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Subject collection: Cell Biology and Disease

  • RESEARCH ARTICLE
    Neurochondrin interacts with the SMN protein suggesting a novel mechanism for spinal muscular atrophy pathology
    Luke W. Thompson, Kim D. Morrison, Sally L. Shirran, Ewout J. N. Groen, Thomas H. Gillingwater, Catherine H. Botting, Judith E. Sleeman
    J Cell Sci 2018 131: jcs211482 doi: 10.1242/jcs.211482 Published 17 April 2018

    Highlighted Article: The essential neural protein neurochondrin interacts with the spinal muscular atrophy (SMA) protein SMN in cell lines and in mice. This might be relevant to the molecular pathology of SMA.

  • REVIEW
    The filamin-B–refilin axis – spatiotemporal regulators of the actin-cytoskeleton in development and disease
    Jacques Baudier, Zandra A. Jenkins, Stephen P. Robertson
    J Cell Sci 2018 131: jcs213959 doi: 10.1242/jcs.213959 Published 13 April 2018

    Summary: Refilins behave as spatiotemporal regulators of the actin-bundling function of filamin and contribute to mechanosensory functions of filamin-B during vertebrate skeletal development.

  • REVIEW
    Amyloid assembly and disassembly
    Edward Chuang, Acacia M. Hori, Christina D. Hesketh, James Shorter
    J Cell Sci 2018 131: jcs189928 doi: 10.1242/jcs.189928 Published 13 April 2018

    Summary: This Review showcases important advances in our understanding of amyloid structure, assembly and disassembly, which are inspiring novel therapeutic strategies for amyloid disorders.

  • REVIEW
    Molecular mobility and activity in an intravital imaging setting – implications for cancer progression and targeting
    Max Nobis, Sean C. Warren, Morghan C. Lucas, Kendelle J. Murphy, David Herrmann, Paul Timpson
    J Cell Sci 2018 131: jcs206995 doi: 10.1242/jcs.206995 Published 6 March 2018

    Summary: Intravital imaging approaches in mice are reviewed with a focus on cancer progression and treatment, where it offers detailed insight into the dynamic interactions between cancer cells and their microenvironment in vivo.

  • RESEARCH ARTICLE
    Regulation of profibrotic responses by ADAM17 activation in high glucose requires its C-terminus and FAK
    Renzhong Li, Tony Wang, Khyati Walia, Bo Gao, Joan C. Krepinsky
    J Cell Sci 2018 131: jcs208629 doi: 10.1242/jcs.208629 Published 20 February 2018

    Summary: ADAM17 mediates fibrosis in diabetic kidney disease. The ADAM17 C-terminus and its phosphorylation at two sites are crucial for enzyme activation and the profibrotic response to high glucose.

  • REVIEW
    From the unfolded protein response to metabolic diseases – lipids under the spotlight
    Nurulain Ho, Chengchao Xu, Guillaume Thibault
    J Cell Sci 2018 131: jcs199307 doi: 10.1242/jcs.199307 Published 8 February 2018

    Summary: This Review focuses on the role of lipid bilayer stress-induced UPR in ER homeostasis and discusses the sensing mechanism and its contribution to metabolic diseases.

  • REVIEW
    Recent insights into the cellular and molecular determinants of aging
    Linhao Ruan, Xi Zhang, Rong Li
    J Cell Sci 2018 131: jcs210831 doi: 10.1242/jcs.210831 Published 2 February 2018

    Summary: This Review highlights the recent advance in identifying various factors that affect the aging process, focusing on how these determinants affect cell lifespan and the fitness of an organism.

  • RESEARCH ARTICLE
    The CCR2 3′UTR functions as a competing endogenous RNA to inhibit breast cancer metastasis
    Jinhang Hu, Xiaoman Li, Xinwei Guo, Qianqian Guo, Chenxi Xiang, Zhiting Zhang, Yingying Xing, Tao Xi, Lufeng Zheng
    J Cell Sci 2017 130: 3399-3413; doi: 10.1242/jcs.202127

    Summary: The CCR2 3′UTR acts as a metastasis suppressor by acting as a competing endogenous RNA for STARD13 and thus inhibiting activation of the RhoA–ROCK1–MLC–F-actin pathway in breast cancer cells.

  • RESEARCH ARTICLE
    The prion protein regulates glutamate-mediated Ca2+ entry and mitochondrial Ca2+ accumulation in neurons
    Agnese De Mario, Caterina Peggion, Maria Lina Massimino, Francesca Viviani, Angela Castellani, Marta Giacomello, Dmitry Lim, Alessandro Bertoli, Maria Catia Sorgato
    J Cell Sci 2017 130: 2736-2746; doi: 10.1242/jcs.196972

    Summary: The cellular prion protein (PrPC) controls neuronal Ca2+ entry through ionotropic glutamate receptors and attenuates the process of Ca2+-induced Ca2+ release (CICR), which in turn limits mitochondrial Ca2+ uptake.

  • RESEARCH ARTICLE
    Dysferlin mediates membrane tubulation and links T-tubule biogenesis to muscular dystrophy
    Julia Hofhuis, Kristina Bersch, Ronja Büssenschütt, Marzena Drzymalski, David Liebetanz, Viacheslav O. Nikolaev, Stefan Wagner, Lars S. Maier, Jutta Gärtner, Lars Klinge, Sven Thoms
    J Cell Sci 2017 130: 841-852; doi: 10.1242/jcs.198861

    Summary: The dysferlin protein is directly involved in the morphogenesis of the T-tubule system, suggesting a new model for the molecular pathology of dysferlin-dependent muscular dystrophy.

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