spacer gif spacer gif spacer gif spacer gif Propose a workshop for 2011 spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search    

The fully linked HTML version of this article has now been published.
JCS ePress online publication date 22 Nov 2005
doi: 10.1242/jcs.02679

This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
jcs.02679v1
118/24/5699    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Votin, V.
Right arrow Articles by Barth, A. I.M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Votin, V.
Right arrow Articles by Barth, A. I.M.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Research Article

Neurite outgrowth involves adenomatous polyposis coli protein and {beta}-catenin


Violet Votin, W. James Nelson, and Angela I.M. Barth*
* Author for correspondence (e-mail: angelab{at}stanford.edu)

Neuronal morphogenesis involves the initial formation of neurites and then differentiation of neurites into axons and dendrites. The mechanisms underlying neurite formation are poorly understood. A candidate protein for controlling neurite extension is the adenomatous polyposis coli (APC) protein, which regulates membrane extensions, microtubules and {beta}-catenin-mediated transcription downstream of Wnt signaling. APC is enriched at the tip of several neurites of unpolarized hippocampal neurons and the tip of only the long axon in polarized hippocampal neurons. Significantly, APC localized to the tip of only one neurite, marked by dephospho-tau as the future axon, before that neurite had grown considerably longer than other neurites. To determine whether neurite outgrowth was affected by {beta}-catenin accumulation and signaling, a stabilized {beta}-catenin mutant was expressed in PC12 cells, and neurite formation was measured. Stabilized {beta}-catenin mutants accumulated in APC clusters and inhibited neurite formation and growth. Importantly, these effects were also observed was independently of the gene transcriptional activity of {beta}-catenin. These results indicate that APC is involved in both early neurite outgrowth and increased growth of the future axon, and that {beta}-catenin has a structural role in inhibiting APC function in neurite growth.
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 JCBHome page
N. M. Rusan, K. Akong, and M. Peifer
Putting the model to the test: are APC proteins essential for neuronal polarity, axon outgrowth, and axon targeting?
J. Cell Biol., October 20, 2008; 183(2): 203 - 212.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
S. A. Purro, L. Ciani, M. Hoyos-Flight, E. Stamatakou, E. Siomou, and P. C. Salinas
Wnt Regulates Axon Behavior through Changes in Microtubule Growth Directionality: A New Role for Adenomatous Polyposis Coli
J. Neurosci., August 20, 2008; 28(34): 8644 - 8654.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
Y. Endo, E. Beauchamp, D. Woods, W. G. Taylor, J. A. Toretsky, A. Uren, and J. S. Rubin
Wnt-3a and Dickkopf-1 Stimulate Neurite Outgrowth in Ewing Tumor Cells via a Frizzled3- and c-Jun N-Terminal Kinase-Dependent Mechanism
Mol. Cell. Biol., April 1, 2008; 28(7): 2368 - 2379.
[Abstract] [Full Text] [PDF]

Home page
 JCBHome page
H. Witte, D. Neukirchen, and F. Bradke
Microtubule stabilization specifies initial neuronal polarization
J. Cell Biol., February 6, 2008; 180(3): 619 - 632.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
M. P. Koester, O. Muller, and G. E. Pollerberg
Adenomatous Polyposis Coli Is Differentially Distributed in Growth Cones and Modulates Their Steering
J. Neurosci., November 14, 2007; 27(46): 12590 - 12600.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
G. G. Farias, A. S. Valles, M. Colombres, J. A. Godoy, E. M. Toledo, R. J. Lukas, F. J. Barrantes, and N. C. Inestrosa
Wnt-7a Induces Presynaptic Colocalization of {alpha}7-Nicotinic Acetylcholine Receptors and Adenomatous Polyposis Coli in Hippocampal Neurons
J. Neurosci., May 16, 2007; 27(20): 5313 - 5325.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Biol. CellHome page
K. Kroboth, I. P. Newton, K. Kita, D. Dikovskaya, J. Zumbrunn, C. M. Waterman-Storer, and I. S. Nathke
Lack of Adenomatous Polyposis Coli Protein Correlates with a Decrease in Cell Migration and Overall Changes in Microtubule Stability
Mol. Biol. Cell, March 1, 2007; 18(3): 910 - 918.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
A. Gartner, X. Huang, and A. Hall
Neuronal polarity is regulated by glycogen synthase kinase-3 (GSK-3{beta}) independently of Akt/PKB serine phosphorylation
J. Cell Sci., October 1, 2006; 119(19): 3927 - 3934.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. Sharma, L. Leung, M. Brocardo, J. Henderson, C. Flegg, and B. R. Henderson
Membrane Localization of Adenomatous Polyposis Coli Protein at Cellular Protrusions: TARGETING SEQUENCES AND REGULATION BY beta-CATENIN
J. Biol. Chem., June 23, 2006; 281(25): 17140 - 17149.
[Abstract] [Full Text] [PDF]


© The Company of Biologists Ltd 2005