KSR: a MAPK scaffold of the Ras pathway?

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Bell, B., Xing, H., Yan, H., Gautam, N. and Muslin, A. J (1999). KSR1 binds to G-proteinsubunits and inhibits -induced mitogen-activated protein kinase activation. J. Biol. Chem 274, 7982-7986.[Abstract/Free Full Text]

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Joneson, T., Fulton, J. A., Volle, D. J., Chaika, O. V., Bar-Sagi, D. and Lewis, R. E (1998). Kinase suppressor of Ras inhibits the activation of extracellular ligand-regulated (ERK) mitogen-activated protein (MAP) kinase by growth factors, activated Ras, and Ras effectors. J. Biol. Chem 273, 7743-7748.[Abstract/Free Full Text]

Karandikar, M., Xu, S. and Cobb, M. H (2000). MEKK1 binds Raf-1 and the ERK2 cascade components. J. Biol. Chem 275, 40120-40127.[Abstract/Free Full Text]

Kornfeld, K., Hom, D. B. and Horvitz, H. R (1995). The ksr-1 gene encodes a novel protein kinase involved in Ras-mediated signaling in C. elegans. Cell 83, 903-913.[Medline]

Michaud, N. R., Therrien, M., Cacace, A., Edsall, L. C., Spiegel, S., Rubin, G. M. and Morrison, D. K (1997). KSR stimulates Raf-1 activity in a kinase-independent manner. Proc. Nat. Acad. Sci. USA 94, 12792-12796.[Abstract/Free Full Text]

Morrison, D. K. and Cutler, R. E., Jr (1997). The Complexity of Raf-1 Regulation. Curr. Opin. Cell Biol 9, 174-179.[Medline]

Muller, J., Cacace, A. M., Lyons, W. E., McGill, C. B. and Morrison, D. K (2000). Identification of B-KSR1, a novel brain-specific isoform of KSR1 that functions in neuronal signaling. Mol. Cell. Biol 20, 5529-5539.[Abstract/Free Full Text]

Schaeffer, H. J., Catling, A. D., Eblen, S. T., Collier, L. S., Krauss, A. and Weber, M. J (1998). MP1: a MEK binding partner that enhances enzymatic activity of the MAP kinase cascade. Science 281, 1668-1671.[Abstract/Free Full Text]

Stewart, S., Sundaram, M., Zhang, Y., Lee, J., Han, M. and Guan, K.-L (1999). Kinase suppressor of Ras forms a multiprotein signaling complex and modulates MEK localization. Mol. Cell. Biol 19, 5523-5534.[Abstract/Free Full Text]

Sugimoto, T., Stewart, S., Han, M. and Guan, K.-L (1997). The kinase suppressor of Ras (KSR) modulates growth factor and Ras signaling by uncoupling elk-1 phopshorylation from MAP kinase activation. EMBO J 17, 1717-1727.[Medline]

Sundaram, M. and Han, M (1995). The C. elegans ksr-1 gene encodes a novel Raf-related kinase involved in Ras-mediated signal transduction. Cell 83, 889-901.[Medline]

Therrien, M., Chang, H. C., Solomon, N. M., Karim, F. D., Wassarman, D. A. and Rubin, G. M (1995). KSR, a novel protein kinase required for RAS signal transduction. Cell 83, 879-888.[Medline]

Therrien, M., Michaud, N. R., Rubin, G. M. and Morrison, D. K (1996). KSR modulates signal propagation within the MAPK cascade. Genes Dev 10, 2684-2695.[Abstract/Free Full Text]

Volle, D. J., Fulton, J. A., Chaika, O. V., McDermott, K., Huang, H., Steinke, L. A. and Lewis, R. E (1999). Phosphorylation of kinase suppressor of Ras by associated kinases. Biochemistry 38, 5130-5137.[Medline]

Xing, H., Kornfeld, K. and Muslin, A. J (1997). The protein kinase KSR interacts with 14-3-3 protein and Raf. Curr. Biol 7, 294-300.[Medline]

Xu, B., English, J. M., Wilsbacher, J. L., Stippec, S., Goldsmith, E. J. and Cobb, M. H (2000). WNK, a novel mammalian serine/threonine kinase lacking the catalytic lysine in subdomain II. J. Biol. Chem 275, 16795-16801.[Abstract/Free Full Text]

Yu, W., Fantl, W. J., Harrowe, G. and Williams, L. T (1997). Regulation of the MAP kinase pathway by mammalian Ksr through direct interaction with MEK and ERK. Curr. Biol 8, 56-64.

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				C. Chen, R. E. Lewis, and M. A. White IMP Modulates KSR1-dependent Multivalent Complex Formation to Specify ERK1/2 Pathway Activation and Response Thresholds J. Biol. Chem., May 9, 2008; 283(19): 12789 - 12796. [Abstract] [Full Text] [PDF]

				G. Galabova-Kovacs, F. Catalanotti, D. Matzen, G. X. Reyes, J. Zezula, R. Herbst, A. Silva, I. Walter, and M. Baccarini Essential role of B-Raf in oligodendrocyte maturation and myelination during postnatal central nervous system development J. Cell Biol., March 5, 2008; 180(5): 947 - 955. [Abstract] [Full Text] [PDF]

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				M. M. McKay and D. K. Morrison Caspase-dependent Cleavage Disrupts the ERK Cascade Scaffolding Function of KSR1 J. Biol. Chem., September 7, 2007; 282(36): 26225 - 26234. [Abstract] [Full Text] [PDF]

				L. Feng, X. Xie, Q. Ding, X. Luo, J. He, F. Fan, W. Liu, Z. Wang, and Y. Chen Spatial regulation of Raf kinase signaling by RKTG PNAS, September 4, 2007; 104(36): 14348 - 14353. [Abstract] [Full Text] [PDF]

				K. Nakamura and G. L. Johnson Noncanonical Function of MEKK2 and MEK5 PB1 Domains for Coordinated Extracellular Signal-Regulated Kinase 5 and c-Jun N-Terminal Kinase Signaling Mol. Cell. Biol., June 15, 2007; 27(12): 4566 - 4577. [Abstract] [Full Text] [PDF]

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				R. L. Kortum, H. J. Johnson, D. L. Costanzo, D. J. Volle, G. L. Razidlo, A. M. Fusello, A. S. Shaw, and R. E. Lewis The Molecular Scaffold Kinase Suppressor of Ras 1 Is a Modifier of RasV12-Induced and Replicative Senescence. Mol. Cell. Biol., March 1, 2006; 26(6): 2202 - 2214. [Abstract] [Full Text] [PDF]

				M. Beeram, A. Patnaik, and E. K. Rowinsky Raf: A Strategic Target for Therapeutic Development Against Cancer J. Clin. Oncol., September 20, 2005; 23(27): 6771 - 6790. [Abstract] [Full Text] [PDF]

				C. E. Rocheleau, A. Ronnlund, S. Tuck, and M. V. Sundaram Caenorhabditis elegans CNK-1 promotes Raf activation but is not essential for Ras/Raf signaling PNAS, August 16, 2005; 102(33): 11757 - 11762. [Abstract] [Full Text] [PDF]

				M. Ebisuya, K. Kondoh, and E. Nishida The duration, magnitude and compartmentalization of ERK MAP kinase activity: mechanisms for providing signaling specificity J. Cell Sci., July 15, 2005; 118(14): 2997 - 3002. [Abstract] [Full Text] [PDF]

				M. Kim, Y. Yan, R. L. Kortum, S. M. Stoeger, M. K. Sgagias, K. Lee, R. E. Lewis, and K. H. Cowan Expression of Kinase Suppressor of Ras1 Enhances Cisplatin-Induced Extracellular Signal-Regulated Kinase Activation and Cisplatin Sensitivity Cancer Res., May 15, 2005; 65(10): 3986 - 3992. [Abstract] [Full Text] [PDF]

				M. Matsuyama, H. Mizusaki, A. Shimono, T. Mukai, K. Okumura, K. Abe, K. Shimada, and K.-i. Morohashi A novel isoform of Vinexin, Vinexin {gamma}, regulates Sox9 gene expression through activation of MAPK cascade in mouse fetal gonad Genes Cells, May 1, 2005; 10(5): 421 - 434. [Abstract] [Full Text] [PDF]

				A. Laine and Z. Ronai Ubiquitin Chains in the Ladder of MAPK Signaling Sci. Signal., April 26, 2005; 2005(281): re5 - re5. [Abstract] [Full Text] [PDF]

				M. Salerno, D. Palmieri, A. Bouadis, D. Halverson, and P. S. Steeg Nm23-H1 Metastasis Suppressor Expression Level Influences the Binding Properties, Stability, and Function of the Kinase Suppressor of Ras1 (KSR1) Erk Scaffold in Breast Carcinoma Cells Mol. Cell. Biol., February 15, 2005; 25(4): 1379 - 1388. [Abstract] [Full Text] [PDF]

				M. Lee, J.-Y. Kim, and W. B. Anderson Src Tyrosine Kinase Inhibitor PP2 Markedly Enhances Ras-independent Activation of Raf-1 Protein Kinase by Phorbol Myristate Acetate and H2O2 J. Biol. Chem., November 19, 2004; 279(47): 48692 - 48701. [Abstract] [Full Text] [PDF]

				G. L. Razidlo, R. L. Kortum, J. L. Haferbier, and R. E. Lewis Phosphorylation Regulates KSR1 Stability, ERK Activation, and Cell Proliferation J. Biol. Chem., November 12, 2004; 279(46): 47808 - 47814. [Abstract] [Full Text] [PDF]

				S. Torii, K. Nakayama, T. Yamamoto, and E. Nishida Regulatory Mechanisms and Function of ERK MAP Kinases J. Biochem., November 1, 2004; 136(5): 557 - 561. [Abstract] [Full Text] [PDF]

				R. Kurzbauer, D. Teis, M. E. G. de Araujo, S. Maurer-Stroh, F. Eisenhaber, G. P. Bourenkov, H. D. Bartunik, M. Hekman, U. R. Rapp, L. A. Huber, et al. Crystal structure of the p14/MP1 scaffolding complex: How a twin couple attaches mitogen-activated protein kinase signaling to late endosomes PNAS, July 27, 2004; 101(30): 10984 - 10989. [Abstract] [Full Text] [PDF]

				M. N. Laurent, D. M. Ramirez, and J. Alberola-Ila Kinase Suppressor of Ras Couples Ras to the ERK Cascade during T Cell Development J. Immunol., July 15, 2004; 173(2): 986 - 992. [Abstract] [Full Text] [PDF]

				S. Kolli, C. I. Zito, M. H. Mossink, E. A. C. Wiemer, and A. M. Bennett The Major Vault Protein Is a Novel Substrate for the Tyrosine Phosphatase SHP-2 and Scaffold Protein in Epidermal Growth Factor Signaling J. Biol. Chem., July 9, 2004; 279(28): 29374 - 29385. [Abstract] [Full Text] [PDF]

				K. Yoshioka Scaffold Proteins in Mammalian MAP Kinase Cascades J. Biochem., June 1, 2004; 135(6): 657 - 661. [Abstract] [Full Text] [PDF]

				R. L. Kortum and R. E. Lewis The Molecular Scaffold KSR1 Regulates the Proliferative and Oncogenic Potential of Cells Mol. Cell. Biol., May 15, 2004; 24(10): 4407 - 4416. [Abstract] [Full Text] [PDF]

				R. J. Nichols and P. Traktman Characterization of Three Paralogous Members of the Mammalian Vaccinia Related Kinase Family J. Biol. Chem., February 27, 2004; 279(9): 7934 - 7946. [Abstract] [Full Text] [PDF]

				A. B. Jaffe, P. Aspenstrom, and A. Hall Human CNK1 Acts as a Scaffold Protein, Linking Rho and Ras Signal Transduction Pathways Mol. Cell. Biol., February 15, 2004; 24(4): 1736 - 1746. [Abstract] [Full Text] [PDF]