|
|
|
||||
| Home Help Feedback Subscriptions Archive Search | |||||
The fully linked HTML version of this article has now been published.
Currently, there is no treatment to cure transmissible spongiform encephalopathies. By taking advantage of the 'prion-resistant' polymorphisms Q171R and E219K that naturally exist in sheep and humans, respectively, we have evaluated a therapeutic approach of lentiviral gene transfer. Here, we show that VSV-G (vesicular stomatitis virus G glycoprotein) pseudotyped FIV- (feline immunodeficiency virus) derived vectors carrying the mouse Prnp gene in which these mutations have been inserted, are able to inhibit prion replication in chronically prion-infected cells. Because lentiviral tools are able to transduce post-mitotic cells such as neurons or cells of the lymphoreticular system, this result might help the development of gene- or cell-therapy approaches to prion disease.
This article has been cited by other articles:
JCS ePress
online publication date 19 Oct 2004
doi: 10.1242/jcs.01484
This Article ![]()
![]()
Full Text (PDF)
![]()
All Versions of this Article:
jcs.01484v1
117/23/5591
most recent![]()
Alert me when this article is cited
![]()
Alert me if a correction is posted
![]()
Services ![]()
![]()
Email this article to a friend
![]()
Similar articles in this journal
![]()
Similar articles in PubMed
![]()
Alert me to new issues of the journal
![]()
Download to citation manager
![]()
![]()
Citing Articles ![]()
![]()
Citing Articles via HighWire
![]()
Citing Articles via Google Scholar
![]()
Google Scholar ![]()
![]()
Articles by Crozet, C. ![]()
Articles by Perrier, V. ![]()
Search for Related Content
![]()
PubMed ![]()
![]()
PubMed Citation
![]()
Articles by Crozet, C.
![]()
Articles by Perrier, V.
![]()
Social Bookmarking ![]()
![]()
What's this?
Research Article
Inhibition of PrPSc formation by lentiviral gene transfer of PrP containing dominant negative mutations
* Author for correspondence (e-mail: vperrier{at}igh.cnrs.fr)
![]()
CiteULike
Complore
Connotea
Del.icio.us
Digg
Reddit
Technorati
Twitter What's this?
![]()
![]()

![]()
![]()
![]()
H. Pflanz, K. Vana, G. Mitteregger, C. Pace, D. Messow, C. Sedlaczek, D. Nikles, H. A. Kretzschmar, and S. F. T. Weiss
Microinjection of lentiviral vectors expressing small interfering RNAs directed against laminin receptor precursor mRNA prolongs the pre-clinical phase in scrapie-infected mice
J. Gen. Virol.,
January 1, 2009;
90(1):
269 - 274.
[Abstract]
[Full Text]
[PDF]
![]()
![]()
![]()

![]()
![]()
![]()
D. Ott, C. Taraborrelli, and A. Aguzzi
Novel dominant-negative prion protein mutants identified from a randomized library
Protein Eng. Des. Sel.,
October 1, 2008;
21(10):
623 - 629.
[Abstract]
[Full Text]
[PDF]
![]()
![]()
![]()

![]()
![]()
![]()
C. R Trevitt and J. Collinge
A systematic review of prion therapeutics in experimental models
Brain,
September 1, 2006;
129(9):
2241 - 2265.
[Abstract]
[Full Text]
[PDF]
![]()
© The Company of Biologists Ltd 2004