Initiating DNA synthesis: from recruiting to activating the MCM complex

QUICK SEARCH:

[advanced]

	Author:		Keyword(s):

Home Help Feedback Subscriptions Archive Search Table of Contents

This Article

	Summary
	Full Text (PDF)
	Alert me when this article is cited
	Alert me if a correction is posted

Services

	Email this article to a friend
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new issues of the journal
	Download to citation manager


Citing Articles

	Citing Articles via HighWire
	Citing Articles via Google Scholar

Google Scholar

	Articles by Lei, M.
	Articles by Tye, B. K.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Lei, M.
	Articles by Tye, B. K.

Aparicio, O. M., Stout, A. M. and Bell, S. P (1999). Differential assembly of Cdc45p and DNA polymerases at early and late origins of DNA replication. Proc. Nat. Acad. Sci. USA 96, 9130-9135.[Abstract/Free Full Text]

Bell, S. and Stillman, B (1992). ATP-dependent recognition of eukaryotic origins of DNA replication by a multiprotein complex. Nature 357, 128-134.[Medline]

Blow, J. J. and Laskey, R. A (1988). A role for the nuclear envelope in controlling DNA replication within the cell cycle. Nature 332, 546-548.[Medline]

Blow, J. J. and Tada, S (2000). A new check on issuing the license. Nature 404, 560-561.[Medline]

Bousset, K. and Diffley, J. F. X (1998). The Cdc7 protein kinase is required for origin firing during S phase. Genes Dev 12, 480-490.[Abstract/Free Full Text]

Brown, G. and Kelly, T. J (1998). Purification of Hsk1, a minichromosome maintenance protein kinase from fission yeast. J. Biol. Chem 34, 22083-22090.

Cheng, L., Collyer, T. and Hardy, C. F (1999). Cell cycle regulation of DNA replication initiator factor, Dbf4. Mol. Cell. Biol 19, 4270-4278.[Abstract/Free Full Text]

Chong, J., Mahbubani, H. M., Khoo, C. Y. and Blow, J. J (1995). Purification of an MCM-containing complex as a component of the DNA replication licensing system. Nature 375, 418-421.[Medline]

Coleman, T. R., Carpenter, P. B. and Dunphy, W. G (1996). The Xenopus Cdc6 Protein is essential for the initiation of a single round of DNA replication in cell-free extracts. Cell 87, 53-63.[Medline]

Coverley, D., Pelizon, C., Trewick, S. and Laskey, R. A (2000). Chromatin-bound Cdc6 persists in S and G2phases in human cells, while soluble Cdc6 is destroyed in a cyclin A-cdk2 dependent process. J. Cell Sci 113, 1929-1938.[Abstract]

Dahmann, C., Diffley, J. F. X. and Nasmyth, K (1995). S-phase-promoting cyclin dependent kinases prevent re-replication by inhibiting the transition of replication origins to a pre-replicative state. Curr. Biol 5, 1257-1269.[Medline]

Diffley, J. F. X. and Cocker, J. H (1992). Protein-DNA interactions at a yeast replication origin. Nature 357, 169-172.[Medline]

Diffley, J. F. X., Cocker, J. H., Dowell, S. J. and Rowley, A (1994). Two steps in the assembly of complexes at yeast replication origins in vivo. Cell 78, 303-316.[Medline]

Donaldson, A. D., Fangman, W. L. and Brewer, B. J (1998). Cdc7 is required throughout the yeast S phase to activate replication origins. Genes Dev 12, 491-501.[Abstract/Free Full Text]

Donovan, S., Harwood, J., Drury, L. S. and Diffley, J. F. X (1997). Cdc6p-dependent loading of Mcm proteins onto pre-replicative chromatin in budding yeast. Proc. Nat. Acad. Sci. USA 94, 5611-5616.[Abstract/Free Full Text]

Dowell, S. J., Romanoski, P. and Diffley, J. F (1994). Interaction of Dbf4, the Cdc7 protein kinase regulatory subunit, with yeast replication origins in vivo. Science 265, 1243-1246.[Abstract/Free Full Text]

Elsasser, S., Lou, F., Wang, B., Campbell, J. and Jong, A (1996). Interaction between yeast Cdc6 protein and B-type cyclin/Cdc28 kinases. Mol. Biol. Cell 7, 1723-1735.[Abstract]

Ferreira, M., Santocanale, C., Drury, L. S. and Diffley, J. F (2000). Dbf4p, an essential S phase-promoting factor, is targeted for degradation by the anaphase-promoting complex. Mol. Cell. Biol 20, 242-248.[Abstract/Free Full Text]

Geraghty, D. S., Ding, M., Heintz, N. H. and Pederson, D. S (2000). Premature structural changes at replication origins in a yeast minichromosome maintenance (MCM) mutant. J. Biol. Chem 275, 18011-18021.[Abstract/Free Full Text]

Hardy, C. F., Dryga, O., Pahl, P. M. B. and Sclafani, R. A (1997). mcm5/cdc46-bob1 bypasses the requirement for the S phase activator Cdc7p. Proc. Nat. Acad. Sci. USA 94, 3151-3155.[Abstract/Free Full Text]

Hendrickson, M., Madine, M., Dalton, S. and Gautier, J (1996). Phosphorylation of MCM4 by cdc2 proteins kinase inhibits the activity ofthe minichromosome maintenance complex. Proc. Nat. Acad. Sci. USA 93, 12223-12228.[Abstract/Free Full Text]

Hennessy, K. M., Lee, A., Chen, E. and Botstein, D (1991). A group of interacting yeast DNA replication genes. Genes Dev 5, 958-969.[Abstract/Free Full Text]

Hereford, L. and Hartwell, L (1974). Sequential gene function in the initiation of S. cerevisiae DNA synthesis. J. Mol. Biol 84, 445-461.[Medline]

Hofmann, J. F. and Beach, D (1994). cdt1 is an essential target of the Cdc10/Sct1 transcription factor: requirement for DNA replication and inhibition of mitosis. EMBO J 13, 425-434.[Medline]

Homesley, L., Lei, M., Kawasaki, Y., Sawyer, S., Christensen, T. and Tye, B. K (2000). Mcm10 and the MCM2-7 complex interact to initiate DNA synthesis and to release replication factors from origins. Genes Dev 14, 913-926.[Abstract/Free Full Text]

Hopwood, B. and Dalton, S (1996). Cdc45 assembles into a complex with Cdc46p/Mcm5p, is required for minichromosome maintenance, and is essential for chromosomal DNA replication. Proc. Nat. Acad. Sci. USA 93, 12309-12314.[Abstract/Free Full Text]

Hua, X. H. and Newport, J (1998). Identification of a preinitiation step in DNA replication that is independent of origin recognition complex and Cdc6, but dependent on cdk2. J. Cell Biol 140, 271-281.[Abstract/Free Full Text]

Ishimi, Y., Komamura-Kohno, Y., You, Z., Omori, A. and Kitagawa, M (2000). Inhibition of Mcm4,6,7 helicase activity by phosphorylation with cyclin A/Cdk2. J. Biol. Chem 275, 16235-16241.[Abstract/Free Full Text]

Izumi, M., Yanagi, K., Mizuno, T., Yokoi, M., Kawasaki, Y., Moon, K.-Y., Hurwitz, J. and Hanaoka, F (2000). Identification of the human homolog of Saccharomyces cerevisiae Mcm10, a critical component for the initiation of DNA synthesis. Nucl. Acids Res 28, 4769-4777.[Abstract/Free Full Text]

Jackson, A. L., Pahl, P. M. B., Harrison, K., Rosamond, J. and Sclafani, R. A (1993). Cell cycle regulation of the yeast Cdc7 protein kinase by association with the Dbf4 protein. Mol. Cell. Biol 13, 2899-2908.[Abstract/Free Full Text]

Jallepalli, P. V., Brown, G. W., Muzi-Falconi, M., Tien, D. and Kelly, T. J (1997). Regulation of the replication initiator protein p65cdc18 by CDK phosphorylation. Genes Dev 11, 2767-2779.[Abstract/Free Full Text]

Jares, P. and Blow, J. J (2000). Xenopus Cdc7 function is dependent on licensing but not on XORC, XCdc6, or CDK activity and is required for XCdc45 loading. Genes Dev 14, 1528-1540.[Abstract/Free Full Text]

Jiang, W., McDonald, D., Hope, T. J. and Hunter, T (1999). Mammalian Cdc7-Dbf4 protein kinase complex is essential for initiation of DNA replication. EMBO J 18, 5703-5713.[Medline]

Kearsey, S. E., Maiorano, D., Holmes, E. C. and Todorov, I (1995). The role of MCM proteins in the control of genome duplication. BioEssays 18, 183-189.

Kihara, M., Nakai, W., Asano, S., Suzuki, A., Kitada, K., Kawasaki, Y., Johnston, L. H. and Sugino, A (2000). Characterization of the yeast Cdc7p/Dbf4p complex purified from insect cells: its protein kinase activity is regulated by Rad53p. J. Biol. Chem 275, 35051-35062.[Abstract/Free Full Text]

Kitada, K., Johnston, L., Sugino, T. and Sugino, A (1992). Temperature-sensitive cdc7 mutations of Saccharomyces cerevisiae are suppressed by the DBF4 gene, which is required for the G1/S cell cycle transition. Genetics 131, 21-29.[Abstract]

Koonin, E. V (1993). A common set of conserved motifs in a vast variety of putative nucleic acid-dependent ATPases including MCM proteins involved in the initiation of eukaryotic DNA replication. Nucl. Acids Res 21, 2541-2547.[Abstract/Free Full Text]

Kubota, Y., Mimura, S., Nishimoto, S.-I., Takisawa, H. and Nojima, H (1995). Identification of the yeast MCM3-related protein as a component of Xenopus DNA replication licensing factor. Cell 81, 601-610.[Medline]

Kubota, Y., Mimura, S., Nishimoto, S., Masuda, T., Nojima, H. and Takisawa, H (1997). Licensing of DNA replication by a multi-protein complex of MCM/P1 protein in Xenopus eggs. EMBO J 16, 3320-3331.[Medline]

Labib, K., Tercero, J. A. and Diffley, J. F (2000). Uninterrupted MCM2-7 function required for DNA replication fork progression. Science 288, 1643-1647.[Abstract/Free Full Text]

Lee, D. G. and Bell, S. P (2000). ATPase switches controlling DNA replication initiation. Curr. Opin. Cell Biol 12, 280-285.[Medline]

Lee, J. K. and Hurwitz, J (2000). Isolation and characterization of various complexes of the minichromosome maintenance proteins of Schizosaccharomyces pombe. J. Biol. Chem 275, 18871-18878.[Abstract/Free Full Text]

Lee, D. G., Makhov, A. M., Klemm, R. D., Griffith, J. D. and Bell, S. P (2000). Regulation of origin recognition complex conformation and ATPase activity: differential effects of single-stranded and double-stranded DNA binding. EMBO J 19, 4774-4782.[Medline]

Lei, M., Kawasaki, Y., Young, M. R., Kihara, M., Sugino, A. and Tye, B. K (1997). Mcm2 is a target of regulation by Cdc7-Dbf4 during the initiation of DNA synthesis. Genes Dev 11, 3365-3374.[Abstract/Free Full Text]

Lipford, J. R. and Bell, S. P (2001). Nucleosomes positioned by ORC facilitate the initiation of DNA replication. Mol. Cell 7, 21-30.

Maine, G. T., Sinha, P. and Tye, B. K (1984). Mutants of S. cerevisiae defective in the maintenance of minichromosomes. Genetics 106, 365-385.[Abstract/Free Full Text]

Maiorano, D., Lemaitre, J.-M. and Mechali, M (2000). Stepwise regulated chromatin assembly of MCM2-7 proteins. J. Biol. Chem 275, 8426-8431.[Abstract/Free Full Text]

Maiorano, D., Moreau, J. and Mechali, M (2000). XCDT1 is required for the assembly of pre-replicative complexes in Xenopus laevis. Nature 404, 622-625.[Medline]

Marahrens, Y. and Stillman, B (1992). A yeast chromosomal origin of DNA replication defined by multiple functional elements. Science 255, 817-822.[Abstract/Free Full Text]

McGarry, T. J. and Kirschner, M. W (1998). Geminin, an inhibitor of DNA replication is degraded during mitosis. Cell 93, 1043-1053.[Medline]

Merchant, A. M., Kawasaki, Y., Chen, Y., Lei, M. and Tye, B. K (1997). A lesion in the DNA replication initiation factor Mcm10 induces pausing of elongation forks through chromosomal replication origins in S. cerevisiae. Mol. Cell. Biol 17, 3261-3271.[Abstract]

Mimura, S. and Takisawa, H (1998). Xenopus Cdc45-dependent loading of DNA polymeraseonto chromatin under the control of S-phase cdk. EMBO J 17, 5699-5707.[Medline]

Moir, D. and Botstein, D (1982). Determination of the order of gene function in the yeast nuclear division pathway using cs and ts mutants. Genetics 100, 565-577.[Abstract/Free Full Text]

Moir, D., Stewart, S. E., Osmond, B. C. and Botstein, D (1982). Cold-sensitive cell-division-cycle mutants of yeast: properties and pseudoreversion studies. Genetics 100, 547-564.[Abstract/Free Full Text]

Nasmyth, K (1993). Control of the yeast cell cycle by the Cdc28 protein kinase. Curr. Opin. Cell Biol 5, 166-179.[Medline]

Nasmyth, K. and Nurse, P (1981). Cell division cycle mutants altered in DNA replication and mitosis in the fission yeast Schizosaccharmomyces pombe. Mol. Gen. Genet 182, 119-124.[Medline]

Nishitani, H. and Nurse, P (1995). p65cdc18 plays a major role controlling the initiation of DNA replication in fission yeast. Cell 83, 397-405.[Medline]

Nishitani, H., Lygerou, Z., Nishimoto, T. and Nurse, P (2000). The Cdt1 protein is required to license DNA for replication in fission yeast. Nature 404, 625-628.[Medline]

Noton, E. and Diffley, J. F (2000). CDK inactivation is the only essential function of the APC/C and the mitotic exit network proteins for origin resetting during mitosis. Mol. Cell 5, 85-95.

Nougarede, R., Della Seta, F., Zarzov, P. and Schwob, E (2000). Hierarchy of S-phase-promoting factors: yeast Dbf4-Cdc7 kinase requires prior S-phase cyclin-dependent kinase activation. Mol. Cell. Biol 20, 3795-3806.[Abstract/Free Full Text]

Nurse, P (1990). Universal control mechanism regulating onset of M-phase. Nature 344, 503-508.[Medline]

Oshiro, G., Owens, J. C., Shellman, Y. and Li, J. J (1999). Cell cycle control of Cdc7p kinase activity through regulation of Dbf4 stability. Mol. Cell. Biol 19, 4888-4896.[Abstract/Free Full Text]

Owens, J. C., Detweiler, C. S. and Li, J. J (1997). CDC45 is required in conjunction with CDC7/DBF4 to trigger the initiation of DNA replication. Proc. Nat. Acad. Sci. USA 94, 12521-12526.[Abstract/Free Full Text]

Pasero, P., Duncker, B. P., Schwob, E. and Gasser, S. M (1999). A role for the Cdc7 kinase regulatory subunit Dbf4 in the formation of the initiation-competent origins of replication. Genes Dev 13, 2159-2176.[Abstract/Free Full Text]

Perkins, G. and Diffley, J. F. X (1998). Nucleotide-dependent prereplicative complex assembly by Cdc6p, a homolog of eukaryotic and prokaryotic clamp-loaders. Mol. Cell 2, 23-32.

Piatti, S., Lengauer, C. and Nasmyth, K (1995). Cdc6 is an unstable protein whose de novo synthesis in G1is important for the onset of S phase and for preventing a \324reductional' anaphase in the budding yeast Saccharomyces cerevisiae. EMBO J 14, 3788-3799.[Medline]

Piatti, S., Bohm, T., Cocker, J. H., Diffley, J. F. X. and Nasmyth, K (1996). Activation of S-phase promoting CDKs in late G1defines a \324point of no return' after which Cdc6 synthesis cannot promote DNA replication in yeast. Genes Dev 10, 1516-1531.[Abstract/Free Full Text]

Prokhorova, T. A. and Blow, J. J (2000). Sequential MCM/P1 subcomplex assembly is required to form a heterohexamer with replication licensing activity. J. Biol. Chem 275, 2491-2498.[Abstract/Free Full Text]

Rao, P. N. and Johnson, R. T (1970). Mammalian cell fusion: studies on the regulation of DNA synthesis and mitosis. Nature 225, 159-164.[Medline]

Rowles, A., Tada, S. and Blow, J. J (1999). Changes in association of the Xenopus origin recognition complex with chromatin on licensing of replication origins. J. Cell Sci 112, 2011-2018.[Abstract]

Santocanale, C. and Diffley, J. F. X (1996). ORC-and Cdc6-dependent complexes at active and inactive chromosomal repliocation origins in Saccharomyces cerevisiae. EMBO J 15, 6671-6679.[Medline]

Santocanale, S. and Diffley, J. F. X (1998). A Mec1-and Rad53-dependent checkpoint controls late-firing origins of DNA replication. Nature 395, 615-618.[Medline]

Sato, M., Gotow, T., You, Z., Komamura-Kohno, Y., Uchiyama, Y., Yabuta, N., Nojima, H. and Ishimi, Y (2000). Electron microscopic observation and single-stranded DNA binding activity of the Mcm4,6,7 complex. J. Mol. Biol 300, 421-431.[Medline]

Sclafani, R. A (2000). Cdc7p-Dbf4p becomes famous in the cell cycle. J. Cell Sci 113, 2111-2117.[Abstract]

Shirahige, K., Hori, Y., Shiraishi, K., Yamashita, M., Takahashi, K., Obuse, C., Tsurimoto, T. and Yoshikawa, H (1998). Regulation of DNA-replication origins during cell-cycle progression. Nature 395, 618-621.[Medline]

Sinha, P., Chang, V. and Tye, B. K (1986). A mutant that affects the function of autonomously replicating sequences in yeast. J. Mol. Biol 192, 805-814.[Medline]

Spradling, A (1999). ORC binding, gene amplification, and the nature of metazoan replication origins. Genes Dev 13, 2619-2623.[Free Full Text]

Takisawa, H., Mimura, S. and Kubota, Y (2000). Eukaryotic DNA replication: from pre-replication complex to initiation complex. Curr. Opin. Cell Biol 12, 690-695.[Medline]

Tanaka, T., Knapp, D. and Nasmyth, K (1997). Loading of an Mcm protein onto DNA replication origins is regulated by Cdc6p and CDKs. Cell 90, 649-660.[Medline]

Tanaka, T. and Nasmyth, K (1998). Association of RPA with chromosomal replication origins requires an Mcm protein, and is regulated by Rad53, and cyclin-and Dbf4-dependent kinases. EMBO J 17, 5182-5191.[Medline]

Thoma, F. and Simpson, R. T (1985). Local protein-DNA interactions may determine nucleosome positions on yeast plasmids. Nature 315, 250-252.[Medline]

Tye, B. K (1999). MCM proteins in DNA replication. Annu. Rev. Biochem 68, 649-686.[Medline]

Tye, B. K. and Sawyer, S (2000). The hexameric eukaryotic MCM helicase: building symmetry from nonidentical parts. J. Biol. Chem 275, 34833-34836.[Free Full Text]

Walker, S. S., Malik, A. K. and Eisenberg, S (1991). Analysis of the interactions of functional domains of a nuclear origin of replication from Saccharomyces cerevisiae. Nucl. Acids Res 19, 6255-6262.[Abstract/Free Full Text]

Walter, J. C (2000). Evidence for sequential action of cdc7 and cdk2 protein kinases during initiation of DNA replication in Xenopus egg extracts. J. Biol. Chem 275, 39773-39778.[Abstract/Free Full Text]

Walter, J. and Newport, J. W (1997). Regulation of replicon size in Xenopus egg extracts. Science 275, 993-995.[Abstract/Free Full Text]

Walter, J. and Newport, J (2000). Initiation of eukaryotic DNA replication: origin unwinding and sequential chromatin association of Cdc45, RPA, and DNA polymerase alpha. Mol. Cell 5, 617-627.

Weinreich, M. and Stillman, B (1999). Cdc7p-Dbf4p kinase binds to chromatin during S phase and is regulated by both the APC and the RAD53 checkpoint pathway. EMBO J 18, 5334-5346.[Medline]

Whittaker, A. J., Royzman, I. and Orr-Weaver, T. L (2000). Drosophila double parked: a conserved, essential replication protein that colocalizes with the origin recognition complex and links DNA replication with mitosis and the down-regulation of S phase transcripts. Genes Dev 14, 1765-1776.[Abstract/Free Full Text]

Wohlschlegel, J. A., Dwyer, B. T., Dhar, S. K., Cvetic, C., Walter, J. C. and Dutta, A (2001). Geminin inhibits eukaryotic DNA replication by binding to Cdt1. Science 290, 2309-2312.[Abstract/Free Full Text]

Yan, H., Merchant, A. M. and Tye, B. K (1993). Cell cycle-regulated nuclear localization of MCM2 and MCM3, which are required for the initiation of DNA synthesis at chromosomal replication origins in yeast. Genes Dev 7, 2149-2160.[Abstract/Free Full Text]

Yoon, H. J., Loo, S. and Campbell, J. L (1993). Regulation of Saccharomyces cerevisiae CDC7 function during the cell cycle. Mol. Biol. Cell 4, 195-208.[Abstract]

You, Z., Komamura, Y. and Ishimi, Y (1999). Biochemical analysis of the intrinsic Mcm4-Mcm6-Mcm7 DNA helicase activity. Mol. Cell. Biol 19, 8003-8015.[Abstract/Free Full Text]

Zachariae, W. and Nasmyth, K (1999). Whose end is destruction: cell division and the anaphase-promoting complex. Genes Dev 13, 2039-2058.[Free Full Text]

Zhou, C. and Jong, A (1990). CDC6 mRNA fluctuates periodically in the yeast cell cycle. J. Biol. Chem 265, 19904-19909.[Abstract/Free Full Text]

Zou, L. and Stillman, B (1998). Formation of a preinitiation complex by S-phase CDK-dependent loading of Cdc45p onto chromatin. Science 280, 593-596.[Abstract/Free Full Text]

Zou, L. and Stillman, B (2000). Assembly of a complex containing Cdc45p, replication protein A, and Mcm2p at replication origins controlled by S-phase cyclin-dependent kinases and Cdc7p-Dbf4p kinase. Mol. Cell. Biol 20, 3086-3096.[Abstract/Free Full Text]

This article has been cited by other articles:

Q. Kan, S. Jinno, K. Kobayashi, H. Yamamoto, and H. Okayama
Cdc6 Determines Utilization of p21WAF1/CIP1-dependent Damage Checkpoint in S Phase Cells
J. Biol. Chem., June 27, 2008; 283(26): 17864 - 17872.
[Abstract] [Full Text] [PDF]

Q. Kan, S. Jinno, H. Yamamoto, K. Kobayashi, and H. Okayama
ATP-dependent activation of p21WAF1/CIP1-associated Cdk2 by Cdc6
PNAS, March 25, 2008; 105(12): 4757 - 4762.
[Abstract] [Full Text] [PDF]

E. Lau, T. Tsuji, L. Guo, S.-H. Lu, and W. Jiang
The role of pre-replicative complex (pre-RC) components in oncogenesis
FASEB J, December 1, 2007; 21(14): 3786 - 3794.
[Abstract] [Full Text] [PDF]

J. J. Lin and A. Dutta
ATR Pathway Is the Primary Pathway for Activating G2/M Checkpoint Induction After Re-replication
J. Biol. Chem., October 19, 2007; 282(42): 30357 - 30362.
[Abstract] [Full Text] [PDF]

B. J. Kim, S.-Y. Kim, and H. Lee
Identification and Characterization of Human Cdc7 Nuclear Retention and Export Sequences in the Context of Chromatin Binding
J. Biol. Chem., October 12, 2007; 282(41): 30029 - 30038.
[Abstract] [Full Text] [PDF]

J. Gray, J. T. Mao, E. Szabo, M. Kelley, J. Kurie, and G. Bepler
Lung Cancer Chemoprevention: ACCP Evidence-Based Clinical Practice Guidelines (2nd Edition)
Chest, September 1, 2007; 132(3_suppl): 56S - 68S.
[Abstract] [Full Text] [PDF]

N. Dissmeyer, M. K. Nowack, S. Pusch, H. Stals, D. Inze, P. E. Grini, and A. Schnittger
T-Loop Phosphorylation of Arabidopsis CDKA;1 Is Required for Its Function and Can Be Partially Substituted by an Aspartate Residue
PLANT CELL, March 1, 2007; 19(3): 972 - 985.
[Abstract] [Full Text] [PDF]

M. A. Rehman, G. Fourel, A. Mathews, D. Ramdin, M. Espinosa, E. Gilson, and K. Yankulov
Differential Requirement of DNA Replication Factors for Subtelomeric ARS Consensus Sequence Protosilencers in Saccharomyces cerevisiae
Genetics, December 1, 2006; 174(4): 1801 - 1810.
[Abstract] [Full Text] [PDF]

K. Hara, K. I. Nakayama, and K. Nakayama
Geminin is essential for the development of preimplantation mouse embryos
Genes Cells, November 1, 2006; 11(11): 1281 - 1293.
[Abstract] [Full Text] [PDF]

A. Kudoh, T. Daikoku, Y. Ishimi, Y. Kawaguchi, N. Shirata, S. Iwahori, H. Isomura, and T. Tsurumi
Phosphorylation of MCM4 at Sites Inactivating DNA Helicase Activity of the MCM4-MCM6-MCM7 Complex during Epstein-Barr Virus Productive Replication.
J. Virol., October 1, 2006; 80(20): 10064 - 10072.
[Abstract] [Full Text] [PDF]

J.-H. Shin and Z. Kelman
The Replicative Helicases of Bacteria, Archaea, and Eukarya Can Unwind RNA-DNA Hybrid Substrates
J. Biol. Chem., September 15, 2006; 281(37): 26914 - 26921.
[Abstract] [Full Text] [PDF]

K. B. Spurgers, D. L. Gold, K. R. Coombes, N. L. Bohnenstiehl, B. Mullins, R. E. Meyn, C. J. Logothetis, and T. J. McDonnell
Identification of Cell Cycle Regulatory Genes as Principal Targets of p53-mediated Transcriptional Repression
J. Biol. Chem., September 1, 2006; 281(35): 25134 - 25142.
[Abstract] [Full Text] [PDF]

P. R. Dohrmann and R. A. Sclafani
Novel Role for Checkpoint Rad53 Protein Kinase in the Initiation of Chromosomal DNA Replication in Saccharomyces cerevisiae
Genetics, September 1, 2006; 174(1): 87 - 99.
[Abstract] [Full Text] [PDF]

N. Nitani, K.-i. Nakamura, C. Nakagawa, H. Masukata, and T. Nakagawa
Regulation of DNA Replication Machinery by Mrc1 in Fission Yeast
Genetics, September 1, 2006; 174(1): 155 - 165.
[Abstract] [Full Text] [PDF]

P. E. Cohen, S. E. Pollack, and J. W. Pollard
Genetic Analysis of Chromosome Pairing, Recombination, and Cell Cycle Control during First Meiotic Prophase in Mammals
Endocr. Rev., June 1, 2006; 27(4): 398 - 426.
[Abstract] [Full Text] [PDF]

T. Dresselhaus, K.-o. Srilunchang, D. Leljak-Levanic, D. N. Schreiber, and P. Garg
The Fertilization-Induced DNA Replication Factor MCM6 of Maize Shuttles between Cytoplasm and Nucleus, and Is Essential for Plant Growth and Development
Plant Physiology, February 1, 2006; 140(2): 512 - 527.
[Abstract] [Full Text] [PDF]

R. J. Fletcher, J. Shen, Y. Gomez-Llorente, C. S. Martin, J. M. Carazo, and X. S. Chen
Double Hexamer Disruption and Biochemical Activities of Methanobacterium thermoautotrophicum MCM
J. Biol. Chem., December 23, 2005; 280(51): 42405 - 42410.
[Abstract] [Full Text] [PDF]

E. Marco and F. Gago
DNA Structural Similarity in the 2:1 Complexes of the Antitumor Drugs Trabectedin (Yondelis) and Chromomycin A3 with an Oligonucleotide Sequence Containing Two Adjacent TGG Binding Sites on Opposing Strands
Mol. Pharmacol., December 1, 2005; 68(6): 1559 - 1567.
[Abstract] [Full Text] [PDF]

E. Queralt and J. C. Igual
Functional Connection Between the Clb5 Cyclin, the Protein Kinase C Pathway and the Swi4 Transcription Factor in Saccharomyces cerevisiae
Genetics, December 1, 2005; 171(4): 1485 - 1498.
[Abstract] [Full Text] [PDF]

E. Milgrom, R. W. West Jr., C. Gao, and W.-C. W. Shen
TFIID and Spt-Ada-Gcn5-Acetyltransferase Functions Probed by Genome-wide Synthetic Genetic Array Analysis Using a Saccharomyces cerevisiae taf9-ts Allele
Genetics, November 1, 2005; 171(3): 959 - 973.
[Abstract] [Full Text] [PDF]

L.-C. Chuang and P. R. Yew
Proliferating Cell Nuclear Antigen Recruits Cyclin-dependent Kinase Inhibitor Xic1 to DNA and Couples Its Proteolysis to DNA Polymerase Switching
J. Biol. Chem., October 21, 2005; 280(42): 35299 - 35309.
[Abstract] [Full Text] [PDF]

B. Chen, H. Pan, L. Zhu, Y. Deng, and J. W. Pollard
Progesterone Inhibits the Estrogen-Induced Phosphoinositide 3-Kinase->AKT->GSK-3{beta}->Cyclin D1->pRB Pathway to Block Uterine Epithelial Cell Proliferation
Mol. Endocrinol., August 1, 2005; 19(8): 1978 - 1990.
[Abstract] [Full Text] [PDF]

C. A. Nieduszynski, J. J. Blow, and A. D. Donaldson
The requirement of yeast replication origins for pre-replication complex proteins is modulated by transcription
Nucleic Acids Res., April 28, 2005; 33(8): 2410 - 2420.
[Abstract] [Full Text] [PDF]

S. I. Reed
Deregulation of Cyclin E in Cancer
Am. Assoc. Cancer Res. Educ. Book, April 1, 2005; 2005(1): 53 - 56.
[Full Text] [PDF]

L. Tsvetkov and D. F. Stern
Interaction of Chromatin-associated Plk1 and Mcm7
J. Biol. Chem., March 25, 2005; 280(12): 11943 - 11947.
[Abstract] [Full Text] [PDF]

M. Anger, P. Stein, and R. M. Schultz
CDC6 Requirement for Spindle Formation During Maturation of Mouse Oocytes
Biol Reprod, January 1, 2005; 72(1): 188 - 194.
[Abstract] [Full Text] [PDF]

K. L. Eward, E. C. Obermann, S. Shreeram, M. Loddo, T. Fanshawe, C. Williams, H.-I. Jung, A. T. Prevost, J. J. Blow, K. Stoeber, et al.
DNA replication licensing in somatic and germ cells
J. Cell Sci., November 15, 2004; 117(24): 5875 - 5886.
[Abstract] [Full Text] [PDF]

D. Shechter, C. Y. Ying, and J. Gautier
DNA Unwinding Is an MCM Complex-dependent and ATP Hydrolysis-dependent Process
J. Biol. Chem., October 29, 2004; 279(44): 45586 - 45593.
[Abstract] [Full Text] [PDF]

E. L. Hendrickson, R. Kaul, Y. Zhou, D. Bovee, P. Chapman, J. Chung, E. Conway de Macario, J. A. Dodsworth, W. Gillett, D. E. Graham, et al.
Complete Genome Sequence of the Genetically Tractable Hydrogenotrophic Methanogen Methanococcus maripaludis
J. Bacteriol., October 15, 2004; 186(20): 6956 - 6969.
[Abstract] [Full Text] [PDF]

P. Francon, J.-M. Lemaitre, C. Dreyer, D. Maiorano, O. Cuvier, and M. Mechali
A hypophosphorylated form of RPA34 is a specific component of pre-replication centers
J. Cell Sci., October 1, 2004; 117(21): 4909 - 4920.
[Abstract] [Full Text] [PDF]

P. Karakaidos, S. Taraviras, L. V. Vassiliou, P. Zacharatos, N. G. Kastrinakis, D. Kougiou, M. Kouloukoussa, H. Nishitani, A. G. Papavassiliou, Z. Lygerou, et al.
Overexpression of the Replication Licensing Regulators hCdt1 and hCdc6 Characterizes a Subset of Non-Small-Cell Lung Carcinomas: Synergistic Effect with Mutant p53 on Tumor Growth and Chromosomal Instability--Evidence of E2F-1 Transcriptional Control over hCdt1
Am. J. Pathol., October 1, 2004; 165(4): 1351 - 1365.
[Abstract] [Full Text] [PDF]

Robert. A. Sclafani, R. J. Fletcher, and X. S. Chen
Two heads are better than one: regulation of DNA replication by hexameric helicases
Genes & Dev., September 1, 2004; 18(17): 2039 - 2045.
[Full Text] [PDF]

W. Zhu, Y. Chen, and A. Dutta
Rereplication by Depletion of Geminin Is Seen Regardless of p53 Status and Activates a G2/M Checkpoint
Mol. Cell. Biol., August 15, 2004; 24(16): 7140 - 7150.
[Abstract] [Full Text] [PDF]

Y. Zhu, C. Alvarez, R. Doll, H. Kurata, X. M. Schebye, D. Parry, and E. Lees
Intra-S-Phase Checkpoint Activation by Direct CDK2 Inhibition
Mol. Cell. Biol., July 15, 2004; 24(14): 6268 - 6277.
[Abstract] [Full Text] [PDF]

S. Ekholm-Reed, J. Mendez, D. Tedesco, A. Zetterberg, B. Stillman, and S. I. Reed
Deregulation of cyclin E in human cells interferes with prereplication complex assembly
J. Cell Biol., June 21, 2004; 165(6): 789 - 800.
[Abstract] [Full Text] [PDF]

Y. Ofir, S. Sagee, N. Guttmann-Raviv, L. Pnueli, and Y. Kassir
The Role and Regulation of the preRC Component Cdc6 in the Initiation of Premeiotic DNA Replication
Mol. Biol. Cell, May 1, 2004; 15(5): 2230 - 2242.
[Abstract] [Full Text] [PDF]

V. M. Vassin, M. S. Wold, and J. A. Borowiec
Replication Protein A (RPA) Phosphorylation Prevents RPA Association with Replication Centers
Mol. Cell. Biol., March 1, 2004; 24(5): 1930 - 1943.
[Abstract] [Full Text] [PDF]

C. R. Cook, G. Kung, F. C. Peterson, B. F. Volkman, and M. Lei
A Novel Zinc Finger Is Required for Mcm10 Homocomplex Assembly
J. Biol. Chem., September 19, 2003; 278(38): 36051 - 36058.
[Abstract] [Full Text] [PDF]

X. Li, Q. Zhao, R. Liao, P. Sun, and X. Wu
The SCFSkp2 Ubiquitin Ligase Complex Interacts with the Human Replication Licensing Factor Cdt1 and Regulates Cdt1 Degradation
J. Biol. Chem., August 15, 2003; 278(33): 30854 - 30858.
[Abstract] [Full Text] [PDF]

R. Dziak, D. Leishman, M. Radovic, B. K. Tye, and K. Yankulov
Evidence for a Role of MCM (Mini-chromosome Maintenance)5 in Transcriptional Repression of Sub-telomeric and Ty-proximal Genes in Saccharomyces cerevisiae
J. Biol. Chem., July 18, 2003; 278(30): 27372 - 27381.
[Abstract] [Full Text] [PDF]

T. Eide, K. A. Tasken, C. Carlson, G. Williams, T. Jahnsen, K. Tasken, and P. Collas
Protein Kinase A-anchoring Protein AKAP95 Interacts with MCM2, a Regulator of DNA Replication
J. Biol. Chem., July 11, 2003; 278(29): 26750 - 26756.
[Abstract] [Full Text] [PDF]

M. J. Fitch, J. J. Donato, and B. K. Tye
Mcm7, a Subunit of the Presumptive MCM Helicase, Modulates Its Own Expression in Conjunction with Mcm1
J. Biol. Chem., July 3, 2003; 278(28): 25408 - 25416.
[Abstract] [Full Text] [PDF]

T. W. Christensen and B. K. Tye
Drosophila Mcm10 Interacts with Members of the Prereplication Complex and Is Required for Proper Chromosome Condensation
Mol. Biol. Cell, June 1, 2003; 14(6): 2206 - 2215.
[Abstract] [Full Text] [PDF]

				Q. Kan, S. Jinno, H. Yamamoto, K. Kobayashi, and H. Okayama ATP-dependent activation of p21WAF1/CIP1-associated Cdk2 by Cdc6 PNAS, March 25, 2008; 105(12): 4757 - 4762. [Abstract] [Full Text] [PDF]

				E. Lau, T. Tsuji, L. Guo, S.-H. Lu, and W. Jiang The role of pre-replicative complex (pre-RC) components in oncogenesis FASEB J, December 1, 2007; 21(14): 3786 - 3794. [Abstract] [Full Text] [PDF]

				J. J. Lin and A. Dutta ATR Pathway Is the Primary Pathway for Activating G2/M Checkpoint Induction After Re-replication J. Biol. Chem., October 19, 2007; 282(42): 30357 - 30362. [Abstract] [Full Text] [PDF]

				B. J. Kim, S.-Y. Kim, and H. Lee Identification and Characterization of Human Cdc7 Nuclear Retention and Export Sequences in the Context of Chromatin Binding J. Biol. Chem., October 12, 2007; 282(41): 30029 - 30038. [Abstract] [Full Text] [PDF]

				J. Gray, J. T. Mao, E. Szabo, M. Kelley, J. Kurie, and G. Bepler Lung Cancer Chemoprevention: ACCP Evidence-Based Clinical Practice Guidelines (2nd Edition) Chest, September 1, 2007; 132(3_suppl): 56S - 68S. [Abstract] [Full Text] [PDF]

				N. Dissmeyer, M. K. Nowack, S. Pusch, H. Stals, D. Inze, P. E. Grini, and A. Schnittger T-Loop Phosphorylation of Arabidopsis CDKA;1 Is Required for Its Function and Can Be Partially Substituted by an Aspartate Residue PLANT CELL, March 1, 2007; 19(3): 972 - 985. [Abstract] [Full Text] [PDF]

				M. A. Rehman, G. Fourel, A. Mathews, D. Ramdin, M. Espinosa, E. Gilson, and K. Yankulov Differential Requirement of DNA Replication Factors for Subtelomeric ARS Consensus Sequence Protosilencers in Saccharomyces cerevisiae Genetics, December 1, 2006; 174(4): 1801 - 1810. [Abstract] [Full Text] [PDF]

				K. Hara, K. I. Nakayama, and K. Nakayama Geminin is essential for the development of preimplantation mouse embryos Genes Cells, November 1, 2006; 11(11): 1281 - 1293. [Abstract] [Full Text] [PDF]

				A. Kudoh, T. Daikoku, Y. Ishimi, Y. Kawaguchi, N. Shirata, S. Iwahori, H. Isomura, and T. Tsurumi Phosphorylation of MCM4 at Sites Inactivating DNA Helicase Activity of the MCM4-MCM6-MCM7 Complex during Epstein-Barr Virus Productive Replication. J. Virol., October 1, 2006; 80(20): 10064 - 10072. [Abstract] [Full Text] [PDF]

				J.-H. Shin and Z. Kelman The Replicative Helicases of Bacteria, Archaea, and Eukarya Can Unwind RNA-DNA Hybrid Substrates J. Biol. Chem., September 15, 2006; 281(37): 26914 - 26921. [Abstract] [Full Text] [PDF]

				K. B. Spurgers, D. L. Gold, K. R. Coombes, N. L. Bohnenstiehl, B. Mullins, R. E. Meyn, C. J. Logothetis, and T. J. McDonnell Identification of Cell Cycle Regulatory Genes as Principal Targets of p53-mediated Transcriptional Repression J. Biol. Chem., September 1, 2006; 281(35): 25134 - 25142. [Abstract] [Full Text] [PDF]

				P. R. Dohrmann and R. A. Sclafani Novel Role for Checkpoint Rad53 Protein Kinase in the Initiation of Chromosomal DNA Replication in Saccharomyces cerevisiae Genetics, September 1, 2006; 174(1): 87 - 99. [Abstract] [Full Text] [PDF]

				N. Nitani, K.-i. Nakamura, C. Nakagawa, H. Masukata, and T. Nakagawa Regulation of DNA Replication Machinery by Mrc1 in Fission Yeast Genetics, September 1, 2006; 174(1): 155 - 165. [Abstract] [Full Text] [PDF]

				P. E. Cohen, S. E. Pollack, and J. W. Pollard Genetic Analysis of Chromosome Pairing, Recombination, and Cell Cycle Control during First Meiotic Prophase in Mammals Endocr. Rev., June 1, 2006; 27(4): 398 - 426. [Abstract] [Full Text] [PDF]

				T. Dresselhaus, K.-o. Srilunchang, D. Leljak-Levanic, D. N. Schreiber, and P. Garg The Fertilization-Induced DNA Replication Factor MCM6 of Maize Shuttles between Cytoplasm and Nucleus, and Is Essential for Plant Growth and Development Plant Physiology, February 1, 2006; 140(2): 512 - 527. [Abstract] [Full Text] [PDF]

				R. J. Fletcher, J. Shen, Y. Gomez-Llorente, C. S. Martin, J. M. Carazo, and X. S. Chen Double Hexamer Disruption and Biochemical Activities of Methanobacterium thermoautotrophicum MCM J. Biol. Chem., December 23, 2005; 280(51): 42405 - 42410. [Abstract] [Full Text] [PDF]

				E. Marco and F. Gago DNA Structural Similarity in the 2:1 Complexes of the Antitumor Drugs Trabectedin (Yondelis) and Chromomycin A3 with an Oligonucleotide Sequence Containing Two Adjacent TGG Binding Sites on Opposing Strands Mol. Pharmacol., December 1, 2005; 68(6): 1559 - 1567. [Abstract] [Full Text] [PDF]

				E. Queralt and J. C. Igual Functional Connection Between the Clb5 Cyclin, the Protein Kinase C Pathway and the Swi4 Transcription Factor in Saccharomyces cerevisiae Genetics, December 1, 2005; 171(4): 1485 - 1498. [Abstract] [Full Text] [PDF]

				E. Milgrom, R. W. West Jr., C. Gao, and W.-C. W. Shen TFIID and Spt-Ada-Gcn5-Acetyltransferase Functions Probed by Genome-wide Synthetic Genetic Array Analysis Using a Saccharomyces cerevisiae taf9-ts Allele Genetics, November 1, 2005; 171(3): 959 - 973. [Abstract] [Full Text] [PDF]

				L.-C. Chuang and P. R. Yew Proliferating Cell Nuclear Antigen Recruits Cyclin-dependent Kinase Inhibitor Xic1 to DNA and Couples Its Proteolysis to DNA Polymerase Switching J. Biol. Chem., October 21, 2005; 280(42): 35299 - 35309. [Abstract] [Full Text] [PDF]

				B. Chen, H. Pan, L. Zhu, Y. Deng, and J. W. Pollard Progesterone Inhibits the Estrogen-Induced Phosphoinositide 3-Kinase->AKT->GSK-3{beta}->Cyclin D1->pRB Pathway to Block Uterine Epithelial Cell Proliferation Mol. Endocrinol., August 1, 2005; 19(8): 1978 - 1990. [Abstract] [Full Text] [PDF]

				C. A. Nieduszynski, J. J. Blow, and A. D. Donaldson The requirement of yeast replication origins for pre-replication complex proteins is modulated by transcription Nucleic Acids Res., April 28, 2005; 33(8): 2410 - 2420. [Abstract] [Full Text] [PDF]

				S. I. Reed Deregulation of Cyclin E in Cancer Am. Assoc. Cancer Res. Educ. Book, April 1, 2005; 2005(1): 53 - 56. [Full Text] [PDF]

				L. Tsvetkov and D. F. Stern Interaction of Chromatin-associated Plk1 and Mcm7 J. Biol. Chem., March 25, 2005; 280(12): 11943 - 11947. [Abstract] [Full Text] [PDF]

				M. Anger, P. Stein, and R. M. Schultz CDC6 Requirement for Spindle Formation During Maturation of Mouse Oocytes Biol Reprod, January 1, 2005; 72(1): 188 - 194. [Abstract] [Full Text] [PDF]

				K. L. Eward, E. C. Obermann, S. Shreeram, M. Loddo, T. Fanshawe, C. Williams, H.-I. Jung, A. T. Prevost, J. J. Blow, K. Stoeber, et al. DNA replication licensing in somatic and germ cells J. Cell Sci., November 15, 2004; 117(24): 5875 - 5886. [Abstract] [Full Text] [PDF]

				D. Shechter, C. Y. Ying, and J. Gautier DNA Unwinding Is an MCM Complex-dependent and ATP Hydrolysis-dependent Process J. Biol. Chem., October 29, 2004; 279(44): 45586 - 45593. [Abstract] [Full Text] [PDF]

				E. L. Hendrickson, R. Kaul, Y. Zhou, D. Bovee, P. Chapman, J. Chung, E. Conway de Macario, J. A. Dodsworth, W. Gillett, D. E. Graham, et al. Complete Genome Sequence of the Genetically Tractable Hydrogenotrophic Methanogen Methanococcus maripaludis J. Bacteriol., October 15, 2004; 186(20): 6956 - 6969. [Abstract] [Full Text] [PDF]

				P. Francon, J.-M. Lemaitre, C. Dreyer, D. Maiorano, O. Cuvier, and M. Mechali A hypophosphorylated form of RPA34 is a specific component of pre-replication centers J. Cell Sci., October 1, 2004; 117(21): 4909 - 4920. [Abstract] [Full Text] [PDF]

				P. Karakaidos, S. Taraviras, L. V. Vassiliou, P. Zacharatos, N. G. Kastrinakis, D. Kougiou, M. Kouloukoussa, H. Nishitani, A. G. Papavassiliou, Z. Lygerou, et al. Overexpression of the Replication Licensing Regulators hCdt1 and hCdc6 Characterizes a Subset of Non-Small-Cell Lung Carcinomas: Synergistic Effect with Mutant p53 on Tumor Growth and Chromosomal Instability--Evidence of E2F-1 Transcriptional Control over hCdt1 Am. J. Pathol., October 1, 2004; 165(4): 1351 - 1365. [Abstract] [Full Text] [PDF]