spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search    

The fully linked HTML version of this article has now been published.
JCS ePress online publication date 3 May 2007
doi: 10.1242/jcs.03462

This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
jcs.03462v1
120/12/1959    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Putney Jr, J. W.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Putney Jr, J. W.

Commentary

New molecular players in capacitative Ca2+ entry


James W. Putney Jr*
* Author for correspondence (e-mail: putney{at}niehs.nih.gov)

Capacitative Ca2+ entry links the emptying of intracellular Ca2+ stores to the activation of store-operated Ca2+ channels in the plasma membrane. In the twenty years since the inception of the concept of capacitative Ca2+ entry, a number of activation mechanisms have been proposed, and there has been considerable interest in the possibility that TRP channels function as store-operated channels. However, in the past two years, two major players in both the signaling and permeation mechanisms for store-operated channels have been discovered: Stim1 and the Orai proteins. Stim1 is an endoplasmic reticulum Ca2+ sensor. It appears to act by redistributing within a small component of the endoplasmic reticulum, approaching the plasma membrane, but does not seem to translocate into the plasma membrane. Stim1 signals to plasma membrane Orai proteins, which constitute pore-forming subunits of store-operated channels.


This article has been cited by other articles:


Home page
 Mol. Cell. Biol.Home page
Y. Gwack, S. Srikanth, M. Oh-hora, P. G. Hogan, E. D. Lamperti, M. Yamashita, C. Gelinas, D. S. Neems, Y. Sasaki, S. Feske, et al.
Hair Loss and Defective T- and B-Cell Function in Mice Lacking ORAI1
Mol. Cell. Biol., September 1, 2008; 28(17): 5209 - 5222.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
W. I. DeHaven, J. T. Smyth, R. R. Boyles, G. S. Bird, and J. W. Putney Jr.
Complex Actions of 2-Aminoethyldiphenyl Borate on Store-operated Calcium Entry
J. Biol. Chem., July 11, 2008; 283(28): 19265 - 19273.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
V. M. Bolotina
Orai, STIM1 and iPLA2{beta}: a view from a different perspective
J. Physiol., July 1, 2008; 586(13): 3035 - 3042.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Biol. CellHome page
V. A. Barr, K. M. Bernot, S. Srikanth, Y. Gwack, L. Balagopalan, C. K. Regan, D. J. Helman, C. L. Sommers, M. Oh-hora, A. Rao, et al.
Dynamic Movement of the Calcium Sensor STIM1 and the Calcium Channel Orai1 in Activated T-Cells: Puncta and Distal Caps
Mol. Biol. Cell, July 1, 2008; 19(7): 2802 - 2817.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
S. Borges, S. Lindstrom, C. Walters, A. Warrier, and M. Wilson
Discrete influx events refill depleted Ca2+ stores in a chick retinal neuron
J. Physiol., January 15, 2008; 586(2): 605 - 626.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
R. G. O'Neil
VASP: a TRPC4-associated phosphoprotein that mediates PKG-induced inhibition of store-operated calcium influx
Am J Physiol Renal Physiol, December 1, 2007; 293(6): F1766 - F1767.
[Full Text] [PDF]

Home page
 PhysiologyHome page
A. M. Hofer and K. Lefkimmiatis
Extracellular Calcium and cAMP: Second Messengers as "Third Messengers"?
Physiology, October 1, 2007; 22(5): 320 - 327.
[Abstract] [Full Text] [PDF]


© The Company of Biologists Ltd 2007