Expression and localisation of synaptotagmin isoforms in endocrine (&bgr;)-cells: their function in insulin exocytosis

QUICK SEARCH:

[advanced]

	Author:		Keyword(s):

Home Help Feedback Subscriptions Archive Search Table of Contents

This Article

	Summary
	Full Text (PDF)
	Alert me when this article is cited
	Alert me if a correction is posted

Services

	Email this article to a friend
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new issues of the journal
	Download to citation manager


Citing Articles

	Citing Articles via HighWire
	Citing Articles via Google Scholar

Google Scholar

	Articles by Gut, A.
	Articles by Lang, J.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Gut, A.
	Articles by Lang, J.

Asfari, M., Janjic, D., Meda, P., Li, G., Halban, P. A. and Wollheim, C. B (1992). Establishment of 2-mercaptoethanol-dependent differentiated insulin-secreting cell lines. Endocrinology 130, 167-178.[Abstract]

Berton, F., Cornet, V., Iborra, C., Garrido, J., Dargent, B., Fukuda, M., Seagar, M. and Marqueze, B (2000). Synaptotagmin I and IV define distinct populations of neuronal transport vesicles. Eur. J. Neurosci 12, 1294-1302.[Medline]

Brown, H., Meister, B., Deeney, J., Corkey, B. E., Yang, S. N., Larsson, O., Rhodes, C. J., Seino, S., Berggren, P. O. and Fried, G (2000). Synaptotagmin III isoform is compartmentalized in pancreatic beta-cells and has a functional role in exocytosis. Diabetes 49, 383-391.[Abstract]

Burgoyne, R. D. and Morgan, A (1998). Calcium sensors in regulated exocytosis. Cell Calcium 24, 367-376.[Medline]

Butz, S., Fernandez-Chacon, R., Schmitz, F., Jahn, R. and Sudhof, T. C (1999). The subcellular localizations of atypical synaptotagmins III and VI. Synaptotagmin III is enriched in synapses and synaptic plasma membranes but not in synaptic vesicles. J. Biol. Chem 274, 18290-18296.[Abstract/Free Full Text]

Eaton, B. A., Haugwitz, M., Lau, D. and Moore, H. P (2000). Biogenesis of regulated exocytotic carriers in neuroendocrine cells. J. Neurosci 20, 7334-7344.[Abstract/Free Full Text]

Elferink, L. A., Peterson, M. R. and Scheller, R. H (1993). A role for synaptotagmin (p65) in regulated exocytosis. Cell 72, 153-159.[Medline]

Ferguson, G. D., Thomas, D. M., Elferink, L. A. and Herschman, H. R (1999). Synthesis degradation, and subcellular localization of synaptotagmin IV, a neuronal immediate early gene product. J. Neurochem 72, 1821-1831.[Medline]

Fernandez-Chacon, R. and Sudhof, T. C (1999). Genetics of synaptic vesicle function: Toward the complete functional anatomy of an organelle. Annu. Rev. Physiol 61, 753-776.[Medline]

Fukuda, M., Kanno, E. and Mikoshiba, K (1999). Conserved N-terminal cysteine motif is essential for homo-and heterodimer formation of synaptotagmins III, V, VI, and X. J. Biol. Chem 274, 31421-31427.[Abstract/Free Full Text]

Fukuda, M. and Mikoshiba, K (2000). Distinct self-dimerization activities of synaptotagmin family: Unique calcium-dependent dimerization properties of synaptotagmin VII. J. Biol. Chem 275, 28180-28185.[Abstract/Free Full Text]

Geppert, M., Goda, Y., Hammer, R. E., Li, C., Rosahl, T. W., Stevens, C. F. and Sudhof, T. C (1994). Synaptotagmin I: a major Ca2+ sensor for transmitter release at a central synapse. Cell 79, 717-727.[Medline]

Gerona, R. R., Larsen, E. C., Kowalchyk, J. A. and Martin, T. F (2000). The C terminus of SNAP25 is essential for Ca2+-dependent binding of synaptotagmin to SNARE complexes. J. Biol. Chem 275, 6328-6236.[Abstract/Free Full Text]

Heidelberger, R., Heinemann, C., Neher, E. and Matthews, G (1994). Calcium dependence of the rate of exocytosis in a synaptic terminal. Nature 371, 513-515.[Medline]

Ibata, K., Fukuda, M., Hamada, T., Kabayama, H. and Mikoshiba, K (2000). Synaptotagmin IV is present at the Golgi and distal parts of neurites. J. Neurochem 74, 518-526.[Medline]

Jahn, R. and Sudhof, T. C (1999). Membrane fusion and exocytosis. Annu. Rev. Biochem 68, 863-911.[Medline]

Lang, J., Fukuda, M., Zhang, H., Mikoshiba, K. and Wollheim, C. B (1997). The first C2 domain of synaptotagmin is required for exocytosis of insulin from pancreatic-cells: action of synaptotagmin at low micromolar calcium. EMBO J 16, 5837-5846.[Medline]

Lang, J., Ushkaryov, Y., Grasso, A. and Wollheim, C. B (1998). Ca2+independent insulin exocytosis induced by-latrotoxin requires latrophilin, a G Protein-coupled receptor. EMBO J 17, 101-110.[Medline]

Lang, J., Zhang, H., Vaidyanathan, V. V., Sadoul, K., Niemann, H. and Wollheim, C. B (1997). Transient expression of botulinum neurotoxin C1 light chain differentially inhibits calcium and glucose induced insulin secretion in clonal-cells. FEBS Lett 419, 13-17.[Medline]

Lang, J (1999). Molecular mechanisms and regulation of insulin exocytosis as a paradigm of endocrine secretion. Eur. J. Biochem 259, 3-17.[Medline]

Li, C., Ullrich, B., Zhang, J. Z., Anderson, R. G., Brose, N. and Sudhof, T. C (1995). Ca2+-dependent and-independent activities of neural and non-neural synaptotagmins. Nature 375, 594-599.[Medline]

Littleton, J. T., Stern, M., Perin, M. and Bellen, H. J (1994). Calcium dependence of neurotransmitter release and rate of spontaneous vesicle fusions are altered in Drosophila synaptotagmin mutants. Proc. Natl. Acad. Sci. USA 91, 10888-10892.[Abstract/Free Full Text]

Littleton, J. T., Serano, T. L., Rubin, G. M., Ganetzky, B. and Chapman, E. R (1999). Synaptic function modulated by changes in the ratio of synaptotagmin I and IV. Nature 400, 757-760.[Medline]

Marqueze, B., Berton, F. and Seagar, M (2000). Synaptotagmins in membrane traffic: Which vesicles do the tagmins tag?. Biochimie 82, 409-420.[Medline]

Martin, F., Moya, F., Gutierrez, L. M., Reig, J. A. and Soria, B (1995). Role of syntaxin in mouse pancreatic beta cells. Diabetologia 38, 860-863.[Medline]

Martinez, I., Chakrabarti, S., Hellevik, T., Morehead, J., Fowler, K. and Andrews, N. W (2000). Synaptotagmin VII regulates Ca2+-dependent exocytosis of lysosomes in fibroblasts. J. Cell Biol 148, 1141-1149.[Abstract/Free Full Text]

Miyazaki, J., Araki, K., Yamato, E., Ikegami, H., Asano, T., Shibasaki, Y., Oka, Y. and Yamamura, K (1990). Establishment of a pancreatic beta cell line that retains glucose-insulin secretion: special reference to expression of glucose transporter isoforms. Endocrinology 127, 126-132.[Abstract]

Mizuta, M., Inagaki, N., Nemoto, Y., Matsukura, S., Takahashi, M. and Seino, S (1994). Synaptotagmin III is a novel isoform of rat synaptotagmin expressed in endocrine and neuronal cells. J. Biol. Chem 269, 11675-11678.[Abstract/Free Full Text]

Mizuta, M., Kurose, T., Miki, T., Shojikasai, Y., Takahashi, M., Seino, S. and Matsukura, S (1997). Localization and functional role of synaptotagmin III in insulin secretory vesicles in pancreatic beta-cells. Diabetes 46, 2002-2006.[Abstract]

Ohara Imaizumi, M., Fukuda, M., Niinobe, M., Misonou, H., Ikeda, K., Murakami, T., Kawasaki, M., Mikoshiba, K. and Kumakura, K (1997). Distinct roles of C2A and C2B domains of synaptotagmin in the regulation of exocytosis in adrenal chromaffin cells. Proc. Natl. Acad. Sci. USA 94, 287-291.[Abstract/Free Full Text]

Osborne, S. L., Herreros, J., Bastiaens, P. I. H. and Schiavo, G (1999). Calcium-dependent oligomerization of synaptotagmins I and II. Synaptotagmins I and II are localized on the same synaptic vesicle and heterodimerize in the presence of calcium. J. Biol. Chem 274, 59-66.[Abstract/Free Full Text]

Regazzi, R., Sadoul, K., Meda, P., Kelly, R. B., Halban, P. A. and Wollheim, C. B (1996). Mutational analysis of VAMP domains implicated in Ca2+-induced insulin exocytosis. EMBO J 15, 6951-6959.[Medline]

Rizo, J. and Sudhof, T. C (1998). C2-domains, structure and function of a universal Ca2+-binding domain. J. Biol. Chem 273, 15879-15882.[Free Full Text]

Rothman, J. E. and Sollner, T. H (1997). Membrane trafficking \320 throttles and dampers: controlling the engine of membrane fusion. Science 276, 1212-1213.[Free Full Text]

Sadoul, K., Lang, J., Montecucco, C., Weller, U., Regazzi, R., Catsicas, S., Wollheim, C. B. and Halban, P. A (1995). SNAP-25 is expressed in islets of Langerhans and is involved in insulin release. J. Cell Biol 128, 1019-1028.[Abstract/Free Full Text]

Thomas, D. M., Ferguson, G. D., Herschman, H. R. and Elferink, L. A (1999). Functional and biochemical analysis of the C2 domains of synaptotagmin IV. Mol. Biol. Cell 10, 2285-2295.[Abstract/Free Full Text]

Vallar, L., Biden, T. J. and Wollheim, C. B (1987). Guanine nucleotides induce Ca2+-independent insulin secretion from permeabilized RINm5F cells. J. Biol. Chem 262, 5049-5056.[Abstract/Free Full Text]

Vician, L., Lim, I. K., Ferguson, G., Tocco, G., Baudry, M. and Herschman, H. R (1995). Synaptotagmin IV is an immediate early gene induced by depolarization in PC12 cells and in brain. Proc. Natl. Acad. Sci. USA 92, 2164-2168.[Abstract/Free Full Text]

Weller, U., Muller, L., Messner, M., Palmer, M., Valeva, A., Tranum Jensen, J., Agrawal, P., Biermann, C., Dobereiner, A., Kehoe, M. A. and Bhakdi, S (1996). Expression of active streptolysin O in Escherichia coli as a maltose-binding-protein\320streptolysin-O fusion protein. The N-terminal 70 amino acids are not required for hemolytic activity. Eur. J. Biochem 236, 34-39.[Medline]

Wollheim, C. B., Meda, P. and Halban, P. A (1990). Isolation of pancreatic islets and primary culture of the intact microorgans or of dispersed islet cells. Methods Enzymol 192, 188-223.[Medline]

Zhang, H., Kelley, W. L., Chamberlain, L. H., Burgoyne, R. D. and Lang, J (1999). Mutational analysis of cysteine-string protein function in insulin exocytosis. J. Cell Sci 112, 1345-1351.[Abstract]

This article has been cited by other articles:

A. Maximov, Y. Lao, H. Li, X. Chen, J. Rizo, J. B. Sorensen, and T. C. Sudhof
Genetic analysis of synaptotagmin-7 function in synaptic vesicle exocytosis
PNAS, March 11, 2008; 105(10): 3986 - 3991.
[Abstract] [Full Text] [PDF]

B. R. Gauthier, D. L. Duhamel, M. Iezzi, S. Theander, F. Saltel, M. Fukuda, B. Wehrle-Haller, and C. B. Wollheim
Synaptotagmin VII splice variants {alpha}, , and {delta} are expressed in pancreatic -cells and regulate insulin exocytosis
FASEB J, January 1, 2008; 22(1): 194 - 206.
[Abstract] [Full Text] [PDF]

M. Dubois, P. Vacher, B. Roger, D. Huyghe, B. Vandewalle, J. Kerr-Conte, F. Pattou, N. Moustaid-Moussa, and J. Lang
Glucotoxicity Inhibits Late Steps of Insulin Exocytosis
Endocrinology, April 1, 2007; 148(4): 1605 - 1614.
[Abstract] [Full Text] [PDF]

T. Tsuboi and M. Fukuda
Synaptotagmin VII modulates the kinetics of dense-core vesicle exocytosis in PC12 cells
Genes Cells, April 1, 2007; 12(4): 511 - 519.
[Abstract] [Full Text] [PDF]

K. L. Lynch and T. F. J. Martin
Synaptotagmins I and IX function redundantly in regulated exocytosis but not endocytosis in PC12 cells
J. Cell Sci., February 15, 2007; 120(4): 617 - 627.
[Abstract] [Full Text] [PDF]

A. Masztalerz, I. S. Zeelenberg, Y. M. Wijnands, R. de Bruijn, A. M. Drager, H. Janssen, and E. Roos
Synaptotagmin 3 deficiency in T cells impairs recycling of the chemokine receptor CXCR4 and thereby inhibits CXCL12 chemokine-induced migration
J. Cell Sci., January 15, 2007; 120(2): 219 - 228.
[Abstract] [Full Text] [PDF]

E. Aganna, J. M Burrin, G. A Hitman, and M. D Turner
Involvement of calpain and synaptotagmin Ca2+ sensors in hormone secretion from excitable endocrine cells.
J. Endocrinol., September 1, 2006; 190(3): R1 - R7.
[Abstract] [Full Text] [PDF]

M. Ahras, G. P. Otto, and S. A. Tooze
Synaptotagmin IV is necessary for the maturation of secretory granules in PC12 cells
J. Cell Biol., April 24, 2006; 173(2): 241 - 251.
[Abstract] [Full Text] [PDF]

S. Seino and T. Shibasaki
PKA-Dependent and PKA-Independent Pathways for cAMP-Regulated Exocytosis
Physiol Rev, October 1, 2005; 85(4): 1303 - 1342.
[Abstract] [Full Text] [PDF]

T. Tsuboi, M. A. Ravier, H. Xie, M.-A. Ewart, G. W. Gould, S. A. Baldwin, and G. A. Rutter
Mammalian Exocyst Complex Is Required for the Docking Step of Insulin Vesicle Exocytosis
J. Biol. Chem., July 8, 2005; 280(27): 25565 - 25570.
[Abstract] [Full Text] [PDF]

N. W. Andrews
Membrane Resealing: Synaptotagmin VII Keeps Running the Show
Sci. Signal., May 3, 2005; 2005(282): pe19 - pe19.
[Abstract] [Full Text] [PDF]

S. S. Shen, W. C. Tucker, E. R. Chapman, and R. A. Steinhardt
Molecular Regulation of Membrane Resealing in 3T3 Fibroblasts
J. Biol. Chem., January 14, 2005; 280(2): 1652 - 1660.
[Abstract] [Full Text] [PDF]

C. Marshall, G. A. Hitman, C. J. Partridge, A. Clark, H. Ma, T. R. Shearer, and M. D. Turner
Evidence that an Isoform of Calpain-10 Is a Regulator of Exocytosis in Pancreatic {beta}-Cells
Mol. Endocrinol., January 1, 2005; 19(1): 213 - 224.
[Abstract] [Full Text] [PDF]

M. Fukuda, E. Kanno, M. Satoh, C. Saegusa, and A. Yamamoto
Synaptotagmin VII Is Targeted to Dense-core Vesicles and Regulates Their Ca2+-dependent Exocytosis in PC12 Cells
J. Biol. Chem., December 10, 2004; 279(50): 52677 - 52684.
[Abstract] [Full Text] [PDF]

M. Fukuda and A. Yamamoto
Effect of Forskolin on Synaptotagmin IV Protein Trafficking in PC12 Cells
J. Biochem., August 1, 2004; 136(2): 245 - 253.
[Abstract] [Full Text] [PDF]

M. Iezzi, G. Kouri, M. Fukuda, and C. B. Wollheim
Synaptotagmin V and IX isoforms control Ca2+-dependent insulin exocytosis
J. Cell Sci., July 1, 2004; 117(15): 3119 - 3127.
[Abstract] [Full Text] [PDF]

M. Fukuda
Molecular Cloning, Expression, and Characterization of a Novel Class of Synaptotagmin (Syt XIV) Conserved from Drosophila to Humans
J. Biochem., May 1, 2003; 133(5): 641 - 649.
[Abstract] [Full Text] [PDF]

R. D. Burgoyne and A. Morgan
Secretory Granule Exocytosis
Physiol Rev, April 1, 2003; 83(2): 581 - 632.
[Abstract] [Full Text] [PDF]

S. Dasgupta and R. B. Kelly
Internalization signals in synaptotagmin VII utilizing two independent pathways are masked by intramolecular inhibitions
J. Cell Sci., April 1, 2003; 116(7): 1327 - 1337.
[Abstract] [Full Text] [PDF]

M. Fukuda, E. Kanno, Y. Ogata, C. Saegusa, T. Kim, Y. P. Loh, and A. Yamamoto
Nerve Growth Factor-dependent Sorting of Synaptotagmin IV Protein to Mature Dense-core Vesicles That Undergo Calcium-dependent Exocytosis in PC12 Cells
J. Biol. Chem., January 24, 2003; 278(5): 3220 - 3226.
[Abstract] [Full Text] [PDF]

M. Hayashi, H. Yamada, S. Uehara, R. Morimoto, A. Muroyama, S. Yatsushiro, J. Takeda, A. Yamamoto, and Y. Moriyama
Secretory Granule-mediated Co-secretion of L-Glutamate and Glucagon Triggers Glutamatergic Signal Transmission in Islets of Langerhans
J. Biol. Chem., January 10, 2003; 278(3): 1966 - 1974.
[Abstract] [Full Text] [PDF]

E. Grimberg, Z. Peng, I. Hammel, and R. Sagi-Eisenberg
Synaptotagmin III is a critical factor for the formation of the perinuclear endocytic recycling compartment and determination of secretory granules size
J. Cell Sci., January 1, 2003; 116(1): 145 - 154.
[Abstract] [Full Text] [PDF]

K. Fujimoto, T. Shibasaki, N. Yokoi, Y. Kashima, M. Matsumoto, T. Sasaki, N. Tajima, T. Iwanaga, and S. Seino
Piccolo, a Ca2+ Sensor in Pancreatic beta -Cells. INVOLVEMENT OF cAMP-GEFII{middle dot}Rim2{middle dot}PICCOLO COMPLEX IN cAMP-DEPENDENT EXOCYTOSIS
J. Biol. Chem., December 20, 2002; 277(52): 50497 - 50502.
[Abstract] [Full Text] [PDF]

M. Fukuda, E. Katayama, and K. Mikoshiba
The Calcium-binding Loops of the Tandem C2 Domains of Synaptotagmin VII Cooperatively Mediate Calcium-dependent Oligomerization
J. Biol. Chem., August 2, 2002; 277(32): 29315 - 29320.
[Abstract] [Full Text] [PDF]

C. Saegusa, M. Fukuda, and K. Mikoshiba
Synaptotagmin V Is Targeted to Dense-core Vesicles That Undergo Calcium-dependent Exocytosis in PC12 Cells
J. Biol. Chem., June 28, 2002; 277(27): 24499 - 24505.
[Abstract] [Full Text] [PDF]

This Article

Summary

Full Text (PDF)

Alert me when this article is cited

Alert me if a correction is posted

Services

Email this article to a friend

Similar articles in this journal

Similar articles in PubMed

Alert me to new issues of the journal

Download to citation manager

Citing Articles

Citing Articles via HighWire

Citing Articles via Google Scholar

Google Scholar

Articles by Gut, A.

Articles by Lang, J.

Search for Related Content

PubMed

PubMed Citation

Articles by Gut, A.

Articles by Lang, J.

				B. R. Gauthier, D. L. Duhamel, M. Iezzi, S. Theander, F. Saltel, M. Fukuda, B. Wehrle-Haller, and C. B. Wollheim Synaptotagmin VII splice variants {alpha}, , and {delta} are expressed in pancreatic -cells and regulate insulin exocytosis FASEB J, January 1, 2008; 22(1): 194 - 206. [Abstract] [Full Text] [PDF]

				M. Dubois, P. Vacher, B. Roger, D. Huyghe, B. Vandewalle, J. Kerr-Conte, F. Pattou, N. Moustaid-Moussa, and J. Lang Glucotoxicity Inhibits Late Steps of Insulin Exocytosis Endocrinology, April 1, 2007; 148(4): 1605 - 1614. [Abstract] [Full Text] [PDF]

				T. Tsuboi and M. Fukuda Synaptotagmin VII modulates the kinetics of dense-core vesicle exocytosis in PC12 cells Genes Cells, April 1, 2007; 12(4): 511 - 519. [Abstract] [Full Text] [PDF]

				K. L. Lynch and T. F. J. Martin Synaptotagmins I and IX function redundantly in regulated exocytosis but not endocytosis in PC12 cells J. Cell Sci., February 15, 2007; 120(4): 617 - 627. [Abstract] [Full Text] [PDF]

				A. Masztalerz, I. S. Zeelenberg, Y. M. Wijnands, R. de Bruijn, A. M. Drager, H. Janssen, and E. Roos Synaptotagmin 3 deficiency in T cells impairs recycling of the chemokine receptor CXCR4 and thereby inhibits CXCL12 chemokine-induced migration J. Cell Sci., January 15, 2007; 120(2): 219 - 228. [Abstract] [Full Text] [PDF]

				E. Aganna, J. M Burrin, G. A Hitman, and M. D Turner Involvement of calpain and synaptotagmin Ca2+ sensors in hormone secretion from excitable endocrine cells. J. Endocrinol., September 1, 2006; 190(3): R1 - R7. [Abstract] [Full Text] [PDF]

				M. Ahras, G. P. Otto, and S. A. Tooze Synaptotagmin IV is necessary for the maturation of secretory granules in PC12 cells J. Cell Biol., April 24, 2006; 173(2): 241 - 251. [Abstract] [Full Text] [PDF]

				S. Seino and T. Shibasaki PKA-Dependent and PKA-Independent Pathways for cAMP-Regulated Exocytosis Physiol Rev, October 1, 2005; 85(4): 1303 - 1342. [Abstract] [Full Text] [PDF]

				T. Tsuboi, M. A. Ravier, H. Xie, M.-A. Ewart, G. W. Gould, S. A. Baldwin, and G. A. Rutter Mammalian Exocyst Complex Is Required for the Docking Step of Insulin Vesicle Exocytosis J. Biol. Chem., July 8, 2005; 280(27): 25565 - 25570. [Abstract] [Full Text] [PDF]

				N. W. Andrews Membrane Resealing: Synaptotagmin VII Keeps Running the Show Sci. Signal., May 3, 2005; 2005(282): pe19 - pe19. [Abstract] [Full Text] [PDF]

				S. S. Shen, W. C. Tucker, E. R. Chapman, and R. A. Steinhardt Molecular Regulation of Membrane Resealing in 3T3 Fibroblasts J. Biol. Chem., January 14, 2005; 280(2): 1652 - 1660. [Abstract] [Full Text] [PDF]

				C. Marshall, G. A. Hitman, C. J. Partridge, A. Clark, H. Ma, T. R. Shearer, and M. D. Turner Evidence that an Isoform of Calpain-10 Is a Regulator of Exocytosis in Pancreatic {beta}-Cells Mol. Endocrinol., January 1, 2005; 19(1): 213 - 224. [Abstract] [Full Text] [PDF]

				M. Fukuda, E. Kanno, M. Satoh, C. Saegusa, and A. Yamamoto Synaptotagmin VII Is Targeted to Dense-core Vesicles and Regulates Their Ca2+-dependent Exocytosis in PC12 Cells J. Biol. Chem., December 10, 2004; 279(50): 52677 - 52684. [Abstract] [Full Text] [PDF]

				M. Fukuda and A. Yamamoto Effect of Forskolin on Synaptotagmin IV Protein Trafficking in PC12 Cells J. Biochem., August 1, 2004; 136(2): 245 - 253. [Abstract] [Full Text] [PDF]

				M. Iezzi, G. Kouri, M. Fukuda, and C. B. Wollheim Synaptotagmin V and IX isoforms control Ca2+-dependent insulin exocytosis J. Cell Sci., July 1, 2004; 117(15): 3119 - 3127. [Abstract] [Full Text] [PDF]

				M. Fukuda Molecular Cloning, Expression, and Characterization of a Novel Class of Synaptotagmin (Syt XIV) Conserved from Drosophila to Humans J. Biochem., May 1, 2003; 133(5): 641 - 649. [Abstract] [Full Text] [PDF]

				R. D. Burgoyne and A. Morgan Secretory Granule Exocytosis Physiol Rev, April 1, 2003; 83(2): 581 - 632. [Abstract] [Full Text] [PDF]

				S. Dasgupta and R. B. Kelly Internalization signals in synaptotagmin VII utilizing two independent pathways are masked by intramolecular inhibitions J. Cell Sci., April 1, 2003; 116(7): 1327 - 1337. [Abstract] [Full Text] [PDF]

				M. Fukuda, E. Kanno, Y. Ogata, C. Saegusa, T. Kim, Y. P. Loh, and A. Yamamoto Nerve Growth Factor-dependent Sorting of Synaptotagmin IV Protein to Mature Dense-core Vesicles That Undergo Calcium-dependent Exocytosis in PC12 Cells J. Biol. Chem., January 24, 2003; 278(5): 3220 - 3226. [Abstract] [Full Text] [PDF]

				M. Hayashi, H. Yamada, S. Uehara, R. Morimoto, A. Muroyama, S. Yatsushiro, J. Takeda, A. Yamamoto, and Y. Moriyama Secretory Granule-mediated Co-secretion of L-Glutamate and Glucagon Triggers Glutamatergic Signal Transmission in Islets of Langerhans J. Biol. Chem., January 10, 2003; 278(3): 1966 - 1974. [Abstract] [Full Text] [PDF]

				E. Grimberg, Z. Peng, I. Hammel, and R. Sagi-Eisenberg Synaptotagmin III is a critical factor for the formation of the perinuclear endocytic recycling compartment and determination of secretory granules size J. Cell Sci., January 1, 2003; 116(1): 145 - 154. [Abstract] [Full Text] [PDF]

				K. Fujimoto, T. Shibasaki, N. Yokoi, Y. Kashima, M. Matsumoto, T. Sasaki, N. Tajima, T. Iwanaga, and S. Seino Piccolo, a Ca2+ Sensor in Pancreatic beta -Cells. INVOLVEMENT OF cAMP-GEFII{middle dot}Rim2{middle dot}PICCOLO COMPLEX IN cAMP-DEPENDENT EXOCYTOSIS J. Biol. Chem., December 20, 2002; 277(52): 50497 - 50502. [Abstract] [Full Text] [PDF]

				M. Fukuda, E. Katayama, and K. Mikoshiba The Calcium-binding Loops of the Tandem C2 Domains of Synaptotagmin VII Cooperatively Mediate Calcium-dependent Oligomerization J. Biol. Chem., August 2, 2002; 277(32): 29315 - 29320. [Abstract] [Full Text] [PDF]

				C. Saegusa, M. Fukuda, and K. Mikoshiba Synaptotagmin V Is Targeted to Dense-core Vesicles That Undergo Calcium-dependent Exocytosis in PC12 Cells J. Biol. Chem., June 28, 2002; 277(27): 24499 - 24505. [Abstract] [Full Text] [PDF]