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JCS ePress online publication date 28 Feb 2006
doi: 10.1242/jcs.02820

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Research Article

The Cdc14p phosphatase affects late cell-cycle events and morphogenesis in Candida albicans


Andrés Clemente-Blanco, Alberto González-Novo, Félix Machín, David Caballero-Lima, Luis Aragón, Miguel Sánchez, Carlos R. Vázquez de Aldana, Javier Jiménez, and Jaime Correa-Bordes*
* Author for correspondence (e-mail: jcorrea{at}unex.es)

We have characterized the CDC14 gene, which encodes a dual-specificity protein phosphatase in Candida albicans, and demonstrated that its deletion results in defects in cell separation, mitotic exit and morphogenesis. The C. albicans cdc14{Delta} mutants formed large aggregates of cells that resembled those found in ace2-null strains. In cdc14{Delta} cells, expression of Ace2p target genes was reduced and Ace2p did not accumulate specifically in daughter nuclei. Taken together, these results imply that Cdc14p is required for the activation and daughter-specific nuclear accumulation of Ace2p. Consistent with a role in cell separation, Cdc14p was targeted to the septum region during the M-G1 transition in yeast-form cells. Interestingly, hypha-inducing signals abolished the translocation of Cdc14p to the division plate, and this regulation depended on the cyclin Hgc1p, since hgc1{Delta} mutants were able to accumulate Cdc14p in the septum region of the germ tubes. In addition to its role in cytokinesis, Cdc14p regulated mitotic exit, since synchronous cultures of cdc14{Delta} cells exhibited a severe delay in the destruction of the mitotic cyclin Clb2p. Finally, deletion of CDC14 resulted in decreased invasion of solid agar medium and impaired true hyphal growth.
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