Subject collection: Cell Biology and Disease
- Proteasome stress leads to APP axonal transport defects by promoting its amyloidogenic processing in lysosomes
Summary: Proteasome inhibition induces rapid and significant reductions of APP axonal transport towards synapses due to increased cell body amyloidogenic processing of APP in lysosomes.
- Neurochondrin interacts with the SMN protein suggesting a novel mechanism for spinal muscular atrophy pathology
Highlighted Article: The essential neural protein neurochondrin interacts with the spinal muscular atrophy (SMA) protein SMN in cell lines and in mice. This might be relevant to the molecular pathology of SMA.
- The filamin-B–refilin axis – spatiotemporal regulators of the actin-cytoskeleton in development and disease
Summary: Refilins behave as spatiotemporal regulators of the actin-bundling function of filamin and contribute to mechanosensory functions of filamin-B during vertebrate skeletal development.
- Amyloid assembly and disassembly
Summary: This Review showcases important advances in our understanding of amyloid structure, assembly and disassembly, which are inspiring novel therapeutic strategies for amyloid disorders.
- Molecular mobility and activity in an intravital imaging setting – implications for cancer progression and targeting
Summary: Intravital imaging approaches in mice are reviewed with a focus on cancer progression and treatment, where it offers detailed insight into the dynamic interactions between cancer cells and their microenvironment in vivo.
- Regulation of profibrotic responses by ADAM17 activation in high glucose requires its C-terminus and FAK
Summary: ADAM17 mediates fibrosis in diabetic kidney disease. The ADAM17 C-terminus and its phosphorylation at two sites are crucial for enzyme activation and the profibrotic response to high glucose.
- From the unfolded protein response to metabolic diseases – lipids under the spotlight
Summary: This Review focuses on the role of lipid bilayer stress-induced UPR in ER homeostasis and discusses the sensing mechanism and its contribution to metabolic diseases.
- Recent insights into the cellular and molecular determinants of aging
Summary: This Review highlights the recent advance in identifying various factors that affect the aging process, focusing on how these determinants affect cell lifespan and the fitness of an organism.
- The CCR2 3′UTR functions as a competing endogenous RNA to inhibit breast cancer metastasis
Summary: The CCR2 3′UTR acts as a metastasis suppressor by acting as a competing endogenous RNA for STARD13 and thus inhibiting activation of the RhoA–ROCK1–MLC–F-actin pathway in breast cancer cells.
- The prion protein regulates glutamate-mediated Ca2+ entry and mitochondrial Ca2+ accumulation in neurons
Summary: The cellular prion protein (PrPC) controls neuronal Ca2+ entry through ionotropic glutamate receptors and attenuates the process of Ca2+-induced Ca2+ release (CICR), which in turn limits mitochondrial Ca2+ uptake.