KSR: a MAPK scaffold of the Ras pathway?

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Bell, B., Xing, H., Yan, H., Gautam, N. and Muslin, A. J (1999). KSR1 binds to G-proteinsubunits and inhibits -induced mitogen-activated protein kinase activation. J. Biol. Chem 274, 7982-7986.[Abstract/Free Full Text]

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				E. Giurisato, J. Lin, A. Harding, E. Cerutti, M. Cella, R. E. Lewis, M. Colonna, and A. S. Shaw The Mitogen-Activated Protein Kinase Scaffold KSR1 Is Required for Recruitment of Extracellular Signal-Regulated Kinase to the Immunological Synapse Mol. Cell. Biol., March 15, 2009; 29(6): 1554 - 1564. [Abstract] [Full Text] [PDF]

				A. Nakamura, M. Naito, T. Tsuruo, and N. Fujita Freud-1/Aki1, a Novel PDK1-Interacting Protein, Functions as a Scaffold To Activate the PDK1/Akt Pathway in Epidermal Growth Factor Signaling Mol. Cell. Biol., October 1, 2008; 28(19): 5996 - 6009. [Abstract] [Full Text] [PDF]

				C. Chen, R. E. Lewis, and M. A. White IMP Modulates KSR1-dependent Multivalent Complex Formation to Specify ERK1/2 Pathway Activation and Response Thresholds J. Biol. Chem., May 9, 2008; 283(19): 12789 - 12796. [Abstract] [Full Text] [PDF]

				G. Galabova-Kovacs, F. Catalanotti, D. Matzen, G. X. Reyes, J. Zezula, R. Herbst, A. Silva, I. Walter, and M. Baccarini Essential role of B-Raf in oligodendrocyte maturation and myelination during postnatal central nervous system development J. Cell Biol., March 5, 2008; 180(5): 947 - 955. [Abstract] [Full Text] [PDF]

				H. Vaidyanathan, J. Opoku-Ansah, S. Pastorino, H. Renganathan, M. L. Matter, and J. W. Ramos ERK MAP kinase is targeted to RSK2 by the phosphoprotein PEA-15 PNAS, December 11, 2007; 104(50): 19837 - 19842. [Abstract] [Full Text] [PDF]

				J. E. Trosky, Y. Li, S. Mukherjee, G. Keitany, H. Ball, and K. Orth VopA Inhibits ATP Binding by Acetylating the Catalytic Loop of MAPK Kinases J. Biol. Chem., November 23, 2007; 282(47): 34299 - 34305. [Abstract] [Full Text] [PDF]

				A. S. Goehring, B. S. Pedroja, S. A. Hinke, L. K. Langeberg, and J. D. Scott MyRIP Anchors Protein Kinase A to the Exocyst Complex J. Biol. Chem., November 9, 2007; 282(45): 33155 - 33167. [Abstract] [Full Text] [PDF]

				E. Castells and J. M. Casacuberta Signalling through kinase-defective domains: the prevalence of atypical receptor-like kinases in plants J. Exp. Bot., October 20, 2007; (2007) erm226v1. [Abstract] [Full Text] [PDF]

				M. M. McKay and D. K. Morrison Caspase-dependent Cleavage Disrupts the ERK Cascade Scaffolding Function of KSR1 J. Biol. Chem., September 7, 2007; 282(36): 26225 - 26234. [Abstract] [Full Text] [PDF]

				L. Feng, X. Xie, Q. Ding, X. Luo, J. He, F. Fan, W. Liu, Z. Wang, and Y. Chen Spatial regulation of Raf kinase signaling by RKTG PNAS, September 4, 2007; 104(36): 14348 - 14353. [Abstract] [Full Text] [PDF]

				K. Nakamura and G. L. Johnson Noncanonical Function of MEKK2 and MEK5 PB1 Domains for Coordinated Extracellular Signal-Regulated Kinase 5 and c-Jun N-Terminal Kinase Signaling Mol. Cell. Biol., June 15, 2007; 27(12): 4566 - 4577. [Abstract] [Full Text] [PDF]

				C. W. Rinker-Schaeffer, J. P. O'Keefe, D. R. Welch, and D. Theodorescu Metastasis Suppressor Proteins: Discovery, Molecular Mechanisms, and Clinical Application. Clin. Cancer Res., July 1, 2006; 12(13): 3882 - 3889. [Full Text] [PDF]

				J.-Y. Roignant, S. Hamel, F. Janody, and J. E. Treisman The novel SAM domain protein Aveugle is required for Raf activation in the Drosophila EGF receptor signaling pathway. Genes & Dev., April 1, 2006; 20(7): 795 - 806. [Abstract] [Full Text] [PDF]

				G. Lu, Y. J. Kang, J. Han, H. R. Herschman, E. Stefani, and Y. Wang TAB-1 Modulates Intracellular Localization of p38 MAP Kinase and Downstream Signaling J. Biol. Chem., March 3, 2006; 281(9): 6087 - 6095. [Abstract] [Full Text] [PDF]

				R. L. Kortum, H. J. Johnson, D. L. Costanzo, D. J. Volle, G. L. Razidlo, A. M. Fusello, A. S. Shaw, and R. E. Lewis The Molecular Scaffold Kinase Suppressor of Ras 1 Is a Modifier of RasV12-Induced and Replicative Senescence. Mol. Cell. Biol., March 1, 2006; 26(6): 2202 - 2214. [Abstract] [Full Text] [PDF]

				M. Beeram, A. Patnaik, and E. K. Rowinsky Raf: A Strategic Target for Therapeutic Development Against Cancer J. Clin. Oncol., September 20, 2005; 23(27): 6771 - 6790. [Abstract] [Full Text] [PDF]

				C. E. Rocheleau, A. Ronnlund, S. Tuck, and M. V. Sundaram Caenorhabditis elegans CNK-1 promotes Raf activation but is not essential for Ras/Raf signaling PNAS, August 16, 2005; 102(33): 11757 - 11762. [Abstract] [Full Text] [PDF]

				M. Ebisuya, K. Kondoh, and E. Nishida The duration, magnitude and compartmentalization of ERK MAP kinase activity: mechanisms for providing signaling specificity J. Cell Sci., July 15, 2005; 118(14): 2997 - 3002. [Abstract] [Full Text] [PDF]

				M. Kim, Y. Yan, R. L. Kortum, S. M. Stoeger, M. K. Sgagias, K. Lee, R. E. Lewis, and K. H. Cowan Expression of Kinase Suppressor of Ras1 Enhances Cisplatin-Induced Extracellular Signal-Regulated Kinase Activation and Cisplatin Sensitivity Cancer Res., May 15, 2005; 65(10): 3986 - 3992. [Abstract] [Full Text] [PDF]

				M. Matsuyama, H. Mizusaki, A. Shimono, T. Mukai, K. Okumura, K. Abe, K. Shimada, and K.-i. Morohashi A novel isoform of Vinexin, Vinexin {gamma}, regulates Sox9 gene expression through activation of MAPK cascade in mouse fetal gonad Genes Cells, May 1, 2005; 10(5): 421 - 434. [Abstract] [Full Text] [PDF]

				A. Laine and Z. Ronai Ubiquitin Chains in the Ladder of MAPK Signaling Sci. Signal., April 26, 2005; 2005(281): re5 - re5. [Abstract] [Full Text] [PDF]

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				R. Kurzbauer, D. Teis, M. E. G. de Araujo, S. Maurer-Stroh, F. Eisenhaber, G. P. Bourenkov, H. D. Bartunik, M. Hekman, U. R. Rapp, L. A. Huber, et al. Crystal structure of the p14/MP1 scaffolding complex: How a twin couple attaches mitogen-activated protein kinase signaling to late endosomes PNAS, July 27, 2004; 101(30): 10984 - 10989. [Abstract] [Full Text] [PDF]

				M. N. Laurent, D. M. Ramirez, and J. Alberola-Ila Kinase Suppressor of Ras Couples Ras to the ERK Cascade during T Cell Development J. Immunol., July 15, 2004; 173(2): 986 - 992. [Abstract] [Full Text] [PDF]

				S. Kolli, C. I. Zito, M. H. Mossink, E. A. C. Wiemer, and A. M. Bennett The Major Vault Protein Is a Novel Substrate for the Tyrosine Phosphatase SHP-2 and Scaffold Protein in Epidermal Growth Factor Signaling J. Biol. Chem., July 9, 2004; 279(28): 29374 - 29385. [Abstract] [Full Text] [PDF]

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