spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search    

The fully linked HTML version of this article has now been published.
JCS ePress online publication date 27 Jul 2004
doi: 10.1242/jcs.01242

This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
jcs.01242v1
117/18/4033    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Beardmore, V. A.
Right arrow Articles by Kallio, M. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Beardmore, V. A.
Right arrow Articles by Kallio, M. J.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Research Article

Survivin dynamics increases at centromeres during G2/M phase transition and is regulated by microtubule-attachment and Aurora B kinase activity


Victoria A. Beardmore, Leena J. Ahonen, Gary J. Gorbsky, and Marko J. Kallio*
* Author for correspondence (e-mail: marko.kallio{at}vtt.fi)

The inhibitor of apoptosis protein survivin is implicated in two key biological events: in the control of cell proliferation and in the regulation of cell lifespan. Although the details of mitotic roles of survivin are unclear, the protein appears to modulate microtubule function and might participate in regulating the spindle checkpoint. Survivin physically associates with Aurora B, a serine-threonine kinase involved in microtubule attachment to centromeres and regulation of chromosome segregation. Here we have examined the dynamics and localization of a survivin-GFP chimera using high-resolution fluorescence microscopy and photobleaching. Survivin forms a bi-partite structure at the inner centromere that undergoes significant stretching during mitosis. Photobleaching experiments revealed marked changes in rates of survivin turnover at centromeres. These were regulated by stage of the cell cycle, microtubule attachment, and Aurora B kinase activity. We hypothesize that changes in the turnover of survivin at centromeres influence the stability of kinetochore-microtubule attachment and signaling of the spindle checkpoint.
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 Nucleic Acids ResHome page
F. Ferri, H. Bouzinba-Segard, G. Velasco, F. Hube, and C. Francastel
Non-coding murine centromeric transcripts associate with and potentiate Aurora B kinase
Nucleic Acids Res., August 1, 2009; 37(15): 5071 - 5080.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
R. Colnaghi, C. M. Connell, R. M. A. Barrett, and S. P. Wheatley
Separating the Anti-apoptotic and Mitotic Roles of Survivin
J. Biol. Chem., November 3, 2006; 281(44): 33450 - 33456.
[Abstract] [Full Text] [PDF]

Home page
 JCBHome page
G. Vader, R. H. Medema, and S. M.A. Lens
The chromosomal passenger complex: guiding Aurora-B through mitosis
J. Cell Biol., June 19, 2006; 173(6): 833 - 837.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Biol. CellHome page
J. Rosa, P. Canovas, A. Islam, D. C. Altieri, and S. J. Doxsey
Survivin Modulates Microtubule Dynamics and Nucleation throughout the Cell Cycle
Mol. Biol. Cell, March 1, 2006; 17(3): 1483 - 1493.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
Q. P. Vong, K. Cao, H. Y. Li, P. A. Iglesias, and Y. Zheng
Chromosome Alignment and Segregation Regulated by Ubiquitination of Survivin
Science, December 2, 2005; 310(5753): 1499 - 1504.
[Abstract] [Full Text] [PDF]


© The Company of Biologists Ltd 2004