A single internalization signal from the di-leucine family is critical for constitutive endocytosis of the type II TGF-(&bgr;) receptor

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Alevizopoulos, A. and Mermod, N (1997). Transforming growth factor-beta: the breaking open of a black box. Bioessays 19, 581-591.[Medline]

Anders, R. A., Arline, S. L., Dore, J. J. and Leof, E. B (1997). Distinct endocytic responses of heteromeric and homomeric transforming growth factor beta receptors. Mol. Biol. Cell 8, 2133-2143.[Abstract/Free Full Text]

Anders, R. A., Dore, J. J., Jr, Arline, S. L., Garamszegi, N. and Leof, E. B (1998). Differential requirement for type I and type II transforming growth factor beta receptor kinase activity in ligand-mediated receptor endocytosis. J. Biol. Chem 273, 23118-23125.[Abstract/Free Full Text]

Benmerah, A., Begue, B., Dautry Varsat, A. and Cerf Bensussan, N (1996). The ear of alpha-adaptin interacts with the COOH-terminal domain of the Eps 15 protein. J. Biol. Chem 271, 12111-12116.[Abstract/Free Full Text]

Boll, H. O., Ohno, H., Songyang, Z., Rapoport, I., Cantley, L. C., Bonifacino, J. S. and Kirchhausen, T (1996). Sequence requirements for the recognition of tyrosine-based endocytic signals by clathrin AP-2 complexes. EMBO J 15, 5789-5795.[Medline]

Bonifacino, J. S. and Weissman, A. M (1998). Ubiquitin and the control of protein fate in the secretory and endocytic pathways. Annu. Rev. Cell Dev. Biol 14, 19-57.[Medline]

Bonifacino, J. S. and Dell'Angelica, E. C (1999). Molecular bases for the recognition of tyrosine-based sorting signals. J. Cell Biol 145, 923-926.[Free Full Text]

Brand, T. and Schneider, M. D (1996). Transforming growth factor-beta signal transduction. Circ. Res 78, 173-179.[Free Full Text]

Bremnes, T., Lauvrak, V., Lindqvist, B. and Bakke, O (1998). A region from the medium chain adaptor subunit (mu) recognizes leucine-and tyrosine-based sorting signals. J. Biol. Chem 273, 8638-8645.[Abstract/Free Full Text]

de Jonge, R. R., Garrigue-Antar, L., Vellucci, V. F. and Reiss, M (1997). Frequent inactivation of the transforming growth factor beta type II receptor in small-cell lung carcinoma cells. Oncol. Res 9, 89-98.[Medline]

Dietrich, J., Backstrom, T., Lauritsen, J. P., Kastrup, J., Christensen, M. D., von Bulow, F., Palmer, E. and Geisler, C (1998). The phosphorylation state of CD3gamma influences T cell responsiveness and controls T cell receptor cycling. J. Biol. Chem 273, 24232-24238.[Abstract/Free Full Text]

Dore, J. J., Jr, Edens, M., Garamszegi, N. and Leof, E. B (1998). Heteromeric and homomeric transforming growth factor-beta receptors show distinct signaling and endocytic responses in epithelial cells. J. Biol. Chem 273, 31770-31777.[Abstract/Free Full Text]

Evan, G. I., Lewis, G. K., Ramsay, G. and Bishop, J. M (1985). Isolation of monoclonal antibodies specific for human c-myc proto-oncogene product. Mol. Cell. Biol 5, 3610-3616.[Abstract/Free Full Text]

Feng, X. H. and Derynck, R (1996). Ligand-independent activation of transforming growth factor (TGF) beta signaling pathways by heteromeric cytoplasmic domains of TGF-beta receptors. J. Biol. Chem 271, 13123-13129.[Abstract/Free Full Text]

Fire, E., Gutman, O., Roth, M. G. and Henis, Y. I (1995). Dynamic or stable interactions of influenza hemagglutinin mutants with coated pits: Dependence on the internalization signal but not on aggregation. J. Biol. Chem 270, 21075-21081.[Abstract/Free Full Text]

Franzen, P., ten Dijke, P., Ichijo, H., Yamashita, H., Schulz, P., Heldin, C. H. and Miyazono, K (1993). Cloning of a TGFtype I receptor that forms a heteromeric complex with the TBF type II receptor. Cell 75, 681-692.[Medline]

Gilboa, L., Wells, R. G., Lodish, H. F. and Henis, Y. I (1998). Oligomeric structure of type I and type II transforming growth factor beta receptors: homodimers form in the ER and persist at the plasma membrane. J. Cell Biol 140, 767-777.[Abstract/Free Full Text]

Goodman, O. B., Jr, Krupnick, J. G., Santini, F., Gurevich, V. V., Penn, R. B., Gagnon, A. W., Keen, J. H. and Benovic, J. L (1996). Beta-arrestin acts as a clathrin adaptor in endocytosis of the beta2-adrenergic receptor. Nature 383, 447-450.[Medline]

Govers, R., ten Broeke, T., van Kerkhof, P., Schwartz, A. L. and Strous, G. J (1999). Identification of a novel ubiquitin conjugation motif, required for ligand-induced internalization of the growth hormone receptor. EMBO J 18, 28-36.[Medline]

Hansen, S. H., Sandvig, K. and van Deurs, B (1993). Clathrin and HA2 adaptors: effects of potassium depletion, hypertonic medium, and cytosol acidification. J. Cell Biol 121, 61-72.[Abstract/Free Full Text]

Heldin, C. H., Miyazono, K. and ten Dijke, P (1997). TGF-beta signalling from cell membrane to nucleus through SMAD proteins. Nature 390, 465-471.[Medline]

Henis, Y. I. and Gutman, O (1983). Lateral diffusion and patch formation of H-2Kk antigens on mouse spleen lymphocytes. Biochim. Biophys. Acta 762, 281-288.[Medline]

Henis, Y. I., Moustakas, A., Lin, H. Y. and Lodish, H. F (1994). The types II and III transforming growth factor-beta receptors form homo-oligomers. J. Cell Biol 126, 139-154.[Abstract/Free Full Text]

Heuser, J. E. and Anderson, R. G. W (1989). Hypertonic media inhibit receptor mediated endocytosis by blocking clathrin-coated pit formation. J. Cell Biol 108, 389-400.[Abstract/Free Full Text]

Honing, S., Sandoval, I. V. and von Figura, K (1998). A di-leucine-based motif in the cytoplasmic tail of LIMP-II and tyrosinase mediates selective binding of AP-3. EMBO J 17, 1304-1314.[Medline]

Kibbey, R. G., Rizo, J., Gierasch, L. M. and Anderson, R. G (1998). The LDL receptor clustering motif interacts with the clathrin terminal domain in a reverse turn conformation. J. Cell Biol 142, 59-67.[Abstract/Free Full Text]

Kingsley, D. M (1994). The TGF-superfamily: new members, new receptors and new genetic tests of function in different organisms. Genes Dev 8, 133-146.[Free Full Text]

Kirchhausen, T., Bonifacino, J. S. and Riezman, H (1997). Linking cargo to vesicle formation: receptor tail interactions with coat proteins. Curr. Opin. Cell Biol 9, 488-495.[Medline]

Kirchhausen, T (1999). Adaptors for clathrin-mediated traffic. Annu. Rev. Cell Dev. Biol 15, 705-732.[Medline]

Lazarovits, J. and Roth, M. G (1988). A single amino acid change in the cytoplasmic domain allows the influenza virus hemagglutinin to be endocytosed through coated pits. Cell 53, 743-752.[Medline]

Lin, H. Y., Wang, X.-F., Ng-Eaton, E., Weinberg, R. A. and Lodish, H. F (1992). Expression cloning of the TGF-type II receptor, a functional transmembrane serine/threonine kinase. Cell 68, 775-785.[Medline]

Lu, S. L., Zhang, W. C., Akiyama, Y., Nomizu, T. and Yuasa, Y (1996). Genomic structure of the transforming growth factor beta type II receptor gene and its mutations in hereditary nonpolyposis colorectal cancers. Cancer Res 56, 4595-4598.[Abstract/Free Full Text]

Luo, K. and Lodish, H. F (1997). Positive and negative regulation of type II TGF-beta receptor signal transduction by autophosphorylation on multiple serine residues. EMBO J 16, 1970-1981.[Medline]

Massague, J (1998). TGF-beta signal transduction. Annu. Rev. Biochem 67, 753-791.[Medline]

Massague, J. and Weis Garcia, F (1996). Serine/threonine kinase receptors: mediators of transforming growth factor beta family signals. Cancer Surv 27, 41-64.[Medline]

Morelon, E. and Dautry-Varsat, A (1998). Endocytosis of the common cytokine receptor gamma chain: Identification of sequences involved in internalization and degradation. J. Biol. Chem 273, 22044-22051.[Abstract/Free Full Text]

Mukherjee, S., Ghosh, R. N. and Maxfield, F. R (1997). Endocytosis. Physiol. Rev 77, 759-803.[Abstract/Free Full Text]

Nakao, A., Imamura, T., Souchelnytskyi, S., Kawabata, M., Ishisaki, A., Oeda, E., Tamaki, K., Hanai, J., Heldin, C. H., Miyazono, K. et al. ( (1997). TGF-beta receptor-mediated signalling through Smad2, Smad3 and Smad4. EMBO J 16, 5353-5362.[Medline]

Ohno, H., Stewart, J., Fournier, M. C., Bosshart, H., Rhee, I., Miyatake, S., Saito, T., Gallusser, A., Kirchhausen, T. and Bonifacino, J. S (1995). Interaction of tyrosine-based sorting signals with clathrin-associated proteins. Science 269, 1872-1875.[Abstract/Free Full Text]

Piek, E., Heldin, C. H. and Ten Dijke, P (1999). Specificity, diversity, and regulation in TGF-beta superfamily signaling. FASEB J 13, 2105-2124.[Abstract/Free Full Text]

Rapoport, I., Chen, Y. C., Cupers, P., Shoelson, S. E. and Kirchhausen, T (1998). Dileucine-based sorting signals bind to the beta chain of AP-1 at a site distinct and regulated differently from the tyrosine-based motif-binding site. EMBO J 17, 2148-2155.[Medline]

Rodionov, D. G. and Bakke, O (1998). Medium chains of adaptor complexesAP-1 and AP-2 recognize leucine-based sorting signals from the invariant chain. J. Biol. Chem 273, 6005-6008.[Abstract/Free Full Text]

Rost, B (1996). PHD: predicting one-dimensional protein structure by profile-based neural networks. Methods Enzymol 266, 525-539.[Medline]

Rost, B. and Sander, C (1993). Prediction of protein secondary structure at better than 70% accuracy. J. Mol. Biol 232, 584-599.[Medline]

Rost, B. and Sander, C (1994). Combining evolutionary information and neural networks to predict protein secondary structure. Proteins 19, 55-72.[Medline]

Sandvig, K., Olsnes, S., Peterson, O. W. and van Deurs, B (1987). Acidification of the cytosol inhibits endocytosis from coated pits. J. Cell Biol 105, 679-689.[Abstract/Free Full Text]

Schmid, S. L (1997). Clathrin-coated vesicle formation and protein sorting: an integrated process. Annu. Rev. Biochem 66, 511-548.[Medline]

Schweizer, A., Kornfeld, S. and Rohrer, J (1997). Proper sorting of the cation-dependent mannose 6-phosphate receptor in endosomes depends on a pair of aromatic amino acids in its cytoplasmic tail. Proc. Nat. Acad. Sci. USA 94, 14471-14476.[Abstract/Free Full Text]

Seed, B. and Aruffo, A (1987). Molecular cloning of the CD2 antigen, the T-cell erythrocyte receptor, by a rapid immunoselection procedure. Proc. Nat. Acad. Sci. USA 84, 3365-3369.[Abstract/Free Full Text]

Setiadi, H., Disdier, M., Green, S. A., Canfield, W. M. and McEver, R. P (1995). Residues throughout the cytoplasmic domain affect the internalization efficiency of P-selectin. J. Biol. Chem 270, 26818-26826.[Abstract/Free Full Text]

Sorkin, A. and Waters, C. M (1993). Endocytosis of growth factor receptors. Bioessays 15, 375-382.[Medline]

Teuchert, M., Berghofer, S., Klenk, H. D. and Garten, W (1999). Recycling of furin from the plasma membrane. Functional importance of the cytoplasmic tail sorting signals and interaction with the AP-2 adaptor medium chain subunit. J. Biol. Chem 274, 36781-36789.[Abstract/Free Full Text]

Trowbridge, I. S (1991). Endocytosis and signals for internalization. Curr. Opin. Cell Biol 3, 634-641.[Medline]

Tugizov, S., Maidji, E., Xiao, J. and Pereira, L (1999). An acidic cluster in the cytosolic domain of human cytomegalovirus glycoprotein B is a signal for endocytosis from the plasma membrane. J. Virol 73, 8677-8688.[Abstract/Free Full Text]

Voorhees, P., Deignan, E., van Donselaar, E., Humphrey, J., Marks, M. S., Peters, P. J. and Bonifacino, J. S (1995). An acidic sequence within the cytoplasmic domain of furin functions as a determinant of trans-Golgi network localization and internalization from the cell surface. EMBO J 14, 4961-4975.[Medline]

Wells, R. G., Gilboa, L., Sun, Y., Liu, X., Henis, Y. I. and Lodish, H. F (1999). Transforming growth factor-beta induces formation of a dithiothreitol-resistant type I/type II receptor complex in live cells. J. Biol. Chem 274, 5716-5722.[Abstract/Free Full Text]

Wieser, R., Attisano, L., Wrana, J. L. and Massague, J (1993). Signalling activity of transforming growth factor beta type II receptors lacking specific domains in the cytoplasmic region. Mol. Cell. Biol 13, 7239-7247.[Abstract/Free Full Text]

Wrana, J. L., Attisano, L., Wieser, R., Ventura, F. and Massague, J (1994). Mechanism of activation of the TGF-receptor. Nature 370, 341-347.[Medline]

Yao, D., Dore, J. J., Jr and Leof, E. B (2000). FKBP12 is a negative regulator of transforming growth factor-receptor internalization. J. Biol. Chem 275, 13149-13154.[Abstract/Free Full Text]

Zhang, J., Ferguson, S. S. G., Barak, L. S., Menard, L. and Caron, M. G (1996). Dynamin and beta-arrestin reveal distinct mechanisms for G protein-coupled receptor internalization. J. Biol. Chem 271, 18302-18305.[Abstract/Free Full Text]

Zhu, H. J. and Sizeland, A. M (1999). A pivotal role for the transmembrane domain in transforming growth factor-beta receptor activation. J. Biol. Chem 274, 11773-11781.[Abstract/Free Full Text]

Zwart, D. E., Brewer, C. B., Lazarovits, J., Henis, Y. I. and Roth, M. G (1996). Degradation of mutant influenza virus hemagglutinins is influenced by cytoplasmic sequences independent of internalization signals. J. Biol. Chem 271, 907-917.[Abstract/Free Full Text]

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				J. Jullien and J. Gurdon Morphogen gradient interpretation by a regulated trafficking step during ligand-receptor transduction Genes & Dev., November 15, 2005; 19(22): 2682 - 2694. [Abstract] [Full Text] [PDF]

				S. Roy, S. Plowman, B. Rotblat, I. A. Prior, C. Muncke, S. Grainger, R. G. Parton, Y. I. Henis, Y. Kloog, and J. F. Hancock Individual Palmitoyl Residues Serve Distinct Roles in H-Ras Trafficking, Microlocalization, and Signaling Mol. Cell. Biol., August 1, 2005; 25(15): 6722 - 6733. [Abstract] [Full Text] [PDF]

				B. Ozdamar, R. Bose, M. Barrios-Rodiles, H.-R. Wang, Y. Zhang, and J. L. Wrana Regulation of the Polarity Protein Par6 by TGF{beta} Receptors Controls Epithelial Cell Plasticity Science, March 11, 2005; 307(5715): 1603 - 1609. [Abstract] [Full Text] [PDF]

				H. Mitchell, A. Choudhury, R. E. Pagano, and E. B. Leof Ligand-dependent and -independent Transforming Growth Factor-{beta} Receptor Recycling Regulated by Clathrin-mediated Endocytosis and Rab11 Mol. Biol. Cell, September 1, 2004; 15(9): 4166 - 4178. [Abstract] [Full Text] [PDF]

				B. Rotblat, I. A. Prior, C. Muncke, R. G. Parton, Y. Kloog, Y. I. Henis, and J. F. Hancock Three Separable Domains Regulate GTP-Dependent Association of H-ras with the Plasma Membrane Mol. Cell. Biol., August 1, 2004; 24(15): 6799 - 6810. [Abstract] [Full Text] [PDF]

				Y. Zhou, S. Scolavino, S. F. Funderburk, L. F. Ficociello, X. Zhang, and A. Klibanski Receptor Internalization-Independent Activation of Smad2 in Activin Signaling Mol. Endocrinol., July 1, 2004; 18(7): 1818 - 1826. [Abstract] [Full Text] [PDF]

				T. Ito, J. D. Williams, D. J. Fraser, and A. O. Phillips Hyaluronan Regulates Transforming Growth Factor-{beta}1 Receptor Compartmentalization J. Biol. Chem., June 11, 2004; 279(24): 25326 - 25332. [Abstract] [Full Text] [PDF]

				E. Fernandez-Salas, L. E. Steward, H. Ho, P. E. Garay, S. W. Sun, M. A. Gilmore, J. V. Ordas, J. Wang, J. Francis, and K. R. Aoki Plasma membrane localization signals in the light chain of botulinum neurotoxin PNAS, March 2, 2004; 101(9): 3208 - 3213. [Abstract] [Full Text] [PDF]

				W. Chen, K. C. Kirkbride, T. How, C. D. Nelson, J. Mo, J. P. Frederick, X.-F. Wang, R. J. Lefkowitz, and G. C. Blobe {beta}-Arrestin 2 Mediates Endocytosis of Type III TGF-{beta} Receptor and Down-Regulation of Its Signaling Science, September 5, 2003; 301(5638): 1394 - 1397. [Abstract] [Full Text] [PDF]

				D. Illenberger, C. Walliser, J. Strobel, O. Gutman, H. Niv, V. Gaidzik, Y. Kloog, P. Gierschik, and Y. I. Henis Rac2 Regulation of Phospholipase C-beta 2 Activity and Mode of Membrane Interactions in Intact Cells J. Biol. Chem., February 28, 2003; 278(10): 8645 - 8652. [Abstract] [Full Text] [PDF]

				K. Janssens, P. ten Dijke, S. H. Ralston, C. Bergmann, and W. Van Hul Transforming Growth Factor-beta 1 Mutations in Camurati-Engelmann Disease Lead to Increased Signaling by Altering either Activation or Secretion of the Mutant Protein J. Biol. Chem., February 21, 2003; 278(9): 7718 - 7724. [Abstract] [Full Text] [PDF]

				D. Yao, M. Ehrlich, Y. I. Henis, and E. B. Leof Transforming Growth Factor-beta Receptors Interact with AP2 by Direct Binding to beta 2 Subunit Mol. Biol. Cell, November 1, 2002; 13(11): 4001 - 4012. [Abstract] [Full Text] [PDF]

				Z. Lu, J. T. Murray, W. Luo, H. Li, X. Wu, H. Xu, J. M. Backer, and Y.-G. Chen Transforming Growth Factor beta Activates Smad2 in the Absence of Receptor Endocytosis J. Biol. Chem., August 9, 2002; 277(33): 29363 - 29368. [Abstract] [Full Text] [PDF]

				E. S. Seto, H. J. Bellen, and T. E. Lloyd When cell biology meets development: endocytic regulation of signaling pathways Genes & Dev., June 1, 2002; 16(11): 1314 - 1336. [Full Text] [PDF]

				T. Matsuzaki, S. Hanai, H. Kishi, Z. Liu, Y. Bao, A. Kikuchi, K. Tsuchida, and H. Sugino Regulation of Endocytosis of Activin Type II Receptors by a Novel PDZ Protein through Ral/Ral-binding Protein 1-dependent Pathway J. Biol. Chem., May 17, 2002; 277(21): 19008 - 19018. [Abstract] [Full Text] [PDF]