gastric carcinomas. Cancer Res 54, 3845-3852.[Abstract/Free Full Text]

Becker, K.-F., Atkinson, M. J., Reich, U., Huang, H.-H., Nekarda, H.,Siewert, J. R. and H\232fler, H (1993). Exon skipping in the E-cadherin gene transcript in metastatic human gastric carcinomas. Hum. Mol. Genetics 2, 803-804.[Free Full Text]

Behrens, J (1999). Cadherins and catenins: role in signal transduction and tumor progression. Cancer Met. Rev 18, 15-30.[Medline]

Behrens, J., Mareel, M. M., Van Roy, F. M. and Birchmeier, W (1989). Dissecting tumor cell invasion: epithelial cells acquire invasive properties after the loss of uvomorulin-mediated cell-cell adhesion. J. Cell Biol 108, 2435-2447.[Abstract/Free Full Text]

Berx, G., Becker, K. F., H\232fler, H. and van Roy, F (1998). Mutations of the human E-cadherin (CDH-1) gene. Human Mutation 12, 226-237.[Medline]

Berx, G., Cleton-Jansen, A.-M., Nollet, F., de Leeuw, J. F., van de Vijver, M. J., Cornelisse, C. and van Roy, F (1995). E-cadherin is a tumour/invasion suppressor gene mutated in human lobular breast cancers. EMBO J 14, 6107-6115.[Medline]

Birchmeier, W. and Behrens, J (1994). Cadherin expression in carcinomas: role in the formation of cell junctions and the prevention of invasiveness. Biochim. Biophys. Acta 1198, 11-26.[Medline]

Brewer, C (1994). Cytomegalovirus plasmid vectors for permanent lines of polarized epithelial cells. Methods Cell Biol 43, 233-245.

Bringuier, P.-P., Giroldi, L. A., Umbas, R., Shimazui, T. and Schalken, J.A (1999). Mechanisms associated with abnormal E-cadherin immunoreactivity in human bladder tumors. Int. J. Cancer 83, 591-595.[Medline]

Bussemakers, M. J. G., Giroldi, L. A., van Bokhoven, A. and Schalken, J.A (1994). Transcriptional regulation of the human E-cadherin gene in human prostate cancer cell lines. Biochem. Biophys. Res. Comm 203, 1284-1290.[Medline]

Christofori, G. and Semb, H (1999). The role of the cell-adhesion molecule E-cadherin as a tumour-suppressor gene. Trends Biochem. Sci 24, 73-76.[Medline]

Damsky, C. H., Richa, J., Solter, D., Knudsen, K. and Buck, C. A (1983). Identification and purification of a cell surface glycoprotein mediating intercellular adhesion in embryonic and adult tissue. Cell 34, 455-466.[Medline]

Daniel, C. W., Strickland, P. and Friedman, Y (1995). Expression and functional role of E-and P-cadherins in mouse mammary ductal morphogenesis and growth. Dev. Biol 169, 511-519.[Medline]

Doki, Y., Shiozaki, H., Tahara, H., Inoue, M., Oka, H., Iihara, K., Kadowaki, T., Takeichi, M. and Mori, T (1993). Correlation between E-cadherin expression and invasiveness in vitro in a human esophageal cancer cell line. Cancer Res 53, 3421-3426.[Abstract/Free Full Text]

Frixen, U. H., Berhens, J., Sachs, M., Eberle, G., Voss, B., Warda, A., L\232chner, D. and Birchmeier, W (1991). E-cadherin-mediated cell-cell adhesion prevents invasiveness of human carcinoma cells. J. Cell Biol 113, 173-185.[Abstract/Free Full Text]

Gayther, S. A., Gorringe, K. L., Ramus, S. J., Huntsman, D., Roviello, F., Grehan, N., Machado, J. C., Pinto, E., Seruca, R., Halling, K. et al. ( (1998). Identification of germ-line E-cadherin mutations in gastric cancer families of European origin. Cancer Res 58, 4086-4089.[Abstract/Free Full Text]

Gossen, M. and Bujard, H (1992). Tight control of gene expression in mammalian cells by tetracycline-reponsive promoters. Proc. Natl. Acad. Sci. USA 89, 5547-5551.[Abstract/Free Full Text]

Guilford, P., Hopkins, J., Harraway, J., McLeod, M., McLeod, N., Harawira, P., Taite, H., Scoular, R., Miller, A. and Reeve, A (1998). E-cadherin germline mutations in familial gastric cancer. Nature 392, 402-405.[Medline]

Gumbiner, B. and Simons, K (1986). A functional assay for proteins involved in establishing an epithelial occluding barrier: identification of a uvomorulin-like peptide. J. Cell Biol 102, 457-468.[Abstract/Free Full Text]

Hajra, K. M., Ji, X. and Fearon, E. R (1999). Extinction of E-cadherin expression in breast cancer via a dominant repression pathway acting on proximal promoter elements. Oncogene 18, 7274-7279.[Medline]

Hall, H. G., Farson, D. A. and Bissell, M. J (1982). Lumen formation by epithelial cell lines in resonse to collagen overlay: a morphogenetic model in culture. Proc. Natl. Acad. Sci. USA 79, 4672-4676.[Abstract/Free Full Text]

Hermiston, M. L. and Gordon, J. I (1995). In vivo analysis of cadherin function in the mouse intestinal epithelium: essential roles in adhesion, maintenance of differentiation and regulation of programmed cell death. J. Cell Biol 129, 489-506.[Abstract/Free Full Text]

Hermiston, M. L. and Gordon, J. I (1995). Inflammatory bowel disease and adenomas in mice expressing a dominant negative N-cadherin. Science 270, 1203-1207.[Abstract/Free Full Text]

Huiping, C., Sigurgeirsdottir, J. R., Jonasson, J. G., Eiriksdottir, G., Johannsdottir, J. T., Egilsson, V. and Ingvarsson, S (1999). Chromosome alterations and E-cadherin gene mutations in human lobular breast cancer. Brit. J. Cancer 81, 1103-1110.[Medline]

Hyafil, F., Morello, D., Babinet, C. and Jacob, R (1980). A cell surfaceglycoprotein involved in the compaction of embryonal carcinoma cells and cleavage stage embryos. Cell 21, 927-934.[Medline]

Jiang, W. G (1996). E-cadherin and its associated protein catenins, cancer invasion and metastasis. Brit. J. Surg 83, 437-446.[Medline]

Jou, T.-S., Stewart, D. B., Stappert, J., Nelson, W. J. and Marrs, J. A (1995). Genetic and biochemical dissection of protein linkages in the cadherin-catenin complex. Proc. Natl. Acad. Sci. USA 92, 5067-5071.[Abstract/Free Full Text]

Keirsebilck, A., Van Hoorde, L., Gao, Y., De Bruyne, G., Bruyneel, E., Vermassen, P., Mareel, M. and van Roy, F (1998). Mechanisms of downregulation of transfected E-cadherin cDNA during formation of invasive tumors in syngeneic mice. Invasion Metastasis 18, 44-56.[Medline]

Lu, Q., Paredes, M., Medina, M., Zhou, J., Cavallo, R., Peifer, M., Orecchio, L. and Kosik, K. S (1999). -catenin, an adhesive junction-associated protein which promotes cell scattering. J. Cell Biol 144, 519-532.[Abstract/Free Full Text]

Mareel, M. M., Behrens, J., Birchmeier, W., De Bruyne, G. K., Vleminckx, K., Hogewus, A., Fiers, W. C. and Van Roy, F. M (1991). Down-regulation of E-cadherin expression in Madin Darby canine kidney (MDCK) cells inside tumors of nude mice. Int. J. Cancer 47, 922-928.[Medline]

Marrs, J. A., Napolitano, E. W., Murphy-Erdosh, C., Mays, R. W., Reichardt, L. F. and Nelson, W. J (1993). Distinguishing roles of the membrane-cytoskeleton and cadherin mediated cell-cell adhesion in generating different Na+-K+-ATPase distributions in polarized epithelia. J. Cell Biol 123, 149-164.[Abstract/Free Full Text]

Marrs, J. A., Andersson-Fisone, C., Jeong, M. C., Cohen-Gould, L., Zurzolo, C., Nabi, I. R., Rodriguez-Boulan, E. and Nelson, W. J (1995). Plasticity in epithelial cell phenotype: modulation by expression of different cadherin cell adhesion molecules. J. Cell Biol 129, 507-519.[Abstract/Free Full Text]

McAteer, J. A., Evan, A. P. and Gardner, K. D (1987). Morphogenetic clonal growth of kidney epithlial cell line MDCK. Anat. Rec 217, 229-239.[Medline]

McNeill, H., Ozawa, M., Kemler, R. and Nelson, W. J (1990). Novel function of the cell adhesion molecule uvomorulin as an inducer of cell surface polarity. Cell 62, 309-316.[Medline]

Moll, R., Mitze, M., Frixen, U. H. and Birchmeier, W (1993). Differential loss of E-cadherin expression in infitrating ductal and lobular breast carcinomas. Am. J. Path 143, 1731-1742.[Abstract]

Montesano, R., Matsumoto, K., Nakamura, T. and Orci, L (1991). Identification of a fibroblast-derived epithlial morphogen and hepatocyte growth factor. Cell 67, 901-908.[Medline]

Nagafuchi, S., Shirayoshi, Y., Okazaki, K., Yasuda, K. and Takeichi, M (1987). Transformation of cell adhesion properties by exogenously introduced E-cadherin cDNA. Nature 329, 341-343.[Medline]

Oda, T., Kanai, Y., Oyama, T., Yoshiura, K., Shimoyama, Y., Birchmeier, W., Sugimura, T. and Hirohashi, S (1994). E-cadherin gene mutation in human gastric carcinoma cell lines. Proc. Natl. Acad. Sci. USA 91, 1858-1862.[Abstract/Free Full Text]

Ojakian, G. K. and Schwimmer, R (1988). The polarized distribution of an apical cell surface glycoprotein is maintained by interactions with the cytopskeleton of Madin-Darby canine kidney cells. J. Cell Biol 107, 2377-2387.[Abstract/Free Full Text]

Ozawa, M., Baribault, H. and Kemler, R (1989). The cytoplasmic domain of the cell adhesion molecule uvomorulin associates with three independent proteins structurally related in different species. EMBO J 8, 1711-1717.[Medline]

Ozawa, M. and Kemler, R (1998). The membrane-proximal region of the E-cadherin cytoplasmic domain prevents dimerization and negatively regulates adhesion activity. J. Cell Biol 142, 1605-1613.[Abstract/Free Full Text]

Perl, A. K., Wilgnebus, P., Dahl, U., Semb, H. and Christofori, G (1998). A causal role for E-cadherin in the transition form adenoma to carcinoma. Nature 392, 190-193.[Medline]

Pollack, A. L., Barth, A. I. M., Altschuler, Y., Nelson, W. J. and Mostov, K. E (1997). Dynamics of-catenin interactions with APC protein regulate epithelial tubulogenesis. J. Cell Biol 137, 1651-1662.[Abstract/Free Full Text]

Pollack, A. L., Runyan, R. B. and Mostov, K. E (1998). Morphogenetic mechanisms of epithelial tubulogenesis: MDCK cell polarity is transiently rearranged without loss of cell-cell contact during scatter factor/hepatocyte growth factor-induced tubulogenesis. Dev. Biol 204, 64-79.[Medline]

Reynolds, A. B., Daniel, J., McCrea, P. D., Wheelock, M. J., Wu, J. andZhang, Z (1994). Identification of a new catenin: the tyrosine kinase substrate p120casassociate with E-cadherin complexes. Mol. Cell. Biol 14, 8333-8342.[Abstract/Free Full Text]

Ringwald, M., Schuh, R., Vestweber, D., Eistetter, H., Lottspeich, F., Engel, J., Dolz, R., Jahnig, F., Epplen, J., Mayer, S. et al. ( (1987). The structure of cell adhesion molecule uvomorulin. Insights into the molecular mechanism of Ca2+-dependent cell adhesion. EMBO J 6, 3647-3653.[Medline]

Rodriguez-Boulan, E. and Nelson, W. J (1989). Morphogenesis of the polarized epithelial phenotype. Science 245, 718-725.[Abstract/Free Full Text]

Santos, O. F. P., Moura, L. A., Roasen, E. M. and Nigam, S. K (1993). Modulation of HGF-induced tubulogenesis and branching by multiple phosphorylation mechanisms. Dev. Biol 159, 535-548.[Medline]

Sommers, C. L., Thompson, E. W., Torri, J. A., Kemler, R., Gelmann, E.P. and Byers, S. W (1991). Cell adhesion molecule uvomorulin expression in human breast cancer cell lines: relationship to morphology and invasive capacities. Cell Growth Diff 2, 365-372.[Abstract]

St Croix, B., Sheehan, C., Rak, J. W., Florenes, V. A., Slingerlnad, J. M. and Kerbel, R. S (1998). E-cadherin-dependent growth suppression is mediated by the cyclin-dependent kinase inhibitor p27KIP1. J. Cell Biol 142, 557-571.[Abstract/Free Full Text]

Stevenson, B. R., Siliciano, J. D., Mooseker, M. S. and Goodenough, D. A (1986). Identification of ZO-1: a high molecular weight polypeptide associated with the tight junction (zonula occludens) in a variety of epithelia. J. Cell Biol 103, 755-766.[Abstract/Free Full Text]

Stewart, D., Barth, A. I. M. and Nelson, W. J (2000). Differential regulation of endogenous cadherin expression in MDCK cells by cell-cell adhesion and activation of beta-catenin signaling. J. Biol. Chem 275, 20707-20716.[Abstract/Free Full Text]

Takeichi, M (1990). Cadherins: a molecular family important in selective cell-cell adhesion. Annu. Rev. Biochem 59, 237-252.[Medline]

Takeichi, M (1993). Cadherins in cancer: implications for invasion and metastasis. Curr. Opin. Cell. Biol 5, 806-811.[Medline]

Troxell, M. L., Chen, Y.-T., Cobb, N., Nelson, W. J. and Marrs, J. A (1999). Cadherin function in junctional complex rearrangement and posttranslational control of cadherin expression. Am. J. Physiol 276, 404-418.

Troxell, M. L., Gopalakrishnan, S., McCormack, J., Poteat, B. A., Pennington, J., Garringer, S. M., Schneeberger, E. E., Nelson, W. J. and Marrs, J. A (2000). Inhibiting cadherin function by dominant mutant E-cadherin expression increases the extent of tight junction assembly. J. Cell Sci 113, 985-996.[Abstract]

Vestweber, D. and Kemler, R (1984). Rabbit antiserum against a purified surface glycoprotein decompacts mouse preimplantation embryos and reacts with specific adult tissue. Exp. Cell Res 152, 169-178.[Medline]

Vleminckx, K., Vakaet Jr., L., Mareel, M., Fiers, W. and Van Roy, F (1991). Genetic manipulation of E-cadherin expression by epithelial tumor cells reveals and invasion suppressor role. Cell 66, 107-119.[Medline]

Vos, C. B. J., Cleton-Jansen, A. M., Berx, G., de Leeuw, W. J. F., ter Haar, N. T., van Roy, F., Cornelisse, C. J., Peterse, J. L. and van de Vijver, M.J (1997). E-cadherin inactivation in lobular carcinoma in situ of the breast: an early event in tumorigenesis. Brit. J. Cancer 76, 1131-1133.[Medline]

Wang, A. Z., Ojakian, G. K. and Nelson, W. J (1990). Steps in the morphogenesis of a polarized epithelium I. Uncoupling the roles of cell-cell and cell-substratum contact in establishing plasma membrane polarity in multicellular epithelial (MDCK) cysts. J. Cell Sci 95, 137-151.[Abstract/Free Full Text]

Yap, A. S (1998). The morphogenetic role of cadherin cell adhesion molecules in human cancer: a thematic review. Cancer Invest 16, 252-261.[Medline]

Yap, A. S., Niessen, C. M. and Gumbiner, B. M (1998). The juxtamembrane region of the cadherin cytoplasmic tail supports lateral clustering, adhesive strengthening and interaction with p120ctn. J. Cell Biol 141, 779-789.[Abstract/Free Full Text]

Yeaman, C., Grindstaff, K. K. and Nelson, W. J (1999). New perspectives on mechanisms involved in generating epithelial cell polarity. Physiol. Rev 79, 73-98.[Abstract/Free Full Text]

Zhu, A. J. and Watt, F. M (1996). Expression of dominant negative cadherin mutant inhibits proliferation and stimulates terminal differentiation of human epidermal keratinocytes. J. Cell Sci 109, 3013-3023.[Abstract]

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				S. Babb-Clendenon, Y.-c. Shen, Q. Liu, K. E. Turner, M. S. Mills, G. W. Cook, C. A. Miller, V. H. Gattone II, K. F. Barald, and J. A. Marrs Cadherin-2 participates in the morphogenesis of the zebrafish inner ear J. Cell Sci., December 15, 2006; 119(24): 5169 - 5177. [Abstract] [Full Text] [PDF]

				J. A. Scott and A. S. Yap Cinderella no longer: {alpha}-catenin steps out of cadherin's shadow J. Cell Sci., November 15, 2006; 119(22): 4599 - 4605. [Abstract] [Full Text] [PDF]

				R. Kroschewski Molecular Mechanisms of Epithelial Polarity: About Shapes, Forces, and Orientation Problems Physiology, April 1, 2004; 19(2): 61 - 66. [Abstract] [Full Text] [PDF]

				K. L. Schmeichel and M. J. Bissell Modeling tissue-specific signaling and organ function in three dimensions J. Cell Sci., June 15, 2003; 116(12): 2377 - 2388. [Abstract] [Full Text] [PDF]

				A. M. Carothers, K. A. Melstrom Jr., J. D. Mueller, M. J. Weyant, and M. M. Bertagnolli Progressive Changes in Adherens Junction Structure during Intestinal Adenoma Formation in Apc Mutant Mice J. Biol. Chem., October 12, 2001; 276(42): 39094 - 39102. [Abstract] [Full Text] [PDF]