Subject collection: Mechanotransduction
- The focal adhesion targeting domain of p130Cas confers a mechanosensing function
- Cellular strain avoidance is mediated by a functional actin cap – observations in an Lmna-deficient cell model
Summary: The strain avoidance response of cells lacking a functional actin cap, such as in Lmna-deficient cells, is impaired. This suggests a crucial role for the actin cap in strain responsiveness.
- ICAP-1 monoubiquitylation coordinates matrix density and rigidity sensing for cell migration through ROCK2–MRCKα balance
Summary: ICAP-1 monoubiquitylation by Smurf1 coordinates fibronectin matrix density and rigidity sensing for cell migration by promoting the switch from a ROCK2- to an MRCKα-mediated contractility pathway.
- α-Catenin stabilises Cadherin–Catenin complexes and modulates actomyosin dynamics to allow pulsatile apical contraction
Highlighted Article: We analyse the function of α-Catenin, a key mechanosensory protein transmitting actomyosin cytoskeletal tension to the cell membrane, in promoting and stabilising apical contraction during dorsal closure in Drosophila.
- MEKK1-dependent phosphorylation of calponin-3 tunes cell contractility
Summary: Phosphorylation of calponin-3 by MEKK1, which is regulated by actomyosin contraction, leads to an increase in cell-generated traction stress, forming a new positive-feedback loop in the cellular contractile machinery.
- Cadherin-11 is a novel regulator of extracellular matrix synthesis and tissue mechanics
Summary: CDH11 regulates collagen and elastin synthesis by both affecting the mechanical properties and contractile function of animal tissues through TGF-β and ROCK pathways.
- Innervation regulates synaptic ribbons in lateral line mechanosensory hair cells
Summary: Hearing and balance rely on mechanosensory hair cell synaptogenesis. Our data shows that innervation is crucial for formation of ribbons, the scaffolding structures that tether synaptic vesicles at the presynaptic site of hair cells.
- Mechanical signals regulate and activate SNAIL1 protein to control the fibrogenic response of cancer-associated fibroblasts
Highlighted article: SNAIL1 is a mechanoresponsive regulator of the fibrogenic response of tumors. The work provides insight into the transcriptional response of tumors to their microenvironment and CAF activation to sustain tumor fibrogenesis.
- E-cadherin-mediated force transduction signals regulate global cell mechanics
Summary: Force transduction at E-cadherin junctions operates in addition to unfurling of cadherin-associated α-catenin. This pathway requires EGFR and triggers the downstream activation of integrin-dependent cell contractility.