Subject collection: Establishing Polarity
- Attenuation of N-glycosylation causes polarity and adhesion defects in the C. elegans embryo
Summary: Upon reduction of N-glycosylation, E-cadherin is not efficiently localized in the cell–cell contact site contributing to adhesion defects in the two-cell C. elegans embryo. This phenotype is rescued by concomitant loss of cell polarity.
- Development and dynamics of cell polarity at a glance
Summary: Cell- and tissue-polarity protein complexes are modular and generate diverse types of polarity, including epithelial, migratory and stem cell polarities, and contribute to cell fate specification.
- The polarity protein Scribble positions DLC3 at adherens junctions to regulate Rho signaling
Highlighted Article: A previously unrecognized PDZ ligand motif in the RhoGAP protein DLC3 is shown to direct the protein to adherens junctions through interaction with the polarity protein Scribble, where it locally regulates RhoA.
- Shot and Patronin polarise microtubules to direct membrane traffic and biogenesis of microvilli in epithelia
Summary: In Drosophila, microtubules are polarised along the apical-basal axis of epithelial cells by the concerted action of Shot and Patronin, two apically localised microtubule binding proteins.
- Scribble is required for pregnancy-induced alveologenesis in the adult mammary gland
Highlighted Article: SCRIB has been identified as a negative regulator of proliferation. However, SCRIB is also required for epithelial proliferation during pregnancy-induced alveologenesis, likely by regulating cell surface levels of prolactin receptor.