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The standard model of Wnt signaling specifies that after receipt of a Wnt ligand at the membranous receptor complex, downstream mediators inhibit a cytoplasmic destruction complex, allowing
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JCS ePress
online publication date 6 May 2008
doi: 10.1242/jcs.025536
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jcs.025536v1
121/11/1793
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Research Article
Plasma membrane recruitment of dephosphorylated
-catenin upon activation of the Wnt pathway
* Author for correspondence (e-mail: m.fornerod{at}nki.nl)
-catenin to accumulate in the cytosol and nucleus and co-activate Wnt target genes. Unexpectedly, shortly after Wnt treatment, we detected the dephosphorylated form of -catenin at the plasma membrane, where it displayed a discontinuous punctate labeling. This pool of -catenin could only be detected in E-cadherin-/- cells, because in E-cadherin+/+ cells Wnt-induced, membranous -catenin was concealed by a constitutive junctional pool. Wnt-signaling-dependent dephosphorylated -catenin colocalized at the plasma membrane with two members of the destruction complex - APC and axin - and the activated Wnt co-receptor LRP6. -catenin induced through the Wnt receptor complex was significantly more competent transcriptionally than overexpressed -catenin, both in cultured cells and in early Xenopus embryos. Our data reveal a new step in the processing of the Wnt signal and suggest regulation of signaling output beyond the level of protein accumulation.
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© The Company of Biologists Ltd 2008