Subject collection: Adhesion
- Drosophila p120-catenin is crucial for endocytosis of the dynamic E-cadherin–Bazooka complex
Summary: In Drosophila, p120-catenin facilitates endocytosis of the dynamic E-cadherin, which is followed by its recycling. Consequently, p120-catenin regulates cell shape and promotes the ability of cells to exchange neighbours.
- KIF17 regulates RhoA-dependent actin remodeling at epithelial cell–cell adhesions
Summary: The kinesin KIF17 activates RhoA signaling at cell–cell contacts to regulate junctional actin, the stability of the apical junctional complex and polarization of epithelial cells.
- A tetraspanin regulates septate junction formation in Drosophila midgut
Highlighted Article: A tetraspanin family protein, Tsp2A is an essential component of septate junctions in the Drosophila endodermal epithelia and is involved in intestinal barrier function.
- PP2A binds to the LIM domains of lipoma-preferred partner through its PR130/B″ subunit to regulate cell adhesion and migration
Highlighted Article: The importance of localised regulation of protein dephosphorylation in cell adhesion and migration through demonstration of a new interaction between the LIM protein LPP and PP2A comprising the Bʹʹ/PR130 subunit.
- A novel high-content analysis tool reveals Rab8-driven cytoskeletal reorganization through Rho GTPases, calpain and MT1-MMP
Summary: Rab8 can induce Rac1- and Tiam1-dependent cortical actin polymerization and focal adhesion disassembly through the proteases MT1-MMP and calpain, and Rho-GTPase-dependent mechanisms.
- Vimentin filaments regulate integrin–ligand interactions by binding to the cytoplasmic tail of integrin β3
Summary: Vimentin filaments underneath the plasma membrane might provide integrin-binding sites to mediate integrin clustering, which in turn can enhance integrin–ligand interaction.