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AbdAlla, S., Zaki, E., Lother, H. and Quitterer, U (1999). Involvement of the amino terminus of the B(2) receptor in agonist-induced receptor dimerization. J. Biol. Chem 274, 26079-26084.[Abstract/Free Full Text]

AbdAlla, S., Lother, H. and Quitterer, U (2000). AT1-receptor heterodimers show enhanced G-protein activation and altered receptor sequestration. Nature 407, 94-98.[Medline]

Bockaert, J. and Pin, J. P (1999). Molecular tinkering of G protein-coupled receptors: an evolutionary success. EMBO J 18, 1723-1729.[Medline]

Barbier, P., Colelli, A., Bolognesi, M. L., Minarini, A., Tumiatti, V., Corsini, G. U., Melchiorre, C. and Maggio, R (1998). Antagonist binding profile of the split chimeric muscarinic m2-trunc/m3-tail. Eur. J. Pharmacol 355, 267-274.[Medline]

Cornea, A., Janovick, J. A., Maya-Nunez, G. and Conn, P. M (2001). Gonadotropin releasing hormone microaggregation: rate monitored by fluorescence resonance energy transfer. J. Biol. Chem 276, 2153-2158.[Abstract/Free Full Text]

Cvejic, S. and Devi, L.A (1997). Dimerization of theopioid receptor: implication for a role in receptor internalization. J Biol. Chem 273, 26959-26964.

Fukushima, Y., Asano, T., Saitoh, T., Anai, M., Funaki, M., Ogihara, T., Katagiri, H., Matsuhashi, N., Yazaki, Y. and Sugano, K (1997). Oligomer formation of histamine H2 receptors expressed in Sf9 and C0S7 cells. FEBS Lett 409, 283-286.[Medline]

George, S. R., Fan, T., Xie, Z., Tse, R., Tam, V., Varghese, G. and O'Dowd, B. F (2000). Oligomerization of-and -opioid receptors. J. Biol. Chem 275, 26128-26135.[Abstract/Free Full Text]

Gouldson, P. R., Higgs, C., Smith, R. E, Dean, M. K., Gkoutos, G. V. and Reynolds, C. A (2000). Dimerization and domain swapping in G-protein-coupled receptors: a computational study. Neuropsychopharmacology 23, 60-.

Grosse, R., Schoneberg, T., Schultz, G. and Gudermann, T (1997). Inhibition of gonadotrophin-releasing hormone receptor signaling by expression of a splice variant of the human receptor. Mol. Endocrinol 11, 1305-1318.[Abstract/Free Full Text]

Hall, R. A., Premont, R. T. and Lefkowitz, R. J (1999). Heptahelical receptor signaling: beyond the G protein paradigm. J. Cell Biol 145, 927-932.[Free Full Text]

Herbert, T. E., Moffett, S., Morello, J.-P., Loisel, T. P., Bichet, D. G., Barret, C. and Bouvier, M (1996). A peptide derived from a2-adrenergic receptor transmembrane domain inhibits both receptor dimerization and activation. J. Biol. Chem 271, 16384-16392.[Abstract/Free Full Text]

Herbert, T. E., Loisel, T. P., Adam, L., Ethier, N., St. Onge, S. and Bovier, M (1998). Functional rescue of a constitutively2AR through receptor dimerzation. Biochem. J 330, 287-293.

Heuss, C. and Gerber, U (2000). G-protein-independent signaling by G-protein-coupled receptors. Trends Neurosci 23, 469-475.[Medline]

Hovius, R., Vallotton, P., Wohland, T. and Vogel, H (2000). Fluorescence techniques: shedding light on ligand-receptor interactions. Trends Pharmacol. Sci 21, 266-273.[Medline]

Jones, K. A., Borowsky, B., Tamm, J. A., Craig, D. A., Durkin, M. M., Dai, M., Yao, W.-J., Johnson, M., Gunwaldsen, C., Huang, L.-Y. et al (1998). GABABreceptors function as a heteromeric assembly of the subunits GABABR1 and GABABR2. Nature 396, 674-679.[Medline]

Jordan, B. A. and Devi, L. A (1999). G-protein-coupled receptor heterodimerization modulates receptor function. Nature 399, 697-700.[Medline]

Karpa, K. D., Lin, R., Kabbani, N. and Levenson, R (2000). The dopamine D3 receptor interacts with itself and the truncated D3 splice variant D3nf: D3nf interaction causes mislocalization of D3 receptors. Mol. Pharmacol 58, 677-683.[Abstract/Free Full Text]

Kaupmann, K., Huggel, K., Heid, J., Flor, P. J., Bischoff, S., Mickel, S. J., McMaster, G., Angst, C., Bittiger, H., Froestl, W. and Bettler, B (1997). Expression cloning of GABA(B) receptors uncovers similarity to metabotropic glutamate receptors. Nature 386, 239-246.[Medline]

Kaupmann, K., Malitschek, B., Schuler, V., Heid, J., Froestl, W., Beck, P., Mosbacher, J., Bischoff, S., Kulik, A., Shigemoto, R. et al (1998). GABA(B)-receptor subtypes assemble into functional heteromeric complexes. Nature 396, 683-687.[Medline]

Kuner, R., Kohr, G., Grunewald, S., Eisenhardt, G., Bach, A. and Kornau, H. C (1999). Role of heteromer formation in GABAB receptor function. Science 283, 74-77.[Abstract/Free Full Text]

Kunishima, N., Shimada, Y., Tsuji, Y., Sato, T., Yamamoto, M., Nakanishi, S., Jingami, H. and Morikawa, K (2000). Structural basis of glutamate recognition by a dimeric metabotropic glutamate receptor. Nature 407, 971-977.[Medline]

Lee, S. P., O'Dowd, B. F., Ng, G. Y., Varghese, G., Akil, H., Mansour, A., Nguyen, T. and George, S. R (2000). Inhibitation of cell suface expression by mutant receptors demonstrates that D2 dopamine receptors exist as oligomers in the cell. Mol. Pharmacol 58, 120-128.[Abstract/Free Full Text]

Maggio, R., Vogel, Z. and Wess, J (1993). Coexpression studies with mutant muscarinic/adrenergic receptors provide evidence for intermolecular \324cross-talk' between G-protein-linked receptors. Proc. Nat. Acad. Sci. USA 90, 3103-3107.[Abstract/Free Full Text]

Maggio, R., Barbier, P., Fornai, F. and Corsini, G. U (1996). Functional role of the third cytoplasmic loop in muscarinic receptor dimerization. J. Biol. Chem 271, 31055-31060.[Abstract/Free Full Text]

Margeta-Mitrovic, M., Jan, Y. N. and Jan, L. Y (2000). A trafficking checkpoint controls GABA(B) receptor heterodimerization. Neuron 27, 97-106.[Medline]

Marshall, F. H., Jones, K. A., Kaupmann, K. and Bettler, B (1999). GABABreceptors \320 the first 7TM heterodimers. Trends Pharmacol. Sci 20, 396-399.[Medline]

Martin, S. C., Russek, S. J. and Farb, D. H (1999). Molecular identification of the human GABABR2: cell surface expression and coupling to adenylyl cyclase in the absence of GABABR1. Mol. Cell. Neurosci 13, 180-191.[Medline]

Mijares, A., Lebesgue, D., Wallukat, G. and Hoebeke, J (2000). From agonist to antagonist: Fab fragments of an agonist-like monoclonal anti-2-adrenoceptor antibody behave as antagonists. Mol.Pharmacol 58, 373-379.[Abstract/Free Full Text]

Milligan, G (2000). Receptors as kissing cousins. Science 288, 65-67.[Free Full Text]

Mohler, H. and Fritschy, J.-M (1999). GABABreceptors make it to the top \320 as dimers. Trends Pharmacol. Sci 20, 87-89.[Medline]

Monnot, C., Bihoreau, C., Conchon, S., Curnow, K. M., Corvol, P. and Clauser, E (1996). Polar residues in the transmembrane domains of the type 1 angiotensin II receptor are required for binding and coupling. Reconstitution of the binding site by co-expression of two deficient mutants. J. Biol. Chem 271, 1507-1513.[Abstract/Free Full Text]

Morello, J. P., Salahpour, A., Laperriere, A., Bernier, V., Arthus, M. F., Lonergan, M., Petaja-Repo, U., Angers, S., Morin, D., Bichet, D. G. and Bouvier, M (2000). Pharmacological chaperones rescue cell-surface expression and function of misfolded V2 vasopressin receptor mutants. J. Clin. Invest 105, 887-895.[Medline]

Nakanishi-Matsui, M., Zheng, Y.-W., Suiciner, D. J., Weiss, E. J., Ludeman, M. J. and Coughlin, S. R (2000). PAR3 is a cofactor for PAR4 activation by thrombin. Nature 404, 609-613.[Medline]

Ng, G.Y., O'Dowd, B. F., Lee, S. P., Chung, H. T., Brann, M. R., Seeman, P., George, S. R (1996). Dopamine D2 receptor dimers and receptor-blocking peptides. Biochem. Biophys. Res. Commun 227, 200-204.[Medline]

Ng, G.Y., Clark, J., Coulombe, N., Ethier, N., Hebert, T. E., Sullivan, R., Kargman, S., Chateauneuf, A., Tsukamoto, N., McDonald, T. et al (1999). Identification of a GABAB receptor subunit, gb2, required for functional GABAB receptor activity. J. Biol. Chem 274, 7607-7610.[Abstract/Free Full Text]

Nimchinsky, E. A., Hof, P. R., Janssen, W. G. M., Morrison, J. H. and Schmauss, C (1997). Expression of dopamine D3receptor dimers and tetramers in brain and in transfected cells. J. Biol. Chem 272, 29229-29237.[Abstract/Free Full Text]

O'Brien, P. J., Prevost, N., Molino, M. M., Hollinger, K., Woolkalis, M. J., Woulfe, D. S.and Brass, L. F (2000). Thrombin responses in human endothelial cells. J.Biol. Chem 275, 13502-13509.[Abstract/Free Full Text]

Overton, M. C. and Blumer, K. J (2000). G-protein-coupled receptors function as oligomers in vivo. Curr. Biol 10, 341-344.[Medline]

Palczewski, K., Kumasaka, T., Hori, T., Behnke, C. A., Motoshima, H.,Fox, B. A., Trong, I. L., Teller, D. C., Okada, T., Stenkamp, R. E. et al (2000). Crystal structure of rhodopsin: a G protein-coupled receptor. Science 289, 739-745.[Abstract/Free Full Text]

Petaja-Repo, U. E., Hogue, M., Laperriere, A., Walker, P. and Bouvier, M (2000). Export from the endoplasmic reticulum represents the limiting step in the maturation and cell surface expression of the human delta opioid receptor. J. Biol. Chem 275, 13727-13736.[Abstract/Free Full Text]

Ray, K. and Hauschild, B. C (2000). Cys-140 is critical for metabotrophic glutamate receptor-1 (mGluR-1) dimerization. J. Biol. Chem 275, 34245-34251.[Abstract/Free Full Text]

Rocheville, M., Lange, D. C., Kumar, U., Sasi, R., Patel, R. C. and Patel, Y. C (2000). Subtypes of the somatostatin receptor assemble as functional homo-and heterodimers. J. Biol. Chem 275, 7862-7869.[Abstract/Free Full Text]

Rocheville, M., Lange, D. C., Kumar, U., Patel, S. C., Patel, R. C. and Patel, Y. C (2000). Receptors for dopamine and somatostatin: formation of hetero-oligomers with enhanced functional activity. Science 288, 154-157.[Abstract/Free Full Text]

Romano, C., Yang, W.-L. and O'Malley, K. L (1996). Metabolic glutamate Receptor 5 Is a disulfide-linked dimer. J. Biol. Chem 271, 28612-28616.[Abstract/Free Full Text]

Romano, C., Miller, J. K., Hyrc, K., Dikranian, S., Mennerick, S., Takeuchi, Y., Goldberg. M. P. and O'Malley, K. L (2001). Covalent and noncovalent interactions mediate metabotropic glutamate receptor mGlu(5) dimerization. Mol. Pharmacol 59, 46-53.[Abstract/Free Full Text]

Scarselli, M., Armogida, M., Chiacchio, S., DeMontis, M. G., Colzi, A., Corsini, G. U. and Maggio, R (2000). Reconstitution of functional dopamine D(2s) receptor by co-expression of amino and carboxyl-terminal receptor fragments. Eur. J. Pharmacol 397, 291-296.[Medline]

Schoneberg, T., Yun, J., Wenkert, D. and Wess, J (1996). Functional rescue of mutant V2 vasopressin receptors causing nephrogenic diabetes insipidus by a co-expressed receptor polypeptide. EMBO J 15, 1283-1291.[Medline]

Schulz, A., Grosse, R., Schultz, G., Gudermann, T. and Schoneberg, T (2000). Structural implication for receptor oligomerization from functional reconstitution studies of mutant V2 vasopressin receptors. J. Biol. Chem 275, 2381-2389.[Abstract/Free Full Text]

Tsuji, Y., Shimada, Y., Takeshita, T., Kajimura, N., Nomura, S., Sekiyama, N., Otomo, J., Usukura, J., Nakanishi, S. and Jingami, H (2000). Cryptic dimer interface and domain organization of the extracellular region of metabotropic glutamate receptor subtype 1. J. Biol. Chem 275, 28144-28151.[Abstract/Free Full Text]

Vila-Coro, A. J., Rodriguez-Frade, J. M., Martin De Ana, A., Moreno-Ortiz, M. C., Martinez, A. C. and Mellado, M (1999). The chemokine SDF-1triggers CXCR4 receptor dimerization and activates the JAK/STAT pathway. FASEB J 13, 1699-1710.[Abstract/Free Full Text]

White, J. H., Wise, A., Main, M. J., Green, A., Fraser, N. J., Disney, G. H., Barnes, A. A., Emson, P., Foord, S. M. and Marshall, F. H (1998). Heterodimerization is required for the formation of a functional GABA(B) receptor. Nature 396, 679-682.[Medline]

Wilson, S., Bergsma, D. J., Chambers, J. K., Muir, A. I., Fantom, K. G., Ellis, C., Murdock, P. R., Herrity, N. C. and Stadel, J. M (1998). Orphan G-protein-coupled receptors: the next generation of drug targets?. Br. J. Pharmacol 125, 1387-1392.[Medline]

Yesilaltay, A. and Jenness, D. D (2000). Homo-oligomeric complexes of the yeast alpha-factor pheromone receptor are functional units of endocytosis. Mol. Biol. Cell 11, 2873-2884.[Abstract/Free Full Text]

Zeng, F.-Y. and Wess, J (1999). Identification and molecular characterization of m3 muscarinic receptor dimers. J. Biol. Chem 274, 19487-19497.[Abstract/Free Full Text]

Zhu, X. and Wess, J (1998). Truncated V2 vasopressin receptors as negative regulators of wild-type V2 receptor function. Biochemistry 37, 15773-15784.[Medline]




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