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First published online 20 June 2006
doi: 10.1242/jcs.03025

Journal of Cell Science 119, 2882-2891 (2006)
Published by The Company of Biologists 2006
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Research Article

The Schizosaccharomyces pombe septation initiation network (SIN) is required for spore formation in meiosis

Andrea Krapp, Philippe Collin, Adisa Cokoja*, Sandra Dischinger, Elena Cano and Viesturs Simanis{ddagger}

Cell Cycle Control Laboratory, Swiss Institute for Experimental Cancer Research (ISREC), 1066 Epalinges, Switzerland

{ddagger} Author for correspondence (e-mail: viesturs.simanis{at}isrec.ch)

Accepted 25 April 2006

When nutrients are abundant, S. pombe cells grow as rods, dividing by fission after formation of a medially placed cell wall or division septum. Septum formation is triggered by a group of proteins, called the septation initiation network or SIN, that trigger contraction of the acto-myosin contractile ring at the end of mitosis. Ectopic activation of the SIN can uncouple septum formation from other cell-cycle events, whereas loss of SIN signalling gives rise to multinucleated cells due to the failure of cytokinesis. When starved, S. pombe cells of opposite mating types fuse to form a diploid zygote that undergoes meiosis and produces four spores. No septa or contractile rings are formed during meiosis. In this study, we have investigated the role of the SIN in meiosis. Our data show that, whereas the meiotic divisions appear normal, SIN mutants cannot form spores. Forespore membrane formation is initiated, but the nuclei are not encapsulated properly. The SIN proteins localise to the spindle pole body in meiosis. The protein kinases Sid1p and Cdc7p do not associate with the spindle pole body until meiosis II, when forespore membrane deposition begins. These data indicate a role for the SIN in regulating spore formation during meiosis.

Key words: Meiosis, Septation, Cell cycle, Fission yeast, Spore


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