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JCS ePress online publication date 31 Aug 2004
doi: 10.1242/jcs.01371

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Research Article

Light-dependent subcellular translocation of Gq{alpha} in Drosophila photoreceptors is facilitated by the photoreceptor-specific myosin III NINAC


Michelle A. Cronin, Fengqiu Diao, and Susan Tsunoda*
* Author for correspondence (e-mail: tsunoda{at}bu.edu)

We examine the light-dependent subcellular translocation of the visual Gq{alpha} protein between the signaling compartment, the rhabdomere and the cell body in Drosophila photoreceptors. We characterize the translocation of Gq{alpha} and provide the first evidence implicating the involvement of the photoreceptor-specific myosin III NINAC in Gq{alpha} transport. Translocation of Gq{alpha} from the rhabdomere to the cell body is rapid, taking less than 5 minutes. Higher light intensities increased the quantity of Gq{alpha} translocated out of the rhabdomeres from 20% to 75%, consistent with a mechanism for light adaptation. We demonstrate that translocation of Gq{alpha} requires rhodopsin, but none of the known downstream phototransduction components, suggesting that the signaling pathway triggering translocation occurs upstream of Gq{alpha}. Finally, we show that ninaC mutants display a significantly reduced rate of Gq{alpha} transport from the cell body to the rhabdomere, suggesting that NINAC might function as a light-dependent plus-end motor involved in the transport of Gq{alpha}.
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