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First published online 6 February 2003
doi: 10.1242/jcs.00298

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Drosophila miniature and dusky encode ZP proteins required for cytoskeletal reorganisation during wing morphogenesis

¹ Laboratory for Development and Evolution, University Museum of Zoology, Department of Zoology, University of Cambridge, Downing Street, Cambridge CB2 3EJ, UK
² Centre de Biologie du Développement, CNRS UMR5547, Université Paul Sabatier, Bât. 4R3, 118 Route de Narbonne 31062, Toulouse, France

^* Author for correspondence (e-mail: roch{at}cict.fr)

Accepted 29 November 2002

We have characterised the function of two Drosophila genes, miniature and dusky, that are required for the morphological reorganisation of the apical membrane during wing epidermis differentiation. These genes encode transmembrane proteins containing a ZP (zona pellucida) domain and are homologous to several vertebrate and invertebrate apical matrix components. miniature and dusky are only expressed in tissues secreting a cuticle, and the Min protein localises to the apical membrane during the early stages of cuticle formation. We propose that Min and Dusky form a novel subfamily within the ZP domain proteins and are specifically involved in the interactions between the apical membrane, the cytoskeleton and the forming cuticle.

Key words: ZP proteins, Cuticulin envelope, Epithelial morphogenesis, Cuticule formation, Drosophila

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Wing development in miniature

JCS 2003 116: 704. [Full Text]  

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