Subject collection: Mitochondria
- Mitochondrial depolarization in yeast zygotes inhibits clonal expansion of selfish mtDNA
Summary: Uncouplers activate mitochondrial degradation in heteroplasmic yeast zygotes and prevent clonal expansion of selfish mitochondrial DNA. This effect requires mitochondrial fission and autophagy.
- Mouse Stbd1 is N-myristoylated and affects ER–mitochondria association and mitochondrial morphology
Highlighted Article: The glycogen-binding protein Stbd1 is N-myristoylated and targeted to ER–mitochondria contact sites. Stbd1 loss- or gain-of-function affects ER–mitochondria association and mitochondrial morphology.
- Sideroflexin 3 is an α-synuclein-dependent mitochondrial protein that regulates synaptic morphology
Summary: Comparative proteomics revealed that mitochondrial proteins are a major target for α-synuclein. Sideroflexin 3 (SFXN3) was identified as one α-synuclein-dependent mitochondrial protein capable of altering synaptic morphology in vivo.
- Diverting CERT-mediated ceramide transport to mitochondria triggers Bax-dependent apoptosis
Highlighted Article: This work shows that mitochondrial translocation of ER ceramides specifically induces apoptosis and highlights a novel approach for probing compartment-specific functions of these biomolecules as key determinants of cell fate.
- The N-terminus of survivin is a mitochondrial-targeting sequence and Src regulator
Summary: The proline-rich N-terminal ten amino acids of survivin is a mitochondrial-targeting domain and a regulator of the proto-oncogene Src. Hence, survivin could act in concert with Src to promote tumorigenesis.
- CCN6 regulates mitochondrial function
Summary: CCN6, or Wnt-induced signaling protein 3 (WISP3), regulates mitochondrial electron transport and ATP synthesis. The influence of CCN6 on mitochondrial function might impact cell growth and differentiation.
- Cooperative and independent roles of the Drp1 adaptors Mff, MiD49 and MiD51 in mitochondrial fission
Highlighted Article: MiD51 and Mff coordinate and regulate the action of Drp1 at the mitochondrial outer membrane during homeostatic mitochondrial fission, as assessed with gene-editing technology.
- Appoptosin interacts with mitochondrial outer-membrane fusion proteins and regulates mitochondrial morphology
Summary: Overexpression of the pro-apoptotic protein appoptosin impairs interaction of the mitochondrial fusion proteins MFN1 and MFN2, and reduces mitochondrial fusion activity, leading to mitochondrial fragmentation.