The fully linked HTML version of this article has now been published.
JCS ePress
online publication date 17 Aug 2004
doi: 10.1242/jcs.01316
Research Article
Myosin Va is required for normal photoreceptor synaptic activity
Richard T. Libby,
Concepcion Lillo,
Junko Kitamoto,
David S. Williams,
and
Karen P. Steel*
* Author for correspondence (e-mail: kps{at}sanger.ac.uk)
Myosin Va is an actin-based motor molecule, one of a large family of unconventional myosins. In humans, mutations in MYO5A cause Griscelli syndrome type 1 and Elejalde syndrome, diseases characterized by pigmentation defects and the prepubescent onset of severe neurological deficits that ultimately lead to a shortened lifespan. Mutations in the Myo5a gene in mouse cause the dilute series of mouse mutants, demonstrating that myosin Va is involved in pigmentation and neural function. Although the reason for the pigmentation abnormalities is well understood, the role of myosin Va in neural function is not. Myosin Va has been found in synaptic terminals in the retina and brain. We report here new physiological evidence for a role of myosin Va in synaptic function. Photoreceptor synapses in neurologically affected myosin Va mutant mice have both anatomical and physiological abnormalities. Thus, myosin Va is required for normal photoreceptor signalling, suggesting that it might function in central nervous system synapses in general, with aberrant synaptic activity potentially underlying the neurological defects observed in dilute lethal mice and patients with Griscelli syndrome type 1 and Elejalde syndrome.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati 
Twitter What's this?
This article has been cited by other articles:
|
|
|
|
 
L. LoGiudice and G. Matthews
The Role of Ribbons at Sensory Synapses
Neuroscientist,
August 1, 2009;
15(4):
380 - 391.
[Abstract]
[PDF]
|
|
|
|
|
|
|
D. Specht, S.-B. Wu, P. Turner, P. Dearden, F. Koentgen, U. Wolfrum, M. Maw, J. H. Brandstatter, and S. tom Dieck
Effects of Presynaptic Mutations on a Postsynaptic Cacna1s Calcium Channel Colocalized with mGluR6 at Mouse Photoreceptor Ribbon Synapses
Invest. Ophthalmol. Vis. Sci.,
February 1, 2009;
50(2):
505 - 515.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. Takagi, Y. Yang, I. Fujiwara, D. Jacobs, R. E. Cheney, J. R. Sellers, and M. Kovacs
Human Myosin Vc Is a Low Duty Ratio, Nonprocessive Molecular Motor
J. Biol. Chem.,
March 28, 2008;
283(13):
8527 - 8537.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. T. Roland, A. K. Kenworthy, J. Peranen, S. Caplan, and J. R. Goldenring
Myosin Vb Interacts with Rab8a on a Tubular Network Containing EHD1 and EHD3
Mol. Biol. Cell,
August 1, 2007;
18(8):
2828 - 2837.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
V. M. Olkkonen and E. Ikonen
When intracellular logistics fails - genetic defects in membrane trafficking
J. Cell Sci.,
December 15, 2006;
119(24):
5031 - 5045.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Watanabe, K. Nomura, A. Ohyama, R. Ishikawa, Y. Komiya, K. Hosaka, E. Yamauchi, H. Taniguchi, N. Sasakawa, K. Kumakura, et al.
Myosin-Va Regulates Exocytosis through the Submicromolar Ca2+-dependent Binding of Syntaxin-1A
Mol. Biol. Cell,
October 1, 2005;
16(10):
4519 - 4530.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Krendel and M. S. Mooseker
Myosins: Tails (and Heads) of Functional Diversity
Physiology,
August 1, 2005;
20(4):
239 - 251.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. S. Kuroda and M. Fukuda
Functional Analysis of Slac2-c/MyRIP as a Linker Protein between Melanosomes and Myosin VIIa
J. Biol. Chem.,
July 29, 2005;
280(30):
28015 - 28022.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Gibbs, S. M. Azarian, C. Lillo, J. Kitamoto, A. E. Klomp, K. P. Steel, R. T. Libby, and D. S. Williams
Role of myosin VIIa and Rab27a in the motility and localization of RPE melanosomes
J. Cell Sci.,
December 15, 2004;
117(26):
6473 - 6483.
[Abstract]
[Full Text]
[PDF]
|
|
|
© The Company of Biologists Ltd 2004
