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JCS ePress online publication date 15 Feb 2005
doi: 10.1242/jcs.01678

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Research Article

Loss of {alpha}10{beta}1 integrin expression leads to moderate dysfunction of growth plate chondrocytes


Therese Bengtsson, Attila Aszodi, Claudia Nicolae, Ernst B. Hunziker, Evy Lundgren-Åkerlund, and Reinhard Fässler*
* Author for correspondence (e-mail: faessler{at}biochem.mpg.de)

Integrin {alpha}10{beta}1 is a collagen-binding integrin expressed on chondrocytes. In order to unravel the role of the {alpha}10 integrin during development, we generated mice carrying a constitutive deletion of the {alpha}10 integrin gene. The mutant mice had a normal lifespan and were fertile but developed a growth retardation of the long bones. Analysis of the skeleton revealed defects in the growth plate after birth characterized by a disturbed columnar arrangement of chondrocytes, abnormal chondrocyte shape and reduced chondrocyte proliferation. Electron microscopy of growth plates from newborn mice revealed an increased number of apoptotic chondrocytes and reduced density of the collagen fibrillar network compared to these structures in control mice. These results demonstrate that integrin {alpha}10{beta}1 plays a specific role in growth plate morphogenesis and function.
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