Subject collection: Ubiquitin
- Derlin-1 promotes ubiquitylation and degradation of the epithelial Na+ channel, ENaC
Summary: Derlin-1 binds to ENaC and promotes its ubiquitylation and degradation via ER-related degradation. The E3 ligase HUWE1 is required and adds K11-linked ubiquitin chains to ENaC prompting its degradation.
- Characterization of the mammalian family of DCN-type NEDD8 E3 ligases
Highlighted Article: The mammalian DCN-type NEDD8 E3 ligases (DCNL1–5) have overlapping and unique functions that might be related to their subcellular distribution and are mostly governed by their unique N-termini.
- REV1 promotes PCNA monoubiquitylation through interacting with ubiquitylated RAD18
Summary: Monoubiquitylation (mUb) of PCNA is a crucial event coordinating DNA damage tolerance pathways. We report here that translesion synthesis polymerase REV1 can promote PCNA–mUb through its preferential association with RAD18–mUb.
- Ubiquitin chain diversity at a glance
Summary: In this Cell Science at a Glance article and accompanying poster, an update is provided on the complexity of ubiquitin chains and their physiological relevance.