Subject collection: Cell Biology and Disease
- Message in a vesicle – trans-kingdom intercommunication at the vector–host interface
Summary: Extracellular vesicles mediate intra- and inter-kingdom cellular communication. This Review examines the emerging theme of extracellular vesicles directing arthropod physiology, microbial pathogenesis and host immunity.
- Nuclear RNA foci from C9ORF72 expansion mutation form paraspeckle-like bodies
Summary: (G4C2)n repeat RNA, associated with frontotemporal dementia and amyotrophic lateral sclerosis, predominantly forms paraspeckle-like bodies independently of the known paraspeckle scaffold, the long non-coding RNA NEAT1.
- Atrophy, oxidative switching and ultrastructural defects in skeletal muscle of the ataxia telangiectasia mouse model
Summary: A skeletal muscle defect is revealed as novel phenotype of Atm-knockout mice, which is relevant for ataxia telangiectasia disease studies and for the role of ATM in oxidative stress, atrophy and aging.
- Differential YAP expression in glioma cells induces cell competition and promotes tumorigenesis
Summary: This study reveals a functional consequence of intratumor heterogeneity in YAP expression, and suggests that tumorigenesis benefits from competitive interactions between heterogeneous tumor cells.
- Desmoglein 2 mutation provokes skeletal muscle actin expression and accumulation at intercalated discs in murine hearts
Summary: By examining desmosomal cadherin-mutant mice, a link between SRF-activation and ectopic skeletal muscle actin expression is described as a novel mechanism during arrhythmogenic cardiomyopathy pathogenesis.
- Tau regulates the microtubule-dependent migration of glioblastoma cells via the Rho-ROCK signaling pathway
Summary: Tau governs remodeling of microtubule and actin networks during the tail retraction phase in migrating U87 cells. It also controls the Rho-ROCK signaling via relocation of p190-RhoGAP and FAK proteins.
- Influence of the extracellular matrix on cell-intrinsic circadian clocks
Summary: Cells in metazoans live within, and interact with, their local extracellular microenvironment. This Review summarises how the extracellular matrix affects the circadian timekeeping mechanism within different cells.
- Lysosomal storage disorders – challenges, concepts and avenues for therapy: beyond rare diseases
Summary: A critical review of the current knowledge on the cellular processes involved in lysosomal storage disorders. How understanding of these rare disorders could be applied to more common diseases is discussed.
- The connexin 30 A88V mutant reduces cochlear gap junction expression and confers long-term protection against hearing loss
Summary: The Clouston syndrome-causing connexin 30 mutant (Cx30-A88V) provides long-term protection against age-related hair cell death and hearing loss in mice.