Subject collection: Stem Cells
- Non-muscle myosin II in disease: mechanisms and therapeutic opportunities
Summary: Non-muscle myosin II (NMII) contributes to diverse diseases, including neuronal disorders, cancer and vascular disease. We address the role of NMII in disease pathology and highlight promising clinical applications of NMII inhibitors for disease and stem-cell-based therapies.
- Human umbilical cord matrix-derived stem cells exert trophic effects on β-cell survival in diabetic rats and isolated islets
Summary: The newly identified paracrine role of umbilical cord stem cells highlights their therapeutic utilities to treat not only the autoimmune-mediated type 1 diabetes but also type 2 diabetes.
- Xenobiotics that affect oxidative phosphorylation alter differentiation of human adipose-derived stem cells at concentrations that are found in human blood
Summary: Some medical drugs and environmental chemical pollutants acting on the oxidative phosphorylation system can alter adipocyte differentiation and adipogenesis and, thus, have important consequences for human health.
- ALS mutant FUS proteins are recruited into stress granules in induced pluripotent stem cell-derived motoneurons
Summary: Mutated FUS protein is aberrantly delocalized and recruited into stress granules in iPSC-derived motoneurons, which provide a new model system for amyotrophic lateral sclerosis.
- Cellular models and therapies for age-related macular degeneration
Summary: Here, we discuss the emerging cell-culture models and potential stem-cell-based therapies for AMD, a blinding disorder that affects millions of people worldwide.