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JCS ePress online publication date 5 Feb 2008
doi: 10.1242/jcs.025502

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Research Article

A distinct population of clonogenic and multipotent murine follicular keratinocytes residing in the upper isthmus


Uffe Birk Jensen, Xiaohong Yan, Charlotte Triel, Seung-Hyun Woo, Rikke Christensen, and David M. Owens*
* Author for correspondence (e-mail: do2112{at}columbia.edu)

The bulge region of adult murine hair follicles harbors epidermal stem cells with multipotent capacity; however, the restricted contributions of these cells under homeostatic conditions indicates that additional stem or progenitor cell populations may be required to maintain squamous and sebaceous lineages. We have identified a distinct population of murine hair follicle keratinocytes residing in the upper isthmus (UI) between the infundibulum and bulge regions that are distinguished by low {alpha}6 integrin levels and are negative for CD34 and Sca-1. Purified UI cells give rise to long-term, stable epidermal, follicular and sebaceous lineages and can self-renew in vivo. These cells are non-quiescent and possess a unique transcript profile compared with bulge stem cells and may represent a distinct reservoir of epidermal stem or progenitor cells.


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U. B. Jensen, X. Yan, C. Triel, S.-H. Woo, R. Christensen, and D. M. Owens
A distinct population of clonogenic and multipotent murine follicular keratinocytes residing in the upper isthmus
Development, March 15, 2008; 135(6): e1 - e1.
[Full Text]


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