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JCS ePress online publication date 1 Nov 2005
doi: 10.1242/jcs.02647

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Research Article

Dishevelled (Dvl-2) activates canonical Wnt signalling in the absence of cytoplasmic puncta


Matthew J. Smalley, Nathalie Signoret, David Robertson, Alan Tilley, Anthony Hann, Ken Ewan, Yanning Ding, Hugh Paterson, and Trevor C. Dale*
* Author for correspondence (e-mail: daletc{at}cardiff.ac.uk)

Dishevelled family proteins are multidomain intracellular transducers of Wnt signals. Ectopically expressed mammalian Dishevelled 2 (Dvl-2) activates downstream signalling and localises to cytoplasmic puncta. It has been suggested that these Dvl-2-containing structures correspond to intracellular vesicles and may be involved in the Wnt signal transduction process. We report that cytoplasmic puncta are primarily formed in cells expressing Dvl-2 at high levels. Lower levels of expression can activate signalling without forming puncta. The structures do not localise with markers of the early or late endocytic pathway and time-lapse analysis demonstrates that Dvl-2 puncta move in a random fashion over short distances but do not originate from the plasma membrane. Based on our findings, we propose that Dvl-2 puncta are protein aggregates that are not required for signalling.
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