Subject collection: Imaging Research Articles
- Dictyostelium EHD associates with Dynamin and participates in phagosome maturation
Highlighted Article: EHD proteins play regulatory functions in the endocytic pathway. We reveal that D. discoideum EHD interacts with Dynamin and controls intraphagosomal proteolysis and pH dynamics during phagosome maturation.
- Two classes of short intraflagellar transport train with different 3D structures are present in Chlamydomonas flagella
Highlighted article: In-depth analyses of IFT train ultrastructure in regenerating Chlamydomonas flagella shows the occurrence of three train types with different 3D structure, implicating differences in function.
- Optogenetic activation reveals distinct roles of PIP3 and Akt in adipocyte insulin action
Summary: Optogenetic activation with new PI3K and Akt probes support that both Akt-dependent and Akt-independent pathways are necessary for consistent GLUT4 translocation.
- Together, the IFT81 and IFT74 N-termini form the main module for intraflagellar transport of tubulin
Summary: Tubulin transport is specifically impaired by mutations to the proposed tubulin-binding domains of the intraflagellar transport proteins IFT81 and IFT74.
- The effects of ER morphology on synaptic structure and function in Drosophila melanogaster
Highlighted Article: The ER within Drosophila motor nerve terminals forms a network of tubules. Loss of the fusion GTPase atlastin fragments synaptic ER. Alteration of ER structure decreases evoked neurotransmitter release.
- Influenza A virus ribonucleoproteins modulate host recycling by competing with Rab11 effectors
Summary: Binding of influenza A virus ribonucleoproteins to the recycling endosome modulates its function, decreasing its sorting efficiency and inducing vesicular clustering.
- Docking-complex-independent alignment of Chlamydomonas outer dynein arms with 24-nm periodicity in vitro
Summary: Axonemal outer dynein arms can form 24-nm repeats by themselves without docking complexes. The docking complex is likely to be a flexible scaffold rather than a molecular ruler.
- Transmembrane protein TMEM170A is a newly discovered regulator of ER and nuclear envelope morphogenesis in human cells
Highlighted Article: TMEM170A is a human ER and nuclear envelope transmembrane protein. Down- and overexpression induce tubular or sheet ER formation, respectively, indicating that TMEM170A is a newly discovered ER-sheet-promoting protein.
- A tetraspanin regulates septate junction formation in Drosophila midgut
Highlighted Article: A tetraspanin family protein, Tsp2A is an essential component of septate junctions in the Drosophila endodermal epithelia and is involved in intestinal barrier function.
- SHIP2 controls plasma membrane PI(4,5)P2 thereby participating in the control of cell migration in 1321 N1 glioblastoma cells
Highlighted Article: SHIP2 modulates the balance between PI(4,5)P2 and PI4P, thereby participating in the control of migration in 1321 N1 glioblastoma cells through the organization of focal adhesions.