spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search    

The fully linked HTML version of this article has now been published.
JCS ePress online publication date 29 Jun 2004
doi: 10.1242/jcs.01222

This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
jcs.01222v1
117/16/3539    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Richardson, G. D.
Right arrow Articles by Collins, A. T.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Richardson, G. D.
Right arrow Articles by Collins, A. T.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Research Article

CD133, a novel marker for human prostatic epithelial stem cells


Gavin D. Richardson, Craig N. Robson, Shona H. Lang, David E. Neal, Norman J. Maitland, and Anne T. Collins*
* Author for correspondence (e-mail: ac43{at}york.ac.uk)

Stem cells are clonogenic cells with self-renewal and differentiation properties, which may represent a major target for genetic damage leading to prostate cancer and benign prostatic hyperplasia. Stem cells remain poorly characterised because of the absence of specific molecular markers that permit us to distinguish them from their progeny, the transit amplifying cells, which have a more restricted proliferative potential. Human CD133 antigen, also known as AC133, was recently identified as a haematopoietic stem cell marker. Here we show that a small population (approximately 1%) of human prostate basal cells express the cell surface marker CD133 and are restricted to the {alpha}2{beta}1hi population, previously shown to be a marker of stem cells in prostate epithelia (Collins, A. T., Habib, F. K., Maitland, N. J. and Neal, D. E. (2001). J. Cell Sci. 114, 3865-3872). {alpha}2{beta}1hi/CD133+ cells exhibit two important attributes of epithelial stem cells: they possess a high in vitro proliferative potential and can reconstitute prostatic-like acini in immunocompromised male nude mice.
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 Proc. Natl. Acad. Sci. USAHome page
G. Bertolini, L. Roz, P. Perego, M. Tortoreto, E. Fontanella, L. Gatti, G. Pratesi, A. Fabbri, F. Andriani, S. Tinelli, et al.
Highly tumorigenic lung cancer CD133+ cells display stem-like features and are spared by cisplatin treatment
PNAS, September 22, 2009; 106(38): 16281 - 16286.
[Abstract] [Full Text] [PDF]

Home page
 Vet PatholHome page
M. J. Hynes, K. M. Huang, and E. H. Huang
REVIEW PAPER: Implications of the "Cancer Stem Cell" Hypothesis on Murine Models of Colon Cancer and Colitis-associated Cancer
Vet. Pathol., September 1, 2009; 46(5): 819 - 835.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
R. Hill and H. Wu
PTEN, Stem Cells, and Cancer Stem Cells
J. Biol. Chem., May 1, 2009; 284(18): 11755 - 11759.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
M. Santisteban, J. M. Reiman, M. K. Asiedu, M. D. Behrens, A. Nassar, K. R. Kalli, P. Haluska, J. N. Ingle, L. C. Hartmann, M. H. Manjili, et al.
Immune-Induced Epithelial to Mesenchymal Transition In vivo Generates Breast Cancer Stem Cells
Cancer Res., April 1, 2009; 69(7): 2887 - 2895.
[Abstract] [Full Text] [PDF]

Home page
 Cold Spring Harb Symp Quant BiolHome page
M.M. Shen, X. Wang, K.D. Economides, D. Walker, and C. Abate-Shen
Progenitor Cells for the Prostate Epithelium: Roles in Development, Regeneration, and Cancer
Cold Spring Harb Symp Quant Biol, January 15, 2009; (2009) sqb.2008.73.050v1.
[Abstract] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
A. S. Goldstein, D. A. Lawson, D. Cheng, W. Sun, I. P. Garraway, and O. N. Witte
Trop2 identifies a subpopulation of murine and human prostate basal cells with stem cell characteristics
PNAS, December 30, 2008; 105(52): 20882 - 20887.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
D. J. Vander Griend, W. L. Karthaus, S. Dalrymple, A. Meeker, A. M. DeMarzo, and J. T. Isaacs
The Role of CD133 in Normal Human Prostate Stem Cells and Malignant Cancer-Initiating Cells
Cancer Res., December 1, 2008; 68(23): 9703 - 9711.
[Abstract] [Full Text] [PDF]

Home page
 Cold Spring Harb Symp Quant BiolHome page
D.M. Raiser, S.J. Zacharek, R.R. Roach, S.J. Curtis, K.W. Sinkevicius, D.W. Gludish, and C.F. Kim
Stem Cell Biology in the Lung and Lung Cancers: Employing Pulmonary Context and Classic Approaches
Cold Spring Harb Symp Quant Biol, November 26, 2008; (2008) sqb.2008.73.036v2.
[Abstract] [PDF]

Home page
 Cold Spring Harb Symp Quant BiolHome page
R.U. Lukacs, D.A. Lawson, L. Xin, Y. Zong, I. Garraway, A.S. Goldstein, S. Memarzadeh, and O.N. Witte
Epithelial Stem Cells of the Prostate and Their Role in Cancer Progression
Cold Spring Harb Symp Quant Biol, November 6, 2008; (2008) sqb.2008.73.012v1.
[Abstract] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
I. Zucchi, S. Astigiano, G. Bertalot, S. Sanzone, C. Cocola, P. Pelucchi, G. Bertoli, M. Stehling, O. Barbieri, A. Albertini, et al.
Distinct populations of tumor-initiating cells derived from a tumor generated by rat mammary cancer stem cells
PNAS, November 4, 2008; 105(44): 16940 - 16945.
[Abstract] [Full Text] [PDF]

Home page
 J. Histochem. Cytochem.Home page
J. Karbanova, E. Missol-Kolka, A.-V. Fonseca, C. Lorra, P. Janich, H. Hollerova, J. Jaszai, J. Ehrmann, Z. Kolar, C. Liebers, et al.
The Stem Cell Marker CD133 (Prominin-1) Is Expressed in Various Human Glandular Epithelia
J. Histochem. Cytochem., November 1, 2008; 56(11): 977 - 993.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
B. Bhatia, M. Jiang, M. Suraneni, L. Patrawala, M. Badeaux, R. Schneider-Broussard, A. S. Multani, C. R. Jeter, T. Calhoun-Davis, L. Hu, et al.
Critical and Distinct Roles of p16 and Telomerase in Regulating the Proliferative Life Span of Normal Human Prostate Epithelial Progenitor Cells
J. Biol. Chem., October 10, 2008; 283(41): 27957 - 27972.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
M. Jaksch, J. Munera, R. Bajpai, A. Terskikh, and R. G. Oshima
Cell Cycle-Dependent Variation of a CD133 Epitope in Human Embryonic Stem Cell, Colon Cancer, and Melanoma Cell Lines
Cancer Res., October 1, 2008; 68(19): 7882 - 7886.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
N. Konishi, K. Shimada, M. Nakamura, E. Ishida, I. Ota, N. Tanaka, and K. Fujimoto
Function of JunB in Transient Amplifying Cell Senescence and Progression of Human Prostate Cancer
Clin. Cancer Res., July 15, 2008; 14(14): 4408 - 4416.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
N. J. Maitland and A. T. Collins
Prostate Cancer Stem Cells: A New Target for Therapy
J. Clin. Oncol., June 10, 2008; 26(17): 2862 - 2870.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
L. S. Hart and W. S. El-Deiry
Invincible, but Not Invisible: Imaging Approaches Toward In Vivo Detection of Cancer Stem Cells
J. Clin. Oncol., June 10, 2008; 26(17): 2901 - 2910.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
M. Mimeault, P. P. Mehta, R. Hauke, and S. K. Batra
Functions of Normal and Malignant Prostatic Stem/Progenitor Cells in Tissue Regeneration and Cancer Progression and Novel Targeting Therapies
Endocr. Rev., April 1, 2008; 29(2): 234 - 252.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
K.E. Schwab, P. Hutchinson, and C.E. Gargett
Identification of surface markers for prospective isolation of human endometrial stromal colony-forming cells
Hum. Reprod., April 1, 2008; 23(4): 934 - 943.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
L. Patrawala, T. Calhoun-Davis, R. Schneider-Broussard, and D. G. Tang
Hierarchical Organization of Prostate Cancer Cells in Xenograft Tumors: The CD44+{alpha}2{beta}1+ Cell Population Is Enriched in Tumor-Initiating Cells
Cancer Res., July 15, 2007; 67(14): 6796 - 6805.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Pathol.Home page
J. Stewart, N. Fleshner, H. Cole, and J. Sweet
Comparison of annexin II, p63 and {alpha}-methylacyl-CoA racemase immunoreactivity in prostatic tissue: a tissue microarray study
J. Clin. Pathol., July 1, 2007; 60(7): 773 - 780.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
R. Francis and C. Richardson
Multipotent hematopoietic cells susceptible to alternative double-strand break repair pathways that promote genome rearrangements
Genes & Dev., May 1, 2007; 21(9): 1064 - 1074.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
J. Miki, B. Furusato, H. Li, Y. Gu, H. Takahashi, S. Egawa, I. A. Sesterhenn, D. G. McLeod, S. Srivastava, and J. S. Rhim
Identification of Putative Stem Cell Markers, CD133 and CXCR4, in hTERT-Immortalized Primary Nonmalignant and Malignant Tumor-Derived Human Prostate Epithelial Cell Lines and in Prostate Cancer Specimens
Cancer Res., April 1, 2007; 67(7): 3153 - 3161.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
C. Li, D. G. Heidt, P. Dalerba, C. F. Burant, L. Zhang, V. Adsay, M. Wicha, M. F. Clarke, and D. M. Simeone
Identification of Pancreatic Cancer Stem Cells
Cancer Res., February 1, 2007; 67(3): 1030 - 1037.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
D. A. Lawson, L. Xin, R. U. Lukacs, D. Cheng, and O. N. Witte
Isolation and functional characterization of murine prostate stem cells
PNAS, January 2, 2007; 104(1): 181 - 186.
[Abstract] [Full Text] [PDF]

Home page
 Hum Reprod UpdateHome page
C.E. Gargett
Uterine stem cells: What is the evidence?
Hum. Reprod. Update, January 1, 2007; 13(1): 87 - 101.
[Abstract] [Full Text] [PDF]

Home page
 Endocr Relat CancerHome page
P Singh, A Uzgare, I Litvinov, S R Denmeade, and J T Isaacs
Combinatorial androgen receptor targeted therapy for prostate cancer.
Endocr. Relat. Cancer, September 1, 2006; 13(3): 653 - 666.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
I. V. Litvinov, D. J. Vander Griend, Y. Xu, L. Antony, S. L. Dalrymple, and J. T. Isaacs
Low-Calcium Serum-Free Defined Medium Selects for Growth of Normal Prostatic Epithelial Stem Cells.
Cancer Res., September 1, 2006; 66(17): 8598 - 8607.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
C. Sagrinati, G. S. Netti, B. Mazzinghi, E. Lazzeri, F. Liotta, F. Frosali, E. Ronconi, C. Meini, M. Gacci, R. Squecco, et al.
Isolation and Characterization of Multipotent Progenitor Cells from the Bowman's Capsule of Adult Human Kidneys
J. Am. Soc. Nephrol., September 1, 2006; 17(9): 2443 - 2456.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
R. Heer, A. T. Collins, C. N. Robson, B. K. Shenton, and H. Y. Leung
KGF suppresses {alpha}2{beta}1 integrin function and promotes differentiation of the transient amplifying population in human prostatic epithelium.
J. Cell Sci., April 1, 2006; 119(Pt 7): 1416 - 1424.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
S. Wang, A. J. Garcia, M. Wu, D. A. Lawson, O. N. Witte, and H. Wu
Pten deletion leads to the expansion of a prostatic stem/progenitor cell subpopulation and tumor initiation
PNAS, January 31, 2006; 103(5): 1480 - 1485.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
M. Mimeault and S. K. Batra
Recent advances on multiple tumorigenic cascades involved in prostatic cancer progression and targeting therapies
Carcinogenesis, January 1, 2006; 27(1): 1 - 22.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
A. T. Collins, P. A. Berry, C. Hyde, M. J. Stower, and N. J. Maitland
Prospective Identification of Tumorigenic Prostate Cancer Stem Cells
Cancer Res., December 1, 2005; 65(23): 10946 - 10951.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
S. Dalrymple, L. Antony, Y. Xu, A. R. Uzgare, J. T. Arnold, J. Savaugeot, L. J. Sokoll, A. M. De Marzo, and J. T. Isaacs
Role of Notch-1 and E-Cadherin in the Differential Response to Calcium in Culturing Normal versus Malignant Prostate Cells
Cancer Res., October 15, 2005; 65(20): 9269 - 9279.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
A. Leri, J. Kajstura, and P. Anversa
Cardiac Stem Cells and Mechanisms of Myocardial Regeneration
Physiol Rev, October 1, 2005; 85(4): 1373 - 1416.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
A.-M. Marzesco, P. Janich, M. Wilsch-Brauninger, V. Dubreuil, K. Langenfeld, D. Corbeil, and W. B. Huttner
Release of extracellular membrane particles carrying the stem cell marker prominin-1 (CD133) from neural progenitors and other epithelial cells
J. Cell Sci., July 1, 2005; 118(13): 2849 - 2858.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
P. E. Burger, X. Xiong, S. Coetzee, S. N. Salm, D. Moscatelli, K. Goto, and E. L. Wilson
Sca-1 expression identifies stem cells in the proximal region of prostatic ducts with high capacity to reconstitute prostatic tissue
PNAS, May 17, 2005; 102(20): 7180 - 7185.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
L. Xin, D. A. Lawson, and O. N. Witte
The Sca-1 cell surface marker enriches for a prostate-regenerating cell subpopulation that can initiate prostate tumorigenesis
PNAS, May 10, 2005; 102(19): 6942 - 6947.
[Abstract] [Full Text] [PDF]

Home page
 Cold Spring Harb Symp Quant BiolHome page
D.A. LAWSON, L. XIN, R. LUKACS, Q. XU, D. CHENG, and O.N. WITTE
Prostate Stem Cells and Prostate Cancer
Cold Spring Harb Symp Quant Biol, January 1, 2005; 70(0): 187 - 196.
[Abstract] [PDF]


© The Company of Biologists Ltd 2004