Subject collection: Invadopodia and Podosomes
- The CD44s splice isoform is a central mediator for invadopodia activity
Summary: CD44s, a splice isoform of the cell surface molecule CD44, plays an essential role in invadopodia activity and, consequently, metastasis during cancer progression.
- The microenvironment controls invadosome plasticity
Summary: This Commentary defines invadosomes and illustrates their plasticity, which depends on various factors, including the matrix microenvironment.
- VEGF-A stimulates podosome-mediated collagen-IV proteolysis in microvascular endothelial cells
Highlighted Article: In microvascular endothelial cells, basement membrane proteins are key determinants of podosome induction and function in response to the canonical angiogenic factor VEGF-A.
- Sorting nexin 9 negatively regulates invadopodia formation and function in cancer cells
Summary: SNX9, differentially regulated by Src, alters the ability of cancer cells to degrade the matrix through regulation of MT1-MMP internalization and/or invadopodia formation and function.
- Talin2-mediated traction force drives matrix degradation and cell invasion
Summary: Talin2, previously presumed to function redundantly with talin1, binds to β integrins more strongly than talin1, and generates traction force to regulate invadopodium formation and cell invasion.
- The role and regulation of Rab40b–Tks5 complex during invadopodia formation and cancer cell invasion
Highlighted Article: Rab40b plays a key role in mediating invadopodia function during breast cancer cell invasion by binding to Tks5 and functioning as a tether mediating MMP2 and MMP9 targeting to the extending invadopodia.